Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

We are seeking a Central Operations Head (COH) to provide strategic leadership across clinical drug supply, Clinical Trial Agreement (CTA), and eTMF management to support global clinical development programs. This role partners cross-functionally with Clinical, Regulatory, Legal, Technical Operations, and Operational Excellence to ensure alignment on trial needs, risk management, and execution priorities.

You will oversee end-to-end delivery across trials, define outsourcing and vendor strategies, and ensure performance through KPIs, KRIs, and governance. This role is accountable for driving operational excellence, ensuring inspection readiness, and maintaining compliance with global regulations and internal standards.

As a leader, you will build and develop a high-performing team, establish scalable processes and best practices, and foster a culture of accountability, innovation, and continuous improvement in a fast-paced biotech environment.

Your role

• Provide strategic direction for clinical drug supply management, clinical trial agreement (CTA) management, and eTMF management activities to support clinical development objectives across all programs and trials
• Collaborate with Trial Management, Regulatory Affairs, Clinical Development, Legal, and Technical Operations to align on trial needs and deliverables
• Collaborate with Operational Excellence & Clinical Compliance and GMP compliance to align on risk assessment, metrics, KPIs, and KRIs for management of clinical drug supply, CTAs, and eTMF
• Define and implement outsourcing strategies (incl. Contract Research Organizations (CROs), Contract Manufacturing Organizations (CMOs) and vendors) in partnership with VP of Global Clinical Operations and Head of Clinical Sourcing & Contracting
• Define functional goals, performance metrics, and resourcing strategies. Drive innovation including adoption of risk-based approaches
• Oversee end-to-end execution of drug supply-/ CTA-/ and eTMF management across clinical trials, ensuring timely, high-quality, and inspection-ready deliverables
• Track CRO, CMO, and vendor performance using metrics, KPIs, and KRIs; lead SMO governance meetings to address escalated issues and drive continuous improvement
• Establish and maintain best practices and standards throughout the trial lifecycle
• Ensure adherence to global regulatory requirements, GCP and internal SOPs. Lead audit and inspection readiness for drug supply-/ CTA-/ and eTMF management and implement effective oversight models for internal teams and outsourced partners. Perform internal quality reviews and ensure inspection readiness of trial documentation
• Lead, coach, and develop a high-performing team. Foster a culture of collaboration, continuous learning, and accountability, while supporting career progression and succession planning across the function
• Select, manage, and govern external vendors. Define expectations, monitor performance via KPIs, and drive accountability through governance forums to ensure quality, timelines, and cost-effectiveness

What You Bring

• 12+ years of trial management experience with 5+ years in leadership position
• Bachelor’s degree in Life Sciences, Pharmacy or related field (required). Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred)
• Significant experience working in global clinical development organization
• Significant experience in outsourcing and oversight
• Expert knowledge in ICH GCP and GMP
• Expert knowledge in computer technologies to plan, forecast, and track documents/ material on all levels
• Expert knowledge in risk assessment and management on program and trial-level
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, IRT) and operational metrics, KPIs, and KRIs
• Familiarity with clinical supply planning, forecasting, and inventory tools
• Independent judgment and objectivity
• Strong analytical and influencing skills
• Ability to drive accountability across functions
• Strong leadership and interpersonal skills

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

We are seeking a Site Management Leader (SML) to oversee all site management and monitoring activities conducted by the CRO in a clinical trial. This role will be assigned to critical clinical trials of the Tango portfolio and serve as the primary contact between sponsor and CRO for site management aspects.

In a fast-paced, small biotech environment, the SML will operationally oversee and manage the end-to-end site management activities as per approved timelines, budget, regulatory requirements, and internal standards. This individual will play a key role in the execution and delivery of clinical trial objectives.

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your role

• Serve as the primary liaison between CTT and CRO for all site management activities
• Oversee CRO performance for site management to ensure compliance with contractual obligations, timelines, and quality standards
• Lead or contribute to the development of the Site Management Oversight Plan and other trial-specific operational plans in collaboration with CTT
• Contribute to the development of a site-related RBQM framework to drive efficiency and ensure quality of critical site management aspects
• Identify trial-level risks and contribute to the development and implementation of risk management and mitigation strategies
• Manage and monitor site identification, feasibility assessments, and site selection processes
• Ensure site readiness for initiation, including training, documentation, and logistical preparedness
• Oversee and support site initiation visits (SIVs) and ensure timely site activation
• Monitor patient recruitment strategies and enrollment progress across clinical sites
• Ensure protocol compliance and data integrity through oversight of site monitoring activities
• Review monitoring visit reports and ensure timely resolution of site issues and follow-up actions
• Collaborate with CRO to address site-level issues. Escalate unresolved issues to CTL and CTT, as needed
• Ensure adherence to ICH GCP, regulatory requirements, and internal SOPs throughout trial conduct
• Participate in audits, inspections, and quality assurance activities related to site management
• Oversee site closure activities and ensure proper documentation and archiving

What You Bring

• 5+ years of trial management experience with 3+ years in site management. Leadership experience (preferred)
• Bachelor’s degree in Life Sciences, Pharmacy or related field
• Experience working in global clinical development organization
• Experience in Oncology development (preferred)
• Knowledge of ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines
• Knowledge of trial/ site risk assessment and management
• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred)
• Experience in outsourcing and oversight
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs
• Strong vendor management and project management skills
• Leadership skills with the ability to lead cross-functional teams
• Strong interpersonal and communication skills
• Strong analytical thinking and decision-making capabilities
• Willingness to travel, as required (typically 10 – 20%)

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

In this newly created role, the Scientific Director, Medical Information & Medical Communications will serve as a senior individual contributor within Medical Affairs, responsible for owning the medical information foundation and scientific narrative across Tango’s pipeline.

This role will be central to ensuring Tango is prepared to support increasing external engagement, regulatory interactions, congress presence, publications, and future commercialization. This is an exciting opportunity to shape foundational capability during a period of significant clinical and organizational inflection.

Your Role

     Medical Information Strategy & Operations

• Lead the end-to-end medical information strategy, including oversight of external MI vendors and call center operations
• Ensure timely, accurate, compliant, and evidence-based responses to external inquiries
• Develop, maintain, and govern medical information content, including SRLs, CRLs, FAQs, and response guidance
• Own medical information SOPs, KPIs, quality metrics, audit readiness, and inspection preparedness
• Ensure alignment with pharmacovigilance, regulatory, and compliance requirements

      Scientific Narrative & Medical Communications

• Develop and maintain Tango’s core scientific platform and data narrative across indications and development stages
• Translate complex clinical, nonclinical, and mechanistic data into clear and compelling content for internal and external audiences
• Ensure consistency of scientific messaging across medical information, field materials, congress assets, and internal communications

      Publications, Congress, & Content Governance

• Partner with Medical Affairs and Clinical teams to support publication planning and execution
• Oversee development of scientific materials for major medical congresses
• Provide medical information support at congresses, as appropriate
• Participate in the Medical Review process to ensure scientific accuracy, compliance, and data integrity

      Cross-Functional Collaboration

• Collaborate closely with Medical Affairs leadership, Clinical Development, Regulatory Affairs, Corporate Communications, and Commercial (as appropriate and compliant)
• Ensure alignment between scientific communications, medical strategy, and enterprise objectives
• Perform additional duties as required to support Medical Affairs goals

What You Bring 

• Advanced scientific degree required (PharmD, PhD, or MD strongly preferred)
• 7–10+ years of experience in Medical Affairs, Medical Information, or Scientific/Medical Communications
• Oncology experience strongly preferred; experience in GI malignancies, NSCLC, or precision oncology highly valued
• Experience in clinical-stage and/or pre-commercial biotech environments
• Exceptional scientific writing, editing, and data-positioning skills
• Strong understanding of clinical development, regulatory pathways, and medical affairs operations
• Demonstrated ability to manage vendors, agencies, and cross-functional stakeholders
• Experience with Veeva MedComms and PromoMats preferred
• Ability to operate effectively through ambiguity in a resource-constrained environment
• Excellent written and oral communication skills

Work Environment

• This role may be remote, with periodic travel to Tango offices and scientific meetings
• Approximately 10–20% travel

#LI-Remote

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

In this new role, reporting to the Vice President, Biometrics you will be working with cross‑functional clinical teams responsible for statistical activities across Tango’s clinical programs, including overseeing statistical deliverables outsourced to clinical CROs. This is an exciting opportunity to make an impact in the development of transformative therapies that may change patients’ lives. You will be a good communicator, collaborative, self-motivated, and forward‑thinking.

Your Role:

• You will serve as a biostatistics expert for Tango’s clinical programs
• Provide strategic input to optimize trial designs in early phase dose escalation studies and late phase registrational studies
• As a biostatistics representative, proactively collaborate with internal and external CRO team members to coordinate the planning and execution of statistical deliverables
• Conduct statistical modeling to enable robust and efficient statistical designs and address identified or potential statistical issues arising with studies
• Contribute to clinical protocol development, including authoring or review of the Statistics section and reviewing of other sections by applying statistical principles
• Author or review the development of statistical analysis plans for clinical trials and oversee the development of tables, figures, and listings, and associated deliverables
• Review electronic case report form (eCRF) designs to ensure data collection meets the requirements of statistical analyses
• Provide statistical input for clinical documents
• Perform QC/QA of statistical deliverables including validation of key analysis results
• Perform ad hoc statistical analyses as needed
• Contribute to clinical study reports, including authoring of statistical methods, and interpretation of study results
• Accountable for assigned statistical activities in support of IND/NDA/MAA or other regulatory submissions; provide thorough review for required components of regulatory submissions including appropriate datasets, define files, reviewer's guides, and other relevant documents
• Address statistical questions/comments from FDA and other regulatory agencies, or IRB/ECs
• Support and contribute to the preparation of publications, including manuscripts, posters, and oral presentations
• Lead standardization and process improvement efforts for Biostatistics function, and contribute to cross-functional process improvement efforts including the definition of biostatics templates and standards
• Represent Tango regarding statistical issues in meetings with external parties including regulatory agencies and corporate partners
• Support inspection readiness activities as needed
• Develop and maintain advanced competencies in statistical methodology and advanced trial designs, particularly in oncology drug development
• Additional duties and responsibilities as required

What You Bring:

• PhD in statistics or related discipline; MS with appropriate years of directly relevant experience
• At least 10 years’ experience in the pharmaceutical or biotech industry
• Oncology experience required
• Experience in the design, analysis, and reporting of clinical trials
• Experience in INDs, NDAs, MAAs, or other regulatory submissions
• In-depth knowledge of statistical methods for clinical trials
• Knowledge of FDA, EMA, and ICH regulations and guidelines
• Proficient in statistical programming (SAS and R)
• Ability to lead statistical efforts for multiple studies
• Fluent in data standards, including SDTM and ADaM
• Experience in outsourced statistical services provided by CROs
• Ability to work independently and act with initiative to address issues
• Excellent written and oral communication skills, including the ability to effectively communicate statistical concepts in a clear and concise manner

#LI-hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts

About the Role

We are seeking a Clinical Trial Manager (CTM) to lead operational aspects of a clinical trial and support the Clinical Trial Leader (CTL), as required. This role will serve as a key member of the Clinical Trial Team (CTT) and as the primary contact for external parties and vendors. CTM may lead the cross-functional CTT for smaller and less complex trials or manage critical aspects of larger and more complex clinical trials under CTL leadership. In addition, CTM will be responsible for site management oversight for trials where no Site Management Leader (SML) is assigned.

In a fast-paced, small biotech environment, the CTM will operationally manage the set-up, conduct and reporting of clinical trials (or parts thereof) as per approved timelines, budget, regulatory requirements, and internal standards. This individual will play a key role in the execution and delivery of clinical trial objectives.

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Key Responsibilities

• Serve as a core member of the Clinical Trial Team (CTT) and act as deputy for the Clinical Trial Leader (CTL) during absences
• Organize and coordinate CTT meetings, including preparing agendas, recording minutes, and tracking follow-up actions
• Facilitate communication and collaboration within the team and with external partners such as Contract Research Organizations (CROs) and vendors
• Contribute to the development and maintenance of trial-level documents and operational plans, including project management, communication, risk management, and quality plans
• Establish and manage trial-related systems and processes (e.g., central laboratories, eCOA/ ePRO) in alignment with protocol requirements
• Monitor CRO/ vendor performance and ensure timely and accurate data integration, transfer, and reconciliation. Escalate issues to the CTL, as needed
• Identify risks and issues and support the development and implementation of mitigation strategies and action plans
• Maintain accurate and up-to-date trial information in systems and communication tools
• Set up and maintain clinical trial insurance in participating countries
• Coordinate with the global supply chain to ensure timely supply and distribution of devices and investigational medicinal products, comparator or co-medication to clinical sites
• Prepare and distribute trial-related correspondence and contribute to the development of materials for meetings, newsletters, and websites
• Lead logistical arrangements and support content development for external meetings such as investigator meetings and advisory boards
• Ensure ongoing inspection and audit readiness. Participate in internal audits and regulatory inspections, as required
• Support budget forecasting and accrual processes. Assist with invoice tracking, and processing in line with vendor contracts
• Act as CTL when assigned, leading cross-functional CTT to operationalize the protocol of a clinical trial
• Lead the development of site management oversight plan and ensure site management oversight including risk management for trials without assigned Site Management Lead (SML)

What you bring: 

• 5+ years of trial management experience. Leadership experience (preferred)
• Bachelor’s degree in Life Sciences, Pharmacy or related field
• Experience working in global clinical development organization
• Experience in Oncology development (preferred)
• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred)
• Experience in outsourcing and oversight
• Knowledge of ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines
• Knowledge of financial planning, tracking, and reporting
• Knowledge of trial risk assessment and management
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and site management metrics, KPIs, and KRIs
• Strong vendor management and project management skills
• Leadership skills with the ability to lead cross-functional teams
• Strong interpersonal and communication skills
• Strong analytical thinking and decision-making capabilities
• Willingness to travel, as required (typically 10–20%)

#LI-HYBRID

#LI-HYBRI

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-HYBRID

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

The Senior Director, Regulatory Affairs CMC, reporting to the Chief Regulatory officer, is responsible for leading the development and execution of global CMC regulatory strategies and content plans across the Tango portfolio, ensuring alignment with scientific principles and risk-based approaches. This role drives the planning, preparation, and delivery of high-quality CMC regulatory submissions, partners cross-functionally with technical and program teams, and provides strategic guidance to support efficient development and successful regulatory outcomes across all stages of the product lifecycle.

Key responsibilities include:

• Develop and execute global CMC regulatory strategy for all Tango products. Refine regulatory strategy as new data become available and re-assess as necessary. Assess regulatory risks and develop mitigations plan, when applicable.
• Develop and get buy-in on regulatory CMC strategy for Health Authority (HA) responses as needed.
• Ensure the CMC development strategy meets global regulatory requirements for registration and over the lifecycle of the product.
• Drive and be accountable for the preparation of dossiers for submission to Health Authorities (NDA/MAA/IND/CTA and post approval changes). Work with the CMC team to develop CMC content and submission plans. Develop strategy for providing responses to HA questions (ensure alignment with CMC functions and global strategy).
• Provide accurate regulatory assessments of chemistry, manufacturing and controls changes to teams/projects and execute regulatory planning and implementation.
• Effectively and tactfully communicate with HA; maintain good rapport and credibility with HA.
• In collaboration with Regulatory Leader, as applicable, determine timing and strategy for HA meetings, prepare company staff for interactions, lead CMC meetings with Health Authorities. Ability to negotiate with HA personnel.
• Provide CMC Regulatory support to health authority inspections.

   

What You Bring:

• Advanced degree with 12+ years of experience developing small molecule, CMC regulatory strategies, with deep expertise in product development and its application to global regulatory strategy; recognized as a subject matter expert in CMC development
• Experience leading interactions with Health Authorities
• Experienced leader with a demonstrated track record of driving results and achieving success
• Strong knowledge of global HA laws, regulations, guidance, and global regulation submission pertaining to small molecule CMC development and registration topics
• Strong understanding of biology, chemistry and/or engineering relevant to pharmaceutical industry
• Experience in communicating cross-functionally. Presents and defends CMC regulatory strategy and opinion to project teams; recognizes global regulatory impact
• Hands on experience in submitting multiple NDAs / MAAs for a new chemical entity and managing the registration process and life cycle management
• Highly organized, detail-oriented, and solution-focused, with the ability to manage multiple priorities and drive execution to completion

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. 

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. 

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. 

Tango’s labs and offices are located at 201 Brookline Avenue, in the vibrant Fenway area of Boston, Massachusetts

Summary 

We are seeking a Clinical Supply Manager (CSM) to lead the end-to-end clinical supply management process of our growing clinical portfolio. This role will serve as the primary sponsor contact for external vendors managing the packaging and labeling, storage, distribution, and return/ destruction of clinical supplies.

In a fast-paced, small biotech environment, the CSM will plan, execute and oversee clinical supplies in alignment with trial timelines, budget, regulatory requirements and internal standards. This individual will play a key role in enabling clinical trial start, patient enrollment, and continuous supply as per trial requirements, proactively identifying and mitigating risks, and ensuring compliance of clinical supply with applicable regulations and internal standards.

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your role

• Develop and maintain global clinical supply strategies, including forecasting needs for investigational products, comparators, and co-medications
• Oversee inventory levels at depots and clinical sites, defining resupply strategies based on usage trends to prevent shortages
• Coordinate distribution, importing, and exporting of materials
• Ensure all activities comply with Good Manufacturing Practices (GMP), ICH guidelines, and internal standards
• Manage external vendors (incl. budget), such as Clinical Manufacturing Organizations (CMO), packaging partners and depots
• Track vendor performance using metrics, KPIs, and KRIs
• Act as the primary clinical supplies contact for Clinical Trial Teams (CTT), Chemistry, Manufacturing, and Controls (CMC), and quality assurance (QA)
• Organize and coordinate meetings with key stakeholders, including decision tracking and action item follow-up
• Generate optimal distribution plans and develop tools, forms etc. to track and document end-to-end processes
• Trigger and track shipments of clinical supply from central depot to regional hubs and local depots
• Contribute to Information Response Technology (IRT) set-up, testing and maintenance in close collaboration with relevant CTT functions to ensure efficiency, timeliness and accuracy of clinical supplies management
• Provide input into label text as well as into packaging and labeling materials
• Identify and assesses risks and issues related to clinical supplies, proactively communicate them and lead the development and implementation of mitigation strategies and action plans
• Ensure inspection and audit readiness of clinical supplies; participate in internal audits and inspection from health authorities, as required.

What You Bring

• 5+ years of supply management experience. Experience in leadership preferred
• Bachelor’s degree in Life Sciences, Pharmacy or related field
• Experience working in global clinical development organization
• Experience in Oncology development (preferred)
• Experience in outsourcing and oversight
• Direct experience with health authority inspections of clinical supply management (preferred)
• Knowledge of relevant regulations and guidelines (GMP, ICH guidelines, HSE)
• Knowledge of appropriate supply chain systems used for forecasting and demand planning as well as supply management metrics, KPIs, and KRIs
• Familiarity with other systems used in clinical trials (e.g., CTMS, IRT, eTMF)
• Strong operational excellence with high attention to details
• Strong vendor management and project management skills
• Leadership skills with the ability to lead cross-functional teams
• Strong interpersonal and communication skills
• Strong analytical thinking and decision-making capabilities

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

We are seeking a Clinical Trial Leader (CTL) to lead cross-functional clinical trial teams (CTTs) in the execution of clinical trials of Tango’s portfolio. This role will chair the CTT and represent the cross-functional team to internal governance bodies. The CTL will be an internal escalation point for other CTT members.

In a fast-paced, small biotech environment, the CTL will operationally lead the set-up, conduct and reporting of clinical trials as per approved timelines, budget, regulatory requirements, and internal standards. This individual will play a key role in the execution and delivery of clinical trial objectives.

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your role

• Lead cross-functional Clinical Trial Team (CTT) in the planning, execution, and reporting of outsourced clinical trial.
• Provide regular updates to internal governance bodies.
• Serve as the primary liaison between the sponsor and CRO to ensure alignment of trial objectives, timelines, and deliverables.
• Oversee CRO performance, ensuring adherence to scope, budget, and timelines.
• Contribute to protocol development and review of key study documents (e.g., ICFs, CRFs, monitoring plans).
• Lead the development of trial-specific plans including risk management, communication, and oversight plans.
• Support site selection and feasibility assessments in collaboration with CRO and internal stakeholders.
• Monitor trial progress through metrics and KPIs.
• In collaboration with Operational Excellence and Compliance, define an optimal RBQM framework to efficiently control quality throughout the trial.
• Proactively identify risks and issues and support the development and implementation of mitigation strategies and action plans.
• Ensure timely delivery of trial milestones including patient recruitment, data collection, and interim analyses.
• Manage trial budgets, change orders, and invoice reconciliation in collaboration with vendor management and finance.
• Ensure study conduct in compliance with ICH GCP, ISO standards, regulatory requirements, and internal standards.
• Participate in audits and inspections. Ensure timely resolution of findings.
• Review and approve essential documents and study deliverables.
• Oversee database lock, clinical study report (CSR) development, and study close-out activities.
• Contribute to regulatory submissions and responses as needed.

What You Bring

• 8+ years of trial management experience with 3+ years in trial leadership position.Bachelor’s degree in Life Sciences, Pharmacy or related field (required).
• Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred).
• Experience working in global clinical development organization.
• Experience in Oncology development (preferred).
• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred).
• Experience in outsourcing and oversight.
• Knowledge of ICH GCP, FDA guidelines, EU CTR and other relevant guidelines.
• Knowledge of financial planning, tracking, and reporting.
• Knowledge of trial risk assessment and management.
• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs.
• Strong vendor management and project management skills.
• Excellent leadership skills with the ability to lead cross-functional teams.
• Strong interpersonal and communication skills.
• Strong analytical thinking and decision-making capabilities.
• Willingness to travel, as required (typically 10–20%)

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview 

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. 

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. 

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. 

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. 

Summary

We are seeking a Global Program Operations Head (GPOH), reporting into the Vice President, Clinical Operations, to lead the strategic and operational execution of a portfolio of clinical trials within a designated disease area. This role partners cross-functionally with Clinical, Medical, Regulatory, and Operational Excellence to ensure programs are aligned with corporate goals, regulatory requirements, and operational feasibility. 

You will drive program-level strategy, oversee trial execution, and manage Contract Research Organizations (CROs) and external vendors, ensuring delivery against timelines, budgets, and quality expectations. Additionally, you will lead and develop a high-performing clinical operations team while supporting governance, risk management, and inspection readiness in a fast-paced biotech environment. 

Your Role 

• Oversee the strategic and operational execution of a portfolio of clinical trials within a designated disease area

• Ensure alignment with corporate goals and regulatory standards

• Represent Global Clinical Operations in Global Program Teams (GPTs) and sub-teams, contributing to program-level strategy and operational planning

• Collaborate with Medical and Regulatory Directors to ensure clinical strategies are scientifically sound, meet regulatory requirements, and are operationally feasible

• Partner with Operational Excellence & Clinical Compliance to align on risk assessment, trial- and site management metrics, KPIs, and KRIs 

• Define and implement outsourcing strategies in partnership with the VP of Global Clinical Operations and Head of Clinical Sourcing & Contracting

• Lead the selection, negotiation, contracting, and performance oversight of CROs and external vendors 

• Monitor trial progress and key deliverables, guiding Clinical Trial Teams (CTTs) in execution planning, issue resolution, and risk mitigation

• Manage program and trial budgets, ensuring accurate forecasting, cost control, and financial accountability

• Track CRO/ vendor performance using metrics, KPIs, KRIs and participate in governance meetings to address escalated issues and drive continuous improvement

• Provide regular updates on trial progress to internal governance bodies, including GPT and Executive Leadership Team

• Support inspection readiness activities and represent the organization during Health Authority inspections 

• Provide leadership, coaching, and performance management to Clinical Trial Leaders (CTLs), Clinical Contract Managers (CTMs), Clinical Trial Specialists (CTSs), and Site Management Leader (SMLs)

• Set clear objectives, deliver ongoing feedback, and develop tailored development plans to support team growth and capability building

• Oversee hiring, onboarding, and training of new team members, fostering a culture of operational excellence and continuous learning

What You Bring 

• 12+ years of trial management experience with 7+ years in leadership position 

• Bachelor’s degree in Life Sciences, Pharmacy or related field (required). Advanced degree, e.g., MS, PharmD, PhD, MBA (preferred). 

• Significant experience working in global clinical development organization

• Experience in Oncology development (preferred)

• Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections

• Significant experience in outsourcing and oversight

• Expert knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines

• Expert knowledge in financial planning, tracking, and reporting

• Expert knowledge in risk assessment and management on program and trial-level

• Executive presence and strategic thinking on corporate-, program-, and trial-level

• Strong decision‑making and sound judgment 

• Strong leadership and interpersonal skills 

• High credibility with senior leadership 

• Familiarity with clinical trial systems (e.g., CTMS, eTMF, EDC, IRT, eCOA) and operational metrics, KPIs, and KRIs

• Willingness to travel, as required (typically 10–20%)

 #LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status

Company Overview 

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. 

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. 

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. 

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. 

Summary

We are seeking a Clinical Contract Manager (CCM) to lead the end-to-end clinical site contracting process in support of our growing clinical portfolio. This role will serve as the primary sponsor contact for Contract Research Organization (CRO) partners and internal stakeholders across Clinical, Legal, Finance, and Compliance. 

In a fast-paced, small biotech environment, the CCM will drive the development, negotiation, execution, and maintenance of Clinical Trial Agreements (CTAs), ensuring alignment with trial timelines, budget, and regulatory requirements. This individual will play a key role in enabling timely site activation, CTA maintenance as per trial requirements, proactively identifying and mitigating risks, and ensuring compliance of CTAs with applicable regulations and internal standards. 

The ideal candidate is highly collaborative, detail-oriented, and comfortable operating in a hands-on environment, with a focus on building scalable processes, tools, and best practices to support efficient and compliant clinical trial execution.

Your Role 

• 5+ years of trial management experience with 3+ years in site management 

• Bachelor’s degree in Life Sciences, Pharmacy or related field 

• Experience working in global clinical development organization 

• Experience in Oncology development (preferred) 

• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred) 

• Experience in outsourcing and oversight 

• Familiarity with clinical trial systems (e.g., CTMS, eTMF) and operational metrics, KPIs, and KRIs 

• Familiarity with site contracting requirements and healthcare compliance (Fair Market Value, SOX Act, Sunshine Act) 

• Knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines 

What You Bring 

• 5+ years of trial management experience with 3+ years in site management 

• Bachelor’s degree in Life Sciences, Pharmacy or related field 

• Experience working in global clinical development organization 

• Experience in Oncology development (preferred) 

• Direct experience with site health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred) 

• Experience in outsourcing and oversight 

• Familiarity with clinical trial systems (e.g., CTMS, eTMF) and operational metrics, KPIs, and KRIs 

• Familiarity with site contracting requirements and healthcare compliance (Fair Market Value, SOX Act, Sunshine Act) 

• Knowledge in ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines 

 #LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.

The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.

This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.

Your role

      Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)

      Scientific Exchange & External Engagement

What You Bring

      Education & Experience

• 8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
• Experience in PDAC, GI malignancies, or NSCLC strongly preferred
• Prior experience supporting clinical-stage or pre-launch oncology assets highly valued

      Skills & Attributes

• Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
• Demonstrated strength in insight generation, synthesis, and communication
• Comfortable operating in a fast-moving, high-accountability biotech environment
• Excellent collaboration skills across matrixed teams
• Strong understanding of U.S. clinical research and healthcare environments

      Compliance & Technical Requirements

• Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
• Commitment to compliant, ethical scientific exchange
• Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)

Work Environment

• Field-based role in the Northeast (Boston/New York), with residence required within assigned territory
• ~ 50% domestic travel expected, with significant time spent with external scientific partners

Why Join Tango Medical Affairs?

• Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
• Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
• Expand and establish Tango as a credible clinical scientific leader in precision oncology
• Work in a lean, collaborative environment where your scientific judgment and execution matter

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Remote

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

The Director, Regulatory Systems and Operations, reporting to our Chief Regulatory Officer, serves as a strategic leader and driver of regulatory infrastructure and execution. This role partners cross-functionally with internal stakeholders to define, implement, and continuously enhance Regulatory Information Management (RIM) systems and databases, ensuring the integrity, accessibility, and scalability of all regulatory information and documentation.

In parallel, this leader plays a critical role within the global regulatory organization as co-lead of the Global Regulatory Subteam, with accountability for the strategic planning, coordination, and execution of regulatory deliverables. The Director ensures alignment of regulatory activities with development timelines and organizational priorities, driving cross-functional collaboration to deliver high-quality submissions on time.

This position works closely with the Regulatory Strategy Leads to proactively shape and advance regulatory plans across the product lifecycle, providing both strategic oversight and operational leadership to enable successful global regulatory outcomes.

Your role

Regulatory Systems

• Lead the implementation and optimization of the Regulatory Information Management System (RIMS), ensuring strong user adoption through effective training and support. Drive continuous improvement of regulatory processes and monitor key global metrics and compliance indicators to advance operational excellence.
• Interface with Tango’s IT, QA and R&D departments and with external partners (if applicable) on local regulatory system management related topics.
• Support optimization of publishing best practices and global submission standards in accordance with regulatory requirements worldwide.
• Build and maintain relationship with external vendor partners (e.g. publishing).
• Support system audit and/or GxP inspection or due diligence with regard to regulatory systems and regulatory documentation.
• Define global processes to ensure compliance with the regulation. Build regulatory policies and procedures and ensure that these processes are adhered to.

Regulatory Project Management

• Lead project management activities related to the preparation and tracking of regulatory documents/submissions.
• Co-lead and coordinate the Global Regulatory Sub-Team (GRST) for assigned programs, driving operational regulatory activities in partnership with the RA strategist. Lead GRST meetings, track key deliverables, and proactively manage risks and mitigation plans.
• Drive timelines and deliverables related to submission documents. Track progress and review project(s) tasks to meet deadlines. Point of contact re: timelines and status of submissions / approvals / responses and commitments globally.
• Lead the day-to-day operation of the Dossier Task Force/filing team and ensure compliance with dossier compilation and global submission processes.
• Establish clear ownership for project tasks, ensure that team members have the tools needed. Communicate process and document standards to stakeholders.
• Identify and communicate critical processes or issues in project(s) and develop solution strategies together with the regulatory lead and project team functional representatives and/or head of function, when relevant.
• Responsible for the overall publishing activities for the assigned product. Establish good relationship with publishing vendor. Ensure timely, high quality dossier assembly and publishing in accordance with Submission Content Plan.

What You Bring

• Minimum of 10 years of Regulatory Operations experience, with a BA/BS or equivalent required; advanced degree preferred
• Strong knowledge of Veeva RIM systems
• Demonstrated success in defining and implementing new operating standards and regulatory processes
• Extensive experience in Regulatory Affairs project management within drug development, including leading cross-functional development teams
• Deep expertise in regulatory publishing requirements and constraints, with hands-on experience managing submissions for IND, CTA, NDA, and MAA applications
• Solid understanding of electronic document management systems, regulatory databases, publishing platforms, and related technologies
• Self-motivated, adaptable, and innovative leader with the ability to prioritize, manage multiple projects, and thrive in a fast-paced, dynamic environment; strong problem-solving skills with the ability to develop and implement effective solutions
• Strong organizational and project management capabilities
• Excellent written and verbal communication skills, including presentation and facilitation 

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary 

Reporting to the Vice President, Investor Relations and Corporate Communications, we are hiring a strategic communicator to oversee Product and Pipeline Communications for vopimetostat, our lead PRMT5 inhibitor, and other oncology pipeline candidates. This is an opportunity to create and deliver communications programs in support of clinical data, development efforts, and potential patient benefits.

Your role

• Lead communications for vopimetostat, covering data, regulatory milestones, and commercial launch
• Develop cross-functional messaging
• Execute disease awareness, branded campaigns, integrations, and digital/social media initiatives
• Partner with Clinical Development and Operations team to support clinical trial communications, including development of digital assets
• Collaborate with Clinical Development, Medical Affairs, Patient Advocacy, Regulatory, Legal, IR, Internal Communications, and external partners
• Represent the function on integrated teams and contribute to business decisions
• Support executive engagement through media, speaking opportunities, and internal communications
• Manage issues proactively to protect reputation; use analytics to assess communication strategies

What You Bring

• Bachelor’s degree with 10 plus years of experience in public relations or communications within the pharmaceutical or biotech industry
• Strong understanding of oncology drug development, regulatory policy, medical meeting and publications strategy
• Expertise in issues management within drug development
• Ability to adapt quickly in fast-changing environments
• Demonstrated success working in cross-functional, matrixed teams with an enterprise approach
• Preferred qualifications: Public relations or communications experience in oncology

This is a Hybrid/Flexible role!

#LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

#LI-Hybrid

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

We are seeking a highly motivated and detail-oriented Corporate & Securities Counsel to join our growing legal team. You will play a critical role in supporting the company’s public company reporting obligations and broader corporate governance needs. Further, you will provide strategic legal guidance on complex corporate matters and partner with senior executives to drive business objectives. The ideal candidate will bring strong securities law experience from a top law firm and/or in-house legal department, with the ability to independently manage SEC filings and contribute to a range of corporate legal matters. In addition, this role will provide general legal support to the legal team and assist with other matters as they arise, consistent with the needs of the department.

Your role:

• Prepare and review periodic and current reports, including Forms 10-K, 10-Q, and 8-K, proxy statements, and Section 16 filings (Forms 3, 4, and 5)
• Support corporate governance matters, including board and committee preparation and maintenance of governance policies and practices
• Assist with disclosure planning and drafting, including earnings releases, investor presentations, and the annual proxy statement
• Advise on securities law compliance, Nasdaq listing standards, and insider trading matters
• Provide legal support for corporate transactions, including financings and equity offerings
• Support cross-functional teams on general corporate matters
• Collaborate with external counsel and internal teams including Finance, Investor Relations, and HR
• Provide training to internal stakeholders on legal, compliance, and contracting best practices
• Partner with internal audit and compliance functions to monitor risk and implement mitigation strategies.

What you bring

• J.D. from an accredited law school and admitted to practice in at least one U.S. jurisdiction
• A minimum of 6-8 years of securities law experience at a top-tier law firm and/or in a public biotech company’s legal department
• Deep knowledge of SEC rules and regulations, Sarbanes-Oxley, listing exchange requirements, and other applicable laws and regulations
• General corporate background and familiarity with equity plans and executive compensation is a plus
• Ability to interpret legal requirements and deliver pragmatic, business-oriented guidance
• Proven capability to manage multiple priorities in a fast-paced, collaborative environment
• Ability to thrive in a team setting and a desire to be innovative in rapidly evolving and fast-paced company

This is a hybrid/flexible role!

#LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

We are seeking a highly motivated and collaborative Director of Compliance to join our growing legal team. You will play a critical role in the development and execution of the Company’s compliance program as the Company transforms from a primarily research and development organization into a commercial company. You will partner with all aspects of the business as you build, implement, and continuously improve Tango’s healthcare compliance program and develop training initiatives designed to identify and mitigate risks.

This position will report to the Vice President, Legal, and will be Tango’s first dedicated healthcare compliance hire. This role requires a proven track record of healthcare compliance leadership and a strong desire to provide cross-functional support across a fast-paced, forward-thinking organization.

Your role

• Execute and lead the day-to-day risk assessment, monitoring and training initiatives to ensure compliance with key regulations
• Partner with internal and external stakeholders to establish key compliance policies and procedures
• Assist in development, implementation, and oversight of healthcare compliance policies and procedures prioritized by ongoing risk assessments and potential commercial infrastructure buildout
• Communicate, prioritize and manage action plans driven by monitoring results, compliance risk assessments, and recommendations
• Provide compliance guidance based on internal requirements and/or external US laws, regulations, industry codes, and accepted guidance from authoritative US agencies (i.e., Office of Inspector General of the US Department of Health and Human Services)
• Manage documentation requirements in relation to team output (e.g., monitoring results, risk assessments, trainings, etc.)
• Develop and implement policies, guidelines, and/or procedures in support of US and global business
• Develop and provide training to internal stakeholders on legal and compliance best practices
• Maintain understanding of Tango’s business objectives and activities and monitor industry and enforcement trends that may impact Tango’s operations and compliance program
• As part of a growing and evolving business, this role will have the opportunity for a diverse workload, visibility as a leader, and continued development opportunities

What you bring

• B.A./B.S degree required; J.D. from an accredited law school (and admitted to practice in at least one U.S. jurisdiction) strongly preferred
• 8+ years of healthcare compliance and/or other related experience in biotech/pharmaceutical organization
• Demonstrated knowledge and understanding of the required elements of compliance programs and applicable industry standards
• Experience with laws, regulations, and industry guidance that affect the pharmaceutical industry including, but not limited to, OIG and PhRMA guidelines, False Claims Act, Anti-Kickback Statute, the US Food, Drug, & Cosmetic Act, and the Stark Law
• Experience executing compliance monitoring in the biotechnology/ pharmaceutical industries
• Ability to lead and facilitate discussions with senior leaders at the country and global levels
• Ability to interpret legal and regulatory requirements and deliver pragmatic, business-oriented guidance
• Ability to work independently and deliver on deadlines while managing multiple projects and priorities in a fast-paced, evolving environment
• Excellent communications skills, both verbal and written, including the ability to effectively lead presentations and deliver trainings
• Exceptional organizational skills and attention to detail and experience advising cross-functional teams

This is a Hybrid/Flexible role!

#LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts

Summary

Tango Therapeutics has an exciting new opportunity for an experienced and innovative translational scientist in our Translational Medicine Team, to lead clinical biomarker development, in vitro diagnostic and companion diagnostic activities in support of ongoing clinical trials.  This role will drive cross functional collaboration among discovery biologists, translational scientists, clinical operations, data management, regulatory, clinical compliance and quality groups to deliver biomarker insights to clinical development teams.  Additionally, this position will administer operational aspects of clinical biomarker assays in clinical trials, including management of internal and external translational collaborations, third party laboratories and other clinical partners.

Your Role

• Oversee design, development, validation, verification and implementation of translational and clinical-grade biomarker assays to inform essential clinical research questions
• Compile clinical biomarker assay data, conduct in-stream analyses, and package those translational insights for communication to key stakeholders throughout the clinical development organization
• Author and contribute content to biomarker plans and clinical study protocols
• Execute risk management of novel clinical biomarker assays, managing oversight and quality control of pre-analytic, analytic, and post-analytic assay components
• Perform technical assessments of existing and novel clinical biomarker assays and assay platforms for suitability, validity, clinical utility, robustness, and feasibility to meet business objectives
• Identify and vet translational and clinical biomarker assay vendors according to Tango’s GxP processes
• Manage relationships with third party vendors to ensure clinical biomarker assay outputs are delivered on-time, on-budget, and on-target to meet or exceed functional requirements and business objectives
• Install data transfer specifications with clinical biomarker assay laboratories, working in partnership with Tango’s clinical data management organization
• Contribute scientific expertise and biomarker data analysis in support of IVD regulatory submissions
• Contribute to optimization of translational medicine business process infrastructure
• Additional duties and responsibilities as required

What You Bring

• Advanced degree in biological sciences or related, with at least 5 years relevant translational clinical experience in biopharma
• Experience in oncology drug development
• Track record of developing successful translational clinical assets in a biopharma setting
• Demonstrated proficiency in clinical biomarker data generation, aggregation and analysis
• Demonstrated facility in a GxP setting
• Familiarity with domestic and/or international regulatory review and approval of IVD assays
• Outstanding analytical skills, a highly organized approach and exceptional attention to detail
• Proven track record as a collaborative team player, with superior communication style and well-developed interpersonal skills
• Ability to thrive in an interdisciplinary setting across pre-clinical and clinical development arenas, and with colleagues at all levels

This is a hybrid/flexible role!

#LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Reporting to the CHRO, the Director, Human Resources Business Partner (HRBP) provides HR leadership and consultation to client groups within multiple functions, including Regulatory, Corporate Strategy, Medical Affairs, and other key late-stage clinical areas. The HRBP is a trusted advisor to leaders, providing expert HR advice and advanced solutions that enable the achievement of business strategies by leveraging a significant understanding of the operating environment. This role drives talent management and helps architect and manage organizational change. The role is responsible for the delivery of HR programs and services such as talent/career development, leader coaching and consultation, employee relations, and performance management.

Your role

• Provides strategic HR leadership and expert guidance to assigned client groups, along with consultation and delivery of HR programs and services to achieve key business objectives
• Leverages previous experience and data to provide critical insights into business and talent trends that inform the overall business and HR priorities. Provides insights in a simple, creative, and relevant way that challenges current thinking, informs business decisions, and shows how decisions impact business outcomes
• Proactively defines, builds, and implements value-added HR strategies and solutions
• Advises functional leaders in solving complex issues related to organization design, development, and change leadership
• Establishes strategies and tactics to enable the business to attract, develop, and retain high-quality talent at all levels to support the growth objectives, opportunities, and strategies of the business
• Leads the strategic workforce planning efforts to ensure the people and talent strategy is in alignment with the organization's long range strategic plan (identification of long-term capability needs, talent acquisition and succession planning)
• Builds strong partnerships within the HR team to enhance the function’s effectiveness in providing solutions to key business needs and to roll out corporate-wide programs that enhance the overall employee experience and support growth and success of overall business strategy
• Works with clients to implement and manage key HR processes, such as year-end performance management (performance assessment, calibration, and compensation planning)
• Partners with Talent Acquisition (TA) to ensure TA strategy is in place to deliver on key hires and growth plans

What you bring

Education and Experience:

• Undergraduate degree in human resources or related, relevant discipline
• Typically requires 10 years of experience or the equivalent combination of education and experience
• Biotech experience required; late-stage or commercial-stage experience strongly preferred

Knowledge and Skills:

• Experience developing and implementing HR strategies
• Track record of developing strategic workforce plans, from conception to implementation
• Highly experienced in talent management, succession planning, and career growth and development
• Strong experience managing and/or leading culture and change management or organizational effectiveness initiatives
• Experience and expert understanding of management development, employee relations, data and analytics

Traits and Qualities:

• Ability to influence positively including in situations without direct authority
• Ability to work independently and collaboratively, in a matrix team environment consisting of internal and external team members
• Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines
• Excellent planning, organization and time management skills including the ability to support, prioritize, and multi-task
• Highly collaborative team player who fosters open communication and develops important relationships with key stakeholders
• Outstanding interpersonal and communication abilities with a high degree of emotional intelligence
• Possess the ability, business maturity and interpersonal savvy to be proactive and establish credibility with all employees across the Company
• Have proven communication skills, both written and verbal, and the ability to present information clearly to a variety of audiences
• Able to learn quickly and take a project from idea to execution (strategy to operational) quickly and independently
• Thrives in high energy and fast paced organization with ongoing simultaneous initiatives
• Builds consensus and alignment and persuades others to take action

#LI-Hybrid

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

Reporting to the Vice President, Biometrics, the Associate Director of Clinical Data Management will be responsible for leading the clinical data management processes across Tango’s clinical trials. This will include clinical trial planning through data generation and database lock. This position will initiate best practices and lead clinical data management process flow as well as support the oversight of data management vendors, data transfers and data handling. This role is ideal for someone who thrives in a dynamic environment, excels at collaboration, and is passionate about ensuring high-quality clinical data to drive impactful decision-making.

Your Role

• Lead the clinical data management partnership with CROs, ensuring seamless execution of Tango’s clinical trials
• Provide oversight for fully outsourced data management activities from RFP to final database lock, working closely with CROs to develop and standardize data handling plans, data transfer specifications, metrics, and data review tools
• Develop and/or author key data management documents, including database design specifications, edit checks, CRF completion guidelines, and Data Management Plans, ensuring compliance with CDASH and SDTM standards
• Partner with cross-functional teams to standardize data collection and reporting processes, enhancing efficiency and data quality
• Guide and monitor data cleaning, discrepancy management, and data reconciliation activities with external vendors and internal stakeholders
• Provide leadership and oversight for user acceptance testing (UAT) of eCRFs and associated edit checks
• Establish, review and monitor data quality metrics to ensure clean, consistent, and analyzable datasets
• Collaborate with internal and external stakeholders (CROs, software vendors, clinical development partners, specialty labs, etc.) to ensure projects are delivered on time and within budget
• Participate in study team meetings, providing updates, addressing issues, and ensuring data is effectively collected, reviewed, and analyzed

What you bring

• Bachelor’s degree in computer science, or a science-based subject with at least 8 years of clinical data management experience in industry, with experience across indications and EDC platforms like Metadata Rave
• 5-8 years of experience leading the data management of clinical trials, from study start up through database lock, within an industry sponsor, ideally focusing on oncology or rare diseases
• Strong vendor management and oversight experience
• Solid technical skills across data platforms; programming experience preferred
• Experienced in designing clinical trials utilizing CDASH and SDTM standard terminology
• Cross collaboration proficiency with other related functions such as Biostatistics, Statistical Programming, and Pharmacovigilance
• Understanding of FDA and ICH GCP guidelines to ensure appropriate reporting of clinical trial data
• Experience in regulatory GCP inspections/audits preferred
• Experience with Spotfire, elluminate or other data visualization software
• Ability to manage multiple projects in a fast-paced environment

This is a Hybrid/Flexible role!

#LI-HYBRID

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Summary

This role will report to the Director of Quality and operate across departments, supporting regulated activities and studies. This new role will support CMC development and clinical disposition activities for Tango’s development programs. Tango works in a matrixed, outsourced model where compliance and inspection readiness are key to our programs as we advance through the development cycle.

The Manager, Quality Assurance will provide GMP QA oversight for Tango’s CMC development programs and clinical supply activities. This role partners cross-functionally with Technical Operations, Regulatory, and external manufacturing partners to ensure compliance with global GMP requirements while supporting the advancement of investigational therapies through clinical development.

Your Role

• Review batch documentation and dispositions materials for use in clinical trials
• Lead & manage strategic GMP QA activities associated with Tango CMC development programs
• Ensure compliance with regulations related to manufacturing, testing, packaging & distribution of investigational drug product and active pharmaceutical ingredients. Identify compliance gaps and propose solutions
• Execute and lead implementation of phase-appropriate quality guidance, review, and approval processes for product development programs across Phases 1–3
• Oversee projects independently, identifying, evaluating, and resolving product quality concerns in compliance with GMP requirements
• Identify trends related to development compounds, operations, etc.
• Ensure timely review, approval, and archival of GMP documentation and quality records
• Participate in GMP audits of CMOs, contract laboratories, and other vendors, providing recommendations regarding vendor qualification and continued use
• Mentor and support internal teams on GMP documentation, quality practices, and regulatory compliance
• Additional duties and responsibilities as assigned

What You Bring

• Bachelor's Degree in Chemistry, Biology, Engineering or related field plus 5 years pharma manufacturing, packaging or laboratory experience
• At least 5 years of direct QA/compliance experience working in biotechnology, pharmaceutical, laboratory, CRO or CMO environment
• Strong knowledge of global GMP regulations (FDA, EMA, ICH) applicable to investigational drug development
• Experience providing QA oversight of drug product development across the pharmaceutical lifecycle Thorough understanding of creation/ review/approval of GMP documents such as specifications, test methods, stability protocols, batch records, and investigations
• Ability to collaborate effectively in a matrixed, cross-functional, and global environment
• Strong oral/written communication skills
• Capable of analyzing a wide variety of information and data to make management decisions regarding potential risks associated with product quality or regulatory compliance
• Able to establish professional relationships and rapport with internal and external peers and experience working collaboratively with teams in a complex, matrixed and global environment
• Strong attention to detail and commitment to maintaining high quality and compliance standards
• Strong project management and organizational skills, with the ability to manage multiple concurrent priorities

This is a Hybrid/Flexible role!

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We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.