Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

We are seeking a Central Operations Head (COH) to provide strategic leadership across clinical drug supply, Clinical Trial Agreement (CTA), and eTMF management to support global clinical development programs. This role partners cross-functionally with Clinical, Regulatory, Legal, Technical Operations, and Operational Excellence to ensure alignment on trial needs, risk management, and execution priorities.

You will oversee end-to-end delivery across trials, define outsourcing and vendor strategies, and ensure performance through KPIs, KRIs, and governance. This role is accountable for driving operational excellence, ensuring inspection readiness, and maintaining compliance with global regulations and internal standards.

As a leader, you will build and develop a high-performing team, establish scalable processes and best practices, and foster a culture of accountability, innovation, and continuous improvement in a fast-paced biotech environment.

Your role

• Provide strategic direction for clinical drug supply management, clinical trial agreement (CTA) management, and eTMF management activities to support clinical development objectives across all programs and trials
• Collaborate with Trial Management, Regulatory Affairs, Clinical Development, Legal, and Technical Operations to align on trial needs and deliverables
• Collaborate with Operational Excellence & Clinical Compliance and GMP compliance to align on risk assessment, metrics, KPIs, and KRIs for management of clinical drug supply, CTAs, and eTMF
• Define and implement outsourcing strategies (incl. Contract Research Organizations (CROs), Contract Manufacturing Organizations (CMOs) and vendors) in partnership with VP of Global Clinical Operations and Head of Clinical Sourcing & Contracting
• Define functional goals, performance metrics, and resourcing strategies. Drive innovation including adoption of risk-based approaches
• Oversee end-to-end execution of drug supply-/ CTA-/ and eTMF management across clinical trials, ensuring timely, high-quality, and inspection-ready deliverables
• Track CRO, CMO, and vendor performance using metrics, KPIs, and KRIs; lead SMO governance meetings to address escalated issues and drive continuous improvement
• Establish and maintain best practices and standards throughout the trial lifecycle
• Ensure adherence to global regulatory requirements, GCP and internal SOPs. Lead audit and inspection readiness for drug supply-/ CTA-/ and eTMF management and implement effective oversight models for internal teams and outsourced partners. Perform internal quality reviews and ensure inspection readiness of trial documentation
• Lead, coach, and develop a high-performing team. Foster a culture of collaboration, continuous learning, and accountability, while supporting career progression and succession planning across the function
• Select, manage, and govern external vendors. Define expectations, monitor performance via KPIs, and drive accountability through governance forums to ensure quality, timelines, and cost-effectiveness

What You Bring

• 12+ years of trial management experience with 5+ years in leadership position
• Bachelor’s degree in Life Sciences, Pharmacy or related field (required). Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred)
• Significant experience working in global clinical development organization
• Significant experience in outsourcing and oversight
• Expert knowledge in ICH GCP and GMP
• Expert knowledge in computer technologies to plan, forecast, and track documents/ material on all levels
• Expert knowledge in risk assessment and management on program and trial-level
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, IRT) and operational metrics, KPIs, and KRIs
• Familiarity with clinical supply planning, forecasting, and inventory tools
• Independent judgment and objectivity
• Strong analytical and influencing skills
• Ability to drive accountability across functions
• Strong leadership and interpersonal skills

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

We are seeking a Site Management Leader (SML) to oversee all site management and monitoring activities conducted by the CRO in a clinical trial. This role will be assigned to critical clinical trials of the Tango portfolio and serve as the primary contact between sponsor and CRO for site management aspects.

In a fast-paced, small biotech environment, the SML will operationally oversee and manage the end-to-end site management activities as per approved timelines, budget, regulatory requirements, and internal standards. This individual will play a key role in the execution and delivery of clinical trial objectives.

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your role

• Serve as the primary liaison between CTT and CRO for all site management activities
• Oversee CRO performance for site management to ensure compliance with contractual obligations, timelines, and quality standards
• Lead or contribute to the development of the Site Management Oversight Plan and other trial-specific operational plans in collaboration with CTT
• Contribute to the development of a site-related RBQM framework to drive efficiency and ensure quality of critical site management aspects
• Identify trial-level risks and contribute to the development and implementation of risk management and mitigation strategies
• Manage and monitor site identification, feasibility assessments, and site selection processes
• Ensure site readiness for initiation, including training, documentation, and logistical preparedness
• Oversee and support site initiation visits (SIVs) and ensure timely site activation
• Monitor patient recruitment strategies and enrollment progress across clinical sites
• Ensure protocol compliance and data integrity through oversight of site monitoring activities
• Review monitoring visit reports and ensure timely resolution of site issues and follow-up actions
• Collaborate with CRO to address site-level issues. Escalate unresolved issues to CTL and CTT, as needed
• Ensure adherence to ICH GCP, regulatory requirements, and internal SOPs throughout trial conduct
• Participate in audits, inspections, and quality assurance activities related to site management
• Oversee site closure activities and ensure proper documentation and archiving

What You Bring

• 5+ years of trial management experience with 3+ years in site management. Leadership experience (preferred)
• Bachelor’s degree in Life Sciences, Pharmacy or related field
• Experience working in global clinical development organization
• Experience in Oncology development (preferred)
• Knowledge of ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines
• Knowledge of trial/ site risk assessment and management
• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred)
• Experience in outsourcing and oversight
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs
• Strong vendor management and project management skills
• Leadership skills with the ability to lead cross-functional teams
• Strong interpersonal and communication skills
• Strong analytical thinking and decision-making capabilities
• Willingness to travel, as required (typically 10 – 20%)

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

In this newly created role, the Scientific Director, Medical Information & Medical Communications will serve as a senior individual contributor within Medical Affairs, responsible for owning the medical information foundation and scientific narrative across Tango’s pipeline.

This role will be central to ensuring Tango is prepared to support increasing external engagement, regulatory interactions, congress presence, publications, and future commercialization. This is an exciting opportunity to shape foundational capability during a period of significant clinical and organizational inflection.

Your Role

     Medical Information Strategy & Operations

• Lead the end-to-end medical information strategy, including oversight of external MI vendors and call center operations
• Ensure timely, accurate, compliant, and evidence-based responses to external inquiries
• Develop, maintain, and govern medical information content, including SRLs, CRLs, FAQs, and response guidance
• Own medical information SOPs, KPIs, quality metrics, audit readiness, and inspection preparedness
• Ensure alignment with pharmacovigilance, regulatory, and compliance requirements

      Scientific Narrative & Medical Communications

• Develop and maintain Tango’s core scientific platform and data narrative across indications and development stages
• Translate complex clinical, nonclinical, and mechanistic data into clear and compelling content for internal and external audiences
• Ensure consistency of scientific messaging across medical information, field materials, congress assets, and internal communications

      Publications, Congress, & Content Governance

• Partner with Medical Affairs and Clinical teams to support publication planning and execution
• Oversee development of scientific materials for major medical congresses
• Provide medical information support at congresses, as appropriate
• Participate in the Medical Review process to ensure scientific accuracy, compliance, and data integrity

      Cross-Functional Collaboration

• Collaborate closely with Medical Affairs leadership, Clinical Development, Regulatory Affairs, Corporate Communications, and Commercial (as appropriate and compliant)
• Ensure alignment between scientific communications, medical strategy, and enterprise objectives
• Perform additional duties as required to support Medical Affairs goals

What You Bring 

• Advanced scientific degree required (PharmD, PhD, or MD strongly preferred)
• 7–10+ years of experience in Medical Affairs, Medical Information, or Scientific/Medical Communications
• Oncology experience strongly preferred; experience in GI malignancies, NSCLC, or precision oncology highly valued
• Experience in clinical-stage and/or pre-commercial biotech environments
• Exceptional scientific writing, editing, and data-positioning skills
• Strong understanding of clinical development, regulatory pathways, and medical affairs operations
• Demonstrated ability to manage vendors, agencies, and cross-functional stakeholders
• Experience with Veeva MedComms and PromoMats preferred
• Ability to operate effectively through ambiguity in a resource-constrained environment
• Excellent written and oral communication skills

Work Environment

• This role may be remote, with periodic travel to Tango offices and scientific meetings
• Approximately 10–20% travel

#LI-Remote

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

In this new role, reporting to the Vice President, Biometrics you will be working with cross‑functional clinical teams responsible for statistical activities across Tango’s clinical programs, including overseeing statistical deliverables outsourced to clinical CROs. This is an exciting opportunity to make an impact in the development of transformative therapies that may change patients’ lives. You will be a good communicator, collaborative, self-motivated, and forward‑thinking.

Your Role:

• You will serve as a biostatistics expert for Tango’s clinical programs
• Provide strategic input to optimize trial designs in early phase dose escalation studies and late phase registrational studies
• As a biostatistics representative, proactively collaborate with internal and external CRO team members to coordinate the planning and execution of statistical deliverables
• Conduct statistical modeling to enable robust and efficient statistical designs and address identified or potential statistical issues arising with studies
• Contribute to clinical protocol development, including authoring or review of the Statistics section and reviewing of other sections by applying statistical principles
• Author or review the development of statistical analysis plans for clinical trials and oversee the development of tables, figures, and listings, and associated deliverables
• Review electronic case report form (eCRF) designs to ensure data collection meets the requirements of statistical analyses
• Provide statistical input for clinical documents
• Perform QC/QA of statistical deliverables including validation of key analysis results
• Perform ad hoc statistical analyses as needed
• Contribute to clinical study reports, including authoring of statistical methods, and interpretation of study results
• Accountable for assigned statistical activities in support of IND/NDA/MAA or other regulatory submissions; provide thorough review for required components of regulatory submissions including appropriate datasets, define files, reviewer's guides, and other relevant documents
• Address statistical questions/comments from FDA and other regulatory agencies, or IRB/ECs
• Support and contribute to the preparation of publications, including manuscripts, posters, and oral presentations
• Lead standardization and process improvement efforts for Biostatistics function, and contribute to cross-functional process improvement efforts including the definition of biostatics templates and standards
• Represent Tango regarding statistical issues in meetings with external parties including regulatory agencies and corporate partners
• Support inspection readiness activities as needed
• Develop and maintain advanced competencies in statistical methodology and advanced trial designs, particularly in oncology drug development
• Additional duties and responsibilities as required

What You Bring:

• PhD in statistics or related discipline; MS with appropriate years of directly relevant experience
• At least 10 years’ experience in the pharmaceutical or biotech industry
• Oncology experience required
• Experience in the design, analysis, and reporting of clinical trials
• Experience in INDs, NDAs, MAAs, or other regulatory submissions
• In-depth knowledge of statistical methods for clinical trials
• Knowledge of FDA, EMA, and ICH regulations and guidelines
• Proficient in statistical programming (SAS and R)
• Ability to lead statistical efforts for multiple studies
• Fluent in data standards, including SDTM and ADaM
• Experience in outsourced statistical services provided by CROs
• Ability to work independently and act with initiative to address issues
• Excellent written and oral communication skills, including the ability to effectively communicate statistical concepts in a clear and concise manner

#LI-hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Legend Biotech is seeking a Cell Therapy Account Specialist, Overlay (Contractor) as part of the Commercial team based in (Boston North, MA, Boston South, MA).

Role Overview

The Cell Therapy Account Specialist is responsible for representing Legend’s products and services to a defined customer base, generating and growing sales and consistently achieving or exceeding sales targets within a specific geographic area.

Key Responsibilities

• Work in partnership to drive Carvykti as the preferred CAR-T therapy for multiple myeloma among both community and institution-based oncology customers. This role involves collaborating with other Carvykti representatives to coordinate activities for impactful engagement within the territory.
• Comprehensive understanding of Legend and competitor products in our therapeutic area, and an in-depth knowledge of the complexities associated with the disease state.
• Ability to navigate a complex account environment and understand the needs/issues of various stakeholders at all levels within the account and triage to appropriate internal stakeholders for support.
• Develops an understanding of the issues and opportunities unique to each geography.
• Provides all insights to the cross functional team on appropriate and timely feedback from interactions with healthcare professionals (HCPs), including account business trends and potential changes in therapeutic landscape.
• Leverages intel and insights to develop and assertively implements an account business plan to meet customer needs and achieve corporate goals.
• Works cooperatively with internal team members on various cross-functional projects related to specific accounts or physicians. May work in collaboration with outside partner companies to co-promote products or services.
• Assists in the identification/resolution of issues and opportunities and communicates proactively to marketing and sales management. Manages a territory budget plan for customer engagements, speaker events and other miscellaneous external expenditures.
• Represents Legend at National and/or local symposiums/conventions.
• Demonstrates initiative and willingness to work hands-on with a sense of urgency, in a fast-paced entrepreneurial environment.
• Demonstrates leadership among peers by consistent application and modeling of appropriate, compliant behavior, and conduct.
• Performs all administrative functions required for the position, including reporting call activity and customer information into the appropriate call reporting system in a timely manner, submitting expenses, etc.
• Reports adverse events to Legend’s Drug Safety department and other internal departments as appropriate per required guidelines.
• Actively promotes the appropriate use of Legend’s products to healthcare professionals in accordance with Corporate, PhRMA, and OIG guidelines.
• Strict compliance with all regulatory agencies, state, and federal law is required.
• Adheres to company policies, procedures, and business ethics.

Requirements

• Bachelor’s Degree from accredited college or university.
• Preferred 3 years of Oncology, specialty healthcare sales experience.
• Proven and consistent track record of meeting/exceeding sales objectives, preferably in specialty markets.
• Experienced managing and executing within large community accounts including strategic planning and problem solving.
• Previous sales experience in cell therapy/bone marrow transplant is a plus.
• Previous product launch experience in a highly competitive environment.
• Exceptional interpersonal, communication (written and presentation) skills.
• Possess superior selling skills honed in highly competitive markets.
• Proven expertise in building relationships and influencing.
• Aptitude for rapid learning and retention of technical and scientific product related information.
• Must set high goals and standard of performance and be self-motivated and able to work with a general level of autonomy.
• Demonstrated team work/collaboration.
• Demonstrated ability to read situations quickly, anticipate and adjust for problems and roadblocks.
• Valid driver’s license.
• Agility in multi-tasking.
• Able to travel up to 50-60% of the time.
• Proven track record of attaining organizational objectives.
• Exceptional organizational and time management skills.
• Ability to perform administrative responsibilities accurately and on time.
• Proficiency in Microsoft Office (Word, Excel, Outlook, PowerPoint).

#Li-JK1

#Li-Remote

The Perfect Addition to Our Team

You are interested in working at the intersection of life sciences and business. You want to join a high growth biotech company in a business strategy role to help support the team by synthesizing and communicating strategic insights from market and competitor developments. You bring to the table the combination of an inquisitive spirit, critical thinking, and analytical skills. You love following innovative science, performing data-driven analyses and contributing strategic insights. You thrive in figuring out the details and understanding the nuances while still making connections to the bigger picture. You look forward to working with and learning from cross-functional leaders across the organization while helping shape long-term strategy

The Opportunity

This individual will lead and support many different aspects of competitive and market intelligence to support new product planning. Example workstreams include competitive monitoring and tracking, conference coverage, and strategy development. The ideal candidate will conduct primary and secondary research to gather market insights and data and use them to inform analysis and planning implications. This individual will be expected to lead the Competitive Intelligence workstream and distill market insights and data in a timely manner to create concise summaries for internal communications. They will also support various strategic workstreams by conducting focused evaluations of market trends and supporting commercial assessments to help drive recommendations.

Responsibilities

Competitive Landscape

• Lead competitive intelligence activities, including tracking, analyzing, synthesizing, and communicating competitor and industry activity across key stakeholders (Strategy, Regulatory Affairs, Medical Affairs, Clinical Development, Clinical Operations, and Business Development).
• Monitor industry activity and emerging trends through conference coverage and external intelligence to inform internal decision-making.

Market Insights

• Gather, analyze, and synthesize market data to support data-driven insights and timely communication to internal stakeholders.
• Design and execute cross-functional primary market research, partnering with internal teams to define objectives, methodologies, and select vendors (HCPs, KOLs, patients, payers, and advanced analytics partners).
• Translate market research, claims analysis, and payer insights into early go-to-market strategy and commercialization readiness.

New Product Planning

• Monitor and routinely update competitor pipeline and strategic direction to inform forward-looking internal program strategy, positioning, and planning.
• Identify gaps and opportunities within the evolving landscape to support early commercial strategy development, including treatment positioning, segmentation, pricing scenarios, and foundational launch assumptions.
• Routinely present insights and strategic recommendations to senior leadership and cross-functional leadership teams to inform decision-making.
• Develop investor- and Board-facing slide decks that articulate competitive differentiation and strategic positioning.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• Bachelor of Science or Arts degree in life sciences (biology, biochemistry, chemistry, etc.) required; advanced degree preferred (PhD, MS, or equivalent).
• 4+ years of experience in biotech/pharma in roles such as competitive intelligence, market insights, or management consulting with a life sciences focus.
• Strong scientific literacy with the ability to interpret clinical and preclinical data.
• Direct experience synthesizing and communicating accurate, timely competitive insights on drug development / corporate strategy.
• Experience in designing and conducting interviews with external experts or KOLs is strongly preferred.
• Excellent communication skills, with the ability to synthesize complex information into clear recommendations and present insights effectively using Microsoft PowerPoint and Excel.
• Ability to work independently in a fast-paced, innovative, and collaborative environment, with a strong team-oriented mindset, can-do attitude, and flexibility to adapt based on new insights and team input.
• This position is a US remote-based position requiring a minimum of 1-2 days per week onsite at the Entrada Therapeutics Headquarters in Boston, MA.

What We Offer: Meaningful Work, Fair Rewards, and Real Support

At Entrada Therapeutics, we understand that compensation and total rewards are a major consideration when exploring a new opportunity. We believe in transparency and equity and are committed to sharing salary ranges for every position, along with insight into our compensation philosophy, in accordance with certain state requirements in the United States and fostering a fair and open environment at the onset.

But we also know it is more than just pay. When you join Entrada, you’ll be part of a mission-driven team with access to comprehensive health, dental and vision coverage; life and disability insurance; with a 401(k) match. We pride ourselves on offering competitive benefits that empower our employees and reflect the value of their contributions – offering paid, gender-inclusive parental leave, holistic support for your health and well-being, education reimbursement, discretionary time off and commuting benefits aligned to your working model. If you find yourself working from our office in Boston’s Seaport District, this puts you steps away from some of the best the city has to offer.

“Our approach to compensation is grounded in transparency, equity and performance for the unique contributions each person brings. At Entrada, we know that meaningful work deserves meaningful reward — and we view compensation as one way we show appreciation for the collaboration, curiosity and commitment that drive our mission forward.”

— Kerry Robert, SVP of People

The salary for this opportunity ranges from$127,000-$166,000. The final base compensation offered will depend on several considerations which include but may not be limited to a candidate’s skills, competencies, experience and other job-related factors permitted by law. The final salary offered may fall outside of this range. #LI-Remote #LI-GG1

About Re:Build Manufacturing

Re:Build Manufacturing is a growing family of industrial and engineering businesses combining enabling technologies, operational superiority, and strategic M&A to build America’s next generation industrial company. At Re:Build we deploy deep expertise in engineering, operations management, and technology to supercharge the performance of our member companies. We leverage deep professional expertise and a candid, principled operating culture to drive differentiated outcomes. Ours is a fast-paced environment where individuals can stretch and be challenged to pursue their fullest potential.

Re:Build was founded to pioneer a profitable model for the revitalization of US manufacturing. We’ve assembled a powerful set of complimentary capabilities and lines of business that enable us to pursue a wide range of end markets. Our acquired businesses are grounded in build-to-print and by-the-hour engineering and design services, and we’re leveraging their combined expertise to migrate to increasingly sophisticated program development and production, as well as the generation of our own products. Our unique set of capabilities lend themselves to highly complex systems and products, and we offer customers a range of services including product and systems design, automation, fabrication, assembly, and large volume contract manufacturing. Our customers span a wide array of industries including aerospace, defense, mobility, healthcare, pharma, biotech, clean tech, chemicals, energy, lifestyle, food production, and industrial equipment.

Who We Are Looking For

Re:Build Harness Solutions is building a digital-first wire harness engineering and manufacturing platform. We are seeking a Technical Engineering Manager to lead technical execution, operational systems, and customer growth for the business. This is not a traditional engineering management role. We are looking for an ambitious leader who thrives in ambiguity, builds scalable systems, and creates long-term customer value through engineering excellence, digital innovation, and operational execution. The ideal candidate combines deep technical expertise in wire harnesses with strong customer engagement, business leadership, and manufacturing systems thinking.

What you get to do

Business & Technical Leadership

• Lead technical strategy and operational execution for the wire harness business
• Develop scalable systems for quoting, design reviews, manufacturing workflows, and customer onboarding
• Track and improve key operational metrics including quote turnaround, smartBuild-ready designs, delivery performance, and ECO reduction
• Support growth planning, investment prioritization, and business reviews

Customer Engagement & Engineering

• Lead technical discovery reviews with customers across aerospace, defense, medical, robotics, and industrial sectors  
• Translate customer requirements into manufacturable, scalable solutions
• Collaborate with commercial teams to establish Re:Build as a trusted engineering and manufacturing partner  
• Drive customer benefit through engineering optimization and rapid execution  

Digital Manufacturing & Process Innovation

• Own and improve digital wire harness workflows using Cadonix Arcadia, QuoteBuilder, AI tools, and smartBuild
• Build repeatable RFQ/RFP and production execution processes
• Partner with digital teams to accelerate automation, validation, and manufacturing integration
• Help establish Re:Build as a center of excellence for digital-native wire harness manufacturing

Manufacturing & Operational Excellence

• Support development of digitally optimized manufacturing capabilities
• Drive continuous improvement across engineering, production, and customer engagement workflows
• Align technical execution with profitability, quality, and delivery goals

What You Bring to the Team

• BS or equivalent experience in Electrical, Mechanical, or Manufacturing Engineering (advanced degree or MBA preferred)  
• 10+ years in engineering and/or manufacturing environments
• 3+ years leading technical teams in wire harness, cable assembly, or electro-mechanical systems
• Strong understanding of wire harness design, manufacturability, and production processes
• Experience with ECAD/wire harness design tools (Cadonix Arcadia preferred)
• Knowledge of automated processing, assembly, testing equipment, and regulated manufacturing environments
• Familiarity with aerospace, defense, medical, or industrial quality standards and ITAR environments
• Proven ability to build scalable systems and operational processes
• Strong customer-facing technical communication skills
• Experience managing fast-paced, high-iteration customer programs
• Ability to balance strategic thinking with hands-on execution
• Demonstrated use of data and leading indicators to drive business outcomes
• Experience with project management, ERP/MES, and PLM/PDM systems
• Comfortable using AI and digital tools to improve productivity and decision-making
• IPC/WHMA-A-620, AS9100, or equivalent

Travel up to 30% required. Preferred location: Kalamazoo, MI (Re:Build Tekna facility), with consideration for candidates near major hardtech hubs.

Compensation Range: The base salary range for this position is $138,000 – $ 208,000 per year. This range represents the Company’s good faith estimate of the base compensation for this role at the time of posting.  Actual compensation will be determined based on several factors, including but not limited to relevant experience, skills, qualifications, internal equity, and geographic location. In addition to base salary, this role may be eligible for annual incentive compensation and/or long-term incentives, subject to Company plans. The Company offers a comprehensive benefits package including medical, dental, vision, retirement, paid time off, and other benefits. 

Export Control Requirement: Due to applicable export control laws and regulations, candidates must be a U.S. citizen or national, U.S. permanent resident (i.e., current Green Card holder), or lawfully admitted into the U.S. as a refugee or granted asylum.

The BIG payoff

We are a company who is going to make a difference in the industries and the regions where we choose to operate. Every employee of Re:Build will share ownership in the company and will share in the financial rewards of the success we achieve together, at all levels of the company!

We want to work with people that reflect the communities in which we operate

Re:Build Manufacturing is proud to be an Equal Employment Opportunity and Affirmative Action employer. We do not discriminate based upon race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status, marital status, parental status, cultural background, organizational level, work styles, tenure and life experiences. Or for any other reason.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts

About the Role

We are seeking a Clinical Trial Manager (CTM) to lead operational aspects of a clinical trial and support the Clinical Trial Leader (CTL), as required. This role will serve as a key member of the Clinical Trial Team (CTT) and as the primary contact for external parties and vendors. CTM may lead the cross-functional CTT for smaller and less complex trials or manage critical aspects of larger and more complex clinical trials under CTL leadership. In addition, CTM will be responsible for site management oversight for trials where no Site Management Leader (SML) is assigned.

In a fast-paced, small biotech environment, the CTM will operationally manage the set-up, conduct and reporting of clinical trials (or parts thereof) as per approved timelines, budget, regulatory requirements, and internal standards. This individual will play a key role in the execution and delivery of clinical trial objectives.

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Key Responsibilities

• Serve as a core member of the Clinical Trial Team (CTT) and act as deputy for the Clinical Trial Leader (CTL) during absences
• Organize and coordinate CTT meetings, including preparing agendas, recording minutes, and tracking follow-up actions
• Facilitate communication and collaboration within the team and with external partners such as Contract Research Organizations (CROs) and vendors
• Contribute to the development and maintenance of trial-level documents and operational plans, including project management, communication, risk management, and quality plans
• Establish and manage trial-related systems and processes (e.g., central laboratories, eCOA/ ePRO) in alignment with protocol requirements
• Monitor CRO/ vendor performance and ensure timely and accurate data integration, transfer, and reconciliation. Escalate issues to the CTL, as needed
• Identify risks and issues and support the development and implementation of mitigation strategies and action plans
• Maintain accurate and up-to-date trial information in systems and communication tools
• Set up and maintain clinical trial insurance in participating countries
• Coordinate with the global supply chain to ensure timely supply and distribution of devices and investigational medicinal products, comparator or co-medication to clinical sites
• Prepare and distribute trial-related correspondence and contribute to the development of materials for meetings, newsletters, and websites
• Lead logistical arrangements and support content development for external meetings such as investigator meetings and advisory boards
• Ensure ongoing inspection and audit readiness. Participate in internal audits and regulatory inspections, as required
• Support budget forecasting and accrual processes. Assist with invoice tracking, and processing in line with vendor contracts
• Act as CTL when assigned, leading cross-functional CTT to operationalize the protocol of a clinical trial
• Lead the development of site management oversight plan and ensure site management oversight including risk management for trials without assigned Site Management Lead (SML)

What you bring: 

• 5+ years of trial management experience. Leadership experience (preferred)
• Bachelor’s degree in Life Sciences, Pharmacy or related field
• Experience working in global clinical development organization
• Experience in Oncology development (preferred)
• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred)
• Experience in outsourcing and oversight
• Knowledge of ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines
• Knowledge of financial planning, tracking, and reporting
• Knowledge of trial risk assessment and management
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and site management metrics, KPIs, and KRIs
• Strong vendor management and project management skills
• Leadership skills with the ability to lead cross-functional teams
• Strong interpersonal and communication skills
• Strong analytical thinking and decision-making capabilities
• Willingness to travel, as required (typically 10–20%)

#LI-HYBRID

#LI-HYBRI

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-HYBRID

About Re:Build Manufacturing

Re:Build Manufacturing is a growing family of industrial and engineering businesses combining enabling technologies, operational superiority, and strategic M&A to build America’s next generation industrial company. At Re:Build we deploy deep expertise in engineering, operations management, and technology to supercharge the performance of our member companies. We leverage deep professional expertise and a candid, principled operating culture to drive differentiated outcomes. Ours is a fast-paced environment where individuals can stretch and be challenged to pursue their fullest potential.

Re:Build was founded to pioneer a profitable model for the revitalization of US manufacturing. We’ve assembled a powerful set of complimentary capabilities and lines of business that enable us to pursue a wide range of end markets. Our acquired businesses are grounded in build-to-print and by-the-hour engineering and design services, and we’re leveraging their combined expertise to migrate to increasingly sophisticated program development and production, as well as the generation of our own products. Our unique set of capabilities lend themselves to highly complex systems and products, and we offer customers a range of services including product and systems design, automation, fabrication, assembly, and large volume contract manufacturing. Our customers span a wide array of industries including aerospace, defense, mobility, healthcare, pharma, biotech, clean tech, chemicals, energy, lifestyle, food production, and industrial equipment.

Who we are looking for

This is an exciting opportunity for an impactful role where you will enjoy considerable autonomy and variety. The Senior Marketing Manager is integral to the team, driving go-to-market initiatives for Re:Build’s cross-industry capabilities in industrial systems, automation, machine design/build, and battery technology. You will work closely with the business development, sales, marketing team, and technical domain experts to develop and support the entire client acquisition process and nurture ongoing relationships with existing clients and trade organizations.

The position requires a highly motivated, “roll-up your sleeves” professional fluent in business-to-business marketing of highly technical products and services. This is a very hands-on role requiring the implementation of the Re:Build marketing and business development process and supporting each company within the organization in meeting annual growth initiatives. It is a high-visibility role that impacts the entire organization.

What you get to do

• Lead the generation and flow of high-quality Marketing Qualified Leads into the sales funnel for the assigned businesses.
• Conduct targeted market and competitive research to identify trends, customer needs, and competitive positioning opportunities that advise strategic decisions.
• Develop, drive, and complete targeted campaigns to improve and sustain pipeline health in collaboration with the demand generation team.  
• Evaluate, adopt, and leverage AI-enabled marketing tools and workflows to improve campaign performance, content development, market research, lead generation, and operational efficiency.
• Champion the responsible use and adoption of AI technologies across marketing initiatives while identifying opportunities for innovation and process improvement.
• Develop, drive, and implement the marketing strategy for the capabilities in our industrial systems, automation, machine design/build, and battery technology.
• Serve as the marketing owner for designated market segments and capabilities, developing and delivering targeted go-to-market strategies that drive awareness, engagement, pipeline growth, and revenue generation.
• Own, plan, manage, and optimize spend for the annual demand generation budget to generate funnel growth and pipeline velocity.
• Develop, implement, and use creative and differentiated ideas to drive high-quality leads into the funnel and position Re:Build in the marketplace as a technical industry leader.
• Develop, drive, author, and compile technical content, including:
  • Case studies
  • Speaking engagements
  • Webinars
  • Print and digital sales/marketing
• Support overall company marketing goals and go-to-market strategy.
• Support and influence the tradeshow calendar by targeting relevant events for our product innovation and engineering services businesses
• Identify, develop, and implement strategy for non-traditional market segments.
• Track and report on the efficacy of marketing programs and initiatives and recommend adjustments to strategy.

What you bring to the Team

• Extreme attention to detail and exceptional organizational skills
• Self-motivated with the ability to work independently
• Comfortable with multitasking in a fast-paced and time-sensitive environment  
• Excellent written and verbal communication skills
• Curious, fast-learning, and resourceful
• Demonstrated curiosity and adaptability in learning and applying emerging AI tools and technologies to enhance marketing effectiveness and productivity.
• Applied understanding of basic marketing principles
• Creative problem-solving skills
• Ability to work well with a remote team
• Ability to prioritize tasks and meet deadlines in a fast-paced environment
• Comfortable with using metrics to strive for continuous improvement and demonstrating the value of marketing initiatives

Education and/or Experience:

• Bachelor’s degree or equivalent experience in engineering, marketing, or a related field
• Minimum of 8 years of professional experience in a marketing position in an industrial systems, engineering, automation, or manufacturing company; experience in engineering-based role prior to working in marketing would be ideal
• Competency and fluency in Account Based Marketing (ABM), Paid Media, Automation, CRO, SEO, PLG, activation, and retention
• Strong background of driving demand-generation programs that deliver measurable business results, including pipeline and revenue
• Proven experience developing and accomplishing unified campaigns across multiple channels, including email, webinars, paid media, events, and social media
• Proficient with Microsoft Office 365 Suite
• Competent with the Adobe Creative Cloud Suite of products (Photoshop, InDesign, and Illustrator)
• Familiarity or experience with HubSpot
• Experience leveraging AI tools (e.g., generative AI, marketing automation, analytics, or content optimization platforms) to improve business outcomes is strongly preferred.

Export Control Requirement: Due to applicable export control laws and regulations, candidates must be a U.S. citizen or national, U.S. permanent resident (i.e., current Green Card holder), or lawfully admitted into the U.S. as a refugee or granted asylum.

The base salary range for this position is $ 105,000 – $150,000 per year. This range represents the Company’s good faith estimate of the base compensation for this role at the time of posting.  Actual compensation will be determined based on several factors, including but not limited to proven experience, skills, qualifications, internal equity, and geographic location. In addition to base salary, this role may be eligible for annual incentive compensation and/or long-term incentives, subject to Company plans. The Company offers a comprehensive benefits package including medical, dental, vision, retirement, paid time off, and other benefits. 

The BIG payoff

We are a company who is going to make a difference in the industries and the communities in which we choose to operate.  Every employee of Re:Build will share ownership in the company and will share in the financial rewards of the success we achieve together, at all levels of the company!

We want to work with people that reflect the communities in which we operate

Re:Build Manufacturing is proud to be an Equal Employment Opportunity and Affirmative Action employer. We do not discriminate based upon race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status, marital status, parental status, cultural background, organizational level, work styles, tenure and life experiences. Or for any other reason.

Re:Build is committed to providing reasonable accommodations for qualified individuals with disabilities in our job application procedures. If you need assistance or an accommodation due to a disability, you may contact us at accommodations.ta@ReBuildmanufacturing.com or you may call us at 617.909.6275.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. 

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. 

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. 

Tango’s labs and offices are located at 201 Brookline Avenue, in the vibrant Fenway area of Boston, Massachusetts

Summary 

We are seeking a Clinical Supply Manager (CSM) to lead the end-to-end clinical supply management process of our growing clinical portfolio. This role will serve as the primary sponsor contact for external vendors managing the packaging and labeling, storage, distribution, and return/ destruction of clinical supplies.

In a fast-paced, small biotech environment, the CSM will plan, execute and oversee clinical supplies in alignment with trial timelines, budget, regulatory requirements and internal standards. This individual will play a key role in enabling clinical trial start, patient enrollment, and continuous supply as per trial requirements, proactively identifying and mitigating risks, and ensuring compliance of clinical supply with applicable regulations and internal standards.

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your role

• Develop and maintain global clinical supply strategies, including forecasting needs for investigational products, comparators, and co-medications
• Oversee inventory levels at depots and clinical sites, defining resupply strategies based on usage trends to prevent shortages
• Coordinate distribution, importing, and exporting of materials
• Ensure all activities comply with Good Manufacturing Practices (GMP), ICH guidelines, and internal standards
• Manage external vendors (incl. budget), such as Clinical Manufacturing Organizations (CMO), packaging partners and depots
• Track vendor performance using metrics, KPIs, and KRIs
• Act as the primary clinical supplies contact for Clinical Trial Teams (CTT), Chemistry, Manufacturing, and Controls (CMC), and quality assurance (QA)
• Organize and coordinate meetings with key stakeholders, including decision tracking and action item follow-up
• Generate optimal distribution plans and develop tools, forms etc. to track and document end-to-end processes
• Trigger and track shipments of clinical supply from central depot to regional hubs and local depots
• Contribute to Information Response Technology (IRT) set-up, testing and maintenance in close collaboration with relevant CTT functions to ensure efficiency, timeliness and accuracy of clinical supplies management
• Provide input into label text as well as into packaging and labeling materials
• Identify and assesses risks and issues related to clinical supplies, proactively communicate them and lead the development and implementation of mitigation strategies and action plans
• Ensure inspection and audit readiness of clinical supplies; participate in internal audits and inspection from health authorities, as required.

What You Bring

• 5+ years of supply management experience. Experience in leadership preferred
• Bachelor’s degree in Life Sciences, Pharmacy or related field
• Experience working in global clinical development organization
• Experience in Oncology development (preferred)
• Experience in outsourcing and oversight
• Direct experience with health authority inspections of clinical supply management (preferred)
• Knowledge of relevant regulations and guidelines (GMP, ICH guidelines, HSE)
• Knowledge of appropriate supply chain systems used for forecasting and demand planning as well as supply management metrics, KPIs, and KRIs
• Familiarity with other systems used in clinical trials (e.g., CTMS, IRT, eTMF)
• Strong operational excellence with high attention to details
• Strong vendor management and project management skills
• Leadership skills with the ability to lead cross-functional teams
• Strong interpersonal and communication skills
• Strong analytical thinking and decision-making capabilities

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

We are seeking a Clinical Trial Leader (CTL) to lead cross-functional clinical trial teams (CTTs) in the execution of clinical trials of Tango’s portfolio. This role will chair the CTT and represent the cross-functional team to internal governance bodies. The CTL will be an internal escalation point for other CTT members.

In a fast-paced, small biotech environment, the CTL will operationally lead the set-up, conduct and reporting of clinical trials as per approved timelines, budget, regulatory requirements, and internal standards. This individual will play a key role in the execution and delivery of clinical trial objectives.

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your role

• Lead cross-functional Clinical Trial Team (CTT) in the planning, execution, and reporting of outsourced clinical trial.
• Provide regular updates to internal governance bodies.
• Serve as the primary liaison between the sponsor and CRO to ensure alignment of trial objectives, timelines, and deliverables.
• Oversee CRO performance, ensuring adherence to scope, budget, and timelines.
• Contribute to protocol development and review of key study documents (e.g., ICFs, CRFs, monitoring plans).
• Lead the development of trial-specific plans including risk management, communication, and oversight plans.
• Support site selection and feasibility assessments in collaboration with CRO and internal stakeholders.
• Monitor trial progress through metrics and KPIs.
• In collaboration with Operational Excellence and Compliance, define an optimal RBQM framework to efficiently control quality throughout the trial.
• Proactively identify risks and issues and support the development and implementation of mitigation strategies and action plans.
• Ensure timely delivery of trial milestones including patient recruitment, data collection, and interim analyses.
• Manage trial budgets, change orders, and invoice reconciliation in collaboration with vendor management and finance.
• Ensure study conduct in compliance with ICH GCP, ISO standards, regulatory requirements, and internal standards.
• Participate in audits and inspections. Ensure timely resolution of findings.
• Review and approve essential documents and study deliverables.
• Oversee database lock, clinical study report (CSR) development, and study close-out activities.
• Contribute to regulatory submissions and responses as needed.

What You Bring

• 8+ years of trial management experience with 3+ years in trial leadership position.Bachelor’s degree in Life Sciences, Pharmacy or related field (required).
• Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred).
• Experience working in global clinical development organization.
• Experience in Oncology development (preferred).
• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred).
• Experience in outsourcing and oversight.
• Knowledge of ICH GCP, FDA guidelines, EU CTR and other relevant guidelines.
• Knowledge of financial planning, tracking, and reporting.
• Knowledge of trial risk assessment and management.
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs.
• Strong vendor management and project management skills.
• Excellent leadership skills with the ability to lead cross-functional teams.
• Strong interpersonal and communication skills.
• Strong analytical thinking and decision-making capabilities.
• Willingness to travel, as required (typically 10–20%)

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview 

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. 

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. 

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. 

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. 

Summary

We are seeking a Global Program Operations Head (GPOH), reporting into the Vice President, Clinical Operations, to lead the strategic and operational execution of a portfolio of clinical trials within a designated disease area. This role partners cross-functionally with Clinical, Medical, Regulatory, and Operational Excellence to ensure programs are aligned with corporate goals, regulatory requirements, and operational feasibility. 

You will drive program-level strategy, oversee trial execution, and manage Contract Research Organizations (CROs) and external vendors, ensuring delivery against timelines, budgets, and quality expectations. Additionally, you will lead and develop a high-performing clinical operations team while supporting governance, risk management, and inspection readiness in a fast-paced biotech environment. 

Your Role 

• Oversee the strategic and operational execution of a portfolio of clinical trials within a designated disease area

• Ensure alignment with corporate goals and regulatory standards

• Represent Global Clinical Operations in Global Program Teams (GPTs) and sub-teams, contributing to program-level strategy and operational planning

• Collaborate with Medical and Regulatory Directors to ensure clinical strategies are scientifically sound, meet regulatory requirements, and are operationally feasible

• Partner with Operational Excellence & Clinical Compliance to align on risk assessment, trial- and site management metrics, KPIs, and KRIs 

• Define and implement outsourcing strategies in partnership with the VP of Global Clinical Operations and Head of Clinical Sourcing & Contracting

• Lead the selection, negotiation, contracting, and performance oversight of CROs and external vendors 

• Monitor trial progress and key deliverables, guiding Clinical Trial Teams (CTTs) in execution planning, issue resolution, and risk mitigation

• Manage program and trial budgets, ensuring accurate forecasting, cost control, and financial accountability

• Track CRO/ vendor performance using metrics, KPIs, KRIs and participate in governance meetings to address escalated issues and drive continuous improvement

• Provide regular updates on trial progress to internal governance bodies, including GPT and Executive Leadership Team

• Support inspection readiness activities and represent the organization during Health Authority inspections 

• Provide leadership, coaching, and performance management to Clinical Trial Leaders (CTLs), Clinical Contract Managers (CTMs), Clinical Trial Specialists (CTSs), and Site Management Leader (SMLs)

• Set clear objectives, deliver ongoing feedback, and develop tailored development plans to support team growth and capability building

• Oversee hiring, onboarding, and training of new team members, fostering a culture of operational excellence and continuous learning

What You Bring 

• 12+ years of trial management experience with 7+ years in leadership position 

• Bachelor’s degree in Life Sciences, Pharmacy or related field (required). Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred). 

• Significant experience working in global clinical development organization

• Experience in Oncology development (preferred)

• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections

• Significant experience in outsourcing and oversight

• Expert knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines

• Expert knowledge in financial planning, tracking, and reporting

• Expert knowledge in risk assessment and management on program and trial-level

• Executive presence and strategic thinking on corporate-, program-, and trial-level

• Strong decision‑making and sound judgment 

• Strong leadership and interpersonal skills 

• High credibility with senior leadership 

• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs

• Willingness to travel, as required (typically 10–20%)

 #LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status

Company Overview 

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. 

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. 

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. 

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. 

Summary

We are seeking a Clinical Contract Manager (CCM) to lead the end-to-end clinical site contracting process in support of our growing clinical portfolio. This role will serve as the primary sponsor contact for Contract Research Organization (CRO) partners and internal stakeholders across Clinical, Legal, Finance, and Compliance. 

In a fast-paced, small biotech environment, the CCM will drive the development, negotiation, execution, and maintenance of Clinical Trial Agreements (CTAs), ensuring alignment with trial timelines, budget, and regulatory requirements. This individual will play a key role in enabling timely site activation, CTA maintenance as per trial requirements, proactively identifying and mitigating risks, and ensuring compliance of CTAs with applicable regulations and internal standards. 

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your Role 

• 5+ years of trial management experience with 3+ years in site management 

• Bachelor’s degree in Life Sciences, Pharmacy or related field 

• Experience working in global clinical development organization 

• Experience in Oncology development (preferred) 

• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred) 

• Experience in outsourcing and oversight 

• Familiarity with clinical trial systems (e.g., CTMS, eTMF) and operational metrics, KPIs, and KRIs 

• Familiarity with site contracting requirements and healthcare compliance (Fair Market Value, SOX Act, Sunshine Act) 

• Knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines 

What You Bring 

• 5+ years of trial management experience with 3+ years in site management 

• Bachelor’s degree in Life Sciences, Pharmacy or related field 

• Experience working in global clinical development organization 

• Experience in Oncology development (preferred) 

• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred) 

• Experience in outsourcing and oversight 

• Familiarity with clinical trial systems (e.g., CTMS, eTMF) and operational metrics, KPIs, and KRIs 

• Familiarity with site contracting requirements and healthcare compliance (Fair Market Value, SOX Act, Sunshine Act) 

• Knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines 

 #LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status

About Every Cure:   

Every Cure is an AI-driven nonprofit, biotech organization on a mission to save and improve lives by repurposing existing medicines for diseases with significant unmet need. We are working to create a world where every drug is used to treat every disease it possibly can, so that no patient suffers when an existing treatment could help them. We are filling a gap left by the current biomedical system, which doesn’t systematically pursue new uses for old drugs. Through artificial intelligence technologies, collaboration with healthcare professionals, and patient advocacy, Every Cure is dedicated to unlocking the full potential of existing medicines to treat every disease and every patient we possibly can. Inspired by Every Cure’s co-founders' work repurposing drugs for Castleman disease and other rare diseases, Every Cure is advancing repurposed treatments for neglected diseases and has been featured in The New Yorker,  New York Times, USA Today, Good Morning America and other news media. Led by a talented leadership team and an outstanding Board of Directors, Every Cure is supported through funding from leading philanthropic organizations like Chan Zuckerberg Initiative, TED’s Audacious Project, and ARPA-H. 

 Our approach:  

• AI-Powered Identification: We use advanced artificial intelligence to analyze the world’s biomedical knowledge and identify FDA-approved drugs that can be repurposed for untreated conditions. This cutting-edge technology enables us to explore new therapeutic possibilities efficiently.  
• Open-Source Commitment: We are dedicated to making our predictive pipeline open-source, fostering collaboration and transparency within the scientific community and unlocking the potential for discovering new treatments.  
• High-Impact Focus: We prioritize drug repurposing opportunities that will relieve the most suffering and have the greatest impact possible.  
• Rigorous Validation: Promising opportunities are thoroughly validated through laboratory and clinical studies to confirm their efficacy and safety before advancing to broader application.  
• Strategic Marketing and Access: We disseminate information about effective repurposed treatments through multiple channels and are committed to ensuring that new cures are accessible to all patients.

Applicants must reside in the state specified at the top of this job posting. Residency in that state is a requirement for consideration and must be maintained for the duration of employment.

The Head of Clinical Development leads Every Cure’s clinical research and development function, serving as both strategic architect and working clinical lead on priority programs. They manage a diverse portfolio of drug repurposing initiatives including Every Cure-sponsored interventional trials (with full sponsor IND accountability and REMS complexity where applicable), collaborative investigator-sponsored trials, and Every Cure-led patient registries, natural history studies, and other real-world studies. They collaborate directly with computational and data science teams to translate AI-driven repurposing hypotheses into clinically testable programs and represent the organization to external partners and stakeholders. This role owns sponsor compliance under ICH E6(R3) including maintenance of the clinical QMS and SOP infrastructure regardless of CRO engagement  and oversees regulatory strategy and dissemination. The HCD supports Every Cure’s CSO and engages directly with external stakeholders including CROs, clinical trial technology vendors, academic investigators, patient advocacy organizations, the IRB of record, and FDA. The HCD helps build and lead a lean internal clinical development team, modeling the working-leader norm expected in a small, mission-driven organization.

How you will make an impact: 

Strategic Leadership of Clinical Development and Medical Affairs

• Set the direction for Every Cure’s clinical research and development, ensuring alignment with the organization’s mission to repurpose FDA-approved drugs for high-impact unmet needs, while personally leading or co-leading priority programs.
• Lead the execution of organizational goals through operational planning and cross-functional integration, personally owning project timelines, quality standards, and accountability metrics for priority programs rather than delegating all execution.
• Provide expert counsel to the CSO, President and Scientific Advisory Council on medical strategy, program development, and organizational growth.

Research and Clinical Development Oversight

• Design, author, and review key study documents (protocols, statistical analysis plans, informed consent documents, clinical study reports, investigator brochures) for Every Cure-sponsored clinical trials, patient registries, natural history studies, and real-world evidence assessments. Own study design decisions end-to-end, from scientific rationale through data integrity and analysis.
• Serve as sponsor medical lead and/or medical monitor on Every Cure-sponsored IND-holding studies (delegating per-study where appropriate), ensuring all research activities are ethically sound, methodologically rigorous, and regulatory compliant under FDA 21 CFR Part 312, ICH E6(R3), and ICH E9 principles.
• Translate complex medical findings into strategic decisions regarding program continuation, optimization, or sunsetting, based on efficacy, feasibility, and patient impact.
• Responsible for compliance and oversight of the Human Subjects Research program at Every Cure, including IRB (Advarra) submissions and amendments, sponsor safety reporting (IND safety reports, DSURs), SAE adjudication, signal detection, and REMS program participation where applicable (e.g., lenalidomide).

Portfolio Strategy and Program Management

• Partner on strategic prioritization and dynamic management of Every Cure’s diverse portfolio of drug repurposing opportunities, applying a risk-adjusted, impact-oriented lens to maximize outcomes.
• Direct the progression of programs through clinical and dissemination stages, using insights from AI models and external scientific inputs. Personally lead CRO and clinical technology vendor selection, contracting input, and ongoing governance (joint steering committees, KPIs, oversight plans) for highest-priority programs.
• Develop and manage resource allocation frameworks across disease areas and therapeutic modalities, ensuring optimal investment of time, talent, and funding toward the most promising interventions.

Leadership and Team Development

• Build, mentor, and lead a lean, high-performing team of clinical research and medical professionals united around a shared vision of maximizing patient impact through drug repurposing, modeling a working-leader norm in which senior leaders contribute directly alongside their teams.
• Define roles, responsibilities, and performance standards for the clinical team while fostering a culture of excellence, integrity, psychological safety, and cross-functional collaboration.
• Promote continuous learning and growth through coaching, training programs, and development opportunities that build both individual capability and team effectiveness.

Stakeholder Engagement, Compliance, and Dissemination

• Act as medical spokesperson and lead regulatory interface for Every Cure in public, scientific, and regulatory forums (including FDA pre-IND and Type B/C meetings), promoting the organization’s mission and sharing results from preclinical and clinical programs.
• Cultivate and manage partnerships with CROs, patient advocacy groups, academic institutions, and regulatory agencies to ensure successful execution and wide-scale impact of therapeutic programs.
• Guide the regulatory approval and post-study dissemination strategies to ensure timely and effective translation of research into therapies accessible to patients, including peer-reviewed publications, policy briefs, and healthcare provider outreach.
• Partner with the Impact lead to provide input and perspective on dissemination and to engage with key stakeholders to ensure medicines reach patients.

What you bring to the team:

Education 

• MD or MD/PhD preferred; PhD DO, or PharmD acceptable

Work Experience (Two-Tier: Head of / VP)

• Minimum for Head of Clinical Development: 8+ years of clinical development experience post-MD (or equivalent), including service as clinical lead on at least one sponsor-held Phase 2 trial from protocol through database lock.
• Demonstrated leadership experience recruiting, mentoring, and managing cross-functional clinical teams, with explicit willingness and proven ability to work hands-on alongside direct reports in a small-organization setting.
• Expertise in drug development, clinical trial design (including interventional trials in rare or ultra-rare populations), and clinical decision-making.
• Sponsor-side experience running Phase 2 trials (distinct from CRO or academic investigator experience).
• Experience working across more than one therapeutic research area.
• Experience with small-sample trial designs and natural history or registry data.
• Proven leadership in driving strategic initiatives and cross-functional collaboration to advance scientific and organizational goals.

Preferred for Vice President designation:

• 12+ years of clinical development experience, including prior functional leadership at a sponsor (Executive Director, Head of, or VP level); multiple sponsor-held INDs led through Phase 2 or beyond; direct experience with REMS programs, risk-based monitoring, or similarly complex regulatory programs; and prior responsibility for building or scaling a clinical QMS under ICH E6(R3) or predecessor standards.

Skills 

• Proficiency in clinical research, real-world evidence assessments, evidence generation, patient registry design, clinical trial execution, and sponsor-side pharmacovigilance.
• Working knowledge of FDA IND regulations (21 CFR Part 312), ICH E6(R3) Good Clinical Practice, ICH E9 statistical principles, 21 CFR Part 11 for electronic records, and REMS program requirements; familiarity with EU CTR a plus.
• Exceptional communication and presentation abilities.
• Demonstrated ability to foster and sustain a collaborative, cross-functional culture grounded in shared organizational mission and values.
• Able to partner effectively with computational and data science teams and critically evaluate AI/ML-driven repurposing hypotheses for clinical translatability.
• Strategic thinker with a focus on urgency, efficiency, and impact.
• Passionate about Every Cure’s mission and values.
• Highly adaptable, thriving in a fast-paced, start-up environment.
• Explicit willingness to be hands-on: comfort authoring and reviewing key clinical documents (protocols, SOPs, CSRs), directly managing vendor/CRO relationships, and working alongside junior staff rather than exclusively through delegation. Candidates seeking a purely oversight or figurehead role are not a fit for this position.

Compensations & Benefits: 

• Your paycheck: Competitive salary based on experience, ranging from $250,000 - $275,000 annually. 
• Health and wellness: Comprehensive plans with medical, dental, and vision coverage, plus a Flexible Spending Account (FSA) for eligible healthcare expenses. 
• Future nest egg: A 403(b)-retirement plan with an employer match of 3.5% helps you save for your future. 
• Relax and recharge: Generous time off, including paid time off and paid holidays. 
• We have you covered: Comprehensive paid leave for family and medical needs, ensuring you have the support you need during important times. 

This role is based in Cambridge, MA, with an expectation of minimum 3 days per week in office.  

Every Cure is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We provide equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, genetics, or any other characteristic protected by federal, state, or local laws.

Real Chemistry is looking for a Senior Strategist to join our growing team!

21GRAMS, part of Real Chemistry, takes an innovative approach to advertising, and focusing on making healthcare more human.  Not just in our work, but in the way we conduct business, approach client relationships, and treat each other. It’s a place where people subscribe to the adage, “Be good to each other, but hard on the work.” A place where people are not just in it for the paycheck, but to make a dent in the universe. Sound like you?

21GRAMS is seeking a Senior Strategist to gather critical data that ensures strategies are accurate and planned accordingly. The Senior Strategist will write clear and forward-thinking strategies involving encouraging and advising creative teams. They will also research clients to understand them and their objectives while producing inventive ideas with team members. 

This is a hybrid role, based in any of our US offices—including New York City, Boston, Chicago, Carmel, Lambertville, or San Francisco—or remotely within the US, depending on team and business needs.

What you’ll do:

• Lead and oversee competitive audits and analysis 
• Show deep command of brand and the brand’s category 
• Attend market research and provide key insights 
• Create research and insight decks 
• Help Strategy Director/Group Strategy Director with brand planning
• Assist with client workshops, oversee development of materials, and facilitate sections of the workshop and breakout groups 

• Manage/Mentor Strategists and Associate Strategists, helping them develop their skills and complete work at the highest levels of quality 

This position is a perfect fit for you if:

• Our Company values – Best Together, Impact-Obsessed, Excellence Expected, Evolve Always and Accountability with an “I” – really speak to you.
• You are adaptable, resilient, and OK with adjusting your scope, responsibilities, and focus as we grow. When things change, so do we. We’re always evolving.
• You are proactive, driven, and resourceful with strong prioritization skills and a desire to dive into the data.
• You are highly organized self-starter, able to work independently and under tight deadlines.

What you should have:

• Bachelor’s Degree in business, marketing, or other related fields
• 2-3 years of experience in strategic management with integrated agencies
• Creative mind and ability to encourage and instigate ideation across departments
• Oral and written communication skills
• A leader that can coach, encourage, and mentor clients, staff, and team members
• Crucial problem-solving abilities
• Strong command for quantitative and qualitative research methodologies and solid understanding of when and how to apply them to a given client challenge

Pay Range: $100,000-$110,000
This is the pay range the Company believes it will pay for this position at the time of this posting.  Consistent with applicable law, compensation will be determined based on job-related, non-discriminatory factors including but not limited to work experience, skills, certifications, and geographical location. The Company reserves the right to modify this pay range at any time. 

Real Chemistry is looking for an SVP, Brand Strategy to join our growing team!  

21GRAMS, part of Real Chemistry, takes an innovative approach to advertising, and focusing on making healthcare more human. Not just in our work, but in the way we conduct business, approach client relationships, and treat each other. It’s a place where people subscribe to the adage, “Be good to each other, but hard on the work.” A place where people are not just in it for the paycheck, but to make a dent in the universe. Sound like you?

This is a hybrid role, based in any of our US offices—including New York City, Boston, Chicago, Carmel, Lambertville or San Francisco—or remotely within the US, depending on team and business needs.

As the SVP, you will be a key leader responsible for shaping and executing our brand strategy to drive growth and enhance brand equity. You will work closely with executive leadership, cross functional teams, and external partners to develop and implement comprehensive brand strategies that align with our business objectives and resonate with our target audience.

What you’ll do: 

• Lead the development of brand positioning, messaging, and creative briefs that effectively communicate brand story
• Collaborate closely with cross-functional teams including Account Management, Creative, and Project Management teams to develop integrated omnichannel campaigns that deliver measurable results
• Stay abreast of industry trends, emerging technologies, and best practices in omnichannel marketing, and incorporate relevant insights into strategy development
• Develop and implementing comprehensive strategies that effectively reach target audiences, drive brand awareness, and ultimately, contribute to the success of our clients' campaigns
• Design and facilitate workshops. Lead Tactical and Brand planning.
• Conduct market research, consumer insights, and competitive analysis to identify trends, opportunities, and challenges in the marketplace
• Drive innovation in brand strategy and marketing approaches to stay ahead of industry trends and maintain a competitive edge
• Establish key performance indicators (KPIs) and metrics to measure the effectiveness of brand initiatives and campaigns, and use insights to inform future strategies
• Provide strategic guidance and mentorship to team members, fostering a culture of collaboration, creativity, and continuous learning

This position is a perfect fit for you if: 

• ​Our Company values – Best Together, Impact-Obsessed, Excellence Expected, Evolve Always and Accountability with an “I” – really speak to you. 

• You are adaptable, resilient, and OK with adjusting your scope, responsibilities, and focus as we grow. When things change, so do we. We’re always evolving. 
• You are proactive, driven, and resourceful with strong prioritization skills and a desire to dive into the data. 
• You are highly organized self-starter, able to work independently and under tight deadlines. 

What you should have:  

• Bachelor’s degree in business administration, Marketing, or related field
• 10+ years of experience in Brand Strategy or related roles within an advertising agency, with a proven track record of developing and implementing successful brand strategies
• Strong leadership skills with the ability to inspire and motivate cross-functional teams
• Excellent analytical and problem-solving abilities, with a data-driven approach to decision-making
• Exceptional communication and presentation skills, with the ability to articulate complex ideas and strategies in a clear and compelling manner
• Demonstrated ability to thrive in a fast-paced, dynamic environment, managing multiple projects and priorities simultaneously

Pay Range: $240,000-$280,000

This is the pay range the Company believes it will pay for this position at the time of this posting.  Consistent with applicable law, compensation will be determined based on job-related, non-discriminatory factors including but not limited to work experience, skills, certifications, and geographical location. The Company reserves the right to modify this pay range at any time.

Real Chemistry is looking for an Account Director to join our growing Medical Communications team! We are open to Account Director, Senior Account Director, and Group Account Director level candidates!

The Account Director for the Scientific and Medical Affairs team serves as the primary client contact, leading client relationships of ~$2M, providing strategic counsel, and overseeing the successful execution of projects for emerging and mid-stage biotech companies as part of our Biotech Center of Excellence (COE). You will ensure high-quality deliverables, proactively identify opportunities for account growth, and manage internal teams effectively. 

This is a hybrid role based in our Boston office. 

What You’ll Do: 

• Serve as the day-to-day client lead and trusted advisor for emerging and mid-stage biotech partners across medical affairs and publication workstreams, leveraging our Biotech COE
• Provide senior-level strategic counsel on key programs, tailoring recommendations to the realities of emerging and mid-stage biotech (e.g., evolving evidence, rapid timelines, and lean teams).
• Oversee account operations to ensure seamless execution of high-quality deliverables - driving proactive issue resolution, clear stakeholder communication, and consistent delivery standards across the Biotech COE
• Drive strategic planning and account growth by identifying opportunities to evolve and expand programs for existing and identified emerging and mid-stage biotech clients. 
• Ensure financial stewardship across the account, including budget oversight, forecasting, resourcing, and profitability management.
• Mentor and develop team members, fostering a collaborative, high-performing environment and contributing to capability-building within the Biotech COE.
• Stay current on industry trends, competitor activity, and relevant regulatory updates - translating insights into practical guidance for biotech clients.
• Support new business efforts for emerging and mid-stage biotech, contributing to pitches and proposals and partnering with the Biotech COE to showcase differentiated expertise. 

What You Should Have: 

• 6+ years of experience in medical affairs and ideally publications, in an agency setting.
• Minimum of 3 years of experience servicing biotech clients.
• Proven leadership skills, with experience managing client relationships and internal teams.
• Strong strategic thinking and problem-solving abilities, with a track record of driving account growth.
• Exceptional communication and presentation skills, with the ability to influence and engage stakeholders at all levels.
• Highly organized, detail-oriented, and able to manage multiple priorities in a fast-paced environment.
• Proficiency in financial management, including budget tracking and forecasting.
• Experience with Advisory boards, investigator meetings, and meeting management.
• Veeva management expertise (preferred but not required).
• Bachelor’s degree or equivalent work experience required. 

This position is a perfect fit for you if:  

• ​Our Company values – Best Together, Impact-Obsessed, Excellence Expected, Evolve Always and Accountability with an “I” – really speak to you. 
• You are adaptable, resilient, and OK with adjusting your scope, responsibilities, and focus as we grow. When things change, so do we. We’re always evolving. 
• You are proactive, driven, and resourceful with strong prioritization skills and a desire to dive into the data. 
• You are a highly organized self-starter, able to work independently and under tight deadlines.  

Job Summary

Real Chemistry has a newly created role on our growing Treasury Team and we are seeking an experienced Treasury Analyst to join as we expand our department to support company growth.  This role will provide operational support on all treasury matters for the company, including such areas as Bank Account Management and Cash Management, reporting to the Manager of Treasury – Cash Operations.  The Treasury Analyst role requires the ability to establish and maintain strong working relationships within a collaborative team and serve as a liaison to business units and external banking partners.

Responsibilities –

Responsibilities include, but are not limited to, the following:

• Cash & Liquidity Management
  • Prepare daily cash reports of worldwide cash balances on a weekly basis for distribution to appropriate parties
  • Monitor daily cash positioning of respective accounts and communicate cash liquidity or any potential liquidity needs based on current cash flow forecasting models and actual transaction activity
  • Assist in effective cash management strategies with short-term investment/redemption recommendations for cash coverage purposes as well as cash consolidation analysis to the Manager of Treasury
• Bank Account Management
  • Maintain the Master bank account database and tracking of current bank requests
  • Manage and execute all requests relating to authorized signer updates, opening and/or closing of bank accounts
  • Liaise with our banking partners to follow up and ensure proper bank account setups, products & services related to accounts are added, and servicing any other banking needs or troubleshooting for the various business units.
  • Work closely with banking institutions to mitigate fraud risk, settle discrepancies and assist with banking integrations
  • Ensure banking institutions are provided with any required documentation as requested including KYC
  • Serve as additional Security Administrator on banking platforms
• Treasury Operations
  • Assist in transition of the banking relationships and implementation of banking infrastructures, as needed, related to the integration of newly acquired companies and/or global expansion initiatives
  • Support the implementation of any Treasury related systems and/or platforms
  • Participate in post-acquisition integration projects, internally and externally, for Treasury functions
  • Complete administrative tasks in conjunction with the Manager of Treasury for existing Debt Facilities such as committed loan notices, rate reset continuation letters, as well as any associated tracking and/or calculations.
  • Adhere to and aid in the documentation of appropriate Internal controls for Treasury processes
  • Additional duties, special projects, and ad hoc analyses as necessary

Required Knowledge & Skills –

• Strong analytical and problem-solving skills
• Detailed oriented, strong attention to accuracy, and self-motivated
• Hard-working, reliable team player and fast learner
• Excellent verbal and written communication skills

Required Education & Experience -

• Bachelor’s degree in finance, accounting, business, or another related field
• MBA, CTP strongly preferred
• Minimum 3-5 years of prior work experience, preferably in a Treasury, Banking, or Finance role
• Experience with banking and e-commerce software and websites (including JPM ACCESS, CIBC, Citi, HSBC, First Merchants, State Street FundConnect, Morgan Money)
• Microsoft Windows and Office proficiency
• Advanced Microsoft Excel skills
• TMS/ERP  preferred (Trovata/NetSuite)
• Solid understanding of Accounting, Finance, and Business principles

Pay Range: $60,000-$70,000

This is the pay range the Company believes it will pay for this position at the time of this posting.  Consistent with applicable law, compensation will be determined based on job-related, non-discriminatory factors including but not limited to work experience, skills, certifications, and geographical location. The Company reserves the right to modify this pay range at any time

Job Summary:

Real Chemistry is looking for an Associate Strategy Director to join our growing team!

21GRAMS, part of Real Chemistry, takes an innovative approach to advertising, and focusing on making healthcare more human. Not just in our work, but in the way we conduct business, approach client relationships, and treat each other. It’s a place where people subscribe to the adage, “Be good to each other, but hard on the work.” A place where people are not just in it for the paycheck, but to make a dent in the universe. Sound like you?

This is a hybrid role, based in any of our US offices—including New York City, Boston, Chicago, Carmel, Lambertville, or San Francisco—or remotely within the US, depending on team and business needs.

What you’ll do:

As the Associate Strategy Director, you will be a key leader responsible for shaping and executing our brand strategy to drive growth and enhance brand equity. You will work closely with executive leadership, cross functional teams, and external partners to develop and implement comprehensive brand strategies that align with our business objectives and resonate with our target audience.

Responsibilities

• Lead the development of brand positioning, messaging, and creative briefs that effectively communicate brand story
• Collaborate closely with cross-functional teams including Account Management, Creative, and Project Management teams to develop integrated omnichannel campaigns that deliver measurable results
• Stay abreast of industry trends, emerging technologies, and best practices in omnichannel marketing, and incorporate relevant insights into strategy development
• Develop and implementing comprehensive strategies that effectively reach target audiences, drive brand awareness, and ultimately, contribute to the success of our clients' campaigns
• Design and facilitate workshops. Lead Tactical and Brand planning.
• Conduct market research, consumer insights, and competitive analysis to identify trends, opportunities, and challenges in the marketplace
• Drive innovation in brand strategy and marketing approaches to stay ahead of industry trends and maintain a competitive edge
• Establish key performance indicators (KPIs) and metrics to measure the effectiveness of brand initiatives and campaigns, and use insights to inform future strategies
• Provide strategic guidance and mentorship to team members, fostering a culture of collaboration, creativity, and continuous learning

This position is a perfect fit for you if: 

• Our Company values – Best Together, Impact-Obsessed, Excellence Expected, Evolve Always and Accountability with an “I” – really speak to you.
• You are adaptable, resilient, and OK with adjusting your scope, responsibilities, and focus as we grow. When things change, so do we. We’re always evolving.
• You are proactive, driven, and resourceful with strong prioritization skills and a desire to dive into the data.
• You are a highly organized self-starter, able to work independently and under tight deadlines.

What you should have:

• Bachelor’s Degree in Business Administration, Marketing, or related field
•  Experience in Brand Strategy or related roles within an advertising agency, with a proven track record of developing and implementing successful brand strategies
• Strong leadership skills with the ability to inspire and motivate cross-functional teams
• Excellent analytical and problem-solving abilities, with a data-driven approach to decision-making
• Exceptional communication and presentation skills, with the ability to articulate complex ideas and strategies in a clear and compelling manner
• Demonstrated ability to thrive in a fast-paced, dynamic environment, managing multiple projects and priorities simultaneously

Pay Range: $125,000-$138,000.00

This is the pay range the Company believes it will pay for this position at the time of this posting.  Consistent with applicable law, compensation will be determined based on job-related, non-discriminatory factors including but not limited to work experience, skills, certifications, and geographical location. The Company reserves the right to modify this pay range at any time. 

Job Description

As an AI Integration Engineer you will play a pivotal role in developing and implementing artificial intelligence solutions that will transform our internal systems and operations. You will work closely with others in the technology team and across various departments to identify areas where AI can improve efficiencies and drive data-driven decision-making. This is a technical hands-on role helping to configure and optimize a variety of technologies.

What you’ll do: 

• Set up and configure the next generation of AI software.
• Design and build integrations for AI tooling to core systems and data.
• In a fast-moving space you’ll be exposed to new tools on a regular basis.
• Integrate AI tools with existing data and systems via API’s and automations.
• Collaborate with various departments to understand their requirements and provide AI solutions.
• Ensure seamless integration and functionality of AI tools within the cloud infrastructure.
• Stay updated with the latest advancements in AI and related technologies.
• Troubleshoot and resolve any issues related to AI tools and their integration.
• Provide training and support to team members on the use of AI tools.

What you should have: 

• Bachelor's degree in Computer Science, Information Technology, or a related field.
• 3+ years of proven experience as a technology professional in a cloud first and progressive IT environment.
• Strong understanding of and a passion for AI.
• Familiarity with the latest LLMs and AI products and their capabilities.
• Proven experience in setting up and configuring AI tools.
• Strong understanding of cloud-based infrastructure and services.
• Ability to switch between different technologies and quickly master new ones.
• Experience in scripting languages such as Python, Ruby, or JavaScript.
• Familiarity with data formats such as JSON, XML, and CSV, and their transformations.
• Experience with OpenAI, Workato and Databricks is preferred.
• Excellent problem-solving skills and attention to detail.
• Strong communication and collaboration skills.
• Passion for technology and continuous learning.
• Healthcare or Advertising industry experience a plus
• Ability to work in an Agile environment and handle multiple projects simultaneously.

This position is a perfect fit for you if: 

• ​Our Company values – Best Together, Impact-Obsessed, Excellence Expected, Evolve Always and Accountability with an “I” – really speak to you. 

• You are adaptable, resilient, and OK with adjusting your scope, responsibilities, and focus as we grow. When things change, so do we. We’re always evolving. 
• You are proactive, driven, and resourceful with strong prioritization skills and a desire to dive into the data. 
• You are highly organized self-starter, able to work independently and under tight deadlines. 

Pay Range: $110,000-$120,000

This is the pay range the Company believes it will pay for this position at the time of this posting.  Consistent with applicable law, compensation will be determined based on job-related, non-discriminatory factors including but not limited to work experience, skills, certifications, and geographical location. The Company reserves the right to modify this pay range at any time

About the Role >>> Senior Director, Global Regulatory Strategy 

As the Senior Director, Global Regulatory Strategy reporting to the Senior Vice President of Regulatory Affairs, your main responsibilities will include the following:  

• Leading the development and execution of innovative regulatory strategies supporting Olema products  
• Representing Regulatory Affairs on cross-functional teams as the subject matter expert and providing regulatory guidance and oversight to the global project teams
• Providing strategic and tactical guidance and leading the development of regulatory submissions (INDs, CTx, briefing documents, IB, NDA, BLA, IMPD etc.)  

This role is based either out of our Boston, MA or San Francisco, CA office and will require domestic and international travel up to 20%. 

Your work will primarily encompass:  

• Develop innovative global regulatory strategies for the Olema portfolio of products, in clinical development and life-cycle management, as needed  
• Represent Regulatory Affairs as the SME across cross-functional teams and provide regulatory guidance/oversight to the global project teams, Study Execution Teams, and the Executive Committee  
• Stay abreast of the regulatory landscape and regulatory requirements impacting drugs, biologics and devices (e.g., companion diagnostics)  
• Be accountable for, provide both strategic and tactical guidance and lead the development of regulatory submissions (INDs, CTX, briefing documents, IB, NDA, BLA, DSUR, IMPD etc.)  
• Represent Olema with global Health Authorities and lead Agency interactions to achieve company objectives  
• Proactively identify gaps and develop risk mitigation strategies for regulatory submissions in alignment with the team(s) and management 
• Ensure Olema’s regulatory activities are robust and in compliance with Health Authority (HA) regulatory requirements  
• Coordinate and maintain all HA reporting schedules in collaboration of cross-functional teams  
• Serve as the point of contact with external parties and vendors supporting regulatory activities (e.g., CROs, contractors etc)   
• Participate in and contribute to cross-functional and departmental objectives  
• Maintain flexibility to adapt and accommodate additional duties as assigned  

And will also include the following:  

• Lead the development of Regulatory Affairs department policies, SOPs, and work instructions  
• Provide Regulatory guidance and leadership to cross-functional teams on software implementation for Regulatory dossiers (e.g., Veeva)  
• Keep the Leadership and the organization fully informed of the regulatory landscape, including HA initiatives, policies and their potential impact on Olema’s programs  
• Lead the global Regulatory team(s) and ensure execution of the regulatory strategies to achieve company objectives  
• Mentor and develop colleagues in the Regulatory department   

Ideal Candidate Profile  >>> Innovative Experienced Regulatory Strategy Leader  

A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role.  

Knowledge:  

• Bachelor’s degree in a scientific discipline  
• Advanced degree in scientific discipline Masters, Pharm D or PhD is preferred   

Experience:  

• 12 years’ experience in Regulatory Affairs in Pharma/Biotech  
• Minimum of 3 years direct leadership experience  
• Strong negotiation skills with health authorities (viz., FDA, EMA, Health Canada, etc.) as well as submissions  
• Experience with leading the NDA/BLA or Marketing Applications is desirable.) 
• Experience in Oncology Therapeutic area is required 
• Experience with development and execution of regulatory strategies in Oncology TA is required  
• Ability to work in a fast-paced environment in a hands-on fashion  
• Excellent oral, written, and presentation skills  
• Strong organizational skills  

Attributes:  

• Self-starter  
• Flexible and proactive, with the ability to manage multiple projects and successfully adapt to changing business needs and priorities

The base pay range for this position is expected to be $270,000 - $290,000 annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits. 

#LI-MK1

About the Role >>> Senior Director, Global Regulatory Strategy 

As the Senior Director, Global Regulatory Strategy reporting to the Senior Vice President of Regulatory Affairs, your main responsibilities will include the following:  

• Leading the development and execution of innovative regulatory strategies supporting Olema products  
• Representing Regulatory Affairs on cross-functional teams as the subject matter expert and providing regulatory guidance and oversight to the global project teams
• Providing strategic and tactical guidance and leading the development of regulatory submissions (INDs, CTx, briefing documents, IB, NDA, BLA, IMPD etc.)  

This role is based either out of our Boston, MA or San Francisco, CA office and will require domestic and international travel up to 20%. 

Your work will primarily encompass:  

• Develop innovative global regulatory strategies for the Olema portfolio of products, in clinical development and life-cycle management, as needed  
• Represent Regulatory Affairs as the SME across cross-functional teams and provide regulatory guidance/oversight to the global project teams, Study Execution Teams, and the Executive Committee  
• Stay abreast of the regulatory landscape and regulatory requirements impacting drugs, biologics and devices (e.g., companion diagnostics)  
• Be accountable for, provide both strategic and tactical guidance and lead the development of regulatory submissions (INDs, CTX, briefing documents, IB, NDA, BLA, DSUR, IMPD etc.)  
• Represent Olema with global Health Authorities and lead Agency interactions to achieve company objectives  
• Proactively identify gaps and develop risk mitigation strategies for regulatory submissions in alignment with the team(s) and management 
• Ensure Olema’s regulatory activities are robust and in compliance with Health Authority (HA) regulatory requirements  
• Coordinate and maintain all HA reporting schedules in collaboration of cross-functional teams  
• Serve as the point of contact with external parties and vendors supporting regulatory activities (e.g., CROs, contractors etc)   
• Participate in and contribute to cross-functional and departmental objectives  
• Maintain flexibility to adapt and accommodate additional duties as assigned  

And will also include the following:  

• Lead the development of Regulatory Affairs department policies, SOPs, and work instructions  
• Provide Regulatory guidance and leadership to cross-functional teams on software implementation for Regulatory dossiers (e.g., Veeva)  
• Keep the Leadership and the organization fully informed of the regulatory landscape, including HA initiatives, policies and their potential impact on Olema’s programs  
• Lead the global Regulatory team(s) and ensure execution of the regulatory strategies to achieve company objectives  
• Mentor and develop colleagues in the Regulatory department   

Ideal Candidate Profile  >>> Innovative Experienced Regulatory Strategy Leader  

A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role.  

Knowledge:  

• Bachelor’s degree in a scientific discipline  
• Advanced degree in scientific discipline Masters, Pharm D or PhD is preferred   

Experience:  

• 12 years’ experience in Regulatory Affairs in Pharma/Biotech  
• Minimum of 3 years direct leadership experience  
• Strong negotiation skills with health authorities (viz., FDA, EMA, Health Canada, etc.) as well as submissions  
• Experience with leading the NDA/BLA or Marketing Applications is desirable.) 
• Experience in Oncology Therapeutic area is required 
• Experience with development and execution of regulatory strategies in Oncology TA is required  
• Ability to work in a fast-paced environment in a hands-on fashion  
• Excellent oral, written, and presentation skills  
• Strong organizational skills  

Attributes:  

• Self-starter  
• Flexible and proactive, with the ability to manage multiple projects and successfully adapt to changing business needs and priorities

The base pay range for this position is expected to be $270,000 - $290,000 annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits. 

#LI-MK1

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.

The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.

This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.

Your role

      Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)

      Scientific Exchange & External Engagement

What You Bring

      Education & Experience

• 8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
• Experience in PDAC, GI malignancies, or NSCLC strongly preferred
• Prior experience supporting clinical-stage or pre-launch oncology assets highly valued

      Skills & Attributes

• Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
• Demonstrated strength in insight generation, synthesis, and communication
• Comfortable operating in a fast-moving, high-accountability biotech environment
• Excellent collaboration skills across matrixed teams
• Strong understanding of U.S. clinical research and healthcare environments

      Compliance & Technical Requirements

• Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
• Commitment to compliant, ethical scientific exchange
• Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)

Work Environment

• Field-based role in Texas, with residence required within assigned territory
• ~ 50% domestic travel expected, with significant time spent with external scientific partners

Why Join Tango Medical Affairs?

• Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
• Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
• Expand and establish Tango as a credible clinical scientific leader in precision oncology
• Work in a lean, collaborative environment where your scientific judgment and execution matter

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Remote

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.

The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.

This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.

Your role

      Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)

      Scientific Exchange & External Engagement

What You Bring

      Education & Experience

• 8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
• Experience in PDAC, GI malignancies, or NSCLC strongly preferred
• Prior experience supporting clinical-stage or pre-launch oncology assets highly valued

      Skills & Attributes

• Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
• Demonstrated strength in insight generation, synthesis, and communication
• Comfortable operating in a fast-moving, high-accountability biotech environment
• Excellent collaboration skills across matrixed teams
• Strong understanding of U.S. clinical research and healthcare environments

      Compliance & Technical Requirements

• Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
• Commitment to compliant, ethical scientific exchange
• Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)

Work Environment

• Field-based role in the Northeast (Boston/New York), with residence required within assigned territory
• ~ 50% domestic travel expected, with significant time spent with external scientific partners

Why Join Tango Medical Affairs?

• Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
• Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
• Expand and establish Tango as a credible clinical scientific leader in precision oncology
• Work in a lean, collaborative environment where your scientific judgment and execution matter

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Remote

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.

The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.

This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.

Your role

      Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)

      Scientific Exchange & External Engagement

What You Bring

      Education & Experience

• 8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
• Experience in PDAC, GI malignancies, or NSCLC strongly preferred
• Prior experience supporting clinical-stage or pre-launch oncology assets highly valued

      Skills & Attributes

• Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
• Demonstrated strength in insight generation, synthesis, and communication
• Comfortable operating in a fast-moving, high-accountability biotech environment
• Excellent collaboration skills across matrixed teams
• Strong understanding of U.S. clinical research and healthcare environments

      Compliance & Technical Requirements

• Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
• Commitment to compliant, ethical scientific exchange
• Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)

Work Environment

• Field-based role in California, with residence required within assigned territory
• ~ 50% domestic travel expected, with significant time spent with external scientific partners

Why Join Tango Medical Affairs?

• Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
• Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
• Expand and establish Tango as a credible clinical scientific leader in precision oncology
• Work in a lean, collaborative environment where your scientific judgment and execution matter

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Remote

Description of Role

Key Responsibilities

Strategic Leadership & Oversight 

• Develop and execute a comprehensive pharmacovigilance (PV) strategy aligned with corporate objectives and regulatory expectations.
• Lead safety governance and benefit-risk management for small molecule assets across development and post-marketing.
• Ensure compliance with global PV regulations (FDA, EMA, ICH, MHRA, etc.).
• Provide strategic safety input into clinical trial designs, protocols, and regulatory submissions.
• Establish and oversee PV partnerships, vendors, and external collaborations. 

Operational & Regulatory Compliance 

• Lead the safety surveillance and signal detection process, ensuring timely identification and mitigation of safety risks.
• Oversee the preparation and submission of safety reports (e.g., DSURs, PSURs, RMPs, SUSARs, IND safety reports, 15-day alerts).
• Ensure robust case processing, signal evaluation, and risk management processes are in place.
• Represent the company in regulatory interactions regarding safety matters (FDA, EMA, etc.). 

Cross-Functional Collaboration 

• Work closely with Clinical Development, Clinical Operations, Regulatory, Medical Affairs, and Commercial teams to integrate safety considerations into decision-making. 
• Partner with Regulatory Affairs to support new drug applications (NDAs) and marketing authorizations.
• Support DSMBs, advisory boards, and investigator meetings with safety expertise. 

Team Leadership & Development 

• Build and lead a high-performing pharmacovigilance team, fostering a culture of scientific excellence and compliance.
• Provide mentorship and guidance to internal safety professionals. 

Compensation

The annual base salary range for this position is $350,000.00 to $380,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.

In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.

Work Location

The Vice President, Pharmacovigilance and Safety role is based in the US, with occasional travel.

POSITION: Full-Time, Exempt

Description of Role

We are seeking a Senior Scientist, Drug Safety (Pharmacovigilance) to support pharmacovigilance activities across Centessa’s clinical-stage development programs. Reporting to Centessa’s Head of Safety and Pharmacovigilance, this role will contribute to the review and analysis of safety data to support ongoing safety surveillance, regulatory compliance, and program execution. The Senior Scientist will work closely with cross-functional partners and external vendors to ensure high-quality safety deliverables and maintain inspection-ready pharmacovigilance processes in a fast-paced, development-focused environment. 

Key Responsibilities

• Provide advanced scientific oversight of ICSR and clinical trial SAE evaluation, ensuring medical accuracy, regulatory reportability, and consistency across global development programs. 
• Lead the development of high-quality case narratives and guide the scientific preparation of regulatory ready case submissions, including SUSARs, in alignment with global reporting requirements. 
• Drive ongoing safety surveillance activities by analyzing aggregate safety data, identifying emerging safety signals, and contributing to risk–benefit assessments for investigational and marketed products. 
• Oversee literature surveillance to identify new or evolving safety information, interpret clinical relevance, and communicate findings to cross-functional stakeholders. 
• Ensure the scientific integrity and quality of safety data through expert review of complex cases and mentorship of junior team members in case assessment and safety data interpretation.  
• Provide senior level scientific input into the preparation and review of DSURs, line listings, safety summaries, and safety-related sections of protocols, Investigator’s Brochures, and regulatory submissions. 
• Serve as the lead drug safety representative on cross-functional study teams, shaping safety strategy, influencing program decision-making, and advising on safety issue management.
• Maintain expert level knowledge of therapeutic areas and global drug safety regulations, guidelines, and evolving best practices (e.g., FDA, EMA, ICH, CIOMS), and apply this expertise to program decisions and safety governance. 
• Collaborate with clinical development, clinical operations, regulatory, medical writing, and quality partners to provide scientific leadership on safety topics and ensure alignment on safety strategy and interpretation.  
• Lead or contribute to complex, cross-functional safety projects, safety signal evaluations, and ad-hoc scientific analyses to support portfolio needs and organizational priorities. 

Qualifications

•  PharmD or PhD in scientific field
• 6+ years of experience of experience in drug safety in the biotech/pharmaceutical industry with 3+ years of pharmacovigilance compliance experience.  
• Prior experience facilitating in Safety Risk Assessment Meetings / Safety Review activities required. 
• Working knowledge of global PV regulations and guidelines applicable to clinical development (e.g., FDA, EMA, ICH, GCP).
• Experience with PV databases and safety surveillance tools (e.g., Argus, ArisGlobal, Vault Safety); familiarity with MedDRA coding preferred.
• Experience supporting clinical safety case processing and aggregate reporting.
• Strong analytical skills, attention to detail, and comfort working across multiple programs.
• Clear communicator who works effectively in small, cross-functional teams.
• CNS experience preferred. 

Compensation 

The annual base salary range for this job level is $145,000 to $190,000. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge. 

In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program. 

Work Location 

Based in the US, with <10% travel.

POSITION: Full-Time, Exempt

Description of Role

The Sr. MSL will serve as a field-based scientific expert responsible for engaging with healthcare professionals (HCPs), supporting clinical development, and ensuring alignment with Centessa’s strategic medical objectives. This role is critical in translating complex scientific data into meaningful clinical insights and fostering compliant, evidence-based dialogue with thought leaders.

Key Responsibilities

Scientific Expertise & Thought Leader Engagement

• Maintain a high level of therapeutic area expertise and scientific knowledge relevant to Centessa’s pipeline and marketed products in alignment with Medical Affairs strategic objectives
• Engage in compliant, non-promotional scientific exchange with key opinion leaders (KOLs), investigators, and other HCPs
• Serve as a trusted scientific resource to external stakeholders, providing accurate and balanced medical information
• Deliver company-approved, high-quality medical/scientific presentations to a variety of audiences including formulary committees and healthcare professionals.
• Provide medical/scientific support for critical Centessa activities including speaker training, advisory boards, and sales training as appropriate
• Ensure accurate, timely, and compliant documentation of field-based activities in accordance with MSL organization guidelines

Clinical Trials Support

• Collaborate with Clinical Operations to identify and evaluate potential clinical trial sites and investigators based on scientific expertise, patient population, and alignment with study objectives
• Provide scientific education and protocol-specific training to investigators and site staff during site initiation visits, ensuring thorough understanding of study rationale and endpoints
• Maintain ongoing engagement with trial sites and investigators to facilitate successful execution of clinical trial objectives, provide ongoing scientific support, address protocol-related inquiries, and ensure high-quality data generation

Medical Conference Attendance & Coverage

• Attend relevant scientific and medical congresses to stay current with emerging data and trends
• Provide real-time insights and post-conference reports to internal teams
• Support Centessa’s presence at congresses through development of pre-conference plans, booth coverage, symposia participation, and KOL engagement
• Senior MSLs will be responsible to leading strategic conference planning, execution, and reporting

Scientific Materials Development

• Contribute to the development of scientific slide decks, FAQs, and educational materials
• Writing and editing Medical Information response letters
• Ensure all materials are medically accurate, evidence-based, and compliant with regulatory standards
• Collaborate with Medical Affairs and Legal teams to ensure scientific content meets internal and external guidelines

Additional Responsibilities:

• Lead MSL strategic initiatives/projects aligned with Medical Affairs and MSL organization strategy
• Develop and implement scientific training plans for the MSL team
• Contribute to MSL organization strategy in collaboration with MSL leadership
• Mentorship of MSL peers

Qualifications

• Advanced degree (PhD, PharmD, MD, DP, PsyD, DNP) in life sciences or a related field (from An Accredited College or University).
• Minimum 4+ years' experience as an MSL for a drug development company in the pharmaceutical/biotech industry
• Demonstrated understanding of sleep medicine and/or associated neuroscientific areas required 
• Exceptional verbal and written communication skills; ability to tailor scientific messages to diverse audiences and ability to interpret and communicate complex scientific data
• Proven ability to build and maintain strong relationships with KOLs, investigators, and internal stakeholders
• Strong understanding of clinical trial design, regulatory requirements, and therapeutic area landscape
• Skilled in developing and delivering scientific presentations in various settings
• Strong understanding of industry regulations and guidelines governing medical interactions
• Ability to align field activities with broader medical and corporate strategies
• Senior MSLs have a proven ability to lead and mentor peers
• Must have a valid driver’s license with a driving record that meets company requirements
• Must reside within the New England region or the New York Metro area.
• Willing and able to travel frequently within assigned territory (Boston, New York, Philadelphia, Baltimore, Detroit, Cleveland, Cincinnati)

Compensation

The annual base salary range for the Senior MSL job level is $190,000 - $230,000.

Individual compensation within these ranges will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.

In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.

Work Location

The Sr. MSL - Northeast is a remote role based in the US, with up to 60-70% travel and occasional weekends

POSITION: Full-Time, Exempt

SUMMARY:

Centessa continues to expand its CMC group and currently seeks an Executive Director of CMC, to lead our small molecule development programs across all CMC functions. This individual will be responsible for driving technical strategies, managing outsourced manufacturing partnerships, and overseeing all aspects of CMC development from early-to late-stage development and clinical studies. This high-impact leadership role requires a blend of scientific expertise, operational savvy, business acumen, technical efficiency, and strategic foresight. The ideal candidate brings deep experience in small molecule drug development, excels at cross-functional collaboration, and thrives in a growth-stage biotech environment.

The Executive Director, CMC will report directly to the SVP, CMC and will have ownership across the CMC function to include strategy, direct reports, team management, cross-functional leadership, and external manufacturing on our pipeline programs. Travel to vendors both domestically and internationally will be required.

RESPONSIBILITIES:

Strategic Leadership

• Oversee the implementation of end-to-end CMC strategy across Centessa’s development programs
• Translate development goals into robust CMC plans, ensuring alignment across R&D/early stage, Clinical, Quality, and Regulatory functions
• Develop long-term development manufacturing strategies that consider Phase 1/Phase 2 forecasting, demand forecasting, investment planning, inventory control, and vendor relationships
• Proactively identify and mitigate technical, production, and supply chain risks

Operational Oversight

• Act as the CMC team representative member in cross-functional developmental teams
• Oversee outsourced manufacturing activities, including CDMO contract negotiations and performance management
• Ensure timely delivery of clinical supply and maintain timelines for Registration/Primary Stability, PPQ/Commercial, and Phase 1/Phase 2 drug substance and drug product batches.
• Manage the development of budgets and timelines for CMC operations and report regularly to leadership
• Drive cross-functional meetings and milestone planning to support timely execution across drug substance and drug product for development programs
• Interface closely with key stakeholders in Quality, Regulatory, Supply Chain, Clinical, Legal, Finance, Project Management, and Non-Clinical teams in the development and execution of CMC plans
• Assist in developing documents and maintain compliance consistent with GLP and GMP standards for pre-clinical, early- and late-stage clinical development (pre-IND through Phase 3+)
• Develop and oversee SOPs, protocols/reports, and phase-appropriate specifications for pharmaceutical development and manufacturing activities
• Oversee technical transfer activities of API and drug product for supply chain resilience

Manufacturing and Technical Execution

• Supervise drug substance and drug product manufacturing and coordination of labeling, packaging, and distribution
• Oversee sourcing, planning, and logistics for raw materials, APIs, excipients, and required specialized critical reagents or equipment to meet production requirements
• Manage analytical method development and validation for starting materials, in-process controls, and final release and stability
• Participate in manufacturing site visits and pre-approval inspection readiness initiatives
• Identify, select, and manage CDMOs for process optimization, non-GMP and GMP manufacture and supply of API and drug product in support of ongoing pre-clinical and clinical programs, including delivery of scalable and cost-effective manufacturing routes that meet business requirements

Regulatory Affairs

• Collaborate with Regulatory Affairs to support the preparation and submission of CMC sections (INDs, IMPDs, NDAs, etc)
• Address CMC-related and pertinent cross-functional questions from regulatory authorities and ensure submission and response timelines are met

QUALIFICATIONS:

• Thorough understanding of cGMP requirements for pharmaceutical products
• Strong organizational, interpersonal, leadership, and decision-making skills
• Ability to work independently in a fast-paced dynamic environment with multiple projects and competing priorities
• Demonstrated ability to coordinate CDMO activities in the development and commercialization of pharmaceutical products
• Excellent organizational skills, project management skills and detail-orientated leadership approach
• Strong experience with chemical and physical characterization of small molecules
• Knowledge of regulatory environment (ICH/FDA/EMA regulations) and experience with organizing and writing regulatory submissions
• Understanding of product quality attributes control strategies as applied to small molecule synthetic processes

EXPERIENCE:

• Master’s degree in Organic Chemistry, Pharmaceutics, Chemical Engineering, or related scientific discipline (PhD strongly preferred).
• Minimum 18 years of pharmaceutical industry experience including at least 8 years in CMC. 
• Strong track record in CMC leadership across small molecule early-phase development and late-stage filing activities, including management of US and international CDMOs
• Extensive experience working with CDMOs and managing external partnerships
• In-depth knowledge of cGMP regulations and best practices in both clinical and commercial manufacturing
• Demonstrated success in process development, scale-up, and validation
• Prior experience drafting and submitting CMC content for regulatory filings in the U.S. and international markets, and interacting with global health authorities (IND, IMPD, NDA, MAA)
• Strong communication, project management, and organizational skills
• Proven ability to lead cross-functional teams in a fast-paced, evolving environment
• Strong skills in identifying and resolving critical issues
• Strong track record in effectively working with senior management

Compensation

The annual base salary range for this job level is $300,000 - $340,000. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.

In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.

POSITION: Full-Time, Exempt

Description of Role

Centessa is growing its clinical development organization. Reporting to the SVP, Clinical Development, the Executive will provide medical leadership and oversight to Centessa’s programs and associated clinical trials. The role requires leadership and contributions both at a strategic level and hands-on project level work.  Executive Director will have prior experience in the biotech/pharma industry, in neurodegenerative/neuropsychiatric therapeutic areas and across the development cycle of an asset (early to late phase).  

RESPONSIBILITIES:

• Primary point of contact for clinical development activities with willingness to work strategically and hands on at the program and clinical trial levels.
• Accountable for the oversight, monitoring and surveillance of overall risk, safety, benefit/efficacy to patients as well as compliant trial execution and optimal integrity of data.
• Responsible for establishing relationships and communication with KOLs, investigators and relevant site medical (or other supportive roles) personnel.
• Lead the clinical development strategy and innovative approaches for the overall clinical pathway for the asset.
• Key clinical development contributor to publication strategy and planning, authoring of publications, posters, etc., and present or support presentations, posters, etc., in conferences and meetings.
• Play a key role in regulatory and health authority interactions.
• Lead clinical development contributor to regulatory activities, submissions, and clinical sections of regulatory/health authority pre-meeting packages and initial applications, routine annual reports, ad hoc safety reports (SUSARs), interim and final CSRs, etc.
• Author asset and clinical trial level plans, charters, documents.
• Determine optimal clinical trial design options that are innovative, patient centric, cost efficient, and enable meeting business goals. 
• Responsible for review, analysis and interpretation of all clinical trial data including assessment of protocol deviations.
• Lead asset level clinical sub-teams and play key leadership role on program team for clinical development.
• Lead asset level and trial level medical forums as needed (safety review committee, ad board, KOL meetings, medical review/discussions of patient cases, cohort review meetings, etc.).  
• Attend and present as needed at core team meetings, investigator meetings, site visits, etc.
• Liaise with cross functional partners, vendors, and CROs to ensure the progression of clinical studies within the expected time frame.
• Provide clinical evaluation and interpretation of pre-clinical results.
• Remain current on the development of  orexin agonists and  the relevant therapeutic areas through review of the scientific literature, interactions with KOLs and other external experts and attendance at relevant scientific meetings, to provide input and guidance for the strategic direction of Centessa clinical stage programs. 

QUALIFICATIONS:

• MD required, MD/PhD strongly preferred (includes internationally recognized equivalent)
• Minimum 10 years of overall experience (academia, clinical practice, pharma/biotech industry, etc.)
• Minimum 5 years of pharmaceutical/biotech industry experience, including managing clinical development and clinical science teams, clinical development programs and clinical trials
• Prior pharma/biotech and line management experience – Required
• CNS therapeutic area (particularly neurodegenerative/neuropsychiatric) experience- Required
• Willingness to deliver project and tactical level work
• Excellent working knowledge of regulations across various agencies (FDA, EMA, etc.) and GCP, & ICH guidelines.  Knowledge or experience supporting regulatory or health authority inspections a plus.
• Experience leading and authoring clinical development inputs into regulatory submissions (IND, CTAs, NDA/BLAs, designation applications, etc.) and representing clinical development in agency interactions.
• Experience authoring and guiding teams with key asset and clinical trial level plans and documents.
• Strong knowledge in clinical development strategy, clinical trial design, regulatory pathways, biostatistics methodologies, and ability to analyze and interpret translational medicine, clinical, and research data as it relates to an asset, patients, etc.
• Possess excellent written and oral communication skills with internal and external stakeholders
• Proven ability to work collaboratively, take initiative, solve complex issues, and deliver results in a fast-paced, team-based matrix environment
• Demonstrate sound judgement in handling complex, confidential, and highly regulated information
• Ability and willingness to travel as required.

The annual base salary range for this level is $300,000.00 to $375,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge.

In addition to base pay, this role is eligible for a discretionary annual bonus. Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, vision, and life insurance, generous paid time off, and a health and wellness program.

Work Location

The Executive Director, Clinical Development role is a remote role based in the US, with occasional travel.

This is a part-time consulting role for 20hr/week. Duration of the project will be approximately 3-4 months. Preference will go to candidates in the Boston area. 

Your impact:

As the AI Adoption Consultant, you will bridge the gap between cutting-edge artificial intelligence and the complex workflows of a modern biotechnology organization. Your mission is to accelerate the integration of AI tools across the enterprise, moving beyond the "hype" to deliver tangible improvements in operational efficiency and scientific output.

You will partner with leaders in Research, Clinical Operations, Finance, IT, and People & Culture to identify high-impact opportunities, design implementation roadmaps, and lead a culture-shifting training program to ensure every employee is "AI-fluent."

Your day-to-day:  

• Conduct deep-dive discovery sessions with functional leads (Finance, IT, Research, etc.) to map existing workflows and identify bottlenecks.
• Build a prioritized "AI Opportunity Roadmap" that balances quick wins with long-term strategic shifts.
• Evaluate and recommend third-party AI tools or internal LLM applications that meet the specific security and compliance standards of the biotech industry.
• Collaborate with the CIO and IT team to ensure AI deployments are scalable, secure, and integrated into the existing tech stack.
• Develop and deliver tailored training modules for diverse audiences—from "AI for Scientists" to "Prompt Engineering for Finance Professionals."
• Create "Office Hours" and internal communities of practice to foster continuous learning and peer-to-peer knowledge sharing.
• Work with Legal and IT to establish clear guidelines for the ethical use of AI, particularly regarding sensitive data and intellectual property.

Must-Haves:

• Experience: 5+ years of experience in digital transformation, management consulting, or a similar role, with at least 1-2 years focused specifically on AI/ML implementation.
• Industry Knowledge: Direct experience in the Biotech or Pharmaceutical sector is highly preferred.
• Technical Fluency: A strong understanding of Large Language Models (LLMs), Generative AI tools, and data orchestration. You don't need to be a coder, but you must be able to speak the language of both data scientists and end-users.
• Communication: Exceptional ability to translate complex technical concepts into "business value" for non-technical stakeholders.
• Education: Bachelor’s degree in a relevant field (CS, Data Science, Business, or Life Sciences).

About the Position 

As Associate Director of RWD Intelligence at Formation Bio, you will lead the strategy and execution of our real-world data (RWD) capabilities, building the data foundations that power drug acquisition, clinical development, and portfolio decision-making. You will own the end-to-end lifecycle of RWD: sourcing, procurement, ingestion, harmonization, quality assurance, and delivery of analysis-ready datasets to downstream consumers across Product, Data Science, Clinical Development, and Business Development.

This role sits at the intersection of data engineering, data science, and drug development. You will build and maintain scalable data infrastructure (pipelines, data models, lakes/marts) while ensuring semantic interoperability across heterogeneous data sources through ontology-driven harmonization frameworks such as OMOP. You will also manage vendor relationships and data procurement, evaluating and integrating new data assets as the portfolio evolves. The ideal candidate combines deep RWD domain expertise with strong data fluency, enabling Formation Bio to treat real-world evidence as a first-class strategic asset.

Responsibilities

• Lead the RWD Intelligence function within Data Science, owning data strategy, sourcing, and delivery of analysis-ready datasets
• Architect and maintain the supporting infrastructure (pipelines, ingestion workflows, data models, lakes/marts) across EHR/EMR, claims, registries, and genomics-linked cohorts
• Drive adoption and extension of harmonization frameworks (e.g., OMOP CDM) across heterogeneous data sources, leveraging AI/ML tools for entity resolution, ontology mapping, data quality monitoring, and automated harmonization
• Manage RWD vendor relationships end-to-end: evaluate providers, negotiate data use agreements, broker new partnerships, and integrate acquired datasets into the platform
• Partner with Data Science, Clinical Development, Business Development, and Engineering teams to define RWD use cases (trial feasibility, synthetic control arms, epidemiology, label expansion) and productize ad hoc pipelines into scalable, production-grade systems
• Foster a culture of data quality rigor, documentation, and reproducibility across all RWD assets

About You 

Required Qualifications

• BSc or MSc in biomedical informatics, computational sciences, epidemiology, or a related quantitative field
• 5+ years of industry experience working directly with real-world data (EHR/EMR, claims, registries, linked biobank data) in pharma, biotech, health tech, or consulting, with at least 2+ years in people management
• Strong data engineering proficiency (pipelines, ingestion frameworks, data models, data lakes/marts) combined with deep working knowledge of biological and medical ontologies (ICD, SNOMED CT, MedDRA, RxNorm, ATC) and harmonization standards, particularly OMOP CDM
• Demonstrated experience with RWD procurement and vendor management: evaluating data providers, negotiating agreements, and integrating new data assets
• Proven ability to deliver RWD-derived insights across multiple drug development use cases (e.g., trial design, epidemiology, comparative effectiveness, label expansion), with familiarity across the development lifecycle from target selection through post-market
• Proficiency with modern AI/ML tools, including large language models, and their applications in data engineering and harmonization workflows
• Strong communication skills with the ability to translate complex data infrastructure concepts for clinical, scientific, and executive audiences

Preferred Qualifications

• PhD in biomedical informatics, epidemiology, computational biology, or a related field
• Experience with large-scale biobank and genomics-linked RWD platforms (UK Biobank, FinnGen, All of Us), with a track record of building RWD infrastructure that directly influenced drug acquisition, licensing, or portfolio decisions
• Familiarity with additional biomedical data modalities (scientific literature mining, -omics datasets, molecular data integration) and with data science/analytics methodologies applied to RWD (causal inference, trial simulation, propensity score methods)
• Background transitioning data infrastructure from research/ad hoc to production-grade systems in regulated environments
• Experience working at the intersection of data engineering, data science, and business strategy in pharma/biotech

Total Compensation Range: $204,500 - $267,000

Company Overview:

PhaseV (HQ in Boston, R&D in Tel Aviv) is a cutting-edge startup, pushing innovation in the drug development process to bring new treatments to more patients, in a more efficient and precise way. Leveraging the power of advanced causal inference and pushing the boundaries of machine learning, PhaseV detects hidden signals in clinical data and extracts actionable insights for planning the optimal trial. The company's proprietary ML-based platform for adaptive clinical trial design and closed-loop execution enables sponsors to easily and quickly unlock the potential of adaptive clinical trials, reveal the optimal adaptive design to meet their trial objectives and execute more efficient, more precise, and more successful clinical trials. Collaborating with 7 of the top pharmaceutical companies, as well as multiple CROs and biotechs, we are poised to make a significant impact on how drugs are developed and brought to market.

Position Overview:

We are seeking a talented Data Scientist to join our team of researchers. The ideal candidate will have a strong foundation in machine learning and statistics with an interest in causal inference. A couple of recent preprints we’ve released to get a sense of the challenges:

• Causal Responder Detection (https://arxiv.org/abs/2406.17571)
• Robust CATE Estimation Using Novel Ensemble Methods. (https://arxiv.org/abs/2407.03690)

Key Responsibilities:

Technical Development:

• Implement and optimize ML algorithms, with a focus on causal ML applications in clinical trials
• Collaborate with senior data scientists to develop and improve our analytical platforms
• Work alongside clinical and biological experts to translate complex problems into technical solutions

Research & Analysis:

• Conduct rigorous statistical analyses of both randomized and observational data
• Develop and validate methods for responder identification and treatment effect estimation
• Document and present methodologies and results for internal and external stakeholders

Collaboration:

• Work cross-functionally with engineering and product teams
• Contribute to technical discussions and peer code reviews
• Support the preparation of technical documentation and research papers

Qualifications:

Education:

• Master's in Computer Science, Statistics, Data Science, Engineering or a related field
• Ph.D. is an advantage but not required

Experience:

• 3+ years of experience in data science or machine learning roles
• Experience with ML in a practical research or industry setting
• Background in statistical modeling and analysis

Skills:

• Strong programming skills in Python (R in addition - an advantage)
• Proficiency in statistical analysis and machine learning
• Experience with data visualization and communication of technical concepts
• Strong analytical and problem-solving skills

Preferred:

• Familiarity with causal inference concepts
• Experience in healthcare or biotech industry
• Experience with large-scale data processing

What We Offer:

• Join us on a mission to bring more effective drugs to more patients.
• The opportunity to work with an amazing team passionate about making a real-world impact.
• Extremely hard and diverse problem setting, in which the team is pushing the envelope.
• A collaborative and dynamic startup environment.
• Professional growth and development opportunities.

Your impact:

As a Senior Clinical Trial Associate, you’ll be a key player in keeping our clinical studies on track—managing the details, supporting the team, and helping bring innovative treatments to patients

Your day-to-day:  

• Coordinates and tracks the distribution and subsequent retrieval of clinical documents, including but not limited to protocols, protocol amendments, IBs, ICF's, monitoring visit reports, etc.
• Supports maintenance of inspection-ready Trial Master File (TMF) according to ICH-GCP and company SOPs
• Perform quality checks on the study TMF with oversight of study COL
• Assists in the preparation of study related documents, i.e., ICF, clinical trial tools and templates, etc. May coordinate and track clinical trial equipment and supplies
• Review and track vendor invoices against contracts with oversight of study COL
• Coordinates and tracks administrative aspects of contract execution and PO generation
• Supports the trial team to produce and distribute study newsletters
• Supports collection and updating of clinical trial insurance
• Supports posting of all agreed clinical trials to publicly available websites
• Assists with various supportive trial activities, i.e., meeting management including agenda distribution and minute taking, internal database maintenance, study team contact list, etc.
• May support additional ad-hoc activities as agreed with the study COL

Must-Haves:

• Bachelor's degree in life sciences or healthcare related field
• 3+ years' experience in a clinical trial support position, experience in Biotech or Pharma strongly preferred
• Strong computer skills including knowledge of Excel, Word, PowerPoint and Outlook
• Solid understanding of the responsibilities and needs of other functions in a clinical trial
• Proven ability to work independently and effectively handle multiple priorities in a fast-paced environment
• Ability to multitask and flex across projects as priorities and deadlines shift
• Ability to maintain confidentiality of proprietary information
• A team player that takes initiative and is proactive 

What makes Rapport special:

• Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start.
• We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
• Your perspective matters. Stick your neck out, share your ideas – we work as a team.
• We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with.
• Leadership that CARES – about you, your growth + development.
• We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together.
• Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
• You get to be YOU! Show up as you are and make every day count.

Your Compensation:

We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this?  We tell you about our hiring range now - we expect the hiring range for this role to be $90,000-$110,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company. 

Hybrid Work Environment:

This role is onsite in our Boston office. We prioritize in person connection with our fellow Rapptors! Our team members come together onsite at our Boston office Monday, Tuesday and Wednesday to create more opportunities for innovation, collaboration, and connection.

Job Title: Delivery and Success Associate - Enterprise
Employment Status: Full-time
Office Hours: Monday - Friday; hybrid schedule
Location: Boston, Massachusetts
Compensation: $62,000 - $75,000 base + variable + equity options
*compensation may be negotiated based on experience level

About Ketryx:

Ketryx is an AI software platform that enables healthcare life sciences companies to ship life-saving regulated products in weeks instead of years.

Exploding product complexity is burying companies in compliance paperwork and blocking innovation. Our AI software removes this friction, dissolving the historical tradeoff between innovation and compliance, and enables regulated industries to innovate at the pace of modern software.

Just two years since launch, Ketryx already touches the lives of 25M patients and powers 3 of the world’s top 5 MedTech companies and 25% of the Fortune 500 MedTech market. Backed by Lightspeed Ventures, our founders are the former Head of AI at Amgen and CTO of Wolfram Cloud.

Healthcare and life sciences is just the beginning for us. Automotive, aerospace, energy — if it’s regulated, it’s because society decided it matters. These products move humanity, shape our future, and are safety-critical. Come join us and help build the AI platform to power safe innovation.

The role

As a Delivery and Success Associate - Enterprise, you’ll work closely with customers who rely on Ketryx to manage safety‑critical and regulated development processes. This is a technical, engineering‑adjacent role.

You’ll support customers from onboarding through long‑term partnership, helping configure the Ketryx platform, supporting requirements and quality workflows, and applying structured problem solving to real challenges. You’ll develop a deep understanding of how regulated teams build, verify, and validate software.

This is an excellent opportunity for early‑career engineers or technically trained professionals who want exposure to regulated industries, verification & validation practices, and customer‑facing technical work, while growing alongside a mission‑driven team.

About you

You bring an engineering mindset to your work. You like understanding how systems fit together, why processes exist, and how to improve them. You’re comfortable learning complex concepts and applying structure and logic to ambiguous problems.

You’re excited by the opportunity to work close to engineering, quality, and regulated product development, while also collaborating directly with customers.

You’re curious, detail‑oriented, and motivated by meaningful work that has real‑world impact.

Responsibilities 

• Support Customer Success: Partner with clients during onboarding and ongoing use of the Ketryx platform, helping them apply best practices for requirements, verification, and quality workflows.
• Configure and Support the Platform: Assist with configuring Ketryx to align with customer development processes, including requirements traceability, documentation workflows, and validation artifacts.
• Apply Engineering & Quality Thinking: Help customers reason through leaving evidence, verification activities, and structured development processes commonly used in regulated and safety‑critical environments.
• Troubleshoot and Problem‑Solve: Investigate technical and workflow challenges, escalate thoughtfully when needed, and follow through to resolution.
• Collaborate Cross‑Functionally: Share customer insights with Product, Engineering, and Quality teams to help improve the platform and internal processes.
• Support Quality & Compliance Efforts: Contribute to accurate, well‑structured documentation within the Quality Management System (QMS) and reinforce strong process discipline.
• Grow Your Technical Skill Set: Build fluency in regulated software development concepts such as requirements management, verification & validation (V&V), and the V‑model.

Required Skills

• Technical or Engineering Background: Bachelor’s degree in engineering, computer science, or a related technical field (or equivalent hands‑on technical experience).
• Exposure to Structured Development: Familiarity with concepts such as requirements, verification & validation, testing, systems engineering, or the V‑model (academic or professional exposure is sufficient).
• Interest in Regulated Industries: Curiosity about or comfort working in regulated, safety‑critical environments (medical devices, biotech, pharma, aerospace, automotive, etc.). Prior regulated experience is a plus, not a requirement.
• Technical Communication Skills: Ability to understand and explain technical concepts clearly, both verbally and in writing.
• Analytical Problem‑Solving: Comfort troubleshooting issues, asking good questions, and reasoning through complex workflows.
• Collaborative Mindset: Enjoys working across teams and building trusted relationships with customers and teammates.

Preferred Skills

• Experience in customer success, professional services, or product operations in B2B SaaS.
• Background in quality, regulatory affairs, or systems engineering.
• Familiarity with Software as a Medical Device (SaMD).
• Experience working in an early stage, product-based start up.

Keywords: customer success, client operations, delivery and success, professional services, systems engineer, Solutions Architect, Software as a Medical Device, SaMD, product management, technology, client management, quality, regulatory, system engineer, B2B, regulation, task management, project management, Greater Boston, MA, SQL, KQL, python, java

Position

Manifold's AI team is actively training protein foundation models on our proprietary experimental datasets. Our generative antibody design model, mBER, has already demonstrated controllable de novo binder design across multiple million-scale screening campaigns, and the team is now scaling foundation model capabilities to push well beyond current performance. We are looking for an AI/ML Scientist to join this effort. You will work alongside our existing model training team to accelerate the development of foundation models fine-tuned on Manifold's data, bringing additional depth in pre-training methodology, architecture development, and large-scale training. Your work will directly improve mBER's design capabilities and unlock new modeling paradigms for the broader team. You'll own foundation model projects end-to-end, from architecture selection and training infrastructure to evaluation against real experimental outcomes, while contributing to the team's shared research agenda.

This is an on-site role and can be based in either Boston, Massachusetts or San Francisco, California. Please only apply if you reside in these cities or are open to relocate. 

Responsibilities

• Advance the team's ongoing foundation model training efforts—pretraining, fine-tuning, and evaluating folding, docking, language, and generative design models on Manifold's proprietary experimental data
• Bring depth in training methodology, architecture selection, and optimization to complement the existing team's expertise
• Develop and scale training pipelines for distributed, multi-GPU and multi-node training runs
• Integrate foundation model outputs into mBER to improve binder design success rates and enable new design capabilities
• Design and execute ML experiments with clear hypotheses, rigorous evaluation frameworks, and systematic analysis
• Establish best practices for mixed-precision training, gradient checkpointing, and computational efficiency at scale
• Produce clear documentation and analysis supporting architecture and training decisions

Required Qualifications

• Demonstrated experience pretraining and/or fine-tuning protein foundation models (folding, docking, language models, or generative design) with published or otherwise demonstrable results
• Strong familiarity with AlphaFold architecture and training methodology
• 2+ years of hands-on experience with PyTorch and/or JAX for deep learning
• Experience with large-scale model training: distributed training, multi-GPU/multi-node setups, mixed precision, gradient checkpointing
• Solid understanding of deep learning architectures (transformers, attention mechanisms, diffusion/flow matching) and optimization techniques
• Experience working with protein structure data (PDB, mmCIF) and/or protein sequence datasets
• Strong statistical analysis and experimental design skills
• Proficiency in Python scientific computing stack (NumPy, Pandas, scikit-learn)
• Self-directed researcher who can balance guidance with independence
• Excellent written and verbal communication skills for cross-functional collaboration

Preferred Qualifications

• Experience with protein generative design methods (e.g., RFdiffusion, ProteinMPNN, flow matching approaches)
• Experience with protein language models (e.g., ESM family)
• Published research in computational biology, protein design, or structural biology
• Experience training on proprietary or domain-specific biological datasets
• Familiarity with Ray for distributed computing
• Experience with Kubernetes (EKS) and cloud computing platforms (AWS)
• Knowledge of protein engineering, directed evolution, or structural biology wet lab techniques
• Experience working with agentic AI coding tools for fast, parallelized execution of modeling experiments
• Previous biotech/pharma industry experience

This Role Might Be Perfect For You If:

• You have deep experience training protein foundation models and want to apply that expertise to some of the richest proprietary experimental datasets in the field
• You're excited about pushing beyond public model performance by leveraging unique, large-scale in vivo screening data
• You thrive in high-ownership roles where you can drive research direction while collaborating with a tight-knit, world-class team
• You want your models to directly impact real drug discovery programs

If you're excited to train the next generation of protein foundation models on uniquely powerful experimental data, please reach out to careers@manifold.bio.

Base Salary Range: $140,000-225,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This role is eligible for:

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

Location: Boston, MA preferred

• Strategy & Leadership
• Define and execute bioanalytical and biomarker strategies across preclinical and clinical programs
• Align biomarker plans with clinical, regulatory, and development objectives
• Serve as a subject matter expert in bioanalysis and translational biomarkers
• Assay Development & Oversight
• Oversee development, validation, and implementation of bioanalytical assays (e.g., PK, ADA, cell-based, molecular assays)
• Guide biomarker assay selection and fit-for-purpose validation strategies
• Ensure assay performance meets regulatory and scientific standards
• Vendor & Study Management
• Select and manage CROs and external labs for bioanalytical and biomarker activities
• Oversee timelines, budgets, and deliverables across studies
• Ensure high-quality data generation and timely reporting
• Clinical Study Support
• Partner with Clinical Operations and Clinical Development to integrate biomarker endpoints into study design
• Review and interpret biomarker and PK/PD data to inform program decisions
• Contribute to clinical study protocols, SAPs, and reports
• Regulatory & Compliance
• Ensure compliance with GLP/GCP and regulatory guidance (FDA, EMA)
• Contribute to regulatory submissions (INDs, BLAs, briefing packages)
• Represent bioanalytical/biomarker strategy in regulatory interactions as needed
• Cross-functional Collaboration
• Work closely with Translational Sciences, Clinical Pharmacology, Regulatory, and CMC teams
• Communicate complex data and insights to internal stakeholders and leadership

• PhD in Biology, Pharmacology, Immunology, Bioanalytical Sciences, or related field (or MS with significant experience)
• 10+ years of experience in bioanalysis and/or biomarker development in biotech/pharma
• Deep expertise in bioanalytical assays (e.g., LC-MS/MS, ELISA, flow cytometry, qPCR, NGS, cell-based assays)
• Strong understanding of PK/PD, immunogenicity, and translational science principles
• Experience supporting clinical-stage programs and regulatory filings
• Proven track record managing CROs and external partnerships
• Strong leadership, communication, and project management skills

• Experience in [oncology, cell/gene therapy, immunology — tailor as needed]
• Familiarity with companion diagnostics or advanced biomarker platforms
• Prior team leadership or people management experience

The salary range for the Director, Bioanalytical / Biomarkers is expected to be between $210,000 and $230,000 per year.  Individual pay may vary based on multiple factors including but not limited to relevant job-related skills, experience, education or training, market factors, and work location.

New Business Designer

About Real Chemistry

At Real Chemistry, making the world a healthier place isn’t just an aspiration—it’s our everyday reality. We combine deep scientific expertise, human‑centered creativity, and data‑driven intelligence to help healthcare brands make meaningful impact. Our Enterprise New Business team plays a critical role in shaping how we show up to prospective clients—bringing clarity, creativity, and polish to high‑stakes pitches and growth opportunities.

The Role

We are looking for a Freelance New Business Designer to join our Enterprise New Business team. This is a highly executional, individual‑contributor role focused primarily on PowerPoint design, including custom pitch templates, layout systems, and presentation polish, with graphic design support as needed.

You will work closely with new business, strategy, and creative partners to help transform complex ideas into clear, visually compelling pitch materials that support Real Chemistry’s growth efforts.

What You’ll Do

• Design and build high‑impact pitch decks primarily in PowerPoint, ensuring clarity, consistency, and visual polish
• Create custom PowerPoint templates and slide systems tailored to individual new business opportunities, while aligning with Real Chemistry brand guidelines
• Translate strategic and written content into clean, engaging layouts that tell a cohesive story
• Apply lgraphic design support as needed (e.g., charts, icons, simple illustrations, visual frameworks)
• Partner closely with new business, strategy, and creative teams to meet tight deadlines and evolving pitch needs
• Ensure all materials meet Real Chemistry’s quality, accessibility, and brand standards

What You Bring

• 8-10+ years of experience in presentation design, design production, or similar role, preferably within an agency, consulting, or new business environment
• Advanced proficiency in PowerPoint, with a strong understanding of master slides, templates, and layout systems
• Solid design fundamentals, including typography, layout, hierarchy, and visual storytelling
• Experience with graphic design using tools such as Adobe Creative Suite (e.g., Illustrator, InDesign) or comparable tools
• Ability to work quickly and accurately under tight deadlines while maintaining attention to detail
• A collaborative, solutions‑oriented mindset and comfort working with cross‑functional partners

Nice to Have

• Experience supporting new business, pitches, RFIs/RFPs, or growth initiatives
• Familiarity with healthcare, life sciences, or highly regulated industries
• Experience adapting or extending established brand systems within presentations

Why Real Chemistry

• Join a high‑visibility enterprise new business team supporting growth across the organization
• Work on a wide range of strategic, creative, and high‑stakes pitch opportunities
• Collaborate with talented teams across strategy, creative, data, and medical
• Flexible, remote‑friendly work environment rooted in Real Chemistry’s people‑first culture

Pay Range: $75-85 per hour 

This is the pay range the Company believes it will pay for this position at the time of this posting.  Consistent with applicable law, compensation will be determined based on job-related, non-discriminatory factors including but not limited to work experience, skills, certifications, and geographical location. The Company reserves the right to modify this pay range at any time

Position

We are seeking a highly-motivated In Vivo Pharmacology Senior Research Associate  who thrives in a fast-paced and creative environment to push the capabilities of our multiplexed in vivo drug discovery platform. Together with senior researchers, you will play a critical role in executing in vivo studies to support internal research projects. This is a hands-on role and you should have extensive experience in multiple aspects of in vivo pharmacology including dosing, necropsy, perfusion, tissue collection and  sample processing, among others. The ideal candidate must be able to work effectively both in a collaborative setting and independently. 

Responsibilities

• Conduct in vivo mouse studies, including dosing via IV, IP, SQ, and other routes as needed.
• Perform necropsy, tissue dissection, perfusion, and blood/tissue collection (in-life and terminal
• Perform blood collections via submandibular cheek bleeds and cardiac punctures.
• Prepare and process tissues for downstream analysis.
• Accurately label samples, track collection, and maintain comprehensive records.
• Follow protocols rigorously and contribute to protocol refinement when needed.
• Ability to follow SOPs and work independently in a high-throughput setting.
• Maintain accurate and organized data entry and analysis.
• Collaborate with cross-functional teams in a dynamic research environment.
• Strong attention to detail with excellent data organization and recordkeeping.
• Assist in maintaining inventories.

Required Qualifications

• Bachelors or Masters and 1-2+ years of experience (biotech/pharma industry preferred) in executing in vivo pharmacology experiments in mice
• Demonstrated expertise executing hands-on in vivo studies
• Collaborative, curious, and flexible with strong communication skills, both written and oral
• Self-motivated, highly organized,  able to work independently with minimal supervision, and able to multitask
• Strong attention to detail
• A genuine passion for science and developing medicines

Preferred Qualifications

• Familiarity with histology, microscopy, or tissue sectioning
• Experience in bioanalytical assays for protein therapeutics (PCR, nucleic acid extraction, ELISA, Western Blot, etc)
• Skilled with common data analysis and productivity software such as Microsoft Office, GraphPad Prism, and ImageJ.
• Experience  writing detailed research project plans and methodological SOPs that guide yours and other team members’ laboratory activities
• Experience in mouse health monitoring is highly preferred

Base Salary Range: $70,000-108,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This role is eligible for:

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

Real Chemistry is looking for an Audio Engineer, Sound Innovation to join our growing team!  

21GRAMS, Real Chemistry’s advertising agency, has done a lot in its first 5+ years. Known for our creativity, we've just been ranked as the #2 creative health agency in the world by Cannes Lions. It takes a team to do ambitious things, and our ambition is to help people connect with healthcare – by making advertising less of an interruption and more worth people’s time because it actually gets them. As an agency with the full capabilities of Real Chemistry at our fingertips, we’ve got endless potential.

ROOM42, Real Chemistry’s in-house production company, is hiring an experienced Audio Production Lead to join our in-house production team. The ideal candidate will possess strong skills in sound editing and mixing. Should be familiar with audio post-production workflows - sound design and mixing for film and video, as well as podcast production. Also be comfortable leading remote recording sessions, directing talent and managing communication between team members. A requirement of this role is to have a strong interest and expertise in generative AI software and workflows related to the audio production industry.

This is a hybrid role, based in any of our US offices—including New York City, Boston, Chicago, Carmel, Lambertville, or San Francisco—or remotely within the US, depending on team and business needs. This role will work according to the Eastern Time zone.

What you’ll do: 

·       Collaborate with team members on creative and efficient ways to incorporate AI into audio production and post-production workflows.

·       Sound design, editing, and mixing for all sorts of projects, ranging from documentary-style films to scripted advertisements, talking heads, animated instructional videos, radio spots, podcasts, sonic branding, and anything else our Creatives can come up with.

·       Manage the casting, directing, recording, and editing of voiceover talent, both AI and real people.

·       Podcast Production: collaborate with team members to develop structure, format, and workflow (incorporating AI) for different podcast series. Manage all recording, editing, and mixing.

·       Contribute and collaborate in a high-volume, fast-paced team environment, maintaining high standards of audio quality.

·       Maintain freshness, creative excellence, and innovation to uphold and enhance the brand.

·       Stay updated on trends and advancements in audio production, post-production, and sound design (especially utilizing generative AI), using this knowledge to inform work and push creative boundaries.

·       Direct and manage the work of outside contractors and freelancers as needed.

This position is a perfect fit for you if: 

·   ​Our Company values – Best Together, Impact-Obsessed, Excellence Expected, Evolve Always and Accountability with an “I” – really speak to you. 

·   You are adaptable, resilient, and OK with adjusting your scope, responsibilities, and focus as we grow. When things change, so do we. We’re always evolving. 

·   You are proactive, driven, and resourceful with strong prioritization skills and a desire to dive into the data. 

·   You are highly organized self-starter, able to work independently and under tight deadlines. 

What you should have:  

·       4+ years of professional experience in audio post-production (experience in a corporate environment, agency – specifically healthcare agency is a plus but not required).

·       Background in music production – a plus but not required.

·       Proficiency in Pro Tools required, familiarity with Adobe Suite is an advantage.

·       Comprehensive knowledge of the latest audio production tools, both traditional and those utilizing AI.

·       Expertise in voiceover recording, directing, and editing.

·       Proficiency with Microsoft Suite, Box, and Frame.io in a corporate environment and the ability to quickly learn and incorporate new software and systems.

·       Strong understanding of broadcast, digital, social, and standard delivery specifications.

·       Excellent communication skills, including the ability to articulate creative concepts and rationale for clients and the team.

·       Exceptionally high creative standards, balanced with an understanding of timeline and budget constraints.

Pay Range: $,100,000 - $115,000
This is the pay range the Company believes it will pay for this position at the time of this posting.  Consistent with applicable law, compensation will be determined based on job-related, non-discriminatory factors including but not limited to work experience, skills, certifications, and geographical location. The Company reserves the right to modify this pay range at any time.

Position

We are seeking an exceptional scientist with expertise in library-based methodologies and substantial wet-lab experience to join our team. In this role, you will lead comprehensive library-based projects from conception to completion, engineering therapeutic proteins with transformative potential. You will develop and execute novel high-throughput screening assays, design and construct DNA libraries using advanced cloning techniques, and analyze complex library screens, including massively parallel in vivo screens powered by our proprietary mCode protein barcoding technology. You will work with a highly interdisciplinary team of creative experimental, computational, and hybrid scientists to advance high-throughput protein engineering and synthetic biology initiatives. As a key member of our growing company, you will contribute to building a culture that embraces scientific boldness and a strong team-focused approach to solving problems.

Required Qualifications

Wet Lab Expertise:

• Masters/PhD or equivalent experience in molecular biology, bioengineering, or a related field.
• Proficiency in standard molecular biology techniques and protocols.
• Hands-on experience with phage-based display approaches.
• Experience designing and constructing diverse DNA libraries for protein engineering applications.
• Proven capability in library-based protein engineering, including experience with high-throughput or multiplexed assay formats.
• Skilled in designing, executing, and analyzing complex experimental workflows from end to end.

Core Competencies:

• Detail-oriented with exceptional organizational and communication skills.
• Curious and flexible, with a strong desire to work collaboratively within a fast-paced and multidisciplinary team environment.
• A love for tinkering with biological parts and solving challenges to develop novel assays.
• Enthusiasm for combining rational design with unbiased approaches to problem-solving.

Preferred Qualifications

• 2+ years of start-up, biotech, or pharma experience in protein engineering or assay development.
• Direct experience with display technologies and selections including phage, yeast, and/or ribosome display.
• Hands-on experience with generating and maintaining overexpression cell lines.
• Hands-on experience with Next Geneneration Sequencing (NGS).
• Experience with handling/processing animal tissues.
• Experience developing or engineering brain shuttle technologies for improved blood-brain barrier transport.
• Familiarity with screening-based methods with an NGS readout, e.g. DMS, MPRA, CRISPR screening, cancer screens, single cell sequencing.
• Experience with data analysis (Python or R).

Base Salary Range: $118,000-138,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This role is eligible for:

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

Position

Come join Manifold as our first full-time People & Talent professional, reporting to the COO. Fueled by a new research collaboration with Roche, we are in the midst of a rapid growth spurt from 35 to 60+ employees, and will be looking to you to help us scale gracefully and efficiently while maintaining all that we love in our onsite culture. You ideally have startup experience in discovery stage biotech, though experience scaling a successful tech company would also be relevant. The ability to flex between talent acquisition, development, employee relations, and compensation planning, and are curious about ways to use technology like Greenhouse, Google Workspace, and AI applications to make life easier. You balance empathetic people leadership with sharp business judgment and creative problem-solving.

Responsibilities

• Responsible for maintaining and evolving a high-functioning People organization
• Lead our talent acquisition processes from sourcing to offer acceptance
• Lead employee onboarding and offboarding across all stages, ensuring seamless transitions and compliance 
• Maintain and update employee records, ensuring data accuracy, confidentiality, and compliance with regulatory requirements 
• Spearhead the performance management process, including managing frameworks, compensation planning, promotion cycles, and career progression pathways aligned with company growth
• Provide leadership coaching and development to managers and employees, promoting a culture of continuous learning and growth
• Manage company benefits, including annual renewals, employee communications, and enrollment 
• Drive employee engagement initiatives and recognition programs, fostering a positive and inclusive workplace culture

Qualifications

• Bachelor's degree in engineering, science, human resources, business administration or related field
• 10+ years of progressive HR leadership experience with demonstrated success in building HR functions
• Experience at a high growth startup in the biotech (or tech) industry strongly preferred
• Strong understanding of comprehensive HR operations including employee benefits, talent acquisition, and people systems
• Excellent organizational and leadership skills with high attention to detail
• Proven track record maintaining confidentiality with sensitive employee information
• Demonstrated ability to serve as a culture ambassador 
• Exceptional interpersonal and communication skills, with ability to work effectively across all levels of the organization
• Hands-on experience building new programs from the ground up
• Ability to develop pragmatic, fit-for-purpose programs that demonstrate immediate impact
• Experience with / ability to quickly master administrative programs such as Greenhouse, Gusto, Carta or other programs

Base Salary Range: $150,000-278,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate’s experience, interview performance, and expected impact.

This role is eligible for:

• Annual performance-based target bonus
• Stock options
• Comprehensive medical, dental, and vision coverage
• 401(k) plan
• Flexible paid time off and holidays
• Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.