The Opportunity

Reporting to the SVP, Human Resources and Talent Acquisition, the Senior Director, HR Business Partner (HRBP) for the Commercial Organization is a strategic leadership role responsible for partnering closely with the Chief Commercial Officer (CCO) and Commercial Leadership Team to build, scale, and optimize a high-performing commercial function. This individual will serve as a trusted advisor, aligning people strategies with business objectives to support the successful transition to and execution of commercialization, including both corporate and field-based teams.

This role will be hired in advance of commercial scale-up and top-line data, within a lean and evolving organization. While the primary focus is supporting the Commercial function, the Senior Director will initially operate as a broad HR Business Partner across the enterprise, flexing support across Clinical, Technical Operations, and G&A as needed. This role requires comfort operating in a highly dynamic, resource-constrained environment, with the ability to balance strategic leadership with hands-on execution. 

As the organization evolves through key clinical and commercial milestones, this role is expected to scale in scope and impact, transitioning from a broad, hands-on HR Business Partner role to a more dedicated commercial HR leadership position.

Responsibilities

Strategic Partnership & Leadership

• Serve as the primary HR partner to the CCO and Commercial Leadership Team, providing strategic counsel on organizational effectiveness, talent, and culture
• Contribute to the development and execution of the commercial strategy by aligning HR initiatives with business priorities
• Act as a thought partner on scaling the organization from pre-commercial to fully commercial operations

Organizational Design & Build-Out

• Lead the design and implementation of the commercial organizational structure, including headquarters and field-based teams (e.g., sales, market access, patient services, marketing)
• Support workforce planning aligned to launch readiness, market expansion, and long-term growth
• Drive role clarity, spans and layers optimization, and organizational efficiency

Talent Strategy & Development

• Partner with leadership to attract, retain, and develop top commercial talent, including building leadership capability across the organization
• Guide succession planning and leadership development initiatives
• Coach senior leaders on performance management, team effectiveness, and change leadership

Performance & Compensation

• Collaborate with Total Rewards to design and implement competitive compensation and incentive programs aligned with commercial goals (including sales incentives and LTI structures)
• Support performance management processes aligned to corporate and commercial objectives, ensuring the foundational elements of a high-performing commercial culture are in place, including clear goal-setting, accountability, and differentiated performance outcomes

Culture & Employee Experience

• Champion a high-performance, patient-centric culture aligned with company values
• Lead change management initiatives to support rapid growth and evolving business needs
• Ensure strong employee engagement across both corporate and geographically dispersed field teams

Employee Relations & Compliance

• Provide guidance on complex employee relations matters with sound judgment and business alignment
• Ensure compliance with all applicable employment laws and company policies, particularly within a distributed field organization

Required Qualifications

• Bachelor’s degree in Human Resources, Business Administration, or related field required; Master’s degree (MBA, MS, or equivalent) strongly preferred
• Minimum of 15+ years of progressive HR experience, including significant HR Business Partner leadership roles
• Demonstrated experience partnering with a Chief Commercial Officer and senior commercial leadership in building and scaling commercial organizations while being willing to operate beyond a single function and support enterprise-wide needs
• Proven success supporting both corporate and field-based teams, including sales organizations
• Experience within biotechnology or pharmaceutical industry required; rare disease experience strongly preferred
• Comfortable navigating ambiguity and shifting priorities, with a willingness to take on both strategic and hands-on HR responsibilities across multiple functions
• Deep expertise in organizational design, talent management, and change leadership in high-growth environments
• Strong business acumen with the ability to translate strategy into actionable HR initiatives

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis.  Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis.
• When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.