Who We Are

Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.  

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.  

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. 

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

Associate Director, AI Operations & Enablement 

The Enterprise AI team sits within Flagship's Information Technology organization and is responsible for AI strategy, governance, tooling, and enablement across the Flagship ecosystem. The team works cross-functionally within IT, Legal, Finance, HR, Communications, and the firm's business and scientific functions to ensure AI is adopted safely, responsibly, and with measurable impact. 

About the Role 

Flagship is hiring an Associate Director, AI Operations & Enablement to accelerate the impact of the Enterprise AI function. Reporting to the Senior Director, AI Transformation Lead, this person will own day-to-day execution across three core capability areas: AI education and capability building, AI strategy and use case portfolio management, and AI tool and vendor management. 

This is an inaugural role on a small, high-visibility team. The successful candidate will operate as a senior individual contributor with broad cross-functional reach, partnering closely with developers, scientists, and business leaders. The role is execution-heavy and ideal for someone who has led enterprise AI programs in a consulting or in-house capacity and is energized by building a function from the ground up. 

What You'll Do 

AI Strategy, Governance & Use Case Portfolio Management 

• Translate Flagship's enterprise AI strategy into function-level execution by partnering with leaders across the firm on AI roadmap creation and delivery. 

• Run a regular cadence of engagement with each business and scientific function to surface, intake, and prioritize use cases.  

• Partner with the AI engineering team to shape use cases, supporting use case owners in identifying the right data, technology, and stakeholders for efficient and effective design.  

• Track use case value/ROI throughout the life cycle and for the AI program overall. 

• Drive solution reuse across functions by maintaining visibility into what has been built, by whom, and what is reusable. 

• Operate the AI Operational Governance Forum by surfacing relevant AI product, feature, and use case developments and supporting decision-making and tracking around risk management. 

• Support the evolution of Flagship’s AI strategy, policies, and roadmap by staying up to date on relevant industry trends and internal needs.  

AI Education & Capability Building 

• Design and execute AI learning programs across the company that drive adoption while shaping responsible, secure, and cost-effective use of AI.  

• Build and oversee operations for the AI change champion network to scale AI adoption. 

• Develop reusable AI enablement assets and partner with Communications and Learning & Development to amplify. 

• Provide hands-on coaching to teams adopting AI tools across the business. 

AI Tool & Vendor Management 

• Provide support on AI tool evaluation, procurement, and lifecycle management across enterprise-wide and function-specific applications. 

• Support ownership, administration, and governance of core enterprise AI platforms, including settings configuration, feature rollout, internal communications, and ongoing user support. 

• Support vendor relationships and contracts in partnership with Procurement and Legal; track usage, license utilization, and consumption against contracted commitments. 

• Coordinate with InfoSec on AI-specific risk reviews, ZDR posture, agentic sandbox governance, and shadow AI monitoring. 

• Maintain the AI tool intake and approval process and the AI Product / Use Case records in Flagship's GRC system of record. 

What You Bring 

Required 

• At least 5 years of progressive experience in technology, AI, digital transformation, or management consulting roles, including meaningful recent experience leading enterprise AI, digital, or technology enablement initiatives. 

• Hands-on AI fluency. Power user of leading LLM platforms (Claude, ChatGPT, Gemini) with practical understanding of capabilities, limitations, and appropriate use by task type. Comfortable rapidly prototyping with low-code tools and AI features. 

• Agentic AI fluency. Working understanding of agentic AI concepts and current capabilities, including autonomous and long-running agents, multi-step tool use, MCP and connector ecosystems, and human-in-the-loop design patterns. Able to evaluate where agentic approaches are appropriate, where they introduce risk, and how to deploy them safely. 

• Use case portfolio management. Demonstrated experience running structured intake, prioritization, and ROI tracking processes for AI or digital initiatives across a federated organization. 

• Vendor and tool management. Experience evaluating, contracting, and administering enterprise SaaS, ideally including AI/LLM platforms. Comfort working with Procurement, Legal, and InfoSec on contract review, DPAs, and risk assessments. 

• Enablement and program delivery. Track record running training programs, hackathons, or change management initiatives for non-technical audiences at scale. 

• Cross-functional execution. Demonstrated effectiveness operating without direct authority across IT, InfoSec, Legal, Finance, HR, and business stakeholders. 

• Communication. Strong written and verbal communication; able to translate between technical and business audiences and produce executive-ready materials. 

• Client-facing experience. Previous experience in a client-facing consulting, customer success, or IT business partner role. 

• Bachelor's degree in a technical, business, or scientific field. 

Preferred 

• Prior experience in life sciences, biotech, or healthcare; comfort with the regulatory and IP-sensitivity considerations of these sectors. 

• Experience administering Claude Enterprise, ChatGPT Enterprise, or M365 Copilot at scale. 

• Familiarity with AI governance frameworks (NIST AI RMF, ISO 42001) and GxP / research integrity considerations. 

• Experience with MCP servers, agentic platforms, and AI workflow automation tools (Zapier, Workato). 

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. 

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. 

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. 

#LI-NM1 

The salary range for this role is $148,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

About the Team 

Enterprise Engineering builds integrated, scalable platforms that power Roku’s core Finance, Accounting, Payments, Supply Chain, and HR processes. We use API-first, data-driven, and increasingly AI-enabled designs to automate complex workflows, improve control and compliance, and reduce manual work for our partners.

About the Role 

We’re hiring a Senior Product Manager to lead finance and payouts platforms within Enterprise Engineering, with a strong focus on AI-driven automation. You will own products that support order-to-cash, revenue accounting, financial close, reconciliations, and partner payouts, working across Controllership, FP&A, Tax, Treasury, Payments, Ads Revenue Operations, and Business Systems. 

You’ll define the vision, roadmap, and execution for capabilities that combine robust finance controls with modern engineering and AI - e.g., ML-assisted reconciliations, anomaly detection, intelligent exception routing, and Gen-AI powered tools for finance users. This is a high-impact senior IC role; you will regularly influence senior stakeholders across regions, while partnering closely with engineering leads and architects.

What You’ll Be Doing

• Own strategy & roadmap for finance and payouts platforms, including AI-enabled capabilities (classification, matching, forecasting, GenAI assistants) 
• Deep-dive workflows across revenue, close, reconciliations, payouts and compliance; map pain points and define automation opportunities 
• Write clear, structured product requirements (data contracts, controls, SLAs, UX) that Engineering and Finance can execute on 
• Partner daily with engineering and architecture to make pragmatic design tradeoffs on platforms, integrations, and AI usage 
• Define and track success metrics (automation %, cycle time, error rates, payout and reconciliation accuracy), and iterate based on results 
• Drive change management: clear comms, training, and adoption plans for new platform and AI features 
• Keep a close pulse on team and stakeholder “vibe” – building trust, surfacing risks early, and fostering a low-ego, high-ownership way of working 

We’re Excited If You Have

• 8+ years of product management, including substantial time on internal platforms or business systems 
• Strong experience in Finance/Accounting technology (e.g., ERP, revenue systems, sub-ledger / journal automation, reconciliations, payouts) 
• Demonstrated ability to translate complex accounting and regulatory requirements into scalable product designs 
• Hands-on experience with AI / ML or intelligent automation in business processes (e.g., matching, anomaly detection, NLP/GenAI assistants, rules + ML hybrids) 
• Strong systems thinking: comfortable with APIs, data models, integrations, monitoring and controls 
• Excellent written and verbal communication; able to tell a crisp story to executives, Finance stakeholders, and engineers 
• Proven track record working effectively across time zones and cultures, maintaining a healthy and productive team “vibe” 
• Experience in media, advertising, or digital platforms with complex revenue and payout models 
• Background in Finance/Accounting (e.g., CPA, Chartered Accountant, or MBA with finance emphasis)

#LI-AB3

About the team

The Advertising Performance group focuses on performance for all participants in the Advertising ecosystem - Advertisers, Publishers and Roku. The systems and solutions span across different disciplines and technologies to perform realtime multi-objective optimization with distributed systems at large scale and low latencies. We use Machine Learning, Reinforcement Learning, AI, Control and Optimization Systems and Auction Dynamics to solve a large set of complex problems. At the core of this is our Machine Learning, Experimentation and Inference Platform that powers the entire landscape which we continuously evolve over time.

About the role 

In this role you will build teams focused on the Ads Auction and Marketplace to optimize yield, gross profit, perform realtime multi-objective optimization across various short and long term objectives, build control and simulation systems, design and run experiments and extend the experimentation framework. 

You will partner closely with other Engineering, Inventory and Product teams to define the vision and strategy for your group and to build and deliver the roadmap.

What you’ll be doing

• Lead the design, implementation, and evolution of real-time ads auction systems powering Roku’s CTV advertising across The Roku Channel and the Roku platform.
• Own and enhance core auction capabilities including ad pod construction, bid evaluation, ranking, pricing, pacing, budget enforcement, and frequency capping.
• Build low-latency, highly reliable distributed services that operate at massive scale, serving billions of ad opportunities with strict latency and uptime requirements.
• Design auction logic that balances viewer experience (ad load, relevance, repetition) with advertiser performance, publisher yield, and platform revenue.
• Develop and optimize SSP-side auction mechanisms, integrating with multiple DSPs, programmatic demand sources, and direct-sold campaigns.
• Partner closely with product managers, data science, ads research teams to translate marketplace and monetization goals into scalable technical solutions.
• Drive yield optimization through auction design, demand shaping, floor strategies, and pricing experiments.
• Lead experimentation using A/B testing, auction simulations, and offline replay frameworks, and make data-driven decisions based on performance metrics and statistical rigor.
• Ensure auction correctness, fairness, explainability, and transparency, while maintaining compliance with privacy, regulatory, and brand-safety requirements.
• Influence the long-term technical roadmap for Roku Ads by proposing architecture improvements, scalability strategies, and performance optimizations.

We are excited if you have

• 5+ years of experience building large-scale distributed systems
• 5+ years working with cloud-based platforms and infrastructure
• Deep experience in building microservices using Java for container platforms such as Docker or Kubernetes
• Solid understanding of databases SQL and NoSQL
• Hands-on Experience working with AWS, GCP or similar cloud services
• Experience with a breadth of protocols and data formats such as REST, WebSockets, HTTPS, JSON, and Protobuf
• Demonstrated ability to drive timely consensus in design with other senior team members
• Bachelors or Master's degree in Computer Science, Engineering, or equivalent

#LI-MS3

About the team

The Advertising Performance group focuses on performance for all participants in the Advertising ecosystem - Advertisers, Publishers and Roku. The systems and solutions span across different disciplines and technologies to perform realtime multi-objective optimization with distributed systems at large scale and low latencies. We use Machine Learning, Reinforcement Learning, AI, Control and Optimization Systems and Auction Dynamics to solve a large set of complex problems. At the core of this is our Machine Learning, Experimentation and Inference Platform that powers the entire landscape which we continuously evolve over time.

About the role 

In this role you will build teams focused on the Ads Auction and Marketplace to optimize yield, gross profit, perform realtime multi-objective optimization across various short and long term objectives, build control and simulation systems, design and run experiments and extend the experimentation framework. 

You will partner closely with other Engineering, Inventory and Product teams to define the vision and strategy for your group and to build and deliver the roadmap.

What you’ll be doing

• Lead the design, implementation, and evolution of real-time ads auction systems powering Roku’s CTV advertising across The Roku Channel and the Roku platform.
• Own and enhance core auction capabilities including ad pod construction, bid evaluation, ranking, pricing, pacing, budget enforcement, and frequency capping.
• Build low-latency, highly reliable distributed services that operate at massive scale, serving billions of ad opportunities with strict latency and uptime requirements.
• Design auction logic that balances viewer experience (ad load, relevance, repetition) with advertiser performance, publisher yield, and platform revenue.
• Develop and optimize SSP-side auction mechanisms, integrating with multiple DSPs, programmatic demand sources, and direct-sold campaigns.
• Partner closely with product managers, data science, ads research teams to translate marketplace and monetization goals into scalable technical solutions.
• Drive yield optimization through auction design, demand shaping, floor strategies, and pricing experiments.
• Lead experimentation using A/B testing, auction simulations, and offline replay frameworks, and make data-driven decisions based on performance metrics and statistical rigor.
• Ensure auction correctness, fairness, explainability, and transparency, while maintaining compliance with privacy, regulatory, and brand-safety requirements.
• Influence the long-term technical roadmap for Roku Ads by proposing architecture improvements, scalability strategies, and performance optimizations.

We are excited if you have

• 5+ years of experience building large-scale distributed systems
• 5+ years working with cloud-based platforms and infrastructure
• Deep experience in building microservices using Java for container platforms such as Docker or Kubernetes
• Solid understanding of databases SQL and NoSQL
• Hands-on Experience working with AWS, GCP or similar cloud services
• Experience with a breadth of protocols and data formats such as REST, WebSockets, HTTPS, JSON, and Protobuf
• Demonstrated ability to drive timely consensus in design with other senior team members
• Bachelors or Master's degree in Computer Science, Engineering, or equivalent

#LI-MS3

About The Team

At Roku, the Viewer Product Team is connecting millions of viewers worldwide to their favourite entertainment, through a uniquely Roku experience. The International Product Team works with functional experts and strategic leaders, to help build and execute on roadmaps for all aspects of the Roku ecosystem in markets around the world. This team works cross-functionally to understand the needs of our consumers and partners, along with other market opportunities, analyses data to draw insights and learnings, collaborates on a thoughtful go-to-market plan to drive the success of the latest features, and works hand-in-hand across marketing, sales, merchandising, data science, engineering and other product teams.

About The Role

We are looking for a strategic, growth-focused, collaborative, and experienced product manager to lead Roku’s viewer (OS / platform) product management function in the UK. In this role, you will oversee our growth & engagement strategy, manage our product roadmap and identify key product priorities that advance Roku’s strategic goals in the UK.  You will play a critical role in accelerating the growth of the Roku business in the UK and work together with other leaders in market to cultivate a strategic plan that positions Roku as one of the future leaders in UK media & streaming.  You will be accountable for setting, and achieving key market goals that are in service of accomplishing our broader UK strategy, and have a hand amongst other key leaders in market in formulating said strategy.

The ideal candidate is a strong product thinker, highly strategic while tactically savvy and skilled at navigating a matrixed environment. They know how to build trust and alignment, manage & optimise a product roadmap, solve complex problems through communication, transparency & critical thinking, and thrive in a fast-paced and collaborative setting.

This position will be located at our office in London and will report to the Director of Product, Management, International Growth. This role will require the ability to travel internationally, as well as domestically (to our offices in Cambridge & Manchester).

What You'll Be Doing

• Manage & optimise Roku’s viewer (OS) product roadmap for the UK
• Own our product growth & engagement strategy across UK, partnering with other key leaders in the UK office
• Drive alignment on key market metrics / goals, and be accountable for achieving goals through product launches & initiatives led by partner teams
• Enable & design in-market experimentation to ensure our products fit the unique needs of the UK market
• Ensure that market-specific needs & opportunities are represented in cross-functional planning and that our product efforts drive tangible business outcomes
• Build and strengthen relationships between the International Product team and other UK based Roku teams (marketing, ad sales, content distribution & monetization)
• Collaborate with stakeholders across the organization to optimize the delivery of new features and ensure strong execution
• Communicate progress and strategy clearly across multiple levels of the organisation, including executive stakeholders both in the UK and abroad

 We’re Excited If You Have

• Product management experience
• Significant experience working in the UK TV or streaming industry, with a deep understanding of the ecosystem, technologies, and customer expectations
• Experience working either for, or with key UK media leaders / partners
• Hands-on (product-led) growth experience
• Experience with lifecycle marketing / user engagement strategy & activation or hands-on experience in understanding and driving long-term consumer retention
• Strong strategic thinking, prioritisation, organisation and execution skills
• Experience working cross-functionally across Product, Engineering, Marketing, and other disciplines to drive projects through completion
• Excellent communication and stakeholder / executive management skills
• Ability to improvise when necessary and solve complex problems with simple, or unexpected solutions
• Bachelor's degree or equivalent experience

#LI-AB3 

About the role

With more than 85 million people using our products globally, we’ve become well-known for products that “just work” right out of the box and integrate almost by magic. That doesn’t happen by accident, which is why we are committed to making sure our products aren’t just intuitive; they’re obvious. Our goal is to help people find what they want and make it easier for people to stream.  We accomplish this using state-of-the-art technology and engineering to make it happen, considering the customer as the center of all that we do.

We are looking for a Senior Software Engineer to focus on developing core features for the Roku platform UI. We are looking for someone with experience building high-performing applications and SDK components who wants to code on a wildly popular consumer electronics platform. This is an excellent role for a senior professional who enjoys a high level of visibility, thrives on having a critical business impact, and is excited to work on a component that touches almost everything streamed on the Roku platform.

About the team

This team spends most of its time working on customer focused features that improve the user experience, from cross-platform device experiences, TV & Player centric UI, and IoT integration with Roku OS. Our product roadmap helps us accelerate our growth and scale, putting surprising new features into the hands of tens of millions of Roku users worldwide.

Our developers and engineers are owners. They are motivated from within, finding and taking on a feature or project simply because that problem needs to be solved and shipped. But that individual must work together with different engineering teams, UI design, product teams, QA, and business leadership to make things happen, which means that engineers succeed here because they can maintain that independent spirit and motivation within a deeply collaborative environment. We are the pragmatic dreamers inventing and re-inventing the world of streaming media.

What You’ll Be Doing

We’re Excited If You Have

#LI-NM1

About the role 

Roku is looking for a Sr. Data scientist to join the Core Analytics team supporting our Viewer Product team. In this role, you will leverage data analytics to support and improve our Live product. You will own end-to-end analytics that shape how viewers discover, engage with, and return to Live experiences on Roku. You will work closely with product management and engineering to identify opportunities to create new features, drive their adoption, and generate value for Roku. This individual will investigate and develop solutions to track, monitor and improve our ecosystem. The successful candidate is quantitatively driven, detail-focused, and possesses an elevated level of problem-solving expertise. 

What you'll be doing 

• Analyze structured and unstructured data and communicate insights to help stakeholders solve business problems, identify trends and make data-driven decisions 

• Advise on key product development strategy decisions to drive our Live product experience 

• Develop and maintain dashboards, reports, and data visualizations to monitor key metrics for operational and systems health 

• Develop necessary data pipelines to power automation, validation and reporting 

• Collaborate with stakeholders to align data science initiatives with organizational goals and strategy design and execute A/B tests 

• Perform exploratory data analysis on emerging trends and execute advanced analysis across the Roku Platform 

• Providing feedback directly to leadership on performance of various initiatives and untapped opportunities 

We're excited if you have 

• 4+ years of work experience with a bachelor's degree or master's degree in quantitative field (e.g., Statistics, Business Analytics, Data Science, Mathematics, Economics, Engineering or Computer Science) 

• 4+ years of experience in product analytics. Experience with platforms in the media and entertainment industry preferred 

• Expertise in SQL, SAS, R, Python or other programming language to query data and perform analysis 

• Demonstrated ability to influence quantitatively meaningful business outcomes 

• Hands on experience with visualization tools like Tableau or Looker 

• Have a bias towards action in resolving issues and operate in a high-energy, fast-paced environment 

• Hands on experience in A/B testing and statistical modeling/forecasting 

This role can be based in either Cambridge, or Manchester. You are required to work in the office for 4 days per week, this is the core requirement of the role

#LI-ST1

About the role 

Roku is looking for a Sr. Data scientist to join the Core Analytics team supporting our Viewer Product team. In this role, you will leverage data analytics to support and improve our Live product. You will own end-to-end analytics that shape how viewers discover, engage with, and return to Live experiences on Roku. You will work closely with product management and engineering to identify opportunities to create new features, drive their adoption, and generate value for Roku. This individual will investigate and develop solutions to track, monitor and improve our ecosystem. The successful candidate is quantitatively driven, detail-focused, and possesses an elevated level of problem-solving expertise. 

What you'll be doing 

• Analyze structured and unstructured data and communicate insights to help stakeholders solve business problems, identify trends and make data-driven decisions 

• Advise on key product development strategy decisions to drive our Live product experience 

• Develop and maintain dashboards, reports, and data visualizations to monitor key metrics for operational and systems health 

• Develop necessary data pipelines to power automation, validation and reporting 

• Collaborate with stakeholders to align data science initiatives with organizational goals and strategy design and execute A/B tests 

• Perform exploratory data analysis on emerging trends and execute advanced analysis across the Roku Platform 

• Providing feedback directly to leadership on performance of various initiatives and untapped opportunities 

We're excited if you have 

• 4+ years of work experience with a bachelor's degree or master's degree in quantitative field (e.g., Statistics, Business Analytics, Data Science, Mathematics, Economics, Engineering or Computer Science) 

• 4+ years of experience in product analytics. Experience with platforms in the media and entertainment industry preferred 

• Expertise in SQL, SAS, R, Python or other programming language to query data and perform analysis 

• Demonstrated ability to influence quantitatively meaningful business outcomes 

• Hands on experience with visualization tools like Tableau or Looker 

• Have a bias towards action in resolving issues and operate in a high-energy, fast-paced environment 

• Hands on experience in A/B testing and statistical modeling/forecasting 

This role can be based in either Cambridge, or Manchester. You are required to work in the office for 4 days per week, this is the core requirement of the role

#LI-ST1

About the role

With so many people using our products globally, we’ve become well-known for products that “just work” right out of the box and integrate almost by magic. That doesn’t happen by accident, which is why we are committed to making sure our products aren’t just intuitive, they’re obvious. To support that commitment, the Roku Ads Test Automation Team focuses on testing Ad products and features for the industry’s most reliable streaming media platform. Our goal is to help people find what they want and make it easier for people to stream. We accomplish this using state-of-the-art technology and engineering to make it happen, with consideration for the customer as the centre of all that we do.

We are seeking an experienced and versatile Software Development Engineer in Test to own quality of ad features on Roku Platform. You will be responsible for end-to-end execution of ad product which includes cross-team collaboration for feature testing, developing test plans, coordinate testing with manual QA, create an automation strategy, deployment of library/feature and more. You should be able to represent automation and QA concerns in meetings with cross-functional, project team members and provide valuable end-user feedback to improve the customer experience. This position requires a solid understanding of software development life-cycle experience with a variety of testing techniques, strong debugging, written and organizational skills, and automation experience.

About The Team

Our team works on qualifying all Ads products and features on Roku Platform. You will be joining a talented, high-performance team of SDETs with a history of delivery. We are looking for someone who can help us keep up this pace and continue delivering high quality as we grow.

What you'll be doing

• Own and execute the feature testing, create test plan documentation, collaborate with developers, product lead and other manual QA
• Develop Automated tests that run on Roku players and TVs
• Convert manual test cases into reliable, repeatable automated tests
• Contribute to the Continuous Integration pipeline by running component builds, creating and running Deployment jobs on individual stages on Jenkins, and running automated functional tests.
• Debug failing tests to improve product and automated test quality
• Promote coding conventions and standards for code re-usability and cleanliness
• Conduct code reviews for improved code quality and optimization

We are excited if you have

• 5+ years of Software Engineering
• 3+ years of hands-on experience with automation systems and unit testing (Python)
• Strong problem-solving, analytical and technical troubleshooting skills
• Solid knowledge and experience developing test plans and test cases
• Strong debugging skills
• Excellent verbal and written communication skills
• Research and documentation skills
• Ability to learn new technologies quickly
• Ability to work independently and be self-directed
• Bachelor's degree in Computer Science or related
• Experience with big data analytics: Splunk, ELK, Hive, Redshift, etc. (nice to have)
• In-depth knowledge of streaming back-ends and formats (nice to have)
• Experience working with Smart/Digital TV (HDMI), Setup Boxes, Wi-Fi
• (2.4Ghz & 5GHz), TV remote controllers (nice to have)
• International product experience (nice to have)

#LI-AB3

About the Role

You will be a SME and technical leader in engineering Infrastructure, productivity and enterprise tooling, partnering with globally distributed Engineering, Product and Security teams and systems.

What You’ll Be Doing

Roku is seeking a world class engineer to be a true force multiplier by owning the strategy, architecture, and long-term execution of engineering infrastructure, enterprise tooling, and AI-assisted workflow automation. This architect/strategist role drives org-wide improvements in engineering productivity, delivery throughput, quality, security posture, and cost efficiency by building platforms, working practices and automation (including AI/LLM-enabled capabilities) that scale across geographies and time zones.

Key Responsibilities

AI-First Automation & Intelligent Tooling

• Define and lead an AI-first automation roadmap for Engineering Infrastructure and Enterprise Tooling (e.g., reducing waste, accelerating reviews, improving incident response, increasing release confidence).
• Architect and ship AI/LLM-enabled workflow automation across the SDLC (e.g. risk assessment, automated build, test and deployment, intelligent test selection, change-impact analysis, auto-triage of build/test failures).
• Establish policies and guardrails for AI usage in internal tools: data handling, prompt/response logging, model/provider selection, evaluation, fallback behaviors, and abuse prevention.

Dev Productivity & Enterprise Tooling (Global Scale)

• Set technical direction and standards for the globally used developer tools, including build systems. Source code management, branching/release strategy, and self-service support tools.
• Architect and evolve, CI/CD and build/test pipelines using Jenkins, Docker, and build systems (Bazel /BitBake/Yocto  preferred) to support multi-site engineering environments.
• Own and scale test and quality workflows leveraging test management systems (e.g., TestRail or equivalent), enabling consistent traceability, reporting, and release sign-off across distributed teams.
• Drive Jira workflow design and automation (templates, guardrails, integrations) to provide consistent cross-org visibility and execution.

Workflow Automation (Cross-Functional, Cross-Geo)

• Design and implement automation spanning Engineering, Product, Marketing, and Partners (e.g., launch readiness, certification/release checklists, partner onboarding, incident/change workflows).
• Replace manual coordination with durable automation and integrations that work reliably across regions/time zones.

Security, Cost, Performance, and Reliability (Distributed Systems)

• Embed secure-by-default controls into pipelines and tooling (access control, secrets handling, audit trails, policy enforcement), including for AI-enabled systems.
• Improve build/test performance and reliability (build times, test duration, flake reduction, pipeline stability) using measurable KPIs and operational rigor.
• Drive cost efficiencies across tooling/infrastructure (compute utilization, caching strategies, license rationalization including AI/runtime costs and ROI tracking.
• This is a highly visible role and you will report directly to a Vice President of Engineering. This requires a very strong technical leader with experience in the development of consumer electronics devices. The right person for this role will have ability to collaborate well with engineering and partner teams.
• Own cross-team architectures and standards; drive adoption through influence, clear technical judgment, and sustained multi-quarter execution.
• Lead design reviews, mentor senior engineers, and unblock the hardest technical problems across distributed teams and systems.
• Provide long-term stewardship via roadmaps, operational maturity (runbooks/SLOs), and incident/postmortem practices suitable for 24/7 global operations.
• Establish yourself as the person others bring their hardest problems to

We’re Excited If You Have

• Bachelor’s in Computer Science or Computer Engineering, or equivalent experience
• Prior experience at Staff, Principal, or Architect level
• Ownership in platform/infrastructure, developer productivity, CI/CD, build systems, or workflow automation, including work spanning globally distributed teams and systems.
• Strong, hands-on knowledge of:

• • Git (workflows, branching strategies, release management)
  • Jenkins (CI/CD pipeline design, scaling, reliability)
  • Docker containers (reproducible build/test execution)

Build systems ( itBake/Yocto preferred)

• Jira (workflow design/automation, cross-team visibility)
• Test management systems (e.g., TestRail or equivalent)
• Demonstrated experience delivering automation at scale, including building platforms/components used by multiple teams.
• Strong systems thinking across security, reliability, performance, and cost tradeoffs.
• Excellent written communication (architecture docs, decision records, operating procedures).
• Experience building AI-assisted developer tooling (e.g., CI insights, test intelligence, code review automation, release risk scoring, incident copilots).
• Experience implementing evaluation/monitoring for AI systems (quality metrics, drift, offline test sets, human feedback loops).
• Extensive experience with software development on embedded Linux,  multi-process architectures and IPC mechanisms
• Experience working in large cross functional teams and ability to influence teams that don't report to you
• Ability to see the big picture while focused on short-term objectives and deliverables
• Ability to multi-task and drive parallel projects and distributed teams with tight deadlines

#LI-NM1

About the Role

You will be a SME and technical leader in engineering Infrastructure, productivity and enterprise tooling, partnering with globally distributed Engineering, Product and Security teams and systems.

What You’ll Be Doing

Roku is seeking a world class engineer to be a true force multiplier by owning the strategy, architecture, and long-term execution of engineering infrastructure, enterprise tooling, and AI-assisted workflow automation. This architect/strategist role drives org-wide improvements in engineering productivity, delivery throughput, quality, security posture, and cost efficiency by building platforms, working practices and automation (including AI/LLM-enabled capabilities) that scale across geographies and time zones.

Key Responsibilities

AI-First Automation & Intelligent Tooling

• Define and lead an AI-first automation roadmap for Engineering Infrastructure and Enterprise Tooling (e.g., reducing waste, accelerating reviews, improving incident response, increasing release confidence).
• Architect and ship AI/LLM-enabled workflow automation across the SDLC (e.g. risk assessment, automated build, test and deployment, intelligent test selection, change-impact analysis, auto-triage of build/test failures).
• Establish policies and guardrails for AI usage in internal tools: data handling, prompt/response logging, model/provider selection, evaluation, fallback behaviors, and abuse prevention.

Dev Productivity & Enterprise Tooling (Global Scale)

• Set technical direction and standards for the globally used developer tools, including build systems. Source code management, branching/release strategy, and self-service support tools.
• Architect and evolve, CI/CD and build/test pipelines using Jenkins, Docker, and build systems (Bazel /BitBake/Yocto  preferred) to support multi-site engineering environments.
• Own and scale test and quality workflows leveraging test management systems (e.g., TestRail or equivalent), enabling consistent traceability, reporting, and release sign-off across distributed teams.
• Drive Jira workflow design and automation (templates, guardrails, integrations) to provide consistent cross-org visibility and execution.

Workflow Automation (Cross-Functional, Cross-Geo)

• Design and implement automation spanning Engineering, Product, Marketing, and Partners (e.g., launch readiness, certification/release checklists, partner onboarding, incident/change workflows).
• Replace manual coordination with durable automation and integrations that work reliably across regions/time zones.

Security, Cost, Performance, and Reliability (Distributed Systems)

• Embed secure-by-default controls into pipelines and tooling (access control, secrets handling, audit trails, policy enforcement), including for AI-enabled systems.
• Improve build/test performance and reliability (build times, test duration, flake reduction, pipeline stability) using measurable KPIs and operational rigor.
• Drive cost efficiencies across tooling/infrastructure (compute utilization, caching strategies, license rationalization including AI/runtime costs and ROI tracking.
• This is a highly visible role and you will report directly to a Vice President of Engineering. This requires a very strong technical leader with experience in the development of consumer electronics devices. The right person for this role will have ability to collaborate well with engineering and partner teams.
• Own cross-team architectures and standards; drive adoption through influence, clear technical judgment, and sustained multi-quarter execution.
• Lead design reviews, mentor senior engineers, and unblock the hardest technical problems across distributed teams and systems.
• Provide long-term stewardship via roadmaps, operational maturity (runbooks/SLOs), and incident/postmortem practices suitable for 24/7 global operations.
• Establish yourself as the person others bring their hardest problems to

We’re Excited If You Have

• Bachelor’s in Computer Science or Computer Engineering, or equivalent experience
• Prior experience at Staff, Principal, or Architect level
• Ownership in platform/infrastructure, developer productivity, CI/CD, build systems, or workflow automation, including work spanning globally distributed teams and systems.
• Strong, hands-on knowledge of:

• • Git (workflows, branching strategies, release management)
  • Jenkins (CI/CD pipeline design, scaling, reliability)
  • Docker containers (reproducible build/test execution)

Build systems ( itBake/Yocto preferred)

• Jira (workflow design/automation, cross-team visibility)
• Test management systems (e.g., TestRail or equivalent)
• Demonstrated experience delivering automation at scale, including building platforms/components used by multiple teams.
• Strong systems thinking across security, reliability, performance, and cost tradeoffs.
• Excellent written communication (architecture docs, decision records, operating procedures).
• Experience building AI-assisted developer tooling (e.g., CI insights, test intelligence, code review automation, release risk scoring, incident copilots).
• Experience implementing evaluation/monitoring for AI systems (quality metrics, drift, offline test sets, human feedback loops).
• Extensive experience with software development on embedded Linux,  multi-process architectures and IPC mechanisms
• Experience working in large cross functional teams and ability to influence teams that don't report to you
• Ability to see the big picture while focused on short-term objectives and deliverables
• Ability to multi-task and drive parallel projects and distributed teams with tight deadlines

#LI-NM1

About the role:

As an Associate or Senior Associate within Jacob (Jake) Rubens’ Pioneering Business Unit (PBU) at  Flagship Pioneering, you will ideate, research, and refine novel venture hypotheses, validate key underlying unknowns of biology or technology, and transition pressure-tested ideas into building a NewCo around the science.  You will help drive every facet of company origination from the early stages including identification and recruitment of critical partners and advisors, establishment of foundational IP, hiring and leadership of the early scientific team, and establishment of working norms and culture for the team.  In this role you will partner with stakeholders across the broader Flagship ecosystem to bring the full experience of Flagship to support your companies.  A successful candidate will become an expert on the foundational science of the company, frame and clearly communicate the strategy, and translate that strategy into a plan and lead operationalization of that plan alongside a Principal or Partner on the venture creation team.

Key Responsibilities:

• Contribute to and lead Flagship explorations to rapidly assess interesting areas of science and develop novel, actionable and high-value venture hypotheses
• Outline key scientific questions to enable venture hypotheses and develop experimental plans to rapidly create value and pressure test ideas
• Identify, build, and maintain relationships with appropriate academic KOLs and thought experts, ie, introducing them to the Flagship model, getting early buy-in, vetting/validation and de-risking key concepts of venture hypotheses
• Understand IP landscape, formulate initial strategy, and write seminal applications for the technology and company. Assess patentability of existing IP landscape, including of key competitors and of potentially licensable estate
• Develop corporate strategy and operations plan for the company. Define value creation, identify application spaces, build out organizational chart, define company goals, timelines and resourcing and identify strategic inflection points to set the company on the path to rapid growth and success
• Develop audience-specific pitches for company
• Support business development activities and continue to evolve the story
• Manage and coordinate early scientific and IP employees. Source, recruit and manage KOLs and early-stage employees as well as relationships with CROs.
• Manage & lead scientific team (internal or external) and daily research. Manage operational tasks, including establishing lab facilities, purchasing, HR, real estate acquisition, etc.
• Become institutional subject matter expert and transfer knowledge to active company team. Stay up to date on the literature, conferences, funding opportunities, and new developments.
• Work closely with and leverage Flagship operations teams (Finance, IP, IT, HR, and Talent) for maximal operational excellence

Professional Experience and Qualifications:

The ideal candidate has a STEM-based PhD or MD from a top university and 2 or more years of experience in life sciences biotech, start-up or entrepreneurial activities. The candidate must have a passion for novel science and be operationally savvy.

 Important skills and capabilities include:

• Proven ability to rapidly become conversant in new areas of science and capable of engaging thought leaders at the deepest level of technological understanding
• Ability to define a clear and compelling value proposition of a given scientific opportunity and effectively and cogently communicate that to technical and non-technical audiences
• Excellent analytical skills and ability to synthesize & communicate complex information rapidly and effectively
• Obsession with mastering the details without losing sight of the big picture
• Energetic self-starter with strong presence and the ability to work effectively in an entrepreneurial environment
• Excellent intellectual agility to rapidly context-switch across projects
• Open, transparent communication style and demonstrated willingness to engage in difficult conversations in a professional and productive manner
• Passion for growth and development, with clear demonstration of openness to both giving and receiving feedback and track record of acting on feedback
• Able to work effectively and pleasantly in teams with demonstrated abilities to lead and manage
• Unmatched sense of urgency with willingness to go the extra mile to drive success

Location:  Cambridge, MA

About Flagship Pioneering:

Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.  

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. 
Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. 

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company’s annual list of the World’s Most Innovative Companies. 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-TD1

Cambridge Mobile Telematics (CMT) is the world’s largest telematics service provider. Its mission is to make the world’s roads and drivers safer. The company’s AI-driven platform, DriveWell® Fusion, gathers sensor data from millions of IoT devices — including smartphones, proprietary Tags, connected vehicles, dashcams, and third-party devices — and fuses them with contextual data to create a unified view of vehicle and driver behavior. Auto insurers, automakers, commercial mobility companies, and the public sector use insights from CMT’s platform to power risk assessment, safety, claims, and driver improvement programs. Headquartered in Cambridge, MA, with offices in Budapest, Chennai, Seattle, Tokyo, and Zagreb, CMT measures and protects tens of millions of drivers across the world every day.

CMT is looking for a creative, collaborative, and highly motivated Machine Learning Intern to help develop applied machine learning capabilities using real-world mobility and behavioral data. This internship is ideal for someone who enjoys solving ambiguous problems, building practical ML workflows, working with messy real-world datasets, and translating technical findings into clear recommendations.

The intern will work on a 12-week applied ML project involving data exploration, labeling strategy, feature engineering, model development, evaluation, and stakeholder-facing analysis. The ideal candidate has strong Python skills, a solid foundation in machine learning, strong initiative, and the ability to make progress in open-ended problem spaces.

Responsibilities:

• Explore real-world mobility datasets and identify useful behavioral, temporal, contextual, and aggregate patterns
• Help define practical data labeling guidelines, quality criteria, and edge-case handling rules
• Build and validate datasets for supervised machine learning experiments
• Develop baseline and improved ML models using Python and standard data science workflows
• Perform feature engineering, model evaluation, error analysis, and iteration
• Assess model performance across relevant data segments and edge cases
• Summarize findings, limitations, risks, and opportunities for technical and product stakeholders
• Produce clear documentation, analysis reports, and final recommendations

Qualifications:

• Currently pursuing a Bachelor’s, Master’s, or PhD degree in Computer Science, Data Science, Machine Learning, Statistics, Engineering, Applied Math, or a related quantitative field
• Strong Python programming skills and comfort working with real-world datasets
• Solid understanding of supervised machine learning, feature engineering, classification metrics, train/test splits, and error analysis
• Experience with common Python data science libraries such as pandas, NumPy, scikit-learn, PyTorch, TensorFlow, or similar tools
• Strong analytical and problem-solving skills, with a bias toward initiative and ownership
• Clear written and verbal communication skills, including the ability to explain technical findings to non-technical stakeholders

Compensation and Benefits:

• Fair and competitive hourly rate based on education level
• Flexible scheduling options depending on role and responsibilities

Additional Perks:

• Feel great working to improve road safety around the world!
• Join one of our many employee resource groups including Black, AAPI, LGBTQIA+, Women, Book Club and Health & Wellness
• CMT will do all that is possible to support our employees and create a positive and inclusive work environment for all!

Commitment to Diversity and Inclusion:

At CMT, we believe the best ideas come from a mix of backgrounds and perspectives. 

We are an equal-opportunity employer committed to creating a workplace and culture where everyone feels valued, respected, and empowered to bring their unique talents and perspectives. Diversity is essential to our success, and we actively seek candidates from all backgrounds to join our growing team. 

We do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status or disability state. CMT is headquartered in Cambridge, MA. To learn more, visit www.cmtelematics.com and follow us on X @cmtelematics.

Why Join Us?

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

The Vice President, Medical Affairs Oncology is a member of the Development Leadership Team reporting to the Chief Medical Officer. This senior executive leader is accountable for the end-to-end design and execution of the Medical Affairs strategy across Parabilis portfolio, including Scientific Communications, Medical Education, Evidence Generation, Key Opinion Leader (KOL) Engagement, Publication Planning, and Medical Information. This role ensures scientific excellence and cross-functional integration across all development programs and builds a scalable Medical Affairs organization capable of supporting global, multi-indication growth.

Key Responsibilities:

Strategic Leadership

• Define and execute the Medical Affairs Oncology strategy aligned with the clinical development roadmap and portfolio priorities.
• Serve as a core member of the Development Leadership Team and contribute to broader
• Development governance and portfolio decision-making.
• Support portfolio-level medical prioritization, lifecycle planning, and cross-indication strategy.

KOL Engagement & Medical Education

• Build and sustain relationships with leading KOLs, academic medical centers, and cooperative groups relevant to Parabilis’ pipeline.
• Design and oversee Medical Education programs that advance understanding of Parabilis’ science, novel mechanisms, and unmet need across tumor types.

Evidence Generation & Publication Strategy

• Lead the development and execution of a robust evidence generation strategy, including investigator-initiated studies, real-world evidence, and health outcomes research
• Oversee development and execution of a comprehensive publication plan aligned with clinical milestones and regulatory timelines
• Build global medical affairs infrastructure to support multi-program, multi-regional growth
• Drive Medical Affairs KPIs and impact metrics in support of portfolio strategy and commercial readiness

Scientific Communications & Medical Information

• Lead scientific communications strategy to accurately and compellingly convey the differentiated profile of Parabilis’ Helicon™ platform and pipeline assets
• Oversee Medical Information function, ensuring timely, accurate, and compliant responses to healthcare professional inquiries
• Oversee the creation of high-quality medical education materials, slide decks, and scientific exchange resources
• Establish scalable medical affairs infrastructure to support launch readiness across tumor types and geographies

Patient Advocacy and Patient Support

• Building trusted partnerships with advocacy organizations across Parabilis' specific tumor types
• Integrating the patient voice into MA strategy, trial design, and evidence generation
• Collaborating with patient communities on disease awareness and education
• Developing patient support programs to improve access, adherence, and trial participation ensuring all patients’ engagement is conducted with ethical rigor and full compliance

Cross-functional Partnership & Commercial Readiness

• Partner closely with Clinical Development, Regulatory Affairs, and New Product Planning to ensure scientific and medical alignment across the development and pre-commercialization continuum
• Support payer strategies by contributing to value dossiers, HEOR data packages

Compliance & Medical Governance

• Lead development and continuous improvement of Medical Affairs SOPs, governance frameworks, and compliance systems
• Ensure all Medical Affairs activities are executed in accordance with applicable regulations, industry codes, and Parabilis’ internal policies

Organizational Leadership

• Build and mentor a high-performing Medical Affairs Oncology team with deep scientific expertise and strong cross-functional collaboration skills
• Establish clear accountability, performance metrics, and a culture of scientific rigor and integrity
• Foster a culture of collaboration, scientific curiosity, and patient-centricity across the Medical Affairs team

What you’ll need to be successful:

• MD required; PharmD or PhD in a relevant biomedical discipline may be considered with commensurate experience
• 15+ years of progressive biopharmaceutical industry experience, with a minimum of 8 years in Medical Affairs with deep scientific expertise in oncology
• Demonstrated success building and leading Medical Affairs organizations, including KOL engagement, evidence generation, and scientific communications
• Experience standing up Medical Affairs capabilities in high-growth, clinical-stage biotech or pharmaceutical environments
• Strong scientific credibility, executive leadership presence, and ability to engage effectively with both internal and external stakeholders
• High emotional intelligence and track record of cross-functional influence across Development, Commercial, and Regulatory functions

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $360,000-$410,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com

Why Join Us?

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

The VP, Development Data Science will build and lead a cross functional data centric matrix to accelerate drug development, support regulatory submissions and guide the Real-World Data (RWD) / Real-World Evidence (RWE) function at Parabilis. This role is responsible for end-to-end strategy and execution of RWD/RWE and clinical data science to inform trial design, contextualize clinical results, support biomarker and translational work, and optimize site and patient selection.

The VP will partner closely with Clinical Development, Clinical Operations, Biostatistics, Translational/Computational Biology, Regulatory, and the broader Data Science & Engineering team to maximize the probability of success of our clinical programs.

• Strategy & Leadership
  • Define and own the Clinical Data Science strategy.
  • Serve as the senior Clinical Data Science leader and primary point of contact for RWD/RWE across programs aligned with portfolio and corporate objectives.
  • Represent Clinical Data Science on cross-functional governance and portfolio forums.
• RWD/RWE & Clinical Analytics
  • Design and oversee RWE studies to contextualize clinical trials, including synthetic/external control arms, patient matching, and trial emulation.
  • Use RWD to inform clinical trial design (eligibility criteria, endpoints, enrichment strategies), dose/regimen selection, and go/no-go decisions.
  • Contribute data science insights for feasibility and site selection, including epidemiology, patient journeys, referral patterns, and diversity/access.
  • Integrate RWD with internal clinical and biomarker data to support forward and reverse translation, target and indication strategy, and mechanism-of-resistance analyses.
  • Establish and maintain best practices in causal inference, comparative effectiveness, and time-to-event modeling relevant to RWE in oncology.
• Data Assets, Partnerships & Infrastructure
  • Identify, evaluate, and prioritize RWD sources (EHR, claims, registries, genomic/omic datasets, imaging, PROs) to support current and future clinical needs.
  • Lead collaboration and contracting with RWD providers and academic/industry partners in coordination with Commercial, Business Development, Legal, and Procurement.
  • Partner with Engineering and Data Science to define requirements for secure, scalable, compliant RWD infrastructure and analytic environments.
  • Ensure data quality, interoperability, and governance suitable for regulatory-grade analyses.
• Team Building & Management
  • Build and lead a high-performing Clinical Data Science team (e.g., RWE epidemiologists, clinical data scientists, etc).
  • Set clear objectives, provide regular feedback, and support growth and succession planning.
  • Foster a culture of scientific rigor, transparency, and effective collaboration with Clinical Development, Biostatistics, and other partners.
• Cross-Functional Collaboration & Communication
  • Work in an integrated way with Clinical and Development teams to define key questions and translate them into analytic and RWE plans.
  • Communicate complex methods, assumptions, and results clearly to clinical, technical, and executive stakeholders.
  • Support regulatory and payer/Health Technology Assessment interactions where RWE and clinical analytics contribute to program strategy (e.g., briefing documents, responses, meeting preparation).
  • Collaborate with Translational and Computational Biology to align biomarker and patient selection strategies with integrated clinical and RWD analytics.
• Governance, Quality & Compliance
  • Ensure RWD/RWE activities meet regulatory, ethical, and privacy standards (e.g., GCP, data de-identification and privacy requirements).
  • Implement documentation, reproducibility, and quality standards for Clinical Data Science analyses.
  • Monitor evolving external expectations for use of RWE in regulatory and payer settings and adapt internal practices accordingly.

What you’ll need to be successful:

• PhD, MD, PharmD, or MS in Epidemiology, Biostatistics, HEOR, Data Science, or a related quantitative field.
• 12–15+ years of experience in pharma/biotech, healthcare technology, or related sectors, with significant focus on RWD/RWE and clinical development; oncology experience strongly preferred.
• Proven track record designing and delivering impactful RWE studies to inform clinical, regulatory, or payer decision-making.
• Strong understanding of clinical trial design, biostatistics fundamentals, and translational/biomarker concepts, ideally in oncology or immuno-oncology.
• Demonstrated experience building, leading, and developing high-performing quantitative teams in a matrixed environment.
• Hands-on familiarity with major RWD types (EHR, claims, registries, genomic/omic datasets) and key vendors/platforms.
• Proficiency with modern analytic tools and programming environments (e.g., R, Python, SQL) and with guiding development of robust, reproducible analytic workflows.
• Excellent communication and influencing skills with the ability to engage effectively with clinicians, statisticians, senior leaders, and external partners.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $325,000-$380,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com

The Opportunity

This Real World Evidence (RWE)/Health Economics (HEOR) Contractor role supports the RWE/HEOR Senior Director in leading RWE execution for pipeline assets. The role is fun and flexible with a mix of both study execution and data analytics. This person will be accountable for developing and delivering components of the evidence generation plan (including RWE and economic value evidence), and driving high-quality deliverables that inform internal decision-making during product development, pre-launch readiness, and lifecycle planning. The role is anchored to 1–2 priority pipeline assets/indications.

This is a remote role based with flexible hours. We are currently seeking an individual with 20-30 hours of weekly availability with potential to increase hours in late 2026/2027.

Responsibilities

• Evidence strategy and planning: Maintain US RWE & HEOR plans for 1–2 priority pipeline assets/indications, aligned to US medical, payer, and access needs; translate strategy into actionable workplans, timelines, and resourcing proposals.
• Study leadership (RWE/HEOR): Own day-to-day leadership for assigned real-world evidence and health outcomes studies (e.g., real-world evidence studies, cost-effectiveness/budget impact analyses, burden of illness, treatment patterns, patient-focused outcomes) including design and execution in partnership with internal functions and external vendors.
• Scientific communication and quality: Draft/review project specifications, protocols, statistical analysis plans, study reports, abstracts, posters, and manuscripts; ensure adherence to SOPs and high scientific/operational quality.
• Analytic execution and statistics: Execute ad hoc analyses in clinical trial, claims and PCOR data as needed for ad hoc and protocol/SAP driven analyses. This may include feasibility or full protocol execution.
• Governance, compliance, and capability building: Complete required training, adhere to company/department SOPs, and contribute to continuous improvement of processes that enable efficient planning, execution, and dissemination of RWE & HEOR deliverables.

Required Qualifications

• Master’s degree or PhD in epidemiology, health economics and outcomes research, public health, biostatistics, or related discipline.
• At least 1+ years of experience in the pharmaceutical industry and/or managed care, hospital, academic, or healthcare consulting environment with exposure to HEOR/RWE strategy and application
• Proficiency with SAS and/or R for statistical programming. Preference for experience in clinical trials OR claims data.
• Expertise in RWE and study designs/methods evidenced by publications and/or contributing to study concept sheets and protocols, reviewing/authoring key sections of statistical analysis plans and study reports, and ensuring publication/disclosure readiness in accordance with ICJME criteria
• Strong communication and presentation skills, demonstrated by developing and presenting clear, decision-oriented materials (e.g., evidence strategy slides, executive readouts) and summarizing outcomes/next steps for senior audiences

Preferred Qualifications

• Demonstrated success developing and executing health outcomes research plans and delivering high-quality data generation outputs.
• Experience managing real-world data sources and vendors (e.g., claims, EHR, registries) and translating findings into actionable insights and value messages.
• Demonstrated ability to influence without authority in a matrix environment, evidenced by aligning cross-functional stakeholders on objectives/trade-offs, documenting decisions, and driving actions to closure.
• Experience in PCOR implementation and validation

Work Location and Condition

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location

Position Summary:

The Senior Director, Commercial Strategy lead is responsible for understanding the evolving needs of the Stargardt community and shaping the brand strategy, including the execution of comprehensive marketing plans. This role will lead brand planning, product launches, and lifecycle management, working closely with cross-functional teams across commercial, medical, regulatory, and clinical functions.

This is a leadership role on the commercial team that will own the go-to-market strategy, lifecycle planning, ensuring seamless collaboration across functions and support market access research ultimately driving meaningful patient impact and delivering strong business results.

Primary Responsibilities:

Brand Strategy & Tactical Execution:

• Develop integrated brand strategies and lifecycle activities to support differentiation and commercialization goals
• Drive disease area strategy, market segmentation, and product positioning based on unmet needs, competitive landscape, and evolving science
• Responsible for creating external (promotional/educational) communication materials for external use with customers (ECPs and Patients)
• Partner with Corporate Communications to support development of the Corp Communications tactics and messages as needed
• Lead the cross-functional workshops for the development of strategic and tactical plans for gildeuretinol

Competitive Strategy and Response:

• Assess emerging trends, market dynamics, and competitive activity to inform commercial decisions
• Lead competitive scenario planning and collaborate with medical, corp. comms, strategic planning and clinical to develop competitive response strategy
• Translate scientific and market insights from ECPs and patients (through market research, ad boards, etc.) into differentiated product strategy and value stories
• Evaluate strategic implications of evolving regulatory, pricing, and access landscapes globally
• Provide input into forecasting assumptions and evaluate ROI for activities
• Collaborate closely with regulatory, medical affairs, market access and corporate communications to ensure alignment of brand vision and execution

Program Team and key workstreams participation:

• Lead development/optimization of TPP
• Generate and communicate ECP/Patient insights to inform Program strategy
• Be the commercial voice on program team and inform decisions impacting commercialization
• Participate in the evidence generation, pubs planning and LCM strategy sub teams to represent the commercial POV

Qualifications:

• Education and Certification
• Advanced degree (MBA) in marketing/ business, or scientific degree preferred
• Requires 12+ years of experience or the equivalent combination of education and experience

• Skills and Key Success Factors:
  • Entrepreneurship spirit with a passion to build, learn and evolve with the team
  • Highly organized and detail oriented with a passion to deliver quality results
  • Excellent verbal and written communication skills, with experience translating complex concepts for various audiences
  • Demonstrated record of intellectual curiosity, innovation and creative problem solving with an entrepreneurial spirit
  • Ability to lead fast-paced projects with a keen sense of urgency to get the job done well
  • Evidence of "hands-on" experience and expertise
  • Proven and successful track record as a team-player and collaborator in small working environments
  • Highest levels of professionalism, confidence, personal values and ethical standards

Other Relevant Information:

• Travel:  Able to travel up to 25% of time

Compensation

• Base Salary Range: $235K - $275K, with the actual contingent upon several factors such as the selected candidate’s education/work experience/training, and other factors (travel requirements, etc.)
• Discretionary Bonus: up to 25% of Base Salary, contingent upon meeting performance components
• Equity: initial grant of incentive stock options
• Benefits: Eligible to participate in group medical/dental/vision insurance plans; short- and long-term disability plans; life insurance; 401(K) plan; flexible time off policies and others. Eligibility and participation requirements vary by plan.

About the Role

We are seeking a Senior Commercial Program Manager to drive operational excellence across the Commercial organization. This role will focus on building scalable processes, improving cross-functional workflows, and ensuring consistent operating rhythms that enable the business to execute effectively against revenue goals.

The ideal candidate combines strong analytical thinking with pragmatic execution skills. They are highly organized, comfortable working across multiple stakeholders, and skilled at translating business priorities into structured processes, clear metrics, and efficient workflows to increase speed, predictability, and efficiency.

This individual will work closely with commercial leadership to run our operating cadences, eliminate friction across cross-functional workflows, and build the infrastructure that lets the business scale. 

Key Responsibilities

Process Design & Workflow Optimization

• Evaluate existing commercial workflows and identify opportunities to streamline processes and reduce friction in partnership with the Commercial team
• Design and implement scalable processes that improve efficiency
• Standardize documentation, handoffs, and communication channels to improve cross-functional alignment
• Reduce manual work and improve repeatability of core commercial processes

Metrics, Reporting & Insights

• Partner with Analytics  to define and maintain key commercial metrics
• Analyze performance trends to identify opportunities for improvement
• Ensure leadership has clear visibility into pipeline health, performance against goals, and operational risks
• Translate data into actionable insights that support decision-making

Cross-Functional Program Leadership

• Drive alignment across Commercial and Operations teams
• Support execution of key commercial initiatives and strategic priorities
• Ensure dependencies are clearly identified and managed
• Help teams stay organized and focused on delivering outcomes

Continuous Improvement

• Identify structural issues that slow execution or create ambiguity
• Proactively propose solutions that improve clarity, accountability, and speed
• Build frameworks that scale with company growth
• Serve as a thought partner to commercial leadership on operational improvements

Commercial Operating Rhythm

• Support the execution of cadences across the Commercial organization, including leadership meetings, quarterly planning, and goal tracking
• Ensure agendas, priorities, and action items are clearly defined and followed through
• Identify opportunities to improve meeting effectiveness and decision-making clarity
• Help leadership maintain focus on highest-impact initiatives

Qualifications

Required

• 6–10 years of experience in program management, business operations, strategy & operations, or commercial operations
• Demonstrated experience improving business processes and operational workflows
• Strong organizational skills and attention to detail
• Experience working with leadership teams to drive execution against strategic priorities
• Strong analytical skills and comfort working with metrics and dashboards
• Excellent communication skills, including ability to synthesize complex topics clearly
• Ability to influence without authority across multiple stakeholders
• Experience supporting structured operating cadences

Preferred

• Experience supporting Sales, Marketing, or Customer Success organizations
• Familiarity with CRM and analytics tools (e.g., Salesforce, HubSpot, Looker)
• Experience working in high-growth or scaling organizations

Position Overview

We are seeking a detail-oriented Director, Compliance to join Iterative Health's growing team in New York, NY or Cambridge, MA. This role will be instrumental in leading the strategic development of compliance programs to ensure our clinical trial optimization solutions meet all regulatory requirements across healthcare, clinical trials, and data privacy domains. The ideal candidate will have deep expertise in healthcare compliance frameworks and the ability to operationalize complex regulatory requirements in a fast-paced health tech environment.

Key Responsibilities

Regulatory Compliance & Risk Management

• Experienced with the compliance aspects of clinical trial & clinical research
• Maintain comprehensive compliance with GDPR, HIPAA, and other applicable data privacy regulations
• Lead SOC 2 Type II audit preparation and ongoing compliance, including controls documentation and evidence collection
• Develop and implement compliance policies and procedures specific to clinical trial technologies and healthcare AI solutions
• Ensure adherence to Anti-Kickback Statute, Stark Law, and PhRMA Code requirements in all business relationships
• Monitor evolving AI regulations and their impact on clinical trial optimization platforms

Quality Management & Documentation

• Oversee Quality Management System (QMS) in partnership with other team members, for maintenance and contractual compliance 
• Establish and maintain comprehensive record retention policies across clinical, regulatory, and business functions
• Manage document control processes for clinical protocols, compliance documentation, and regulatory correspondence
• Coordinate with clinical operations team to ensure GCP compliance in trial management and data collection

Contract & Vendor Compliance

• Review and negotiate compliance terms in customer agreements, vendor contracts, and clinical trial agreements
• Conduct vendor risk assessments and ongoing compliance monitoring for third-party service providers
• Ensure contract compliance with healthcare customer requirements, including BAAs and data processing agreements
• Support commercial team with compliance aspects of customer onboarding and due diligence processes

Training & Cross-Functional Support

• Develop and deliver compliance training programs for employees across all functions
• Serve as primary compliance liaison with external auditors, regulators, and certification bodies
• Collaborate with legal, clinical, and product teams on regulatory strategy and risk mitigation
• Maintain compliance calendar and ensure timely completion of regulatory filings and renewals

Required Qualifications

Education & Experience

• Bachelor’s degree in Life Sciences, Business, or a related field plus 8+ years of compliance experience in healthcare, biotech, or clinical research organizations; advanced degree preferred
• OR Juris Doctor (JD) or other advanced degree plus 5+ years of compliance experience in healthcare, biotech, or clinical research organizations
• Direct experience with clinical trial regulations and GCP requirements
• Proven track record managing compliance programs in regulated industries

Technical Expertise

• Employment law and HR compliance expertise, including workplace privacy, salary transparency, employee data protection, and regulatory training requirements
• Corporate governance and general business compliance including anti-corruption, export controls, and corporate record-keeping requirements
• Privacy program management across all business functions, including vendor privacy assessments and cross-border data transfer compliance
• Financial compliance awareness including regulatory reporting requirements
• Deep knowledge of GDPR and HIPAA requirements and implementation
• Hands-on experience with SOC 2 audits and information security compliance frameworks
• Familiarity with clinical research regulations (GCP, ICH guidelines, 21 CFR Part 11)
• Understanding of AI/ML regulatory landscape in healthcare and clinical trials

Core Competencies

• Strong analytical and problem-solving skills with ability to translate complex regulations into actionable policies
• Excellent written and verbal communication skills for regulatory correspondence and training delivery
• Project management experience with ability to manage multiple compliance initiatives simultaneously
• Detail-oriented approach with strong documentation and process improvement capabilities

Preferred Qualifications

• Professional certifications (CIPP, CISA, CCEP, CHRC, or similar compliance credentials)
• Experience with international regulations (EU Clinical Trials Regulation, other global markets)
• Background in clinical research or pharmaceutical compliance
• Familiarity with AI ethics and algorithmic bias considerations in healthcare
• Experience with healthcare technology or SaaS compliance programs

About the Role

The Regional Director is responsible for owning and optimizing site-level performance across a portfolio of GI-focused clinical research sites. This role ensures operational excellence by aligning teams around key performance goals, elevating site capabilities, and maintaining consistency in trial execution. As a strategic operations leader, the Regional Director plays a central role in connecting site level performance with broader business objectives.

Responsibilities

• Manages staff across multiple sites, ensuring execution is aligned with protocol, regulatory requirements, and IH standards.
• Owns overall performance of assigned sites, including enrollment, data quality, compliance, and team culture.
• Ensures sites are set up for success (i.e. staffed appropriately and equipped with the appropriate equipment and training) and makes recommendations to allocate resources based on business needs. 
• Builds strong relationships and collaborates with PIs to align their engagement with study goals and operational strategy.
• Influences study portfolio, optimizing for profitability and value to patients. 
• Identifies and manages issues, concerns and problems related to site performance.
• Leads and develops CRCs, and other site-based research staff through clear expectations, performance coaching, and team development.
• Serves as a visible, hands-on people manager who builds high-performing, accountable teams.
• Identifies levers to drive site level KPIs through monitoring KPIs and performance trends, escalating to appropriate parties. 
• Implements corrective actions or process improvements as needed.
• Serves as the primary operational liaison between site staff and central functions.
• Drives a culture of ownership, collaboration, and continuous improvement across all assigned sites.

What We’re Looking For

Required Qualifications

• Knowledgeable about the critical elements for success in clinical trials: Ability to review protocols, programs, and assess the success of a project.
• Ability to influence change management and model flexibility
• Problem-Solving Skills: Ability to identify problems, develop and implement solutions.
• Strategic Planning: Ability to plan for short, medium and long term success and make recommendations for growth
• Ability to use data as a tool, identify trends, and draw conclusions. 
• Project Management: Demonstrated ability to successfully manage people/projects.
• Proactive problem-solving abilities and follow-through.
• Practices professionalism and integrity in all actions. 
• Communication Skills: Excellent written and verbal communication skills. 
• Working knowledge of CTMS, eDC and other core research systems. 
• Ability to travel: Up to 30% travel to provide operational oversight, hold team meetings, and attend other professional meetings/conferences as needed.

Preferred Qualifications

• Experience in managing a large site network and demonstrated success in achieving targets and optimizing operations.
• Experience with gastroenterology and/or hepatology studies. 

What We Offer

• Medical, dental, and vision insurance
• Life and disability insurance
• Parental leave
• Stock options
• Flexible work hours
• Unlimited paid time off

We are seeking a strategic and data-driven People Business Partner role to partner closely with leaders across corporate functions and site-based operational teams in support of a high performing, highly distributed healthcare services organization. This role will act as a trusted advisor, aligning people strategies with business priorities to support growth, scalability, and performance across the organization. Operating in a high-growth, M&A driven environment, this role requires a strong balance of strategic thinking and hands-on execution. The People Business Partner will play a key role driving organizational effectiveness, enabling leadership and supporting change initiatives while fostering a high-performing, mission-driven culture. This individual must be comfortable pivoting between both a strategic and hands-on level of engagement, with a strong focus on change and performance management,
talent/leadership development, organizational design, employee relations and integration.

Key Responsibilities

Strategic Business Partnership
● Serve as a trusted advisor, coach and thought partner to department, team and operational leaders, providing guidance on organizational strategy, workforce planning, employee relations issues and talent implications of business decisions
● Translate business priorities into actionable HR strategies that drive growth, scalability, and operational excellence to enable a high performing and engaged workforce.
● Develop a deep understanding of IH business units, financial drivers, and market industry dynamics to proactively shape people initiatives that help transform the business as we grow and scale our infrastructure.
● Serve as a strategic liaison and advisor between the business and People Team Center of Excellence’s (COE) to align HR service delivery with business priorities
● Identify opportunities to implement data-informed people strategies that strengthen organizational health, culture and maturity while directly impacting leadership effectiveness and team performance
● Lead workforce planning with business partners, anticipating skills and capabilities needed to scale the organization beyond current state – develop plans in conjunction with TA to identify talent profiles and succession bench ready for promotion to increased level of scope and responsibility

Talent and Performance Management
● Drive talent and performance management processes that reinforce accountability, ownership and high standards of behaviors / values alignment to support our high-performance culture
● Partner with leaders on succession planning, leadership development, compensation strategies and retention initiatives across the enterprise
● Use data and insights to inform talent decisions and effectively balance business needs with employee advocacy
● Coach and develop leaders to engage, motivate and lead high performing teams, identifying least effective performance and partnering with team leaders to address performance issues early on.

Change Management and Culture
● Lead change management efforts across our growing and evolving teams/structures to support effective communication, accountability and alignment to our strategic priorities
● Champion a culture of innovation, collaboration, and continuous improvement aligned with Iterative Health’s mission
● Support leaders in navigating ambiguity and leading through transformational change as an organization, providing insights and serving as a “thought partner” on operational and people challenges that dynamic growth brings.

Employee Relations and Coaching
● Provide expert coaching on employee relations, leadership effectiveness, and team dynamics to enable a highly engaged, productive workforce while maintaining consistency and alignment to IH policies and procedures.
● Support positive culture building initiatives and drive employee engagement initiatives with team leaders to build highly engaged, motivated team members.
● Ensure compliance with employment laws and company policies – identify opportunities to improve, create and implement policies and procedures that balance business needs with operational realities M&A

HR Integration
● Partner with internal stakeholders including People COE’s on due diligence, integration planning, and execution as part of pre and post-acquisition integration process
● Support organizational design, talent assessment, and cultural integration efforts to ensure seamless onboarding of acquired entities and team members to IH
● Anticipate, identify and mitigate people-related risks associated with rapid growth and change, including supporting HR initiatives focused on harmonization of system, processes and policies across the growing enterprise.

HR Program Execution
● Partner with COE to deliver best-in-class HR transformational initiatives to support a growing and scaling workforce
● Own HR projects in support of strategic HR agenda focused on employee engagement, leadership development, performance management, and operationalizing best in class people initiatives and infrastructure that will attract, develop and retain talent.

Qualifications
● 7–10+ years of progressive HR experience, including working in a fast-scaling, high-growth, complex and ambiguous start-up environment
● Experience in healthcare, clinical research, medtech, life sciences, or related industries strongly preferred
● Experience supporting a highly distributed, growing multi-site location network both domestically and globally is strongly preferred
● Demonstrated experience across a wide range of HR functional domains
● Strong business acumen with the ability to link HR strategy to financial and operational outcomes
● Proven ability to communicate and influence senior leaders as well as operate as a strategic partner, understanding the operational and strategic priorities of the business and how people strategies can make an impact
● Experience in organizational design, change management, and talent strategy
● Data-driven, analytical mindset with comfort leveraging data and analytics to inform decisions
● Excellent communication, coaching, and stakeholder management skills
● Comfort navigating through ambiguity and managing multiple competing priorities
● A builder and inventor mindset – orientation towards thinking outside the box to pilot and test programs and initiatives to iterate before applying a one-size fits all approach.

COMPANY DESCRIPTION

Mirai Bio is a Flagship-backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. Mirai’s platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

THE ROLE

We are seeking a Senior Director / Vice President of Scientific Strategy & Research Enablement to help architect and scale the research engine that powers this platform. Reporting to the SVP/Head of Platform, this role will operate at the intersection of scientific strategy, platform development, and execution, ensuring that our research organization has the infrastructure, partnerships, and operational frameworks necessary to move rapidly from invention to discovery.

This individual will play a key role in shaping how our science is executed—designing the systems, workflows, and external collaborations that enable scientists to focus on innovation while accelerating the generation of high-quality data and platform insights.

The ideal candidate will combine a strong understanding of modern research environments with the ability to build scalable systems that increase scientific productivity and translate platform capabilities into impactful programs.  This is an individual contributor role that is part of extended Executive Leadership team, and with opportunities for growth.

KEY RESPONSIBILITIES

Scientific Strategy and Research Enablement

• Partner closely with the SVP/Head of Platform and scientific leaders to translate research strategy into an integrated framework for execution across internal teams and external collaborators.
• Design and implement the infrastructure that supports discovery, including research workflows, collaboration frameworks, and data systems that enable efficient experimentation and decision-making.
• Identify opportunities to increase research velocity and rigor by optimizing experimental pipelines, data generation, and knowledge flow across the organization.
• Lead initiatives that remove barriers to scientific progress and improve how the organization generates, integrates, and interprets experimental data.
• Help ensure the organization’s scientific output is communicated clearly and effectively to internal and external stakeholders.
• Collaborate with research, finance, and leadership teams to align resources with the highest-impact scientific opportunities.
• Establish mechanisms for tracking research progress, milestones, and data generation across internal and partnered programs.
• Contribute to building a culture of scientific rigor, transparency, and operational excellence within the research organization.

Platform Development and External Scientific Partnerships

• Develop and manage a network of external collaborators and technology providers that extend the capabilities of the platform.
• Continuously evaluate emerging technologies, experimental capabilities, and vendors that can expand the company’s research toolkit.
• Structure and oversee scientific collaborations and SOWs to ensure alignment on experimental design, data quality and deliverables.

PROFESSIONAL EXPERIENCE & QUALIFICATIONS

Required

• Bachelor’s degree in life sciences, biotechnology, or related field; PhD required
• 10+ years of experience in biotechnology or pharmaceutical R&D, with exposure to discovery-stage research environments.
• Demonstrated experience enabling or managing complex research programs, scientific collaborations, or research infrastructure.
• Strong understanding of laboratory research workflows and modern approaches to data generation and management.
• Exceptional communication skills and the ability to synthesize complex scientific concepts into clear strategic narratives.

Preferred

• Experience in early-stage or venture-backed biotechnology companies.
• Familiarity with in vivo delivery technologies, genetic medicines, or nucleic acid therapeutics.

ABOUT FLAGSHIP PIONEERING:

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-TL1

The salary range for this role is $275,000 - $340,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Mirai Bio currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Mirai Bio's good faith estimate as of the date of publication and may be modified in the future.

COMPANY DESCRIPTION

Mirai Bio is a Flagship-backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. Mirai’s platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

THE ROLE

We are seeking a Senior Director / Vice President of Scientific Strategy & Research Enablement to help architect and scale the research engine that powers this platform. Reporting to the SVP/Head of Platform, this role will operate at the intersection of scientific strategy, platform development, and execution, ensuring that our research organization has the infrastructure, partnerships, and operational frameworks necessary to move rapidly from invention to discovery.

This individual will play a key role in shaping how our science is executed—designing the systems, workflows, and external collaborations that enable scientists to focus on innovation while accelerating the generation of high-quality data and platform insights.

The ideal candidate will combine a strong understanding of modern research environments with the ability to build scalable systems that increase scientific productivity and translate platform capabilities into impactful programs.  This is an individual contributor role that is part of extended Executive Leadership team, and with opportunities for growth.

KEY RESPONSIBILITIES

Scientific Strategy and Research Enablement

• Partner closely with the SVP/Head of Platform and scientific leaders to translate research strategy into an integrated framework for execution across internal teams and external collaborators.
• Design and implement the infrastructure that supports discovery, including research workflows, collaboration frameworks, and data systems that enable efficient experimentation and decision-making.
• Identify opportunities to increase research velocity and rigor by optimizing experimental pipelines, data generation, and knowledge flow across the organization.
• Lead initiatives that remove barriers to scientific progress and improve how the organization generates, integrates, and interprets experimental data.
• Help ensure the organization’s scientific output is communicated clearly and effectively to internal and external stakeholders.
• Collaborate with research, finance, and leadership teams to align resources with the highest-impact scientific opportunities.
• Establish mechanisms for tracking research progress, milestones, and data generation across internal and partnered programs.
• Contribute to building a culture of scientific rigor, transparency, and operational excellence within the research organization.

Platform Development and External Scientific Partnerships

• Develop and manage a network of external collaborators and technology providers that extend the capabilities of the platform.
• Continuously evaluate emerging technologies, experimental capabilities, and vendors that can expand the company’s research toolkit.
• Structure and oversee scientific collaborations and SOWs to ensure alignment on experimental design, data quality and deliverables.

PROFESSIONAL EXPERIENCE & QUALIFICATIONS

Required

• Bachelor’s degree in life sciences, biotechnology, or related field; PhD required
• 10+ years of experience in biotechnology or pharmaceutical R&D, with exposure to discovery-stage research environments.
• Demonstrated experience enabling or managing complex research programs, scientific collaborations, or research infrastructure.
• Strong understanding of laboratory research workflows and modern approaches to data generation and management.
• Exceptional communication skills and the ability to synthesize complex scientific concepts into clear strategic narratives.

Preferred

• Experience in early-stage or venture-backed biotechnology companies.
• Familiarity with in vivo delivery technologies, genetic medicines, or nucleic acid therapeutics.

ABOUT FLAGSHIP PIONEERING:

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-TL1

The salary range for this role is $275,000 - $340,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Mirai Bio currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Mirai Bio's good faith estimate as of the date of publication and may be modified in the future.

The Position

Reporting to our Co-CEO’s, the SVP of Program Leadership & Development will drive the advancement of our clinical-stage pipeline. This individual will be responsible for end-to-end leadership of one or more key development programs translating scientific innovation into clinical, regulatory, and commercial success.

The SVP of Program Leadership & Development will play a critical role in shaping program strategy, guiding cross-functional execution, and maximizing asset value from early development through late-stage trials and potential regulatory approval.

This role will serve as a core member of the Senior Leadership Team, partnering closely with Clinical Operations, Medical, Regulatory, Biometrics, CMC, Commercial and other functional leaders to drive the successful execution of Amylyx’s development portfolio.

In a lean and evolving biotech environment, this individual will operate both as an enterprise leader and a hands-on program leader, directly supporting key assets while building a scalable program leadership organization over time.

The Opportunity

This is a unique opportunity to shape and define how program leadership is executed within a growing biotech organization at a critical inflection point.

Build a New Function from the Ground Up - design and implement a modern program leadership model, including the evolution from traditional program management to a strategic Program Lead and Program Manager structure.

Operate as a True Peer to Clinical and Medical Leadership - serve as an equal partner to senior leaders across Clinical Operations, Medical, and Regulatory, helping shape asset strategy and execution.

Drive Impact Across the Full Development Lifecycle - lead programs spanning early-phase IND-enabling work through Phase 3 and potential NDA submission, with direct impact on key value-driving milestones.

Balance Strategy and Execution in a Lean Environment - play a dual role as both a strategic leader and hands-on program leader, directly influencing outcomes while building for future scale.

Shape Organizational Culture and Ways of Working - establish a highly collaborative, accountable, and transparent operating model that strengthens alignment across functions and reduces organizational friction.

Scale with the Portfolio - build and develop a high-performing team over time, aligned to the growth of the pipeline and key clinical milestones.

Responsibilities

Strategic Program Leadership

• Partner with Clinical Operations and Medical leadership to define and execute development strategies and plans across programs
• Drive program-level decision-making, including risk assessment, trade-offs, and prioritization
• Ensure alignment between asset strategy, clinical execution, and regulatory pathways
• Present program updates, risks, and opportunities to Executive Leadership and Board of Directors

Cross-Functional Integration & Alignment

• Serve as the central integrator across Medical, Clinical Operations, Regulatory, Biometrics, CMC, Commercial and other key functions
• Drive clarity of roles, decision-making, and accountability across program teams
• Proactively identify and resolve cross-functional misalignment, gaps, and competing priorities

Hands-On Program Execution

• Directly serve as Program Lead for one or more key assets, particularly in the early phase of the role
• Lead cross-functional team meetings, execution planning, and milestone delivery
• Translate strategic objectives into clear, aligned execution plans

Build & Scale Program Leadership

• Design and implement a program leadership model, including Program Leads and Program Managers
• Hire, develop, and lead program leadership talent over time as the organization grows
• Establish best practices, governance frameworks, and ways of working that enable scalability

Portfolio & Executive Contribution

• Contribute to portfolio prioritization, resource allocation, and strategic planning discussions at the leadership level
• Provide clear, actionable insights and recommendations to executive leadership
• Support the evolution of Amylyx’s development organization as it scales toward key clinical and regulatory milestones

Required Qualifications

• Advanced degree (PhD, MD, PharmD, or MD) in a relevant scientific discipline preferred; equivalent experience in drug development and program leadership will also be considered
• 20+ years of experience in the pharmaceutical or biotechnology industry, including significant experience leading cross-functional drug development programs
• Lead integrated clinical development plans (CDPs)
• Overseen protocol design, endpoints, and trial execution
• Demonstrated success in regulatory interactions (FDA, EMA)
• Significant experience leading cross-functional drug development programs, ideally spanning early development through late-stage clinical and/or regulatory milestones
• Demonstrated success in regulatory interactions (FDA, EMA)
• Prior experience serving as a Program Lead, Development Team Leader (DTL), Asset Team Lead or equivalent role, with accountability for cross-functional program execution
• Demonstrated ability to partner with Clinical Operations, Medical, and Regulatory leaders as a peer, influencing strategy and execution
• Experience operating in a biotech or similarly lean, fast-paced environment, with comfort navigating ambiguity and evolving priorities
• Proven track record of building or scaling teams and/or functions within a matrixed organization
• Strong leadership and collaboration skills, with the ability to align diverse stakeholders and drive decision-making in complex environments
• Hands-on, execution-oriented leadership style, with willingness to engage directly in program delivery when needed
• Excellent communication and interpersonal skills, with the ability to bridge scientific, clinical, and business perspectives

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis.  Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

About Graphcore

Graphcore is one of the world’s leading innovators in Artificial Intelligence compute.  

It is developing hardware, software and systems infrastructure that will unlock the next generation of AI breakthroughs and power the widespread adoption of AI solutions across every industry.  

As part of the SoftBank Group, Graphcore is a member of an elite family of companies responsible for some of the world’s most transformative technologies. Together, they share a bold vision: to enable Artificial Super Intelligence and ensure its benefits are accessible to everyone.   

Graphcore’s teams are drawn from diverse backgrounds and bring a broad range of skills and perspectives. A melting pot of AI research specialists, silicon designers, software engineers and systems architects, Graphcore enjoys a culture of continuous learning and constant innovation.  

The Role:

We are developing the next generation of AI compute, a large-scale system-on-chip (SoC) designed to power future high-performance AI systems. As the SoC Validation Lead, you will be responsible for enabling pre-production software to run reliably on new silicon quickly and efficiently, before showing that the silicon meets the highest standards of quality, reliability and functionality, ready for production deployment.

You will lead a team delivering post-silicon validation across the full AI SoC, working across silicon, firmware, and platform levels. The role requires a deep technical understanding, strong hands-on debug experience, and the ability to collaborate effectively with hardware, software, and systems engineering teams.

Responsibilities:

• Define and lead post-silicon validation strategy
  Develop and refine the overall post-silicon validation approach for our AI SoCs, ensuring reliable and timely delivery of validated silicon, architectural correctness, feature robustness, and at-scale system reliability.
• Drive cross-domain debug and issue resolution
  Lead investigation and resolution of complex issues spanning silicon, firmware, operating systems, and platform interactions. Ensure that fixes are effective and sustainable.
• Promote collaboration and shared understanding
  Work closely with design, software, and validation teams to align on quality objectives and debug priorities. Use data-driven insights and clear communication to maintain focus and alignment across teams.
• Advance automation and scalable validation
  Encourage the use of emulation, prototyping, and large-scale validation infrastructure to improve coverage and reduce time to debug.
• Support continuous improvement
  Foster a culture that values learning, transparency, and improvement in validation methods, automation, and analysis.
• Engage with leadership and customers
  Provide clear and concise updates on validation progress, risks, and quality indicators to executive teams and key partners. Contribute to product readiness assessments and roadmap decisions.

About you:

• A systems thinker comfortable working across hardware, software, and integration boundaries.
• A collaborative leader who builds trust and alignment across diverse teams.
• Skilled in technical problem solving and debugging complex post-silicon issues.
• A clear communicator who can simplify complexity and support sound decision-making in fast-paced environments.
• Committed to developing people and promoting an inclusive, high-performing team culture.

Qualifications:

• Bachelor’s degree in Electronic Engineering or equivalent; Master’s preferred.
• 20+ years in silicon, system, or platform validation, including 10+ years in technical leadership.
• Proven experience leading post-silicon validation and bring-up for complex SoCs (AI, GPU, or CPU).
• Strong understanding of SoC architecture, coherency protocols, power management, and interconnects.
• Expertise in debug tools, DFT infrastructure, and validation automation frameworks.
• Proficient in C/C++, Python, and Linux-based environments; experience with large-scale validation clusters is an advantage.
• Excellent communication, collaboration, and stakeholder management skills.

About Graphcore 

At Graphcore, we’re building the future of AI compute.

We’re a team of semiconductor, software and AI experts, with deep experience in creating the complete AI compute stack - from silicon and software to infrastructure at datacenter scale.

As part of the SoftBank Group, backed by significant long-term investment, we are delivering key technology into the fast-growing SoftBank AI ecosystem.

To meet the vast and exciting AI opportunity, Graphcore is expanding its teams around the world.

We are bringing together the brightest minds to solve the toughest problems, in a place where everyone has the opportunity to make an impact on the company, our products and the future of artificial intelligence.

Job Summary 

We are seeking a Director of Silicon Logical Design to lead and scale our Logical Design group within the Silicon department. This role is accountable for the overall strategy, technical direction, execution quality and team development for Graphcores microarchitecture and RTL design efforts. 

The Director will be responsible for ensuring that our logical design methodologies, architectures and RTL implementations meet world class standards for performance, power, area, and schedule. This leader will partner closely with Architecture, Physical Design, Verification, DFT and Program Management teams to ensure successful, predictable silicon delivery aligned with Graphcores long term product roadmap. 

The Team 

The Logical Design team deliver the micro-architecture and RTL that realise our advanced chip architectures. As Director, you will guide this multi site team, strengthen cross functional collaboration, and drive the evolution of our design flows and capabilities. 

Responsibilities and Duties 

Leadership & Strategy 

• Define and execute the strategic roadmap for Logical Design, ensuring alignment with Graphcores silicon and product strategy. 

• Lead, grow and mentor a high performing RTL/micro architecture design organisation. 

• Establish and implement best in class design methodologies, documentation standards and quality metrics. 

• Drive continuous improvement across team structure, workflows, tooling, and design processes. 

Technical Ownership 

• Provide technical oversight of micro architecture specification and RTL development across all major blocks and subsystems. 

• Guide architectural feasibility studies, contribute to architectural trade offs and micro architecture definition. 

• Oversee the integration of third party IP, complex application specific blocks, and high performance custom designs. 

• Ensure robust design sign off through high quality linting, synthesis, CDC/RDC, timing closure and coverage metrics. 

Cross-Functional Collaboration 

• Partner closely with Physical Design, Verification, DFT, Architecture and Program Management teams to ensure cohesive planning and execution. 

• Foster strong communication across teams and global sites, ensuring alignment on priorities, risks and deliverables. 

• Support silicon bring-up and debug efforts by providing expert guidance and deep understanding of RTL behaviour and architecture. 

Execution & Delivery 

• Own delivery of high quality, on schedule RTL for multiple parallel silicon programs. 

• Establish scalable project planning and tracking practices, including resource planning and risk mitigation. 
• Champion design automation and infrastructure improvements to accelerate productivity and improve design quality. 

Essential Skills & Experience 

• Degree in Computer Science, Electrical Engineering or a related field; advanced degree preferred. 

• Extensive experience in digital logical design, micro-architecture and RTL development for large scale, high performance silicon projects. 

• Proven success leading and developing technical teams in a semiconductor environment. 

• Deep expertise in SystemVerilog or VHDL and familiarity with modern digital design flows. 

• Strong ability to diagnose and resolve complex design issues, including via scripting/programming (Python, Tcl, etc.). 

• Demonstrated excellence in cross functional leadership and communication across global teams. 

• Strong organisational skills with ability to manage multiple priorities and drive execution in fast-paced environments. 

Desirable Experience 

• Processor or accelerator micro architecture. 

• High-speed serial interfaces and complex, high bandwidth IP blocks. 

• Arithmetic pipeline design and floating point datapaths. 

• Advanced synthesis, timing analysis, power analysis, and logical equivalence checking. 

• Design-for-test methodologies. 

• Power integrity and silicon device level understanding. 

• Experience with silicon bring-up and post-silicon validation. 

• Program planning and multi-project execution leadership. 

About the Role

As the Director, Strategy & Operations - Growth, you will report to the VP, Growth and serve as the leader of Iterative Health's biological specimen collections business. This is a senior, highly autonomous role for an operator who is equally comfortable setting strategy and rolling up their sleeves to execute. You will own the go-to-market strategy, lead the full build-out of the business, and hold accountability for performance. You will also lead and develop the team that runs the day-to-day of collections operations. The ideal candidate brings a strong strategic and analytical foundation from management consulting or a high-growth startup environment, paired with the operational horsepower and ownership mindset to build something from the ground up.

Responsibilities

Go-to-Market Strategy

• Own the go-to-market strategy for Iterative Health's biological specimen collections business — defining the service offering, target customer segments, competitive positioning, and path to scale
• Define what we sell and how we sell it: Work with Business Development to scope the collections service model, establish pricing frameworks, and develop the materials and narrative needed to bring the offering to market
•  Identify and size the resourcing, infrastructure, and capability requirements needed to support the strategy and inform investment decisions

Business Build-Out

•  Lead the end-to-end build-out of the biological specimen collections business — standing up operational capabilities, and establishing the processes and infrastructure needed to execute at scale
• Own vendor contracting and relationships, including selection, negotiation, onboarding, and ongoing performance management for all collections-related vendors
• Partner with the Business Development team to develop and progress a pipeline of collections studies, supporting sponsor engagement and proposal development
• Work cross-functionally with site operations leaders to identify and onboard the right site network to support collections studies

Business Performance Ownership

• Own execution quality and sponsor satisfaction on active collections studies, serving as the senior point of escalation and ensuring trials are delivered to the highest standard
• Define and track KPIs across the business; use performance data to identify gaps, course-correct quickly, and communicate progress to senior leadership

Team Leadership

• Lead, develop, and hold accountable a team that includes pre-screeners, central Clinical Research Coordinators, and a Clinical Operations Manager — setting clear performance targets and maintaining a high-performance culture
• Train team members on workflows, protocols, and quality standards, and ensure the team has the tools, processes, and support needed to execute at pace
• Set the operational tempo for the team — running structured operations, maintaining visibility into study and team performance, and driving accountability at every level

Required Qualifications

• BS/BA or higher degree; advanced degree (MBA, MPH, or equivalent) strongly preferred
• 7+ years of experience in a strategic and operational role, with meaningful exposure to building or scaling a business — prior experience in management consulting, a high-growth startup, or a general management capacity is strongly preferred
• Experience leading cross-functional build-outs — standing up new capabilities, managing vendors, and driving commercial pipelines
• Proven people leadership experience with the ability to recruit, develop, and hold accountable a high-performing team
• Exceptional organizational and project management skills with the ability to manage multiple high-stakes workstreams simultaneously
• Strong executive presence and communication skills — able to represent the business credibly with sponsors, vendors, and senior internal stakeholders
• Comfortable operating with significant autonomy and building structure in ambiguous, fast-moving environments

Preferred Qualifications

• Experience in life sciences, clinical research, or healthcare services — particularly in biological specimen collections studies

About the Role

As the Manager, Growth, you will play a critical operational role at the center of Iterative Health's two core growth engines in Cardiology: expanding our sponsor portfolio and scaling our site network. This is a high-visibility, high-impact role for a sharp operator who thrives on process ownership, cross-functional coordination, and getting things done in a fast-moving environment. You will own the internal mechanics of business development — keeping the pipeline moving, deals progressing, and sponsors well-served — while simultaneously driving the operational build-out of new clinical research sites from contract execution through first study activation. The ideal candidate brings a strategic and operational mindset, is energized by variety, and is able to manage multiple workstreams with rigor and speed.

Responsibilities

Sponsor Growth: Business Development & Alliance Management Support

• Own the end-to-end internal business development process from initial sponsor engagement through contract execution, serving as the single internal touchpoint for new contracts
• Keep the business development pipeline organized and visible by maintaining up-to-date reporting on opportunity status, next steps, and deal progression
• Support the Director of Research Partnerships in preparing for key sponsor interactions — developing pitches and proposals, building conference materials, and ensuring the team shows up well-prepared for high-stakes meetings
• Support sponsor account meetings through internal data gathering, performance reporting, and post-meeting follow-through
• Continuously identify opportunities to streamline and improve the business development process to accelerate deal pull-through and reduce time to contract close

Site Network Growth: De Novo Site Builds 

• Partner with the Director of Clinical Research to support the end-to-end process of standing up de novo clinical research sites 
• Serve as the operational connective tissue during site stand-up, tracking progress, surfacing blockers, and ensuring all cross-functional inputs come together on schedule
• Work with the Director of Clinical Research to continuously evaluate and improve the site stand-up process — identifying inefficiencies, building out playbooks, and creating repeatable frameworks that scale as the network grows

Required Qualifications

•  BS/BA or higher degree
• 4+ years of experience in a strategic and operational role, such as management consulting, business operations, or growth/strategy at a high-growth startup
• Demonstrated ability to own and manage complex, cross-functional processes end-to-end with strong attention to detail
•  Excellent organizational skills with experience managing multiple projects and workstreams simultaneously in a fast-paced environment
• Strong communicator with the ability to synthesize information, build materials, and engage effectively with internal and external stakeholders
• Comfortable working with ambiguity and building structure where it doesn't yet exist

Preferred Qualifications

• Experience in life sciences, clinical research, or healthcare 
• Familiarity with clinical trial operations, site networks, or sponsor/CRO relationships

POS-32553

Job Description

At HubSpot, we aim to give employees the same thoughtful, high-quality experience we offer our customers, every day of their journey with us — from their first day in the office to their last. As part of the Global Facilities team, the Senior Manager, Facilities – Americas leads operations across our Americas offices, ensuring safe, reliable, and inspiring workplaces where employees and visitors can do their best work.

This role owns day-to-day facilities operations and workplace experience for our directly leased and partner-managed spaces in the Americas, manages regional vendors and building relationships, and leads a distributed team of coordinators and contingent staff. You will partner closely with Real Estate, Security, Business Technology, Workplace Experience and other key stakeholders to deliver a data-informed, employee-centric facilities strategy that scales with HubSpot’s growth.

In this role you will

Regional leadership & team management

• Lead and develop a high-performing regional facilities team (full-time, temporary, and contractor staff) across multiple Americas locations (e.g., Cambridge, San Francisco, Bogotá), providing coaching, direction, and day-to-day support.
• Set clear goals and priorities aligned to global Facilities and drive consistent operational standards across sites.
• Delegate and oversee work through our internal ticketing system, ensuring timely, high-quality responses to employee and stakeholder requests.

Facilities operations & maintenance

• Own day-to-day facilities operations for the Americas offices, including office readiness, space standards, and preventative maintenance for core building systems (HVAC, plumbing, electrical, furniture, fixtures, and equipment).
• Coordinate and resolve building and infrastructure issues (e.g., furniture failures, water heater problems, IDF/MDF spaces) in partnership with vendors, building engineers, and internal teams, from initial triage through to resolution and communication.
• Ensure that meeting rooms, cafes, collaboration spaces, and wellness areas meet high standards of quality, functionality, and cleanliness, supporting employee productivity and comfort.
• Maintain and update team workflows for all americas offices 

Vendor, building & contract management

• Serve as the primary Facilities point of contact for property managers, landlords, and key building stakeholders across the Americas region, maintaining strong relationships and clear operating rhythms.
• Source, scope, and manage vendors for services such as janitorial, carpet and floor care, furniture, blinds, mechanical/plumbing, and specialty trades — including obtaining quotes, validating scope, scheduling work, and monitoring performance.
• Partner with Procurement and Finance on purchase requests, POs, and cost optimization (e.g., scheduling to avoid overtime labor where possible, aligning work with building access windows).

Workplace experience & front-of-house support

• Ensure a consistently excellent front-of-house and visitor experience in Americas offices, including reception standards, wayfinding, and event support in collaboration with on-site teams.
• Oversee coordination of mail, shipping/receiving, and logistics, including high-value and international shipments in partnership with Business Technology and external carriers.
• Support office events, intentional gatherings, and other on-site activities by ensuring facilities, services, and vendors are aligned to program needs.
• Manage large office moves, terminations including desk assignments. 
• Maintain and update floorplans when changes happen or new offices open, this includes updating the CAFM system to ensure floorplans are up to date.
• Review and coordinate parking assignments notifying the appropriate individuals to provide access.

Health, safety, security & emergency readiness

• Act as a key regional contact for facilities-related emergencies, coordinating with Security, IT, and local building teams to respond to incidents across Americas sites (e.g., IDF/MDF issues, building systems failures, safety concerns).
• Maintain and contribute to emergency contact lists, playbooks, and on-site procedures for multiple locations, ensuring information is current, accurate, and visible to the right stakeholders.
• Partnering with Security and local offices leads to support physical security practices (e.g., access control, cameras, vendor access) and align with HubSpot’s safety expectations.

Projects, space changes & cross-functional collaboration

• Lead and support facilities components of office projects in the Americas (e.g., reconfigurations, furniture changes, programmatic improvements, capital projects) in partnership with Real Estate, Construction partners, BT, and local stakeholders.
• Collaborate closely with global Facilities and Real Estate peers to ensure alignment on standards, data, and reporting, and to share best practices across regions.
• Use ticketing and space data to identify trends, propose improvements, and inform prioritization and investment decisions across the Americas portfolio.

Documentation, communication & knowledge sharing

• Maintain and enhance Facilities documentation for Americas offices, including wiki content, emergency information, operating procedures, and office-specific guides.
• Communicate proactively with employees, partners, and leadership about facilities work, impacts, and timelines, ensuring transparency and building trust.

Our ideal candidate

• Has 7+ years of experience in facilities management, workplace operations, property management, or a related field, including multi-site responsibility and complex office environments.
• Has at least 5+ Years of people management experience, leading and developing distributed teams and working with contingent staff and vendors.
• Demonstrates strong vendor and stakeholder management skills and is comfortable working directly with landlords, property managers, and specialty contractors to solve operational issues.
• Is highly organized, able to prioritize across multiple offices, manage competing deadlines, and stay calm and effective in time-sensitive or emergency situations.
• Communicates clearly and empathetically in writing and in person, tailoring their style for employees, senior leaders, vendors, and building teams.
• Is data-informed and comfortable using ticketing systems and basic reporting to spot patterns, drive improvements, and measure the impact of facilities programs.
• Brings a strong customer-first mentality, with a passion for creating inclusive, welcoming, and accessible spaces for all employees and visitors.
• Aligns with HubSpot’s HEART values and is eager to collaborate across regions and functions to help our global team thrive.

Knowledge of Health & Safety practices, building systems, environmental sustainability, and physical security is a strong plus. Additional languages are a plus.

Diversity & inclusion

Confidence can sometimes hold people back from applying for a role, but there’s no such thing as a “perfect” candidate. HubSpot is a place where everyone can grow, so however you identify and whatever background you bring, please apply if this role excites you and you’re eager to support our teams across the Americas every day.

About HubSpot

HubSpot (NYSE: HUBS) is a leading customer relationship management (CRM) platform that provides software and support to help businesses grow better. We build marketing, sales, service, and website management products that start free and scale to meet our customers’ needs at any stage of growth. We’re also building a company culture that empowers people to do their best work and supports a diverse, inclusive workplace.

Thanks to the work of every employee globally, HubSpot has been recognized for our culture and as a great place to work by Glassdoor, Great Place to Work, Comparably, Fortune, Entrepreneur, and more. Today, thousands of employees work across the globe in HubSpot offices and remotely.

By submitting an application, candidates agree that HubSpot may collect their personal data for recruiting, global organization planning, and related purposes, as outlined in HubSpot’s Privacy Notice.

Our Mission: Helping Millions of Organizations Grow Better

Team Overview

Our Enterprise Sales team drives growth by connecting large organizations (500–5,000 employees) with HubSpot’s solutions. We balance transactional and complex deals, collaborating with internal teams to achieve shared goals.

In this role, you’ll get to: 

• Position the value of HubSpot’s software, focusing on companies primarily between 500-5000 employees
• Educate and guide prospects through the buyer’s journey to help them learn how HubSpot can grow their business
• Manage a pipeline of self-sourced leads to identify, engage, and develop relationships with potential buyers
• Dissect and qualify prospects’ business goals to determine if HubSpot can be a strategic investment for their business’ growth
• Close business with new and existing customers at or above quota level
• Partner with marketing and technology departments to execute sales strategy as the company introduces enhancements to existing solutions and/or releases new products
• Bring your thinking, strategies, and ideas to advance our company’s values, unique culture, and vision for the future

We are looking for people who have:

• A minimum of 5 years managing full sales cycles (prospecting to close)
• A minimum of 3 years of SaaS sales experience
• Proven and consistent track record as a top producer in sales roles
• Experience delivering product demos to diverse audiences
• Experience in value-based selling (e.g., Challenger Sale)
• Commitment to achieving ambitious sales targets
• A positive outlook and hold themselves accountable to results
• A strong growth mindset and desire for continuous learning
• Resilience and adaptability

#LI-PZ1

Please note: This role is hired on an ongoing basis, and we are currently targeting start dates in Q2 2026 and beyond. If you choose to apply, your information will be reviewed by our team and we will reach out to you if your background aligns with available or future openings. 

As a Growth Specialist (Account Executive) on the Mid-Market sales team, you will identify, source and close good-fit prospects. Using strong consultative selling skills, you will balance contacting warm inbound leads and driving self-sourced leads for your pipeline, while also partnering closely with internal stakeholders to achieve team goals and work towards HubSpot’s mission.

In this role, you’ll get to:

• Position the value of HubSpot’s software and the Inbound methodology to medium-sized businesses 
• Educate and guide prospects through the buyer’s journey to help them learn how HubSpot can grow their business
• Identify and Prospect into good fit accounts that may or may not have HubSpot knowledge or experience
• Manage a pipeline of inbound and self-sourced leads to identify, engage, and develop relationships with potential buyers
• Dissect and qualify prospects’ business goals to determine if HubSpot can be a strategic investment for their business’ growth
• Close business with new and existing customers at or above quota level
• Partner with marketing and technology departments to execute sales strategy as the company introduces enhancements to existing solutions and/or releases new products
• Bring your thinking, strategies, and ideas to advance our company’s values, unique culture, and vision for the future
• Work with and develop business development representatives who partner with you to also develop pipeline opportunities

We are looking for people who:

• Have extensive relevant full-cycle sales experience
• Have the desire and commitment to do what it takes to be successful in sales
• Can effectively communicate with internal teams while being remote and working autonomously
• Have a positive outlook, growth mindset and a strong ability to take responsibility for their successes and failures
• Have exceptional consultative selling and closing skills
• Demonstrate top tier organizational skills and a repeatable sales process
• Are Top Producers in their current role
• Have a sharp focus on their goals and a belief that their daily, weekly and monthly activities will help achieve them

Minimum qualifications for the Mid-Market Account Executive:

• 3+ years of relevant full-cycle sales experience
• Prospecting and closing net new business
  • Strong Hunter Mentality
• Cross-selling/up-selling to current customers
• Multi approach out-bounding methods to draw in new business

HubSpot welcomes individuals to join our Sales team as a Business Development Representative (BDR). As part of our commitment to building a hybrid company, BDRs can be flexible with their work location with the choice to either be based in Cambridge, Massachusetts, or remotely in the US. 

🚀 Join HubSpot as an Outbound Business Development Representative (BDR)
📍 Cambridge, MA or Remote (US)

We’ll be honest — sales isn’t easy, and it’s not for everyone. But for those who love a challenge, thrive on results, and want to launch a long-term path in sales, it’s incredibly rewarding.

If you’re looking to “try out” sales or just dip a toe in, this probably isn’t the role for you. But, if you’re the kind of person who wakes up hungry to compete, thrives on setting and smashing goals, and wants to build a career in tech sales from the ground up — we want to talk to you.

At HubSpot, our BDRs are not only the first point of contact for our prospects—they’re also developing the skills and mindset to become our next generation of Account Executives. This is not a placeholder job — it’s the first chapter of a high-growth sales career designed for those who want to build skills, embrace feedback, move fast, and grow even faster.

The Role:
As an Outbound BDR, you’ll play a key role in HubSpot’s growth engine. You'll be the first touchpoint for many of our future customers, sparking conversations through strategic outreach, uncovering pain points, and qualifying leads. You’ll partner closely with Account Executives to deliver high-quality meetings that drive pipeline, impact, and revenue. Along the way, you’ll sharpen your sales toolkit daily and gain exposure to a world-class sales organization.

What You’ll Do:

• Own and execute outbound prospecting through high-volume outreach (60–100+ activities/day) via phone, email, and LinkedIn.
• Collaborate with Account Executives to target strategic accounts and refine outreach strategy.
• Qualify leads based on fit, need, and urgency — and book quality discovery meetings.
• Hit (and exceed) KPIs for activity, meetings delivered, and pipeline impact.
• Grow fast. Learn fast. Get coached. Apply it. Repeat.
  
  

What You Won’t Do:

• Coast. We move fast, we test, we iterate, and we compete.
• Wait for someone to tell you what to do. We value self-starters who take ownership.
• Treat this as “just a job.” This is a foundational role, setting you up for a successful long term career in sales.
  
  

We’re Looking For People Who:
✅ Are eager to grow long-term within a sales path–if your focus is split between sales and other paths like customer success, marketing, operations, etc, this role likely won’t be the best fit.
✅ Are resilient, coachable, and crave feedback to improve.
✅ Are curious and ask why, not just how.
✅ Set high standards for themselves — and hit them.
✅ Are technologically fluent, adapting to new technologies and leveraging AI in your day-to-day.
✅ Communicate clearly, write thoughtfully, and can confidently conduct a cold call.
✅ Are energized by a fast-paced environment and a bit of friendly competition.
✅ Either have past sales success or have demonstrated excellence in goal-driven roles (think: fundraising, athletics, service industry, etc).

Tools We Use (and You’ll Learn):

• HubSpot (of course)!
• LinkedIn Sales Navigator
• AI Powered Tools across all aspects of the role for research & outreach
• Slack, Zoom, LeadIQ, Google Suite, Zoominfo, and more
  
  

To Apply:
📝 No cover letter required.
📄 Submit your resume.
👉 If you're new to sales, show us your grit: include examples of how you've hit ambitious goals in other roles.
📊 If you’ve been in sales before, highlight metrics like quota attainment.

Important information about the position.

Bottom Line:
We’re looking for future stars, not just seat-fillers. If you want to grow into an elite sales professional and are ready to work hard, get uncomfortable, and see what you're really capable of — this is your shot.

HubSpot welcomes individuals to join our Sales team as a Business Development Representative (BDR). As part of our commitment to building a hybrid company, BDRs can be flexible with their work location with the choice to either be based in Cambridge, Massachusetts, or remotely in the US. 

🚀 Join HubSpot as an Outbound Business Development Representative (BDR)
📍 Remote (US) or Cambridge, MA

We’ll be honest — sales isn’t easy, and it’s not for everyone. But for those who love a challenge, thrive on results, and want to launch a long-term path in sales, it’s incredibly rewarding.

If you’re looking to “try out” sales or just dip a toe in, this probably isn’t the role for you. But, if you’re the kind of person who wakes up hungry to compete, thrives on setting and smashing goals, and wants to build a career in tech sales from the ground up — we want to talk to you.

At HubSpot, our BDRs are not only the first point of contact for our prospects—they’re also developing the skills and mindset to become our next generation of Account Executives. This is not a placeholder job — it’s the first chapter of a high-growth sales career designed for those who want to build skills, embrace feedback, move fast, and grow even faster.

The Role:
As an Outbound BDR, you’ll play a key role in HubSpot’s growth engine. You'll be the first touchpoint for many of our future customers, sparking conversations through strategic outreach, uncovering pain points, and qualifying leads. You’ll partner closely with Account Executives to deliver high-quality meetings that drive pipeline, impact, and revenue. Along the way, you’ll sharpen your sales toolkit daily and gain exposure to a world-class sales organization.

What You’ll Do:

• Own and execute outbound prospecting through high-volume outreach (60–100+ activities/day) via phone, email, and LinkedIn.
• Collaborate with Account Executives to target strategic accounts and refine outreach strategy.
• Qualify leads based on fit, need, and urgency — and book quality discovery meetings.
• Hit (and exceed) KPIs for activity, meetings delivered, and pipeline impact.
• Grow fast. Learn fast. Get coached. Apply it. Repeat.
  
  

What You Won’t Do:

• Coast. We move fast, we test, we iterate, and we compete.
• Wait for someone to tell you what to do. We value self-starters who take ownership.
• Treat this as “just a job.” This is a foundational role, setting you up for a successful long term career in sales.
  
  

We’re Looking For People Who:
✅ Are eager to grow long-term within a sales path–if your focus is split between sales and other paths like customer success, marketing, operations, etc, this role likely won’t be the best fit.
✅ Are resilient, coachable, and crave feedback to improve.
✅ Are curious and ask why, not just how.
✅ Set high standards for themselves — and hit them.
✅ Are technologically fluent, adapting to new technologies and leveraging AI in your day-to-day.
✅ Communicate clearly, write thoughtfully, and can confidently conduct a cold call.
✅ Are energized by a fast-paced environment and a bit of friendly competition.
✅ Either have past sales success or have demonstrated excellence in goal-driven roles (think: fundraising, athletics, service industry, etc).

Tools We Use (and You’ll Learn):

• HubSpot (of course)!
• LinkedIn Sales Navigator
• AI Powered Tools across all aspects of the role for research & outreach
• Slack, Zoom, LeadIQ, Google Suite, Zoominfo, and more
  
  

To Apply:
📝 No cover letter required.
📄 Submit your resume.
👉 If you're new to sales, show us your grit: include examples of how you've hit ambitious goals in other roles.
📊 If you’ve been in sales before, highlight metrics like quota attainment.

Important information about the position.

Bottom Line:
We’re looking for future stars, not just seat-fillers. If you want to grow into an elite sales professional and are ready to work hard, get uncomfortable, and see what you're really capable of — this is your shot.

POS-9034

About the Team

Commerce Hub is building the backbone for businesses to sell, bill, get paid, and manage revenue inside HubSpot. Our systems handle billions of dollars in transactions for our customers, so correctness, clarity, and predictability matter. We’re creating an AI-first commerce platform that’s deeply integrated with HubSpot’s CRM - simple, consistent, and extensible across every part of the seller and buyer experience.

About the Role

We’re looking for a Principal Software Engineer to help shape the technical future of Commerce Hub. This is a very hands-on role. You’ll write code, dive into services, review tough designs, debug messy systems, and directly own the architecture behind some of the most critical surfaces in CPQ, Billing, Payments, and Revenue OS.

What You’ll Do

Build a simple, consistent, extensible platform

• Shape the technical roadmap across CPQ, Billing, and Payments with strong, opinionated patterns.
• Define and evolve core domain models so pricing, products, contracts, invoices, and payments behave predictably everywhere.
• Create frameworks that make the platform easy to extend without adding complexity.

Be a deeply hands-on, high-leverage builder

• Write code regularly. Lead design reviews and build high-impact systems end-to-end.
• Own large multi-team initiatives that span CPQ, Billing and Payments.
• Take prototypes to production at scale.

Lead architectural direction

• Set patterns for extensibility, contract boundaries, financial correctness, event-driven consistency, and how AI/agents safely interact with commerce objects.
• Push for simplicity where the domain wants to get complicated, and consistency where surfaces can drift.

Partner deeply with product leadership

• Influence product strategy across CPQ, Buyer Portal, and Revenue OS.
• Help teams make clear tradeoffs between speed, correctness, compliance, and long-term platform health.

Raise the bar across the org

• Mentor senior engineers and tech leads.
• Drive thoughtful design decisions and guide learnings from incidents and large migrations.
• Help teams align on patterns that reduce complexity and increase reliability.

What You Bring

• Proven experience building and scaling distributed systems with strict correctness requirements.
• Background working with complex state machines, financial flows, or high-integrity data models.
• Strong architectural instincts with a bias toward simplicity, consistency, and well-defined boundaries.
• The ability to work horizontally across many teams and get alignment on platform patterns.
• A habit of turning ambiguity into clear plans and working software—and staying hands-on every step of the way.

POS-9034

About the Team

Commerce Hub is building the backbone for businesses to sell, bill, get paid, and manage revenue inside HubSpot. Our systems handle billions of dollars in transactions for our customers, so correctness, clarity, and predictability matter. We’re creating an AI-first commerce platform that’s deeply integrated with HubSpot’s CRM - simple, consistent, and extensible across every part of the seller and buyer experience.

About the Role

We’re looking for a Principal Software Engineer to help shape the technical future of Commerce Hub. This is a very hands-on role. You’ll write code, dive into services, review tough designs, debug messy systems, and directly own the architecture behind some of the most critical surfaces in CPQ, Billing, Payments, and Revenue OS.

What You’ll Do

Build a simple, consistent, extensible platform

• Shape the technical roadmap across CPQ, Billing, and Payments with strong, opinionated patterns.
• Define and evolve core domain models so pricing, products, contracts, invoices, and payments behave predictably everywhere.
• Create frameworks that make the platform easy to extend without adding complexity.

Be a deeply hands-on, high-leverage builder

• Write code regularly. Lead design reviews and build high-impact systems end-to-end.
• Own large multi-team initiatives that span CPQ, Billing and Payments.
• Take prototypes to production at scale.

Lead architectural direction

• Set patterns for extensibility, contract boundaries, financial correctness, event-driven consistency, and how AI/agents safely interact with commerce objects.
• Push for simplicity where the domain wants to get complicated, and consistency where surfaces can drift.

Partner deeply with product leadership

• Influence product strategy across CPQ, Buyer Portal, and Revenue OS.
• Help teams make clear tradeoffs between speed, correctness, compliance, and long-term platform health.

Raise the bar across the org

• Mentor senior engineers and tech leads.
• Drive thoughtful design decisions and guide learnings from incidents and large migrations.
• Help teams align on patterns that reduce complexity and increase reliability.

What You Bring

• Proven experience building and scaling distributed systems with strict correctness requirements.
• Background working with complex state machines, financial flows, or high-integrity data models.
• Strong architectural instincts with a bias toward simplicity, consistency, and well-defined boundaries.
• The ability to work horizontally across many teams and get alignment on platform patterns.
• A habit of turning ambiguity into clear plans and working software—and staying hands-on every step of the way.

POS-32567

Application deadline: 5pm ET Friday 5/8

About the role

The Salesforce Competitive Expert is a senior, customer-facing specialist who owns HubSpot’s competitive strategy against Salesforce in our most complex, upmarket CRM evaluations and rip-and-replace motions. You’ll operate as a highly autonomous, intrapreneurial leader within PreSales, managing your own book of strategic deals while building the playbooks, assets, and enablement that help HubSpot systematically win more Salesforce competes and drive NNARR.

What you’ll do

• Act as the lead Salesforce competitive expert on qualified strategic deals—joining discovery, technical validation, and executive meetings to de-risk decisions and secure tech wins against Salesforce.
• Own and continuously evolve the Salesforce Competitive Playbook, codifying winning narratives, talk tracks, demo strategies, and “assertive selling” motions for Salesforce rip-and-replace and net-new CRM evaluations.
• Partner with Account Executives, core SEs, and implementation partners to design solution blueprints, migration paths, and TCO/ROI cases that build unshakable confidence in choosing HubSpot over Salesforce.
• Deliver scalable enablement for Sales, PreSales, and partners (training, battlecards, assets) that elevates our collective ability to compete and increases win rates on Salesforce deals.
• Serve as the central feedback loop from the field to Competitive Intelligence, Product, and Marketing, surfacing patterns from wins/losses and informing roadmap and GTM strategy.
• Proactively analyze pipelines to prioritize high-impact opportunities, manage your own bandwidth, and protect capacity in line with Expert Program guardrails.

What you’ll bring

• Deep Salesforce expertise (must-have): Extensive, hands-on Salesforce experience (e.g., Admin / Sales Cloud configuration, implementation, or architecture) with certified-level depth and the ability to “speak admin to admin.”
• HubSpot & operator credibility: Strong HubSpot CRM fluency plus real-world operator experience using HubSpot to drive business outcomes, enabling you to translate between both ecosystems with empathy and authority.
• Autonomy & business ownership: Proven track record of working independently, managing your own portfolio of complex deals, and building new processes/playbooks from scratch in ambiguous, high-stakes environments.
• Competitive, strategic mindset: You think several moves ahead, love deconstructing competitor strategies, and can reframe “Salesforce as the safe choice” into a compelling case for HubSpot through narrative, TCO, and technical validation.
• Executive presence & communication: Comfort engaging technical stakeholders and C‑level executives, simplifying complex concepts, and driving clear, confident decisions in the room.
• Innovative, system-builder orientation: You’re passionate about helping HubSpot win upmarket and naturally turn one-off deal work into reusable assets, frameworks, and enablement that scale across regions and specialties.

The Role:

Reporting to the Senior Director of Pharmacovigilance (PV) Operations, the Associate Director, PV Operations will provide vendor oversight and review of ICSR processing for assigned investigational products. They will ensure compliance and adherence to Safety processes and SOPs as well as manage and analyze data from the Global Safety Database. This SME will be responsible for PV operations’ role in Phase 1, 2, & 3 clinical studies, inclusive of inspection readiness, reconciliation, SMP maintenance, and site and regulatory authority reporting oversight. They will work in close collaboration with PV physicians and PV scientists on operational safety and case quality issues.

Responsibilities:

• Manage and support the relationship with safety vendor(s) to ensure effectiveness, quality and compliance of all outsourced activities.
• Provide Sponsor oversight of operational safety responsibilities, including the timely and accurate execution of the processes defined within the applicable Safety Management plans.
• Participate in daily management, operational oversight and execution of operational safety tasks for assigned Nuvalent clinical programs.
• Review incoming adverse event reports and communications from vendors to determine action required and ensure prompt review, follow-up, and timely submission of expedited safety reports.
• Oversee case workflow (case receipt through submission) between safety vendor and Nuvalent Pharmacovigilance team.
• Ensure safety case queries are resolved as per defined processes (interfacing with safety physicians, clinical operations team, other cross-functional teams within Nuvalent, and clinical vendors, as required) and facilitate case closure within required timelines.
• Serve as PV operations SME on safety reporting processes according to study protocol.
• Participate in the development and maintenance of SOPs, forms, plans, systems, and guidance documents to ensure compliance with all applicable regulatory requirements or guidelines, GVP and industry best practices.
• Serve as resource and contact for other functions within the company for pharmacovigilance
• operational activities.
• Serve as Pharmacovigilance representative for the operational aspects of the SAE reconciliation
•  
• Responsible for the development of safety management plans for assigned programs, and associated documents to ensure that study-specific and Regulatory Authority reporting requirements are met and that workflow responsibilities between CROs, and Nuvalent are clearly delineated and adhered to

Competencies Include:

• Excellent written and verbal communication skills.
• Demonstrated communications expertise with the ability to articulate, influence, and work successfully with internal/external stakeholders and within a matrixed environment.
• Ability to plan and handle multiple responsibilities simultaneously and still meet high quality and timeliness standards under pressure.
• Demonstrated contribution to strategy and innovation. Contributes to or leads actionable strategies.
• Demonstrated project management and prioritization capabilities.

Qualifications:

• Bachelor’s degree in Nursing, RN, Pharmacy, Pharm D., or other relevant health-care related fields.
• 8-10 years of progressive drug safety experience in a biotech/pharma company.
• Clinical Development experience.
• Strong knowledge of current and emerging regulatory requirements including EMA GVP Modules, FDA IND and NDA reporting requirements, ICH, CIOMS
• Ability to interpret and follow regulatory guidelines.
• Proven knowledge of Good Documentation Practices and cGXPs.
• Basic knowledge of MedDRA coding.
• Experience in ICSR case-processing and reporting.
• Experience working in and with safety databases.
• Direct experience managing relationships with service providers or external business partners

Additional Information:

Nuvalent is committed to fair and equitable compensation practices, aiming to provide employees with competitive total rewards packages.

The targeted salary range reflects what Nuvalent reasonably and in good faith expects to offer for this position at the time of posting, but the final salary determination may be within or outside this range based on various factors, including, but not limited to, experience, skills, education, and market factors.  The range will be reviewed regularly and is subject to change.

Nuvalent also offers a comprehensive benefit package to support our employees at each stage of their career, financial, health, and well-being journey, including medical, dental, and vision insurance, 401(k) retirement savings plan, generous paid time off (including a summer and winter company shutdown), and much more.

About Every Cure:   

Every Cure is an AI-driven nonprofit, biotech organization on a mission to save and improve lives by repurposing existing medicines for diseases with significant unmet need. We are working to create a world where every drug is used to treat every disease it possibly can, so that no patient suffers when an existing treatment could help them. We are filling a gap left by the current biomedical system, which doesn’t systematically pursue new uses for old drugs. Through artificial intelligence technologies, collaboration with healthcare professionals, and patient advocacy, Every Cure is dedicated to unlocking the full potential of existing medicines to treat every disease and every patient we possibly can. Inspired by Every Cure’s co-founders' work repurposing drugs for Castleman disease and other rare diseases, Every Cure is advancing repurposed treatments for neglected diseases and has been featured in The New Yorker,  New York Times, USA Today, Good Morning America and other news media. Led by a talented leadership team and an outstanding Board of Directors, Every Cure is supported through funding from leading philanthropic organizations like Chan Zuckerberg Initiative, TED’s Audacious Project, and ARPA-H. 

 Our approach:  

• AI-Powered Identification: We use advanced artificial intelligence to analyze the world’s biomedical knowledge and identify FDA-approved drugs that can be repurposed for untreated conditions. This cutting-edge technology enables us to explore new therapeutic possibilities efficiently.  
• Open-Source Commitment: We are dedicated to making our predictive pipeline open-source, fostering collaboration and transparency within the scientific community and unlocking the potential for discovering new treatments.  
• High-Impact Focus: We prioritize drug repurposing opportunities that will relieve the most suffering and have the greatest impact possible.  
• Rigorous Validation: Promising opportunities are thoroughly validated through laboratory and clinical studies to confirm their efficacy and safety before advancing to broader application.  
• Strategic Marketing and Access: We disseminate information about effective repurposed treatments through multiple channels and are committed to ensuring that new cures are accessible to all patients.

Applicants must reside in the state specified at the top of this job posting. Residency in that state is a requirement for consideration and must be maintained for the duration of employment.

The Head of Clinical Development leads Every Cure’s clinical research and development function, serving as both strategic architect and working clinical lead on priority programs. They manage a diverse portfolio of drug repurposing initiatives including Every Cure-sponsored interventional trials (with full sponsor IND accountability and REMS complexity where applicable), collaborative investigator-sponsored trials, and Every Cure-led patient registries, natural history studies, and other real-world studies. They collaborate directly with computational and data science teams to translate AI-driven repurposing hypotheses into clinically testable programs and represent the organization to external partners and stakeholders. This role owns sponsor compliance under ICH E6(R3) including maintenance of the clinical QMS and SOP infrastructure regardless of CRO engagement  and oversees regulatory strategy and dissemination. The HCD supports Every Cure’s CSO and engages directly with external stakeholders including CROs, clinical trial technology vendors, academic investigators, patient advocacy organizations, the IRB of record, and FDA. The HCD helps build and lead a lean internal clinical development team, modeling the working-leader norm expected in a small, mission-driven organization.

How you will make an impact: 

Strategic Leadership of Clinical Development and Medical Affairs

• Set the direction for Every Cure’s clinical research and development, ensuring alignment with the organization’s mission to repurpose FDA-approved drugs for high-impact unmet needs, while personally leading or co-leading priority programs.
• Lead the execution of organizational goals through operational planning and cross-functional integration, personally owning project timelines, quality standards, and accountability metrics for priority programs rather than delegating all execution.
• Provide expert counsel to the CSO, President and Scientific Advisory Council on medical strategy, program development, and organizational growth.

Research and Clinical Development Oversight

• Design, author, and review key study documents (protocols, statistical analysis plans, informed consent documents, clinical study reports, investigator brochures) for Every Cure-sponsored clinical trials, patient registries, natural history studies, and real-world evidence assessments. Own study design decisions end-to-end, from scientific rationale through data integrity and analysis.
• Serve as sponsor medical lead and/or medical monitor on Every Cure-sponsored IND-holding studies (delegating per-study where appropriate), ensuring all research activities are ethically sound, methodologically rigorous, and regulatory compliant under FDA 21 CFR Part 312, ICH E6(R3), and ICH E9 principles.
• Translate complex medical findings into strategic decisions regarding program continuation, optimization, or sunsetting, based on efficacy, feasibility, and patient impact.
• Responsible for compliance and oversight of the Human Subjects Research program at Every Cure, including IRB (Advarra) submissions and amendments, sponsor safety reporting (IND safety reports, DSURs), SAE adjudication, signal detection, and REMS program participation where applicable (e.g., lenalidomide).

Portfolio Strategy and Program Management

• Partner on strategic prioritization and dynamic management of Every Cure’s diverse portfolio of drug repurposing opportunities, applying a risk-adjusted, impact-oriented lens to maximize outcomes.
• Direct the progression of programs through clinical and dissemination stages, using insights from AI models and external scientific inputs. Personally lead CRO and clinical technology vendor selection, contracting input, and ongoing governance (joint steering committees, KPIs, oversight plans) for highest-priority programs.
• Develop and manage resource allocation frameworks across disease areas and therapeutic modalities, ensuring optimal investment of time, talent, and funding toward the most promising interventions.

Leadership and Team Development

• Build, mentor, and lead a lean, high-performing team of clinical research and medical professionals united around a shared vision of maximizing patient impact through drug repurposing, modeling a working-leader norm in which senior leaders contribute directly alongside their teams.
• Define roles, responsibilities, and performance standards for the clinical team while fostering a culture of excellence, integrity, psychological safety, and cross-functional collaboration.
• Promote continuous learning and growth through coaching, training programs, and development opportunities that build both individual capability and team effectiveness.

Stakeholder Engagement, Compliance, and Dissemination

• Act as medical spokesperson and lead regulatory interface for Every Cure in public, scientific, and regulatory forums (including FDA pre-IND and Type B/C meetings), promoting the organization’s mission and sharing results from preclinical and clinical programs.
• Cultivate and manage partnerships with CROs, patient advocacy groups, academic institutions, and regulatory agencies to ensure successful execution and wide-scale impact of therapeutic programs.
• Guide the regulatory approval and post-study dissemination strategies to ensure timely and effective translation of research into therapies accessible to patients, including peer-reviewed publications, policy briefs, and healthcare provider outreach.
• Partner with the Impact lead to provide input and perspective on dissemination and to engage with key stakeholders to ensure medicines reach patients.

What you bring to the team:

Education 

• MD or MD/PhD preferred; PhD DO, or PharmD acceptable

Work Experience (Two-Tier: Head of / VP)

• Minimum for Head of Clinical Development: 8+ years of clinical development experience post-MD (or equivalent), including service as clinical lead on at least one sponsor-held Phase 2 trial from protocol through database lock.
• Demonstrated leadership experience recruiting, mentoring, and managing cross-functional clinical teams, with explicit willingness and proven ability to work hands-on alongside direct reports in a small-organization setting.
• Expertise in drug development, clinical trial design (including interventional trials in rare or ultra-rare populations), and clinical decision-making.
• Sponsor-side experience running Phase 2 trials (distinct from CRO or academic investigator experience).
• Experience working across more than one therapeutic research area.
• Experience with small-sample trial designs and natural history or registry data.
• Proven leadership in driving strategic initiatives and cross-functional collaboration to advance scientific and organizational goals.

Preferred for Vice President designation:

• 12+ years of clinical development experience, including prior functional leadership at a sponsor (Executive Director, Head of, or VP level); multiple sponsor-held INDs led through Phase 2 or beyond; direct experience with REMS programs, risk-based monitoring, or similarly complex regulatory programs; and prior responsibility for building or scaling a clinical QMS under ICH E6(R3) or predecessor standards.

Skills 

• Proficiency in clinical research, real-world evidence assessments, evidence generation, patient registry design, clinical trial execution, and sponsor-side pharmacovigilance.
• Working knowledge of FDA IND regulations (21 CFR Part 312), ICH E6(R3) Good Clinical Practice, ICH E9 statistical principles, 21 CFR Part 11 for electronic records, and REMS program requirements; familiarity with EU CTR a plus.
• Exceptional communication and presentation abilities.
• Demonstrated ability to foster and sustain a collaborative, cross-functional culture grounded in shared organizational mission and values.
• Able to partner effectively with computational and data science teams and critically evaluate AI/ML-driven repurposing hypotheses for clinical translatability.
• Strategic thinker with a focus on urgency, efficiency, and impact.
• Passionate about Every Cure’s mission and values.
• Highly adaptable, thriving in a fast-paced, start-up environment.
• Explicit willingness to be hands-on: comfort authoring and reviewing key clinical documents (protocols, SOPs, CSRs), directly managing vendor/CRO relationships, and working alongside junior staff rather than exclusively through delegation. Candidates seeking a purely oversight or figurehead role are not a fit for this position.

Compensations & Benefits: 

• Your paycheck: Competitive salary based on experience, ranging from $250,000 - $275,000 annually. 
• Health and wellness: Comprehensive plans with medical, dental, and vision coverage, plus a Flexible Spending Account (FSA) for eligible healthcare expenses. 
• Future nest egg: A 403(b)-retirement plan with an employer match of 3.5% helps you save for your future. 
• Relax and recharge: Generous time off, including paid time off and paid holidays. 
• We have you covered: Comprehensive paid leave for family and medical needs, ensuring you have the support you need during important times. 

This role is based in Cambridge, MA, with an expectation of minimum 3 days per week in office.  

Every Cure is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We provide equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, genetics, or any other characteristic protected by federal, state, or local laws.

The Senior Employer Branding Manager is responsible for developing and executing strategies that highlight our culture, values, and employee experience to attract top talent and engage current employees. This role combines storytelling, content creation, video and photography production, and data-driven program design to position CMT as an employer of choice. You’ll own the employee-facing content that shapes how it feels to work here — from the company newsletter to the videos and photos that show the real humans behind the mission — and you’ll support the in-person events that bring our culture to life. This role reports to the Head of Branding and Internal Communications.

Responsibilities:

• Develop and lead the execution of a comprehensive employer branding strategy aligned with CMT’s culture and talent goals
• Own the company newsletter end-to-end — editorial calendar, writing, editing, and measurement — making it something employees actually open and read
• Craft compelling content across written, social, video, and photo formats (social posts, career site updates, blogs, internal comms, employee spotlights, team stories, recruiting videos, event recaps) that highlights our mission, values, and employee experience, ensuring consistency across all touchpoints
• Build and run crowdsourced content programs that get people across the company creating — employee creator programs, content challenges, employee advocacy — equipping teammates with templates, prompts, and light coaching so the stories come from the people living them
• Partner with People Operations, Marketing, and Leadership to design campaigns that engage potential candidates and inspire current employees
• Analyze eNPS, engagement survey data, and other employee sentiment metrics to identify what’s working and where to invest — then design programs that move the numbers
• Monitor and manage CMT’s employer reputation across online sources where candidates and employees rate us — Glassdoor, LinkedIn, Google, Indeed, Comparably, Built In, and emerging platforms — tracking sentiment, responding to reviews, surfacing themes for leadership, and building proactive engagement strategies
• Manage external partners when needed — videographers, photographers, freelance writers, designers, and agencies — keeping work on brand, on schedule, and on budget
• Provide general support for in-person employee and recruiting events — offsites, all-hands, career fairs, campus recruiting, ERG events — from planning through on-site execution
• Analyze campaign performance and employer brand metrics to refine strategies and ensure alignment with organizational objectives
• Lead projects to amplify our presence in the job market, including developing employee advocacy programs, applying for workplace awards, and partnering with industry organizations
• Work across teams to identify opportunities for alignment between employer branding efforts and broader brand and content goals
• Stay updated on employer branding trends, tools, and technologies to keep strategies fresh and competitive
• Complete any additional tasks as they arise

Qualifications:

• Bachelor’s degree or equivalent years of experience and/or certification in Marketing, Communications, or a related field
• 5+ years of experience in employer branding, internal communications, talent marketing, content creation, or a related discipline
• Proven ability to develop and execute strategic branding initiatives that deliver measurable results
• Exceptional storytelling skills, with experience crafting engaging content across written, social, video, and photo formats
• Fluency with video editing — you can take raw footage and turn it into something worth watching, using tools like Adobe Premiere, Final Cut, CapCut, or similar
• Comfortable behind a camera — shooting and editing photography for newsletters, social, the career site, and on-site event coverage
• Experience building programs that get other people creating — employee advocacy, creator programs, crowdsourced content — and the coaching instincts to make non-marketers comfortable contributing
• Analytical mindset — comfortable working with eNPS, engagement survey data, and campaign performance metrics, and translating what you find into programs that actually move the numbers
• Experience managing external creative partners (videographers, photographers, freelancers, agencies) on brand, on schedule, and on budget
• Strong project management skills, with the ability to manage multiple priorities and stakeholders effectively
• Comfortable providing hands-on support for in-person events — logistics, setup, run-of-show, on-site execution
• Excellent interpersonal skills, with a demonstrated ability to work collaboratively across teams and departments
• Proficiency in social media platforms, content management systems, and employer branding tools (LinkedIn Talent Brand / Careers Pages / Life Tab, Canva, or similar)
• A solution-oriented mindset with a proactive approach to problem-solving
• Writing and content samples / portfolio required with application — please include examples of written content, video, and any employee-facing programs you’ve built

Nice to Haves:

• Experience with motion graphics, animation, or more advanced video production
• Experience with workplace awards submissions (Built In, Glassdoor, Great Place to Work, etc.)
• Familiarity with HR systems and engagement platforms (Greenhouse, Culture Amp, Lattice, or similar)

Compensation and Benefits:

• Fair and competitive salary based on skills and experience, and annual performance bonus
• Equity may be awarded in the form of Restricted Stock Units (RSUs)
• Medical, Dental, Vision and Life Insurance, matching 401k, short-term & long-term disability and parental leave
• Unlimited Paid Time Off including vacation, sick days & public holidays
• Flexible scheduling and work from home policy depending on role and responsibilities

Additional Perks:

• Work on a mission with real impact: crashes prevented, injuries avoided, lives protected around the world
• Join an industry leader — 65 million drivers protected, powering 140+ programs across 25 countries
• Be part of the team inventing the future of mobility and road safety
• Move fast, own outcomes, do work that matters
• High ownership, small teams, and direct access to leadership — no layers between your work and its impact
• Unlimited PTO, flexible scheduling, competitive salary, annual performance bonus, RSUs, and full benefits including medical, dental, vision, and 401k match
• Summer Fridays
• Comprehensive wellness, education, and employee assistance programs

About Cambridge Mobile Telematics:

Cambridge Mobile Telematics (CMT) is the world’s largest telematics and AI company for safer mobility. Its mission is to make the world’s roads and drivers safer. The company’s AI-driven platform, DriveWell Fusion®, proactively identifies and reduces driving risk, leading to fewer crashes and injuries. To date, CMT’s technology has helped prevent over 126,000 crashes worldwide. CMT enables partners to measure risk, detect crashes, provide life-saving assistance, and streamline claims. Headquartered in Cambridge, MA, CMT operates globally with offices in Budapest, Hungary; Chennai, India; Seattle, Washington; Tokyo, Japan; and Zagreb, Croatia. Learn more at www.cmt.ai.

About Alltrna 

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.

Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics. 

For more information, visit www.alltrna.com

Sr. Director Program Management & Business Operations

Position Summary:

Alltrna is seeking a talented and highly motivated Sr. Director Program Management and Business Operations, reporting to the President & CFO.  The successful candidate is a proven leader with extensive experience in leading research and early drug development program teams from research through the clinic with a particular initial focus on IND enabling and early/mid-stage clinical development. The candidate will be a member of the Company’s Leadership Team and will serve as Chief of Staff to the team to drive collaboration, cross-functional clarity, alignment and execution on key priorities and initiatives required to meet the goals of the organization.

Key Responsibilities:

Program Management:

• Work closely with the Chief Medical Officer to lead the program team for the Company’s lead program, AP003, and future programs instilling a culture of scientific rigor, open debate, collaborative teamwork, sense of urgency and accountability
• Possess a comprehensive understanding of the drug discovery process to guide program teams to define the key scientific questions, program strategy and objectives, translating these into optimal deliverables, cross-functional plans, timelines and budgets
• Identify bottlenecks, risks, issues and proactively develop appropriate mitigation proposals with input from team members
• Ensure all key decisions are identified and properly assessed as to their impact and alternative scenarios developed and evaluated, where appropriate
• Work closely with finance and functional teams to develop the operational plans to support program activities with realistic timelines, budget, and resource planning and monitor performance against plans
• Interface with and drive collaboration between the various functional teams and with the Leadership Team on program-related matters.
• Be the key accountable person for communicating matters related to the programs to management including strategy, work product, updates and issues; producing the one “source of truth” for program-related topics and timelines
• Point person for alliance management and coordination, as needed
• Lead and/or manage strategic or platform development projects as required and collaborate with Chief Scientific Officer and Research Leadership Team to coordinate relevant content for quarterly business review meetings

Operations:

• Collaborate with Leadership Team in development of strategic plans, company goals, long-range planning assumptions, portfolio-level reports and analyses to support business processes and strategic discussions
• Develop and deliver impactful presentations that effectively distill complex issues to the critical points and lead to increased understanding and optimized strategic planning & decision-making

• Prepare strategic communications utilizing a clear understanding of the business strategy and issues; develop and maintain consistent, relevant content for use in executive-level communications and to further organizational and business goals

• Lead the Scientific Communications process, working with the Scientific Communications Committee

• Manage schedule, agenda, and content for Leadership Team, Board of Directors and Town Hall meetings

• Proactively seek opportunities for organizational improvements (e.g. team structure, processes, communication, etc.)

Other:

• Support CEO / LT with partnership discussions and negotiations, including background research, preparation of presentation materials, supporting diligence activities, participating in analysis of terms, etc.
• Assist in mapping competitive landscape and proactively identify potential and emerging competitive threats and opportunities
• Promote strategic discussions on external trends, competitor strategies, and potential disruptors, and translate these into strategic choices/ recommendations
• Collect insights and intelligence from a variety of sources including literature searches, reviewing analyst research, KOL and patient group interactions, etc.

Key Competencies:

• This is a highly visible leadership role that requires exceptional interpersonal and communication skills, creative thinking, and early drug development experience that allows one to recognize opportunities/challenges and modify strategy accordingly
• The individual will need to have self-confidence and poise to manage complicated programs and projects with multiple stakeholders

• The individual will need a sense of urgency and can-do attitude to develop therapies for patients with significant unmet medical needs

Minimum Qualifications:

• BS/MS Degree in a scientific discipline, ideally life science or chemistry.
• At least 15 years relevant experience in pharma or biotech drug discovery and development, as well as a comprehensive understanding of drug discovery (preclinical and clinical).
• 10+ years of Program Management experience, preferably in early-stage drug discovery and development.
• Experience in the development of advanced therapies to treat rare genetic disease is a plus
• Demonstrated experience leading cross-functional teams; strong interpersonal and communication skills
• Scientific curiosity and passion for discovering new, innovative medicines.
• Openness to embrace new technologies and digital approaches in drug discovery
• Proven track record in driving successful, collaborative drug discovery teams.

The salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

About Alltrna 

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.

Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics. 

For more information, visit www.alltrna.com

Sr. Director Program Management & Business Operations

Position Summary:

Alltrna is seeking a talented and highly motivated Sr. Director Program Management and Business Operations, reporting to the President & CFO.  The successful candidate is a proven leader with extensive experience in leading research and early drug development program teams from research through the clinic with a particular initial focus on IND enabling and early/mid-stage clinical development. The candidate will be a member of the Company’s Leadership Team and will serve as Chief of Staff to the team to drive collaboration, cross-functional clarity, alignment and execution on key priorities and initiatives required to meet the goals of the organization.

Key Responsibilities:

Program Management:

• Work closely with the Chief Medical Officer to lead the program team for the Company’s lead program, AP003, and future programs instilling a culture of scientific rigor, open debate, collaborative teamwork, sense of urgency and accountability
• Possess a comprehensive understanding of the drug discovery process to guide program teams to define the key scientific questions, program strategy and objectives, translating these into optimal deliverables, cross-functional plans, timelines and budgets
• Identify bottlenecks, risks, issues and proactively develop appropriate mitigation proposals with input from team members
• Ensure all key decisions are identified and properly assessed as to their impact and alternative scenarios developed and evaluated, where appropriate
• Work closely with finance and functional teams to develop the operational plans to support program activities with realistic timelines, budget, and resource planning and monitor performance against plans
• Interface with and drive collaboration between the various functional teams and with the Leadership Team on program-related matters.
• Be the key accountable person for communicating matters related to the programs to management including strategy, work product, updates and issues; producing the one “source of truth” for program-related topics and timelines
• Point person for alliance management and coordination, as needed
• Lead and/or manage strategic or platform development projects as required and collaborate with Chief Scientific Officer and Research Leadership Team to coordinate relevant content for quarterly business review meetings

Operations:

• Collaborate with Leadership Team in development of strategic plans, company goals, long-range planning assumptions, portfolio-level reports and analyses to support business processes and strategic discussions
• Develop and deliver impactful presentations that effectively distill complex issues to the critical points and lead to increased understanding and optimized strategic planning & decision-making

• Prepare strategic communications utilizing a clear understanding of the business strategy and issues; develop and maintain consistent, relevant content for use in executive-level communications and to further organizational and business goals

• Lead the Scientific Communications process, working with the Scientific Communications Committee

• Manage schedule, agenda, and content for Leadership Team, Board of Directors and Town Hall meetings

• Proactively seek opportunities for organizational improvements (e.g. team structure, processes, communication, etc.)

Other:

• Support CEO / LT with partnership discussions and negotiations, including background research, preparation of presentation materials, supporting diligence activities, participating in analysis of terms, etc.
• Assist in mapping competitive landscape and proactively identify potential and emerging competitive threats and opportunities
• Promote strategic discussions on external trends, competitor strategies, and potential disruptors, and translate these into strategic choices/ recommendations
• Collect insights and intelligence from a variety of sources including literature searches, reviewing analyst research, KOL and patient group interactions, etc.

Key Competencies:

• This is a highly visible leadership role that requires exceptional interpersonal and communication skills, creative thinking, and early drug development experience that allows one to recognize opportunities/challenges and modify strategy accordingly
• The individual will need to have self-confidence and poise to manage complicated programs and projects with multiple stakeholders

• The individual will need a sense of urgency and can-do attitude to develop therapies for patients with significant unmet medical needs

Minimum Qualifications:

• BS/MS Degree in a scientific discipline, ideally life science or chemistry.
• At least 15 years relevant experience in pharma or biotech drug discovery and development, as well as a comprehensive understanding of drug discovery (preclinical and clinical).
• 10+ years of Program Management experience, preferably in early-stage drug discovery and development.
• Experience in the development of advanced therapies to treat rare genetic disease is a plus
• Demonstrated experience leading cross-functional teams; strong interpersonal and communication skills
• Scientific curiosity and passion for discovering new, innovative medicines.
• Openness to embrace new technologies and digital approaches in drug discovery
• Proven track record in driving successful, collaborative drug discovery teams.

The salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

We are seeking an experienced Business Development Specialist to identify, pursue, and capture new business opportunities within the DoD and the Intelligence Community. The successful candidate will have a strong background in business development and a proven track record of winning new S&T programs. This role requires exceptional communication skills, strategic thinking, and the ability to build relationships with customers. You will partner with Portfolio Leads, Chief Engineers, Business Development, Contracts, Proposal, and Capture teams to bring operationally impactful and technically captivating programs to MORSE.

Responsibilities:

• Execute MORSE's business development strategy aimed at expanding our presence within the DoD and the intelligence community.

• Identify potential business opportunities and work collaboratively to develop compelling proposals that highlight our unique value proposition.

• Build and maintain relationships with key decision-makers within the DoD and the intelligence community, including program managers, acquisition officials, and other stakeholders.

• Collaborate with cross-functional teams, including engineering, sales, and marketing, to ensure effective capture, proposals, and delivery of new programs.

• Gather and analyze market intelligence on industry trends, competitor activity, and customer needs to support business development efforts and identify new business opportunities.

• Stay abreast of emerging trends and technologies relevant to our product lines and identify opportunities for growth and expansion.

Requirements:

• Bachelor's degree in a related field (e.g., business administration, engineering, computer science).

• 2-5 years of experience in business development, preferably within the DoD or the intelligence community.

• Experience selling in technical domains such as artificial intelligence, software, or related areas is highly desired.

• Knowledge of DARPA, the US Army, Air Force, Navy and other organizations in the Intelligence Community or Dept. of Defense is highly desired.

• Proven track record of success in winning new programs and growing revenue through business development initiatives.

• Strong understanding of the DoD and intelligence community acquisition processes, including the Federal Acquisition Regulation (FAR) and Defense Federal Acquisition Regulation Supplement (DFARS).

• Excellent communication skills, both written and verbal, with the ability to articulate complex ideas simply and persuasively.

• Familiarity with greenfield business development and the ability to operate effectively in fast-paced environments.

We are seeking an experienced Business Development Specialist to identify, pursue, and capture new business opportunities within the DoD and the Intelligence Community. The successful candidate will have a strong background in business development and a proven track record of winning new S&T programs. This role requires exceptional communication skills, strategic thinking, and the ability to build relationships with customers. You will partner with Portfolio Leads, Chief Engineers, Business Development, Contracts, Proposal, and Capture teams to bring operationally impactful and technically captivating programs to MORSE.

Responsibilities:

• Execute MORSE's business development strategy aimed at expanding our presence within the DoD and the intelligence community.

• Identify potential business opportunities and work collaboratively to develop compelling proposals that highlight our unique value proposition.

• Build and maintain relationships with key decision-makers within the DoD and the intelligence community, including program managers, acquisition officials, and other stakeholders.

• Collaborate with cross-functional teams, including engineering, sales, and marketing, to ensure effective capture, proposals, and delivery of new programs.

• Gather and analyze market intelligence on industry trends, competitor activity, and customer needs to support business development efforts and identify new business opportunities.

• Stay abreast of emerging trends and technologies relevant to our product lines and identify opportunities for growth and expansion.

Requirements:

• Bachelor's degree in a related field (e.g., business administration, engineering, computer science).

• 2-5 years of experience in business development, preferably within the DoD or the intelligence community.

• Experience selling in technical domains such as artificial intelligence, software, or related areas is highly desired.

• Knowledge of DARPA, the US Army, Air Force, Navy and other organizations in the Intelligence Community or Dept. of Defense is highly desired.

• Proven track record of success in winning new programs and growing revenue through business development initiatives.

• Strong understanding of the DoD and intelligence community acquisition processes, including the Federal Acquisition Regulation (FAR) and Defense Federal Acquisition Regulation Supplement (DFARS).

• Excellent communication skills, both written and verbal, with the ability to articulate complex ideas simply and persuasively.

• Familiarity with greenfield business development and the ability to operate effectively in fast-paced environments.

As a Chief Engineer (CE) at MORSE, you play a technical, strategic, programmatic, and management role driving our programs, people, and path forward. You will spearhead technical vision, work with customers to plot out the future efforts, and guide a team to execute. As a Chief Engineer - Battle Management, you will lead the design and development of mission-critical web and mobile applications that fuse complex data, enhance situational awareness, and accelerate the entire decision-making cycle—from planning to execution. 

 Responsibilities: 

• Define and champion the technical vision for our Battle Management systems, creating a roadmap that integrates advanced software architecture, data fusion, and intelligent user interfaces.

• Lead Agile, multi-disciplinary teams of 5-50+ Aerospace Engineers, Software Engineers, Mobile Developers, Human-Computer Interaction Engineers, and Cloud Engineers.

• Lead technical strategy for the development of intuitive software applications that make complex data readily available and actionable for warfighters in high-stakes environments with care for effective user experiences (UX) 

• Manage program execution, ensuring schedule and budget adherence, and overseeing successful program delivery.

• Act as a primary technical liaison with government customers and industry partners, translating their strategic needs into actionable, cutting-edge R&D programs.

• Proactively identify and shape new opportunities, lead technical proposal efforts, and own the capture process to expand MORSE's impact and portfolio in Battle Management, Command and Control (C2), and Mission Planning.

Requirements:

• US Citizenship and ability to obtain and maintain a Security Clearance. Active Secret, Top Secret, or TS/SCI is preferred. 

• A master's degree or PhD in a relevant discipline (e.g., Systems Engineering, Computer Science, Aerospace Engineering, Physics) or equivalent experience.

• 10+ years of experience leading technical teams, with a proven track record of designing and delivering complex, software-intensive systems for the defense or aerospace industry.

• Deep, hands-on experience designing architectures for complex, real-time distributed systems, such as Command and Control (C2), mission planning, or large-scale situational awareness platforms.

  Strong domain knowledge in one or more of the following: sensor fusion, mission planning, electronic warfare, or air/space operations

• Demonstrated understanding of underlying physical principles relevant to the domain (e.g., kinematics, sensor physics, RF propagation) and experience incorporating physical models into software systems.

• Proven leadership in modern software development, including service-oriented architectures, event-driven systems, and building applications for real-time data visualization.

• Proven leadership skills, with a track record of successfully managing high-performing technical teams.

• Proven experience in business development and program capture within the DoD or IC, including leading technical volumes for proposals and shaping customer requirements.

• Strong analytical and problem-solving abilities, with the capacity to absorb complex technical information quickly.

• Excellent written and verbal communication skills, with the ability to present technical information clearly and persuasively to both technical and non-technical audiences.

MORSE is searching for a Lead Data Scientist with expertise in data analysis, data science, and algorithm development in one or more of a variety of fields including visual classification, big data, natural language processing, machine translation, time sequenced data, and advanced metrics. You will lead teams and strategy for Algorithm Test and Evaluation (T&E) of AI and machine learning models and algorithms to give national security customers insights into the capabilities of applying AI to solve real world problems.

Responsibilities:

• Define goals and expectations for algorithm T&E performance

• Research artificial intelligence data splitting, metrics, and T&E methodology

• Lead strategy and coordination with algorithm development vendors

• Work with customers, stakeholders, and other vendors to present concepts, analyses, and test results

• Present a path forward and solutions to solve complex data problems

• Work with MORSE’s current team of engineers and scientists to transition algorithms to software applications and real-time embedded systems.

Requirements:

• US CITIZENSHIP REQUIRED and an Active Top Secret U.S. Security Clearance with SCI eligibility (TS/SCI) 

• Masters or Ph.D in Data Science, Computer Science, Engineering, Applied Mathematics, Physics, Physical or Biological Sciences or a related field

• 7+ years of experience in Data Science, Artificial Intelligence, or Machine Learning

• Expertise in artificial intelligence, machine learning, and data science 

• Experience in algorithm development and testing

• Excellent communication and presentation skills

• Self-starter and driven

• Ability to be onsite 4-5 days/week 

MORSE Corp is seeking a Technical Recruiter to join our Talent Acquisition team in all aspects of recruiting for our growing and highly talented workforce. You will source candidates, screen, and facilitate the recruiting process for high-caliber engineering reqs in a broad set of technical domains. These domains include software engineering, data science, machine learning/AI, human factors, and aerospace. Additionally, you will help develop and optimize MORSE's recruiting strategy, to include skill-need discovery, sourcing methods, employer branding, university/student engagement, and screening techniques.

RESPONSIBILITIES

• Partner with hiring managers across our teams and programs to identify talent needs and suitable candidates for software, data science, and engineering roles 

• Utilize outbound sourcing strategies to find talented candidates from entry to executive level

• Own the full cycle recruiting process from initial contract (sourcing or application) to onboarding

• Find creative ways to establish the MORSE employer brand and attract talent 

• Integrate the MORSE values into all aspects of the recruiting process

REQUIREMENTS

• US CITIZENSHIP REQUIRED 

• 1+ years of experience in technical recruiting, either corporate or agency

• Hands-on experience using recruiting and sourcing tools such as job boards, social media, applicant tracking systems (Greenhouse) search engines, and other active methods of reaching active and passive candidates

• Demonstrated capability to source top technical talent spanning the range from entry-level to executive

• Ability to screen candidates and assess technical and corporate fit

• Outstanding organizational, time management, and process management skills and exceptional attention to detail

• Proven interpersonal skills and experience building strong relationships with candidates

The Role:

Reporting to the Head of Nuvalent Medical Affairs, the Senior Director of Medical Affairs Operations will serve as a strategic thought partner to the Head of Medical Affairs and the Medical Affairs Leadership Team (MALT). This role provides operational leadership, discipline, and alignment across Medical Affairs, ensuring that objectives, processes, and resources are optimized to deliver impact at scale. The incumbent will drive operational excellence, enable cross-functional collaboration, and oversee field operations, insights, and analytics to support the organization’s growth and transformation.

Responsibilities:

• Strategic Partnership & Leadership
  • Act as a trusted advisor to the Head of Medical Affairs and MALT, shaping operational strategy and execution.
  • Drive strong cross-functional team planning and alignment (e.g. MALT, MALT/CLT, Medical Strategy, and IEGT), ensuring smooth ways of working and operational discipline, with seamless execution of strategic priorities.
• Performance Management and Launch Readiness
  • Lead KPI and objectives planning, tracking, and reporting to ensure accountability and transparency.
  • Develop dashboards and reporting frameworks to provide real-time visibility into Medical Affairs performance, risks, and resource utilization; establish frameworks for measuring impact and continuous improvement.
• Operational Excellence and Continuous Improvement
  • Define and evolve ways of working within Medical Affairs, including process development, capability building, and cross-functional orchestration.
  • Drive continuous process improvement and simplification, including SOP development and refinement to ensure scalability and compliance.
• Financial Stewardship
  • Oversee budget planning, forecasting, and resource allocation to ensure fiscal discipline and strategic investment.
  • Partner with Finance to align operational spend with organizational priorities.
• Risk Management & Executive Communications
  • Identify, assess, and mitigate operational risks, ensuring proactive management and transparent escalation to leadership.
  • Craft and deliver executive communications that synthesize operational performance, risks, and strategic initiatives for senior leadership and board audiences.
• Strategic Initiatives and Capability Building
  • Support and enable key initiatives such as regional expansion, organizational transformation, and business model evolution.
  • Support Medical capability building initiatives, ensuring teams are equipped with the skills, processes, and tools to deliver impact.
• Knowledge & Communication
  • Establish central knowledge management systems to ensure accessibility and transparency of information.
  • Facilitate effective team communication and alignment across Medical Affairs and field teams.
• Field Operations & Analytics
  • Provide oversight of field operations, insights generation, and analytics to inform strategy and decision-making.
  • Ensure robust mechanisms for capturing and translating field intelligence into actionable insights.
• Team Facilitation & Culture
  • Foster a high-performance culture through facilitation, coaching, and team development.
  • Enable collaboration, accountability, and continuous learning across Medical Affairs.

Competencies Include:

• Strategic thinker with operational rigor.
• Collaborative leader who builds trust and alignment across diverse stakeholders.
• Skilled in change management and organizational transformation.
• Adept at balancing strategic priorities with tactical execution.
• Committed to fostering a culture of accountability, transparency, and innovation.

Qualifications:

• Advanced degree in life sciences, healthcare, or related field; MBA or equivalent preferred.
• 10+ years of experience in Medical Affairs, clinical development, or related operational leadership roles.
• Proven track record of leading cross-functional teams and driving operational excellence in complex organizations.
• Strong financial acumen with experience in budget management and forecasting.
• Expertise in KPI development, performance tracking, and analytics.
• Exceptional communication, facilitation, and stakeholder management skills.
• Ability to synthesize complexity into clear, actionable frameworks for executive and board-level audiences.

Additional Information:

Nuvalent is committed to fair and equitable compensation practices, aiming to provide employees with competitive total rewards packages.

The targeted salary range reflects what Nuvalent reasonably and in good faith expects to offer for this position at the time of posting, but the final salary determination may be within or outside this range based on various factors, including, but not limited to, experience, skills, education, and market factors.  The range will be reviewed regularly and is subject to change.

Nuvalent also offers a comprehensive benefit package to support our employees at each stage of their career, financial, health, and well-being journey, including medical, dental, and vision insurance, 401(k) retirement savings plan, generous paid time off (including a summer and winter company shutdown), and much more.

About Sail 

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering. 

The Role

The Sr Director, Delivery will be responsible for advancing Sail’s targeted nanoparticle delivery platform, with a particular focus on lipid nanoparticle (LNP) technologies for cell-specific delivery of RNA therapeutics. This role will lead the strategy and execution of delivery innovation from early discovery through preclinical development, enabling robust, scalable, and translatable delivery solutions across Sail’s pipeline.

This individual will bring deep technical expertise in lipid nanoparticle design and formulation, as well as demonstrated experience in targeted delivery approaches, including ligand-mediated targeting, bioconjugation, and receptor-specific delivery strategies. They will play a central role in shaping Sail’s delivery capabilities, expanding tissue and cell-type reach, and unlocking new therapeutic applications.

The Sr Director will operate at the intersection of Platform, Programs and Technical Development, working cross-functionally to translate delivery innovations into high-impact programs. They will lead a team of scientists and serve as a key thought partner to senior leadership on delivery strategy, platform investments, portfolio prioritization, and technical risk.

This role is accountable for the foundational and Delivery capability at Sail, ensuring that targeted nanoparticle systems are not only innovative but also translatable and scalable, enabling continued pipeline progression to development candidates.

Responsibilities 

Delivery Leadership and Strategy

• Lead and grow Sail’s Delivery team, advancing lipid nanoparticle (LNP) and targeted delivery technologies.
• Drive innovation in targeted nanoparticles, including design, formulation, ligand selection and conjugation, receptor-mediated uptake, and cytosolic delivery.
• Define and execute delivery strategy across tissues and disease areas, guiding nanoparticle engineering for precise targeting and biodistribution.
• Develop and apply high-throughput screening approaches to evaluate delivery performance, including biodistribution, cellular uptake, and functional expression.
• Partner with Program teams to advance multiple development candidates, improving efficiency, specificity, and translatability.
• Partner with Technical Development to ensure scalable, robust processes supporting progression to clinic.

Cross-Functional & Operational Leadership

• Lead cross-functional delivery efforts to advance programs from concept through candidate nomination.
• Collaborate with ligand design and program teams to align delivery strategies with disease biology and therapeutic goals.
• Identify and mitigate key delivery risks to enable program success.
• Drive integrated planning across delivery activities, aligning timelines, milestones, and resources.
• Manage external collaborations, including CROs and technology partners.
• Advise senior leadership on delivery strategy, portfolio prioritization, and execution risks.

Qualifications

• PhD or MD in drug delivery, chemical engineering, materials science, pharmaceutical sciences, or a related discipline with 12+ years of relevant industry experience.
• Deep expertise in lipid nanoparticle (LNP) systems, including formulation development, lipid chemistry, and in vitro/in vivo evaluation of delivery performance.
• Demonstrated experience in targeted delivery approaches, including ligand conjugation, receptor-mediated targeting, and nanoparticle surface engineering.
• Strong understanding of nucleic acid delivery challenges, including biodistribution, cellular uptake, endosomal escape, and immunogenicity.
• Experience advancing delivery technologies toward IND-enabling studies or clinical translation, with an appreciation for scalability, manufacturability, and regulatory considerations.
• Proven track record of advancing delivery technologies from discovery through preclinical development.
• Experience building and leading multidisciplinary scientific teams in a fast-paced biotech environment.
• Ability to operate strategically while remaining deeply connected to scientific detail and execution.
• Strong cross-functional leadership skills, with experience working across chemistry, biology, process development, and translational teams.
• Excellent communication skills, with the ability to influence senior stakeholders and clearly articulate complex technical concepts.

Salary Range: $235,000 - $290,000 

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law. 

About Sail

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role

The Director, Translational Biology & Biomarkers will be responsible for advancing biomarker strategies and translating scientific insights into actionable clinical outcomes. This leader will build the Biomarkers strategy to support Sail’s transition into clinical development, building internal capabilities while leveraging CRO capabilities.

This individual will bring broad technical expertise in bioassay development and bioanalytical measurements, qualification/validation, and data interpretation. The role will oversee development of PK, immunogenicity, and pharmacodynamic/bioassays across discovery and clinical stages aligned with the company’s expanding portfolio. In addition to supporting the lead program advancing to clinical development, the individual will also guide bioassay needs across several additional programs to increase assay standardization and robustness across functions.

Responsibilities

Translational Biomarker Strategy

• Own and execute clinical biomarker plans in alignment with program team goals and clinical function.
• Design and execute Sail’s biomarker strategies to support a clinical-stage portfolio, including biomarker-driven clinical study design and incorporation of biomarker endpoints for decision-making in early-stage clinical trials.
• Provide scientific and technical leadership for development, qualification, validation, and lifecycle management of PK, ADA, neutralizing antibody, cell-based potency, and pharmacodynamic assays.
• Ensure assays are fit-for-purpose and aligned with regulatory expectations (GLP/GCLP), in close collaboration with Preclinical Pharmacology, Regulatory, Clinical, and Quality teams.
• Oversee internal and external assay development activities, including CRO and central laboratory management, ensuring scientific rigor, data integrity, and timeline adherence.
• Review and approve assay validation plans, reports, and work orders from analytical laboratories.
• Analyze and interpret biomarker and immunogenicity data and communicate biological and clinical implications to support program decisions.
• Define data transfer specifications in collaboration with translational science, data management, and data science teams to ensure high-quality clinical biomarker datasets.
• Represent the Biomarker function at internal and external meetings and provide project status updates related to biomarker deliverables.

Cross-Functional & Operational Leadership

• Partner with Clinical Operations to ensure appropriate collection, shipment, and analysis of clinical samples.
• Coordinate with internal and external stakeholders (CROs, central labs, clinical sites) to address specimen-related and assay-related issues.
• Manage timelines, budgets, and external partnerships for bioanalytical and biomarker programs.
• Advise senior and matrixed leaders on bioanalytical risk, strategy, and development trade-offs.

Qualifications

• PhD or MD in Immunology, Cell Biology, or related scientific discipline with 10+ years of experience in a Biotech or Pharmaceutical setting; or equivalent combination of education and experience.
• Demonstrated expertise in bioassay development, qualification, validation, and regulatory submission support.
• Deep knowledge of PK, immunogenicity, cell-based functional assays, potency assays, and biomarker assay development.
• Strong understanding of drug development, regulatory processes, and clinical development, including GLP/GCLP bioanalytical expectations.
• Proven experience building and leading scientific teams in a growing biotech environment.
• Strong strategic thinking, sound judgment, and ability to operate effectively in a fast-paced, matrixed organization.
• Track record of advancing multiple programs simultaneously and implementing creative, solution-oriented strategies.
• Excellent interpersonal, communication, and organizational skills.

Salary Range: $200,000 - $250,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

The Role:

Reporting to the Director, Global Regulatory Affairs, the Senior Manager, Regulatory Affairs role will integrate regulatory strategic development, submission management expertise, and hands-on execution to support the IND/CTA stage of development through NDA/MAA.

The Senior Manager, Regulatory Affairs will contribute to the development and implementation of regulatory strategy as a member of the global regulatory affairs function and clinical study team(s). This role will manage the process for preparation, submission and internal review and approval of regulatory documents, including providing technical regulatory input for global documents to streamline development.

The Senior Manager, Regulatory Affairs must be kept current, innovative, and compliant with the constant changing Health Authority requirements to facilitate regulatory processes and compliance maintenance from IND/CTAs through NDA/MAA. 

Responsibilities:

• Participates as a regulatory representative for Clinical Study Team (CST) on development programs assigned working closely with product development team (PDT) lead to develop the global regulatory strategy; work closely with regulatory operations and program management to track timelines and ensure deliverables are achieved
• As part of the regulatory clinical study team, you will support preparation, review, compilation, and execution of submissions for regulatory agencies for US and ROW (e.g., IND/CTAs, NDA/MAA, DSURs, Amendments, and Responses to Regulatory Agency Requests for Information, etc.)
• Provide regulatory guidance and support to senior regulatory affairs members on various projects, as needed, to further development programs (pediatric development planning, regulatory interactions, NDA planning)
• Ensure collaboration with and coordination of cross-functional project teams for timely execution of regulatory submissions, maintaining compliance with global regulatory standards and commitments, and providing regulatory guidance and oversight
• Support regulatory operations during the regulatory submissions handoff process, as the primary point of contact for external publishing vendors, ensuring submission packages are accurate, formatted correctly, and validated.
• Maintain the regulatory information system and ensure proper archiving, searchability, and accessibility of regulatory content including correspondence with regulatory agencies
• Manage regulatory submission processes, develop and maintain regulatory tracking tools and infrastructure, as assigned Conduct regulatory intelligence and competitive intelligence and summarize key impacts to global strategy development teams, as appropriate
• Ensure compliance with internal SOPs, regulations and applicable laws. Drafts and reviews Regulatory Affairs SOPs and work instructions and provides Regulatory feedback on other departmental SOPs, where required

Competencies Include:

• Excellent attention to detail and ability to complete efficient and detailed technical data review
• Excellent organization, communication, and multi-tasking skills
• Exceptional interpersonal skills and experience contributing to productive teams and fostering cross functional relationships
• Strong desire to contribute as a member of an engaged and collaborative cross-functional project development team

 Qualifications:

• 6-8 years of experience in Regulatory Affairs or combination of education and direct experience.
• Bachelor or advanced degree in a scientific field or equivalent work experience is required.  Master’s degree a plus.
• Proven experience in evaluation, preparation and compilation of quality dossiers in all required formats and/or experience in regulatory processes.
• Solid understanding of the e-CTD specifications for electronic submissions.
• Knowledge and practical understanding of ICH Guidelines regarding GMP/GCP, ICH Guidelines for CTD/eCTD and CDER requirements for the drug approval process.
• Previous participation in preparing and/or leading regulatory submissions (IND, CTA, NDA, etc.). Experience with preparing meeting packages is a plus.
• Experience in interpretation of regulations, guidelines and precedents related to drug development in the US and EU.
• Strong understanding of regulatory eCTD structure and clinical trial conduct and design
• Proficiency with electronic submission publishing software and document management information systems (i.e., docuBridge, Veeva Vault RIM)
• Ability to plan, prioritize and contribute to work and projects in a systematic and efficient manner with emphasis on streamlining processes

Additional Information:

Nuvalent is committed to fair and equitable compensation practices, aiming to provide employees with competitive total rewards packages.

The targeted salary range reflects what Nuvalent reasonably and in good faith expects to offer for this position at the time of posting, but the final salary determination may be within or outside this range based on various factors, including, but not limited to, experience, skills, education, and market factors.  The range will be reviewed regularly and is subject to change.

Nuvalent also offers a comprehensive benefit package to support our employees at each stage of their career, financial, health, and well-being journey, including medical, dental, and vision insurance, 401(k) retirement savings plan, generous paid time off (including a summer and winter company shutdown), and much more.