Position Overview:

Beam is seeking a highly motivated individual to join our Supply Chain team. The Supply Planning & Network leader will be responsible managing the global supply network performance by conducting risk-based inventory reviews and developing strategic options to address demand uncertainties and enhance network capabilities. He/she will be accountable to ensure uninterrupted supply of clinical and future commercial products via Beam’s S&OP process. This role will report to the Sr. Director of Global Supply Chain Planning and partner with TechOps, Clinical Ops, Commercial Patient Ops, Quality, Finance, and CMC teams to lead short-term integrated production planning and long-range strategic supply chain planning of Beam’s product portfolio. The role will be responsible for leading a global inventory management program to ensure critical material availability at Beam NC & CDMO mfg sites. The role will be integral to enhancing site planning and scheduling capabilities at Beam’s mfg site in Durham, NC and partnering with SAP business lead on further advancing technology capabilities. The ideal candidate will have a demonstrated track record of leading in a dynamic environment. They will also possess the ability to successfully interface with multidisciplinary teams and build strong cross functional relationships.

Responsibilities:

• Production & Capacity Planning: Develop and maintain a rolling 12–24-month master production schedule (MPS) aligned with demand forecasts and manufacturing constraints.
• External Network Collaboration: Lead planning and partner with key stakeholders to ensure supply continuity across the Contract Manufacturing Organizations (CMOs) and 3PLs.
• Sales & Operations Planning (S&OP): Drive the monthly S&OP cycle, including rough-cut capacity planning and scenario analysis. Partner cross-functionally to refine demand forecasts and execute supply network analysis to support both tactical and strategic goals.
• Inventory Optimization: Ensures appropriate inventory levels to minimize excess while preventing stockouts, specifically managing shelf-life/expiry for temperature-sensitive products like Critical Materials (pDNA, mRNA, gRNA, mAb, lipids), Drug Substance, and Bulk/Finished Drug Product.
• Clinical/Launch Readiness: Orchestrate supply for clinical trials or support new product introductions (NPI) and commercial launches.
• Risk Management: Proactively identify supply disruptions and develop mitigation strategies or business continuity plans.
• Process Improvement: Drive Global Supply Chain excellence through project management, process enhancement, and the deployment of digital tools that streamline business execution and strategic decision-making.
• Metrics: Leverage data-driven KPIs to track performance, ensuring accountability and optimizing the balance between operational efficiency and financial health.
• Systems: Optimize supply and inventory planning accuracy through utilization of SAP, driving improved stock maintenance and network visibility. Spearhead the design and execution of SAP enhancements, including Integrated Business Planning (IBP) and Jurisdictional Control (JC), to streamline end-to-end supply chain functions.
• Other duties as assigned.

Qualifications:

• BS/BA degree in Business, Science, Engineering or related field with 8-10+ years of experience in global supply chain from pharma, biotech or cell & gene therapy companies.
• Master's degree or MBA preferred.
• Prior drug development, manufacturing, and clinical operations experience is a plus.
• Final title/scope of role will be commensurate with experience.
• Passion for patients, collaborative and effective leader.
• Knowledge of practical implications of Sarbanes-Oxley controls.
• Knowledge of continuous improvement methodologies and tools.
• Strong organizational and facilitation skills, with high degree of customer focus.
• Expertise and track record in manufacturing and supply chain execution and oversight.
• Extensive experience in supply chain planning, SAP ERP system, capacity modeling, supply network strategy and optimization.
• Expertise and have a proven track record in supply chain risk management.
• Solid knowledge of regulatory requirements, regulatory guidance, including pharmaceutical GMPs and ICH guidance.
• Current on Biopharma supply chain, manufacturing technologies, supplier network, CMO network, performance and capacity.
• Possesses understanding and application of principles, concepts, practices, and standards for DS and DP manufacturing in the biopharma industry.
• Strong communication, negotiation, and interpersonal skills.
• Strong analytical skills and ability to clearly communicate at tactical and strategic level with team and Sr Management.
• Ability to work in a dynamic and challenging environment.
• Some travel may be required.
• Must be able to work onsite, not a remote role.

Position Overview:

The Vice President, Compliance is a strategic leader responsible for designing, implementing, and continuously improving the company’s Corporate Compliance Program to oversee promotional materials, field training, and HCP/patient programs. As an objective advisor, the Vice President, Compliance ensures the organization operates with integrity and in compliance with all applicable laws, regulations, and internal policies. Reporting to the Chief Legal Officer, the Vice President, Compliance partners with executive leadership, the legal and compliance function, the Audit Committee of the Board of Directors, and employees at all levels to foster a culture of ethical conduct and accountability.

Beam is transitioning to a commercial stage company, and this position plays a critical role in developing a culture of compliance.  Additionally, ex vivo cell therapy and in vivo gene therapy have unique commercial and operational needs that require a strategic leader to collaborate with commercial, medical, and manufacturing to build a commercial process that delivers for patients compliantly.

Key Responsibilities:

• Develop, execute, and evolve a comprehensive compliance strategy and program focusing on healthcare compliance and aligning with business objectives and legal requirements that meets the unique needs of cell and gene therapy.
• Provide proactive strategic advice to the business to help drive commercial success and ensure compliance with applicable laws and company policies, including federal and state anti-kickback and false claims laws; U.S. and other country anticorruption laws; the federal Food, Drug and Cosmetic Act; and federal and state transparency laws.
• Serve as Chair of the Beam Compliance Committee and as Data Privacy Officer.
• Provide regular updates on the Compliance Program to executive leadership and the Audit Committee of the Board of Directors.
• Review business strategy plans and business development opportunities for compliance risks and advise the business on how to mitigate those risks.
• Develop and maintain trusting relationships with key client groups, such as commercial and clinical, and serve as a trusted and strategic advisor and resource.
• Act as a compliance champion to reinforce a culture of integrity and raise awareness of compliance as a collective responsibility of all company personnel.
• Champion open communication by ensuring employees feel empowered to raise concerns without fear of retaliation.
• Oversee ongoing education initiatives to enhance understanding of the Code of Business Conduct & Ethics, Beam policies and procedures, and emerging compliance risks, and seeking opportunities for continuous learning across the organization.
• Continuously assess the effectiveness of the compliance program through data-driven audits, risk assessments, and performance metrics. Identify gaps and support the design and tracking of corrective actions to strengthen compliance controls.
• Manage and conduct compliance investigations, working with internal business partners to identify appropriate corrective and preventive actions.
• Stay ahead of regulatory and industry code changes and industry and enforcement trends impacting compliance areas and proactively advise leadership on potential impacts and necessary adaptations.
• Serve as a trusted advisor to the Board of Directors, Chief Legal Officer, executive leadership team, and other functions, providing actionable guidance on compliance matters and risk mitigation.
• Engage with outside counsel, regulatory agencies, and industry groups to understand and benchmark the best practices and ensure the compliance regime meets or exceeds industry standards.

Qualifications:

• Bachelor’s degree required, Juris Doctorate or advanced degree a plus.
• Cell and gene therapy experience a must.
• Relevant experience (typically 7 years or more, or equivalent combination of education, training, and experience) with a deep understanding of compliance issues confronting the pharmaceutical/biotech industry.
• Demonstrated knowledge and understanding of the requirements for effective compliance programs as set forth in the OIG Compliance Program Guidance for Pharmaceutical Manufacturers and the U.S. Sentencing Guidelines.
• Demonstrated effectiveness operating in complex organizational and regulatory environments and experience with Code implementation (PhRMA, EFPIA, IFPMA)
• Demonstrated knowledge and understanding of the legal and regulatory framework affecting the pharmaceutical industry including sales and marketing, OIG and other industry guidance documents, regulations on the promotion of marketed products, clinical trial regulations, patient privacy and issues arising under the False Claims Act, anti-bribery/anti-corruption laws, and other related laws.
• Business focused and solution oriented.
• Excellent written, oral and presentation skills.
• Proven ability to work with all levels of management.
• Strong problem-solving and analytical skills.
• Self-motivated and able to perform role independently, with a minimum level of supervision.
• Demonstrated ability to partner effectively with others in addressing complex issues.
• Strong influencing skills and sound business judgment.
• Ability to appropriately prioritize issues.
• Outstanding attention to detail.

The Opportunity

Reporting to the SVP, Human Resources and Talent Acquisition, the Senior Director, HR Business Partner (HRBP) for the Commercial Organization is a strategic leadership role responsible for partnering closely with the Chief Commercial Officer (CCO) and Commercial Leadership Team to build, scale, and optimize a high-performing commercial function. This individual will serve as a trusted advisor, aligning people strategies with business objectives to support the successful transition to and execution of commercialization, including both corporate and field-based teams.

This role will be hired in advance of commercial scale-up and top-line data, within a lean and evolving organization. While the primary focus is supporting the Commercial function, the Senior Director will initially operate as a broad HR Business Partner across the enterprise, flexing support across Clinical, Technical Operations, and G&A as needed. This role requires comfort operating in a highly dynamic, resource-constrained environment, with the ability to balance strategic leadership with hands-on execution. 

As the organization evolves through key clinical and commercial milestones, this role is expected to scale in scope and impact, transitioning from a broad, hands-on HR Business Partner role to a more dedicated commercial HR leadership position.

Responsibilities

Strategic Partnership & Leadership

• Serve as the primary HR partner to the CCO and Commercial Leadership Team, providing strategic counsel on organizational effectiveness, talent, and culture
• Contribute to the development and execution of the commercial strategy by aligning HR initiatives with business priorities
• Act as a thought partner on scaling the organization from pre-commercial to fully commercial operations

Organizational Design & Build-Out

• Lead the design and implementation of the commercial organizational structure, including headquarters and field-based teams (e.g., sales, market access, patient services, marketing)
• Support workforce planning aligned to launch readiness, market expansion, and long-term growth
• Drive role clarity, spans and layers optimization, and organizational efficiency

Talent Strategy & Development

• Partner with leadership to attract, retain, and develop top commercial talent, including building leadership capability across the organization
• Guide succession planning and leadership development initiatives
• Coach senior leaders on performance management, team effectiveness, and change leadership

Performance & Compensation

• Collaborate with Total Rewards to design and implement competitive compensation and incentive programs aligned with commercial goals (including sales incentives and LTI structures)
• Support performance management processes aligned to corporate and commercial objectives, ensuring the foundational elements of a high-performing commercial culture are in place, including clear goal-setting, accountability, and differentiated performance outcomes

Culture & Employee Experience

• Champion a high-performance, patient-centric culture aligned with company values
• Lead change management initiatives to support rapid growth and evolving business needs
• Ensure strong employee engagement across both corporate and geographically dispersed field teams

Employee Relations & Compliance

• Provide guidance on complex employee relations matters with sound judgment and business alignment
• Ensure compliance with all applicable employment laws and company policies, particularly within a distributed field organization

Required Qualifications

• Bachelor’s degree in Human Resources, Business Administration, or related field required; Master’s degree (MBA, MS, or equivalent) strongly preferred
• Minimum of 15+ years of progressive HR experience, including significant HR Business Partner leadership roles
• Demonstrated experience partnering with a Chief Commercial Officer and senior commercial leadership in building and scaling commercial organizations while being willing to operate beyond a single function and support enterprise-wide needs
• Proven success supporting both corporate and field-based teams, including sales organizations
• Experience within biotechnology or pharmaceutical industry required; rare disease experience strongly preferred
• Comfortable navigating ambiguity and shifting priorities, with a willingness to take on both strategic and hands-on HR responsibilities across multiple functions
• Deep expertise in organizational design, talent management, and change leadership in high-growth environments
• Strong business acumen with the ability to translate strategy into actionable HR initiatives

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis.  Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis.
• When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

The Opportunity

The Associate Director, HCP Marketing will be a critical member of the Marketing team and will be responsible for leading the healthcare professional (HCP) engagement strategy to support the launch of avexitide for post-bariatric hypoglycemia (PBH). This role will focus on identifying, understanding and engaging key HCP segments, including thought leaders and early adopters, to build awareness of PBH and the role of avexitide in its treatment. This individual will partner closely with the sales force and field-facing teams, including Thought Leader Liaisons (TLLs), to ensure aligned, educational, and impactful engagement with the HCP community. Through the development of targeted promotional strategies and educational initiatives, this individual will help shape the HCP understanding of PBH, drive informed clinical dialogue and support successful product adoption at launch.

This is a unique opportunity for a strategic, collaborative, and results-oriented HCP marketer to build a high-impact engagement platform in a complex and underserved therapeutic area.

Responsibilities

• Lead the development and execution of the HCP marketing strategy to support the launch of avexitide in the U.S., with a focus on raising awareness and understanding of post-bariatric hypoglycemia (PBH) among key clinical audiences
• Identify and prioritize HCP targets, including early adopters, influencers, and thought leaders, to inform segmentation, messaging, engagement strategies, and opportunities for advisory boards and speaker programs
• Develop and deploy unbranded and branded educational materials and tools, speaker content and engagement tools across personal and non-personal channels to support HCP understanding of PBH and avexitide
• Partner closely with the sales force and TLLs to align on field strategies, deliver compelling resources and ensure consistent and aligned execution across U.S. regions
• Create field-facing resources, engagement tools and training (e.g., leave-behinds, visual aids, digital content, trainings, etc.) that support effective HCP conversations and reinforce key clinical messages
• Lead the planning and execution of HCP-focused conference and symposium activities, including booth presence, branded and unbranded materials, and sponsored programs in collaboration with cross-functional teams
• Drive the planning and execution of advisory boards and speaker program activities, including associated content development
• Oversee tracking of budget accruals, forecasts, and actuals, and ensure successful and timely completion of projects within budget
• Manage the end-to-end process for the development, review / approval, printing, and fulfillment of all HCP-facing materials
• Help manage external agencies and partners to ensure timely, high-quality deliverables that meet agreed-upon objectives, key performance indicators (KPIs), timelines, and budgets
• Ensure compliance with all Medical, Legal, and Regulatory (MLR) requirements in the development and deployment of HCP-facing materials
• Leverage customer and market insights, claims, and performance data to develop insight-driven marketing strategy and content, continuously optimize programs and identify opportunities for innovation

Required Qualifications

• Bachelor’s degree required
• 8+ years of pharmaceutical or biotech experience, with at least 3 years focused on HCP Marketing
• Proven success in developing and executing HCP engagement strategies
• Experience supporting field teams and partnering with Sales, Field Marketing and Thought Leader Liaison to drive brand messaging and education
• Demonstrated ability to translate complex clinical information into clear, compelling promotional messaging for HCP audiences
• Strong project management and organizational skills, with the ability to lead multiple high-priority initiatives simultaneously
• Effectively managing external partners, agencies and budgets
• Navigate Medical, Legal, and Regulatory (MLR) review and approval processes
• Strong communication, strategic thinking, relationship-building skills, and a results-oriented mindset

Preferred Requirements

• Advanced degree; PharmD preferred
• Experience in rare disease or product launch environments
• Familiarity in digital HCP engagement, thought leader strategy and clinically complex therapeutic areas

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

About PhaseV

PhaseV is a Boston-based technology company that redefines clinical development at scale with its enterprise-ready, multi-modal AI/ML platform — accelerating decisions, de-risking trials, and driving more efficient portfolio strategies. With over $65M raised from Accel, Insight, and others, we are poised to make a significant impact on how drugs are developed and brought to market.

Trusted by 45+ pharmaceutical sponsors and CROs, our causal AI technology identifies responder subgroups with greater precision, optimizes trial designs, life cycle management, site selection, and monitors trial performance in real-time to help bring treatments to patients faster. 

The Role

We're hiring our first dedicated marketer to lead our marketing strategy in support of our continued growth.  This is a rare opportunity to continue to architect our brand presence and dramatically expand PhaseV’s share of voice 

You will report to the Head of Strategy and Transformation, and work directly with the PhaseV leadership team to implement marketing strategies that build our sales pipeline, enable our sales team, and generate the target ROI. This includes refining the PhaseV story and pitch, and establishing PhaseV as the category leader in AI-powered clinical development. This role combines strategic thinking with hands-on execution—you'll set the vision and roll up your sleeves to make it happen in partnership with Business Development, Strategy, and Product.

What You'll Own

Pipeline & Lead Generation

• Own marketing’s contribution to pipeline generation in partnership with Business Development and Alliance Management
• Build and continuously improve PhaseV’s lead engine across channels (events, digital campaigns, outbound support, partnerships)
• Develop targeted marketing initiatives to support strategic opportunities
• Define, track, and report key funnel metrics (Marketing QL → Sales QL →Pipeline → Signed)
• Partner with BD to operationalize lead capture and follow-up workflows, ensuring conferences and campaigns convert into active opportunities
• Test and scale new growth experiments (paid LinkedIn, SEO, search/social, email, webinars, newsletter, blog, sponsored content, nurture sequences) to expand top-of-funnel awareness and engagement
• Own marketing attribution and performance analytics to ensure spend translates into measurable commercial outcomes
• Create and manage social media presence, particularly LinkedIn thought leadership

Brand & Narrative

• Develop and execute PhaseV's overall brand, marketing, and PR strategy across all channels
• Craft storytelling that cuts through the complexity of causal ML and clinical trials—moving audiences emotionally, intellectually, and commercially
• Manage external PR agency to secure coverage, speaker opportunities, and category-defining moments
• Own and refine PhaseV's visual brand and identity, managing external designers, as needed
• Ensure our website is built and optimized to serve as the central hub of our brand and engage our audience effectively

Events & Conferences

• Track, prioritize, and manage PhaseV's conference pipeline, standardize pre-/post-event workflows, clearly defined handoffs with conference attendees
• Lead our presence at major industry events from booth strategy to activations to follow-up campaigns
• Maximize commercial outcomes through pre-, during-, and post-event workflows
• Identify and execute ad-hoc opportunities for lead engagement (i.e. organizing sponsor dinners or other side-engagements) 

Cross-Functional Leadership

• Set marketing priorities and plan in partnership with Business Development, Alliance Management, Strategy, and Product teams to ensure message-market alignment
• Define KPI targets and report marketing performance to leadership team and drive marketing decisions
• Identify new business opportunities through market insights and customer feedback
• Define and manage marketing budget in collaboration with Finance

What You Bring

Required Experience

• 6+ years of modern marketing experience in brand, content, digital, or integrated marketing roles, including examples of driving marketing decisions
• 3+ years of exposure to pharmaceuticals, biotech, or healthcare
• Proven track record building brand identity and contributing to sales metrics, ideally at high-velocity startups
• Experience developing and measuring analytically rigorous full-funnel marketing campaigns
• Demonstrated ability to present to and influence executive teams
• Project management expertise in fast-moving, cross-functional environments
• Experience launching innovative products or establishing new market categories

Skills & Attributes

• Builder: Excited to own marketing from zero to one and thrive in a start-up environment
• Operator: You can run multiple workstreams at speed with precision and sound judgment
• Storyteller: You can make complex science and technology commercially compelling  
• Business Partner: Obsessed with pipeline impact and sales enablement
• High Taste Level: You prioritize clarity, design, tone, and quality
• Cross-Functional Leader: You build strong partnerships across BD, Product, Strategy, and leadership

Preferred

• Global marketing experience across varied business landscapes
• Experience with technical products involving complex scientific concepts
• Track record of successful product launches in competitive, technical markets
• Fluency with modern marketing tools and platforms

What we offer

• Join us on a mission to change the world for the better
• The opportunity to work with a mission-driven team pushing the frontier of data driven AI/ML powered clinical development
• A diverse and intellectually rigorous environment focused on solving some of the most complex challenges in clinical development
• A collaborative and dynamic startup environment
• Professional growth and development opportunities
• Competitive compensation and equity participation
• Comprehensive benefits, 401(k) match, and flexible hybrid culture

PhaseV is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.