About Sail 

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering. 

The Role

The Sr Director, Delivery will be responsible for advancing Sail’s targeted nanoparticle delivery platform, with a particular focus on lipid nanoparticle (LNP) technologies for cell-specific delivery of RNA therapeutics. This role will lead the strategy and execution of delivery innovation from early discovery through preclinical development, enabling robust, scalable, and translatable delivery solutions across Sail’s pipeline.

This individual will bring deep technical expertise in lipid nanoparticle design and formulation, as well as demonstrated experience in targeted delivery approaches, including ligand-mediated targeting, bioconjugation, and receptor-specific delivery strategies. They will play a central role in shaping Sail’s delivery capabilities, expanding tissue and cell-type reach, and unlocking new therapeutic applications.

The Sr Director will operate at the intersection of Platform, Programs and Technical Development, working cross-functionally to translate delivery innovations into high-impact programs. They will lead a team of scientists and serve as a key thought partner to senior leadership on delivery strategy, platform investments, portfolio prioritization, and technical risk.

This role is accountable for the foundational and Delivery capability at Sail, ensuring that targeted nanoparticle systems are not only innovative but also translatable and scalable, enabling continued pipeline progression to development candidates.

Responsibilities 

Delivery Leadership and Strategy

• Lead and grow Sail’s Delivery team, advancing lipid nanoparticle (LNP) and targeted delivery technologies.
• Drive innovation in targeted nanoparticles, including design, formulation, ligand selection and conjugation, receptor-mediated uptake, and cytosolic delivery.
• Define and execute delivery strategy across tissues and disease areas, guiding nanoparticle engineering for precise targeting and biodistribution.
• Develop and apply high-throughput screening approaches to evaluate delivery performance, including biodistribution, cellular uptake, and functional expression.
• Partner with Program teams to advance multiple development candidates, improving efficiency, specificity, and translatability.
• Partner with Technical Development to ensure scalable, robust processes supporting progression to clinic.

Cross-Functional & Operational Leadership

• Lead cross-functional delivery efforts to advance programs from concept through candidate nomination.
• Collaborate with ligand design and program teams to align delivery strategies with disease biology and therapeutic goals.
• Identify and mitigate key delivery risks to enable program success.
• Drive integrated planning across delivery activities, aligning timelines, milestones, and resources.
• Manage external collaborations, including CROs and technology partners.
• Advise senior leadership on delivery strategy, portfolio prioritization, and execution risks.

Qualifications

• PhD or MD in drug delivery, chemical engineering, materials science, pharmaceutical sciences, or a related discipline with 12+ years of relevant industry experience.
• Deep expertise in lipid nanoparticle (LNP) systems, including formulation development, lipid chemistry, and in vitro/in vivo evaluation of delivery performance.
• Demonstrated experience in targeted delivery approaches, including ligand conjugation, receptor-mediated targeting, and nanoparticle surface engineering.
• Strong understanding of nucleic acid delivery challenges, including biodistribution, cellular uptake, endosomal escape, and immunogenicity.
• Experience advancing delivery technologies toward IND-enabling studies or clinical translation, with an appreciation for scalability, manufacturability, and regulatory considerations.
• Proven track record of advancing delivery technologies from discovery through preclinical development.
• Experience building and leading multidisciplinary scientific teams in a fast-paced biotech environment.
• Ability to operate strategically while remaining deeply connected to scientific detail and execution.
• Strong cross-functional leadership skills, with experience working across chemistry, biology, process development, and translational teams.
• Excellent communication skills, with the ability to influence senior stakeholders and clearly articulate complex technical concepts.

Salary Range: $235,000 - $290,000 

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law. 

About Sail

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role

The Director, Translational Biology & Biomarkers will be responsible for advancing biomarker strategies and translating scientific insights into actionable clinical outcomes. This leader will build the Biomarkers strategy to support Sail’s transition into clinical development, building internal capabilities while leveraging CRO capabilities.

This individual will bring broad technical expertise in bioassay development and bioanalytical measurements, qualification/validation, and data interpretation. The role will oversee development of PK, immunogenicity, and pharmacodynamic/bioassays across discovery and clinical stages aligned with the company’s expanding portfolio. In addition to supporting the lead program advancing to clinical development, the individual will also guide bioassay needs across several additional programs to increase assay standardization and robustness across functions.

Responsibilities

Translational Biomarker Strategy

• Own and execute clinical biomarker plans in alignment with program team goals and clinical function.
• Design and execute Sail’s biomarker strategies to support a clinical-stage portfolio, including biomarker-driven clinical study design and incorporation of biomarker endpoints for decision-making in early-stage clinical trials.
• Provide scientific and technical leadership for development, qualification, validation, and lifecycle management of PK, ADA, neutralizing antibody, cell-based potency, and pharmacodynamic assays.
• Ensure assays are fit-for-purpose and aligned with regulatory expectations (GLP/GCLP), in close collaboration with Preclinical Pharmacology, Regulatory, Clinical, and Quality teams.
• Oversee internal and external assay development activities, including CRO and central laboratory management, ensuring scientific rigor, data integrity, and timeline adherence.
• Review and approve assay validation plans, reports, and work orders from analytical laboratories.
• Analyze and interpret biomarker and immunogenicity data and communicate biological and clinical implications to support program decisions.
• Define data transfer specifications in collaboration with translational science, data management, and data science teams to ensure high-quality clinical biomarker datasets.
• Represent the Biomarker function at internal and external meetings and provide project status updates related to biomarker deliverables.

Cross-Functional & Operational Leadership

• Partner with Clinical Operations to ensure appropriate collection, shipment, and analysis of clinical samples.
• Coordinate with internal and external stakeholders (CROs, central labs, clinical sites) to address specimen-related and assay-related issues.
• Manage timelines, budgets, and external partnerships for bioanalytical and biomarker programs.
• Advise senior and matrixed leaders on bioanalytical risk, strategy, and development trade-offs.

Qualifications

• PhD or MD in Immunology, Cell Biology, or related scientific discipline with 10+ years of experience in a Biotech or Pharmaceutical setting; or equivalent combination of education and experience.
• Demonstrated expertise in bioassay development, qualification, validation, and regulatory submission support.
• Deep knowledge of PK, immunogenicity, cell-based functional assays, potency assays, and biomarker assay development.
• Strong understanding of drug development, regulatory processes, and clinical development, including GLP/GCLP bioanalytical expectations.
• Proven experience building and leading scientific teams in a growing biotech environment.
• Strong strategic thinking, sound judgment, and ability to operate effectively in a fast-paced, matrixed organization.
• Track record of advancing multiple programs simultaneously and implementing creative, solution-oriented strategies.
• Excellent interpersonal, communication, and organizational skills.

Salary Range: $200,000 - $250,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

About Sail:

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role:

Sail Biomedicines is seeking a Research Associate II to join our Preclinical Manufacturing team, supporting the production of RNA and lipid nanoparticle (LNP) drug substances and drug products. As part of the Technical Operations group, you will contribute directly to the development and delivery of preclinical materials for both internal and partnered programs.

Thisis a hands-on, lab-based role requiring strong experimental execution, attention to detail, and cross-functional collaboration. You will play a key role in advancing scalable RNA and LNP manufacturing processes to enable pipeline progress.

Responsibilities:

• Support the production of RNA cargo molecules and lipid nanoparticle (LNP) formulations for preclinical studies
• Execute hands-on laboratory work involving eRNA synthesis, purification, and LNP encapsulation
• Contribute to the development, optimization, and scale-up of high-yield, high-quality RNA/LNP processes
• Operate and maintain lab-scale instrumentation, including AKTA (FPLC), TFF systems, PCR, HPLC, capillary electrophoresis, UV-Vis, and light scattering platforms
• Perform analytical characterization and quantification of RNA and other nucleic acids
• Analyze experimental data and document results in electronic lab notebooks (ELN) and technical reports
• Collaborate cross-functionally with research, analytical, and process development teams to support project goals

Required Qualifications:

• B.S. with 2+ years of industry experience or M.S. in Molecular Biology, Biochemistry, Biochemical Engineering, or a related field
• Hands-on experience in one or more of the following areas:
  • RNA/DNA production and purification
  • LNP formulation and characterization
  • Chromatography (e.g., AKTA/FPLC, HPLC)
  • Tangential flow filtration (TFF)
  • Automated liquid handling systems
• Strong understanding of experimental design, data analysis, and technical documentation
• Proficiency in core laboratory techniques, including aseptic technique, buffer preparation, and instrument operation/programming
• Experience with analytical methods such as capillary electrophoresis, UV-Vis, or light scattering is preferred

Preferred Qualifications:

• Detail-oriented with strong organizational and documentation skills
• Curious, proactive, and comfortable working both independently and in collaborative environments
• Effective communicator with the ability to clearly present technical data and insights

Salary Range: $75,000 - $100,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

About Sail:

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is also making unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role:

Sail Biomedicines is seeking a motivated Senior Research Associate / Scientist I to join our Vaccines, Immunoassay & Pharmacology team. This role will develop, optimize, and execute bioassays to characterize biological activity, mechanism, and immune responses for candidates enabled by Sail’s eRNA™ delivery platform, supporting in vivo PK/PD, toxicology, and translational decision-making.

This is a lab-based, onsite role with substantial hands-on experimental work, collaborative problem-solving, and close partnership with cross-functional teams. The ideal candidate brings strong experience in mammalian cell culture, flow cytometry, serology/immunoassays (e.g., ELISA/MSD), qPCR, and excellent scientific documentation. You will generate high-quality data, troubleshoot assays, and contribute to advancing Sail’s platform and pipeline.

Responsibilities:

Bioassay Development & Execution

• Develop, optimize, and execute cell-based and immunoassay workflows to support PK/PD, tox, and pharmacology readouts (e.g., potency/functional assays, biomarker assays, serology).
• Design and build multiparameter flow cytometry panels (marker selection, titrations, controls, compensation, gating strategy) for in vivo study sample analysis.
• Develop and run serology assays (e.g., binding antibody, neutralization/surrogate neutralization where applicable, cytokine/chemokine readouts) using ELISA, MSD, or related platforms.
• Qualify/validate assays as appropriate: establish accuracy/precision, sensitivity, range, robustness, and implement cross-study controls and reference standards.
• Own assay readiness: generate SOPs, templates, and training materials; ensure reproducibility and knowledge transfer.

Sample Operations & Study Support

• Coordinate sample receipt, accessioning, and tracking from internal studies and CRO-supported work; maintain chain-of-custody, storage conditions, and inventory.
• Perform sample processing (e.g., PBMC isolation, plasma/serum handling), ensuring consistency and biosafety compliance.

Data, Documentation & Collaboration

• Analyze, interpret, and summarize data; maintain rigorous records in ELN and associated databases.
• Present findings internally (lab meetings, project teams) with clear conclusions, limitations, and next steps.
• Partner with Biology, Analytics, and Computational/AI teams to define assay requirements, experimental design, and data structure/metadata.
• Contribute to reports, tech memos, and experiments that support IP and regulatory-facing documentation where relevant.
• Manage multiple concurrent experiments while maintaining high standards for lab safety, quality, and timelines.

Required Qualifications:

• B.S. or M.S. in Immunology, Bioengineering, Biochemistry, Molecular Biology, Chemistry, or related field.
• 2–4+ years relevant laboratory experience (industry preferred).
• Hands-on experience with flow cytometry and mammalian cell culture; experience with one or more of: PBMC isolation, primary cell handling, qPCR, ELISA/MSD, or related immunoassays.
• Working knowledge of assay development principles (controls, standard curves, variability, qualification/validation concepts).
• Strong experimental design and troubleshooting skills; able to optimize protocols and document changes clearly.
• Excellent organization and time management; able to prioritize and execute in a fast-paced environment.
• Strong written/verbal communication, including presenting data and writing concise summaries.
• Self-directed, collaborative, detail-oriented; demonstrates scientific curiosity and integrity.

Preferred Qualifications:

• Experience working with non-human primate (NHP) samples and associated biosafety practices.
• Basic working knowledge of biostatistics (e.g., variability, curve fitting, outlier handling, assay acceptance criteria).
• Experience with FlowJo, GraphPad Prism, and Microsoft Office (Excel/PowerPoint); familiarity with ELN best practices.
• Experience in a matrixed project environment supporting multiple programs.

Salary Range: $80,000 - $115,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

Type: Onsite 

About Sail:

Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail’s platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is building a wealth of data, enabling unparalleled use of generative AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role:

The Associate Director/Director of Clinical Supply Chain will be responsible for the strategic planning, execution, and oversight of end-to-end clinical supply operations across Sail’s clinical programs. This role will lead clinical supply strategy from first-in-human through late-stage trials, ensuring uninterrupted supply of critical materials, intermediates, products and finished good from/between suppliers through to clinical sites while maintaining regulatory compliance, cost control, and operational excellence. This position requires strong cross-functional leadership, hands-on execution capability, and deep expertise in global transportation logistics and clinical supply chain management within a biotech environment.

Responsibilities:

• Develop and execute clinical supply strategies for all clinical programs, aligned with clinical development plans and CMC timelines.
• Lead demand forecasting, supply planning, and inventory management
• Define packaging, labeling, and distribution strategies appropriate for trial design, geography, and regulatory requirements.
• Oversee clinical packaging, labeling, storage, and global distribution activities through CMOs, CPOs, depots, and logistics providers.
• Ensure timely availability of clinical supplies to investigational sites, minimizing risk of stock-outs or excess inventory.
• Manage external vendors (CMOs, packaging/labeling vendors, depots, couriers).
• Establish and manage contracts, budgets, KPIs, and performance reviews for supply chain partners.
• Serve as the primary supply chain interface with external manufacturing and logistics partners.
• Partner closely with Clinical Operations, CMC, Quality, Regulatory, and Finance to align supply plans with trial execution and regulatory strategy.
• Provide supply chain risk assessments and mitigation plans to program teams and leadership.
• Support clinical protocol development by advising on supply chain feasibility and complexity.
• Ensure all clinical supply activities comply with GxP, ICH, FDA, EMA, and global regulatory requirements.
• Support audits and inspections related to clinical supply operations.
• Author, review, and approve SOPs, plans, and supply-related documentation.
• Develop and manage clinical supply chain budgets, forecasts, and cost controls.
• Implement process improvements, digital tools, and best practices to enhance efficiency and scalability.
• Build and scale clinical supply chain capabilities as Sail’s pipeline grows.

Required Qualifications:

• Bachelor’s degree in Supply Chain, Life Sciences, Engineering, or a related field (advanced degree preferred).
• 8+ years of direct experience in clinical supply chain, pharmaceutical supply chain, or related roles in biotech/pharma.
• Proven experience supporting Phase 1–3 clinical trials, including global studies.
• Strong knowledge of GxP, clinical packaging/labeling, and global distribution requirements.
• Demonstrated ability to manage external vendors and complex cross-functional projects.
• Excellent communication, problem-solving, and leadership skills.
• Demonstrated experience managing global clinical supply chains for multiple chemical and biological entities.
• Experience in a clinical-stage or high-growth biotech environment.

Preferred Qualifications:

• Experience driving clinical supply chain operations.
• Familiarity with IRT/RTSM systems and clinical supply forecasting tools.
• Experience supporting regulatory inspections and audits.
• Technical background in clinical or commercial manufacturing of multiple therapeutic modalities i.e. small molecules, ADC and biologics

Salary Range: $175,000 - $240,000

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate based on race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.