WHO WE ARE

          We are a company where people matter. 

          We are family driven. 

          We are financially strong.

          And we are looking for problem-solvers to join our growing team.

BENEFITS

• Up to 10% Retirement Contribution
• $600 per Year Wellness Incentive 
• Two Weeks Starting Paid Time Off
• Medical, Dental, and Vision - Eligible first day of the month following hire date.

JOIN A TOP WORKPLACE - https://www.youtube.com/watch?v=7nlFHnnfvhk  

OPPORTUNITY

The primary purpose of this position is to perform required quality control analysis of incoming, manufacturing and outgoing material with authority to make acceptance, production adjustment, and/or rejection decisions. This position may also provide technical support to operations and sales.

As QC Chemist, primary responsibilities include:

• Perform required quality control analysis of incoming, manufacturing and outgoing material with authority to make acceptance, production adjustment, and/or rejection decisions.
• Record and maintain analysis/records accurately, neatly, legibly and completely.
• Prioritize daily laboratory activities to meet production schedules.
• Perform instrument maintenance, calibrations, quality control checks, solution preparations, and solution standardizations.
• Provide technical support and assistance to operations/production regarding manufacturing adjustment of non-conforming materials and quality issues.
• Maintain a clean and neat laboratory at all times.
• Adhere to all safety SOPPs
• Initiate corrective actions on identified non-capable procedures or practices.
• Maintain and properly store sample retains.
• Communicate to supervisor concerns about standard laboratory procedures, operational problems, quality trends, etc.
• Maintain a professional attitude and demeanor at all times, treat others with courtesy and respect, and respond to all requests in a professional manner.
• Promote complete customer satisfaction through quality and service to both internal and external customers.
• All staff members are responsible for reporting food safety problems to their supervisor or the SQF Practitioner upon observation of a known or potential issue.
• Uphold Hydrite’s Standard of Excellence through a continuous commitment to maintain quality facilities and provide quality products and services to internal and external customers
• Perform all duties outlined in relevant SOPs and all other duties to be assigned.
• Participate in RCRA, regulatory, health & safety and process training activities as required.  Review changes/additions with your supervisor.  Must be RCRA compliant.

REPORTING STRUCTURE

• This position reports to the QC Lab Manager.

EXPERIENCE AND EDUCATIONAL CRITERIA

• Bachelor’s Degree in Chemistry or related field is required.
• Must have good communication and interpersonal skills, including the ability to read, write, and speak in English.
• Proficiency in computer skills and good working knowledge with all MS Office applications.
• Ability to accurately transfer written and verbal information and documentation and enter data into existing computer system.
• Must be self-motivated and able to work independently as well as in a group setting.
• Able to apply mathematical and problem solving skills for resolution.
• Must possess good laboratory analytical skills.
• A drug screening is required during the pre-employment process. 

BENEFITS

Benefits and perks include 401k and profit sharing, medical/dental/vision/life insurance, paid time off, tuition reimbursement, adoption assistance, legal services insurance, scholarship awards for children of employees, summer picnic, community giving events, free family wellness coaching including nutritionist and fitness coach.

WHY HYDRITE?  

Watch this Why Hydrite video to find out:  https://vimeo.com/201673899

WANT TO STAY CONNECTED?  FIND US ON SOCIAL MEDIA

• LinkedIn: linkedin.com/company/hydrite-chemical-co-
• Facebook: facebook.com/hydrite
• YouTube:https://www.youtube.com/watch?v=Bs_493NR8RI

Learn more about Hydrite on our website: www.hydrite.com/careers

Director, Formulation Sales – East Coast

Location: Remote

Reports To: Chief Commercial Officer

Type: Full-Time

Salary Range: USD $140,000–$175,000 per annum (base) + performance-based incentives, commensurate with experience

MAKE YOUR DEBUT

About Debut

Debut is a vertically integrated biotechnology company pioneering the next generation of high-performance cosmetic active ingredients. We combine AI-driven discovery with proprietary bioprocessing to develop the highest performing and clinically proven active ingredients that outperform conventionally sourced alternatives. From molecule to market, Debut controls the full value chain: ingredient discovery, formulation science, clinical validation, and scaled manufacturing delivering novel active ingredients to the global beauty industry faster and with better efficacy data than traditional suppliers.

Summary

Debut is seeking a commercially driven, highly connected Director of Formulation Sales to own and grow our East Coast formulation business. This is a hunter and closer role focused exclusively on selling custom-developed finished formulations to beauty brands, not an ingredient sales role. The right candidate has spent their career inside the beauty contract manufacturing ecosystem, knows how prestige and emerging brands buy, and understands how to move a formulation brief from first conversation to signed commercial agreement. The ideal candidate is deeply embedded in the East Coast beauty community, with active beauty relationships. They will carry an established book of brand relationships, arrive ready to engage immediately, and be comfortable presenting to a VP of Product Development. Reporting directly to the Chief Commercial Officer, this person will serve as Debut’s primary commercial driver for East Coast formulation revenue.

Essential Functions

• Own and drive Debut’s East Coast formulation sales strategy, with full accountability for revenue achievement and expansion of the active customer base across prestige, masstige, and indie beauty segments in the East Coast market.
• Leverage an existing, active network of decision-maker relationships at major beauty brands with a concentration in East Coast-headquartered prestige, masstige and indie brands including VP-level and above contacts in product development, R&D, and procurement, to open doors, secure formulation briefs, and accelerate commercial cycles. Proactively identify, prioritize, and pursue new brand partnerships across skincare and color cosmetics to continuously expand Debut’s East Coast brand portfolio.
• Lead the full formulation sales cycle from initial brand engagement through briefing, proposal, sampling, pricing, and first production purchase order, coordinating closely with Debut’s R&D, Operations and formulation teams throughout. Awarded formulations are manufactured and filled by Debut’s CM partners, and this role is responsible for managing a smooth commercial handoff to ensure seamless execution.
• Develop deep understanding of each brand customer’s NPD roadmap, franchise architecture, launch/portfolio priorities and translate that intelligence into tailored product/formulation proposals that integrate Debut’s active ingredient platform.
• Represent Debut at US and international industry trade shows, brand summits, and brand innovation strategy sessions. Plan and execute brand-facing activations in coordination with the marketing and R&D teams ensuring Debut’s custom formulation capabilities are compellingly presented.
• Build and maintain a rigorous, accurate sales pipeline detailed in Debut’s CRM, providing the CCO with clear visibility into project status, revenue forecasts, and market intelligence on a regular cadence.
• Serve as a trusted commercial partner to brand customers throughout the product development lifecycle, managing the relationship from initial briefing through launch and beyond with the goal of securing repeat ongoing business. Translate market feedback including brand needs, competitive dynamics, and formulation trends into actionable insights that inform Debut’s formulation roadmap, and collaborate cross-functionally with R&D, operations, and the broader commercial team to ensure brand commitments are met.
• Operate with a high degree of autonomy and entrepreneurial urgency in a fast-moving, early-stage commercial environment, building a strong project pipeline while simultaneously closing business.

Education and Experience

The successful candidate will have a genuine passion for beauty and deep roots in the Prestige, Masstige and Indie beauty world. They are a product user, a relationship builder, and a closer.  Someone who understands how brands think and can credibly represent Debut’s formulation capabilities at every stage of the NPD process. They are organized, resilient, and motivated by winning. A bachelor’s degree is required; a background in cosmetic science, chemistry, or product development is a strong plus.

• 8+ years of experience in sales or in beauty product development within the contract manufacturing field or ingredient sales, with a meaningful portion of that time spent selling formulation or custom development services directly to beauty brands.
• Established, active network of decision-maker relationships at major beauty brands, with meaningful concentration in West Coast-headquartered companies across skincare and/or color cosmetics. Candidates must be able to demonstrate existing, active brand relationships, not historical contacts in their application materials.
• Customer-centric mindset with the ability to act as a true extension of a brand’s product development team. Strong interpersonal skills and a natural ability to build trust at every level of an organization.
• Demonstrated track record of meeting and exceeding revenue targets in a B2B formulation or contract manufacturing sales role, with experience managing complex sales cycles from prospecting through to contract execution.
• Strong technical fluency sufficient to engage credibly with brand R&D and product development teams on formulation performance, ingredient claims, and product development timelines without needing to be a chemist.
• Exceptional communication, presentation, and negotiation skills, with the ability to craft and deliver compelling product narratives tailored to brand-specific business priorities. Assertive and confident in closing.
• Willingness and ability to travel domestically and internationally as business needs require, including attendance at Debut’s innovation shows or key industry trade shows.
• Proficiency with CRM platforms (Monday, Salesforce or equivalent) and demonstrated discipline in pipeline management and forecasting. Accountable, KPI-focused, and goal-oriented.
• Experience working in or alongside an early-stage, high-growth company is a plus. Comfort operating in an environment where structure is still being built is essential. Self-motivated, proactive, and able to manage multiple priorities against tight timelines.

Essential Physical Characteristics

The physical characteristics described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable qualified individuals with disabilities to perform the essential functions of a job, on a case-by-case basis.

• Frequent sitting, standing, and walking during customer meetings, trade shows, and extended travel.
• Repetitive use of hands to operate computers, mobile devices, and presentation equipment.
• Ability to carry and transport sales materials and samples weighing up to 30 pounds.
• Frequent domestic and international air travel.
• Ability to navigate diverse physical environments including manufacturing facilities, trade show floors, and customer offices.

Condition of Employment

As part of Debut’s pre-employment process, prospective candidates will undergo a background check prior to beginning employment. Additional types of background investigations may be conducted based on the job-related activities of the position.

Debut is an equal opportunity employer. All applicants will be considered for employment without attention to age, nationality, sex, marital status, pregnancy status, caregiving responsibilities, race, religion, language, disability, or mental health conditions. Employment decisions at Debut are based on merit, qualifications, and business needs.

ABOUT THE TEAM

Anduril’s Tactical Recon & Strike (TRS) is a division with two missions: 1) build highly capable autonomous drones, and 2) build solid rocket motors at scale. We transform products like Ghost, Anvil, Bolt, and Altius from early concepts into fully operational capabilities by partnering closely with specialist engineering, operations, and production teams. Through our Anduril Rocket Motor Systems (RMS) team, we design and manufacture solid rocket motors using advanced materials, proprietary formulations, and high-volume production methods—delivering safe, reliable propulsion systems that support a wide range of mission requirements. TRS hires software engineers & hardware engineers, who are excited to build across a diverse and powerful portfolio—from autonomous aerial systems to high-performance solid rocket motors. Our teams contribute to highly capable autonomous robotics systems and propulsion products that operate reliably in the most demanding mission environment.

ABOUT THE JOB

Anduril – Rocket Motor Systems is seeking a Lead Scientist to join our organization. The Rocket Motor Systems business line designs, develops, and manufactures next-generation solid rocket motors for defense and space applications. The ideal candidate has extensive experience with numerous types of energetic materials and demonstrated expertise in one area of solid composite propellant manufacture and formulation. This role requires considerable knowledge of energetic materials chemistry, significant experience in rocket motor manufacturing, and demonstrated effectiveness as the principal investigator on internal research and development efforts.

WHAT YOU'LL DO

• Execute production rocket motor contracts as the program propellant chemist.
• Act as the principal investigator on at least one internal research and development effort.
• Provide technical guidance on explosives chemistry and manufacturing.
• Maintain databases and analyze technical data to ensure specification and regulatory compliance.
• Support implementation of innovative techniques and technologies.

REQUIRED QUALIFICATIONS

• Ph.D. in Chemistry, Chemical Engineering, Aerospace Engineering, or a related field plus two years of experience; or a master’s degree plus four years of experience; or a bachelor’s degree plus six years of experience.
• Minimum of two years of relevant experience within the aerospace/defense industry, preferably in solid rocket motor production.
• Demonstrated expertise in some area of rocket motor manufacture, e.g., composite propellants, energetic materials, case/nozzle/insulation design, solid rocket motor manufacturing.
• Demonstrated problem-solving skills and the ability to operate in a fast-paced, challenging environment.
• Ability to obtain and hold a U.S. Secret Security Clearance

PREFERRED QUALIFICATIONS

• Ph.D. or M.S. in Chemistry with a concentration in energetic materials, polymer chemistry, or reactive materials.
• Minimum of three years of relevant experience within the aerospace/defense industry, preferably in solid rocket motor production.
• Demonstrated experience formulating propellants at laboratory or production size.
• Active DOD Secret or Top-Secret security clearance.
• At least one publication or presentation within the defense industry in a relevant journal or at a relevant conference.

Director, Formulation Sales – West Coast

Location: San Diego, CA (Debut’s Headquarters)

Reports To: Chief Commercial Officer

Type: Full-Time

Salary Range: USD $140,000–$175,000 per annum (base) + performance-based incentives, commensurate with experience

MAKE YOUR DEBUT

About Debut

Debut is a vertically integrated biotechnology company pioneering the next generation of high-performance cosmetic active ingredients. We combine AI-driven discovery with proprietary bioprocessing to develop the highest performing and clinically proven active ingredients that outperform conventionally sourced alternatives. From molecule to market, Debut controls the full value chain: ingredient discovery, formulation science, clinical validation, and scaled manufacturing delivering novel active ingredients to the global beauty industry faster and with better efficacy data than traditional suppliers.

Summary

Debut is seeking a commercially driven, highly connected Director of Formulation Sales to own and grow our West Coast formulation business. This is a hunter and closer role focused exclusively on selling custom-developed finished formulations to beauty brands, not an ingredient sales role. The right candidate has spent their career inside the beauty contract manufacturing ecosystem, knows how prestige and emerging brands buy, and understands how to move a formulation brief from first conversation to signed commercial agreement. The ideal candidate is deeply embedded in the West Coast beauty community, with active relationships across the LA, San Francisco, and Pacific Northwest markets. They will carry an established book of brand relationships, arrive ready to engage immediately, and be comfortable presenting to a VP of Product Development. Reporting directly to the Chief Commercial Officer, this person will serve as Debut’s primary commercial driver for West Coast formulation revenue.

Essential Functions

• Own and drive Debut’s West Coast formulation sales strategy, with full accountability for revenue achievement and expansion of the active customer base across prestige, masstige, and indie beauty segments in the West Coast market.
• Leverage an existing, active network of decision-maker relationships at major beauty brands with a concentration in West Coast-headquartered prestige, masstige and indie brands including VP-level and above contacts in product development, R&D, and procurement, to open doors, secure formulation briefs, and accelerate commercial cycles. Proactively identify, prioritize, and pursue new brand partnerships across skincare and color cosmetics to continuously expand Debut’s West Coast brand portfolio.
• Lead the full formulation sales cycle from initial brand engagement through briefing, proposal, sampling, pricing, and first production purchase order, coordinating closely with Debut’s R&D, Operations and formulation teams throughout. Awarded formulations are manufactured and filled by Debut’s CM partners, and this role is responsible for managing a smooth commercial handoff to ensure seamless execution.
• Develop deep understanding of each brand customer’s NPD roadmap, franchise architecture, launch/portfolio priorities and translate that intelligence into tailored product/formulation proposals that integrate Debut’s active ingredient platform.
• Represent Debut at US and international industry trade shows, brand summits, and brand innovation strategy sessions. Plan and execute brand-facing activations in coordination with the marketing and R&D teams ensuring Debut’s custom formulation capabilities are compellingly presented.
• Build and maintain a rigorous, accurate sales pipeline detailed in Debut’s CRM, providing the CCO with clear visibility into project status, revenue forecasts, and market intelligence on a regular cadence.
• Serve as a trusted commercial partner to brand customers throughout the product development lifecycle, managing the relationship from initial briefing through launch and beyond with the goal of securing repeat ongoing business. Translate market feedback including brand needs, competitive dynamics, and formulation trends into actionable insights that inform Debut’s formulation roadmap, and collaborate cross-functionally with R&D, operations, and the broader commercial team to ensure brand commitments are met.
• Operate with a high degree of autonomy and entrepreneurial urgency in a fast-moving, early-stage commercial environment, building a strong project pipeline while simultaneously closing business.

Education and Experience

The successful candidate will have a genuine passion for beauty and deep roots in the Prestige, Masstige and Indie beauty world. They are a product user, a relationship builder, and a closer.  Someone who understands how brands think and can credibly represent Debut’s formulation capabilities at every stage of the NPD process. They are organized, resilient, and motivated by winning. A bachelor’s degree is required; a background in cosmetic science, chemistry, or product development is a strong plus.

• 8+ years of experience in sales or in beauty product development within the contract manufacturing field or ingredient sales, with a meaningful portion of that time spent selling formulation or custom development services directly to beauty brands.
• Established, active network of decision-maker relationships at major beauty brands, with meaningful concentration in West Coast-headquartered companies across skincare and/or color cosmetics. Candidates must be able to demonstrate existing, active brand relationships, not historical contacts in their application materials.
• Customer-centric mindset with the ability to act as a true extension of a brand’s product development team. Strong interpersonal skills and a natural ability to build trust at every level of an organization.
• Demonstrated track record of meeting and exceeding revenue targets in a B2B formulation or contract manufacturing sales role, with experience managing complex sales cycles from prospecting through to contract execution.
• Strong technical fluency sufficient to engage credibly with brand R&D and product development teams on formulation performance, ingredient claims, and product development timelines without needing to be a chemist.
• Exceptional communication, presentation, and negotiation skills, with the ability to craft and deliver compelling product narratives tailored to brand-specific business priorities. Assertive and confident in closing.
• Willingness and ability to travel domestically and internationally as business needs require, including attendance at Debut’s innovation shows or key industry trade shows.
• Proficiency with CRM platforms (Monday, Salesforce or equivalent) and demonstrated discipline in pipeline management and forecasting. Accountable, KPI-focused, and goal-oriented.
• Experience working in or alongside an early-stage, high-growth company is a plus. Comfort operating in an environment where structure is still being built is essential. Self-motivated, proactive, and able to manage multiple priorities against tight timelines.

Essential Physical Characteristics

The physical characteristics described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable qualified individuals with disabilities to perform the essential functions of a job, on a case-by-case basis.

• Frequent sitting, standing, and walking during customer meetings, trade shows, and extended travel.
• Repetitive use of hands to operate computers, mobile devices, and presentation equipment.
• Ability to carry and transport sales materials and samples weighing up to 30 pounds.
• Frequent domestic and international air travel.
• Ability to navigate diverse physical environments including manufacturing facilities, trade show floors, and customer offices.

Condition of Employment

As part of Debut’s pre-employment process, prospective candidates will undergo a background check prior to beginning employment. Additional types of background investigations may be conducted based on the job-related activities of the position.

Debut is an equal opportunity employer. All applicants will be considered for employment without attention to age, nationality, sex, marital status, pregnancy status, caregiving responsibilities, race, religion, language, disability, or mental health conditions. Employment decisions at Debut are based on merit, qualifications, and business needs.

Who We are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description: 

Calico is seeking an experienced Process Chemist to join our laboratory-based chemical development team. The ideal candidate brings extensive hands-on experience in process research, route scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable efficient, safe, and scalable manufacturing of small-molecule intermediates and APIs. This is a lab-focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings into robust processes. 

Key Responsibilities: 

• Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates
• Perform laboratory experiments to improve yields, selectivity, throughput, and impurity control
• Conduct detailed reaction analysis using, HPLC, GC, LC-MS, and other analytical techniques
• Perform impurity identification and synthesis
• Identify and mitigate process risks related to safety, scalability, and robustness
• Collaborate with cross-functional partners including analytical chemistry, formulations, and quality assurance 
• Prepare clear, data-driven reports and present experimental results to project teams
• Support technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions
• Maintain accurate lab documentation and adhere to all safety and compliance standards

Position Requirements: 

• PhD in Organic Chemistry or related field with 8+ years of relevant industrial experience in process chemistry
• Strong expertise in synthetic organic chemistry and reaction mechanism fundamentals
• Demonstrated success in developing scalable synthetic processes
• Proficiency with standard analytical instruments and data interpretation
• Excellent problem-solving, organization, and communication skills
• Ability to work independently while contributing effectively to a team environment
• Familiarity with cGMP and ICH guidelines 
• Strong attention to detail and a commitment to high-quality experimentation
• Ability to manage multiple projects and shifting priorities
• A proactive, collaborative mindset with enthusiasm for process improvement
• Must be willing to work onsite 5 days a week

The estimated base salary range for this role is $198,000 - $241,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

What You’ll Do: We are searching for a highly motivated Medicinal Chemist to join our drug discovery team at the Associate Director level.  Reporting to the Executive Director of Chemistry, the candidate will be expected to co-lead, or lead, preclinical medicinal chemistry programs from hit to candidate nomination. A highly qualified candidate will have experience in CNS drug discovery and an in-depth understanding of designing efficacious and safe brain-penetrant small molecules. While MapLight has in-house laboratories for pre-clinical research, many activities like chemical synthesis are outsourced to external vendors. Experience managing remote CRO teams, logistics across multiple partners, and coordinating internal drug discovery activities across different time zones is essential. This is a fantastic opportunity to join a small medicinal chemistry team and have a significant impact in addressing unmet patient needs by advancing MapLight’s pipeline.

Responsibilities:

• Co-lead, or lead, preclinical medicinal chemistry programs from hit to candidate nomination.
• Design and execute successful medicinal chemistry strategies to meet project and corporate goals.
• Conduct multi-parameter optimization to deliver orally bioavailable, brain-penetrant candidates without secondary pharmacology, ADME, or safety concerns of initial hits.
• Apply structure-based drug design principles utilizing in-house resources and external computational partners.
• Manage chemistry and tiered screening cascade at external contract research organizations (CROs).  This includes maintaining a good relationship, overseeing synthesis or experimental plans, project tracking, evaluation of results, and assisting in troubleshooting. May require assessment of analytical data including NMR, LCMS, HPLC, UV-VIS, and DSC.
• Apply previous experience with successful hit finding strategies to find novel chemical equity, including scaffold-hopping approaches.
• Coordinate with in-house drug discovery team to ensure compounds are distributed in support of other disciplines.
• Provide regular project updates to Leadership and Project Teams that include relevant updates. May include in-depth SAR, ADME, and PK analyses.
• Co-lead, or lead, patent strategy to protect existing or novel chemical matter with Maplight legal partners, when appropriate.
• You can participate and work effectively with multiple cross-functional teams.
• You have strong interpersonal skills and understand relationships are key to being successful.
• You are a leader. Teams love working with you, and you are someone who takes pride in mentoring and supporting the careers of others.
• You’re a team player who is willing to roll-up your sleeves and get the job done.

Qualifications:

• PhD in Chemistry or Medicinal Chemistry with 10+ years’, or BS/MS 15+ years’, pharmaceutical experience successfully (co)leading preclinical drug discovery programs. 
• Contemporary knowledge of Medicinal Chemistry concepts with strong working knowledge of computational chemistry, biology, pharmacology, drug metabolism, and pharmacokinetics.
• Prior experience in CNS drug discovery is essential, including a successful track record of delivering brain-penetrant candidate compounds for brain disorders.
• Track record of successfully managing projects remotely through multiple and CRO partners.
• Clear record of accomplishments as exemplified through patents and/or publications.

Travel: Candidate can expect to travel 4-6 times a year to meet with collaborators and/or attend both discovery and all-company meetings.

Location: This is a hybrid position with three days per week onsite at our office in Burlington, MA. 

Location: Pensacola, FL

Position Summary

The Analytical Development Chemist will develop and validate analytical methods, provide analytical support for product development, and design, write, and execute technical documents such as protocols and reports. This role will serve as a subject matter expert for analytical methods and technical writing. 

Compensation & Benefits 

• Employee Ownership (ESOP): Company-funded retirement contribution of approximately 18% of pay, plus 401(k) 
• Competitive base salary with performance-based bonus opportunity 
• Comprehensive benefits package: Medical, Dental, Vision, Life, Disability, FSA, and Pet Insurance 
• Generous paid time off, paid holidays, and parental leave 
• Fitness and tuition reimbursement programs 

Essential Duties & Responsibilities

• Responsible for development and validation of analytical methods (Assay, Impurities, Dissolution, Cleaning, and Residual Solvents). 
• Designs, writes, and executes method validation protocols, reports, and other technical documents in accordance with current industry standards as well as regulatory requirements, i.e. FDA, USP, EP. 
• Coordinate validation projects and ensure all validation documentation is finalized, current and archived as required. 
• Oversee development of analytical services projects including formulations support to stability and validation. 
• Must be able to understand and interpret data from formulation design to in-vitro/in-vivo performance and design experiments to support product development. 
• Must be able to understand the purpose and objective of the studies to appropriately design laboratory experiments and protocols 
• Coordinates analytical method transfer and training of testing with the Quality Control Laboratory and serves as a technical resource for investigations. 
• All other tasks as requested or assigned. 

Required Qualifications

• Bachelor’s or master’s degree in chemistry or related field.  PhD preferred. 
• Experience: 3+ years required with advanced degree (research or work experience) work experience with BS degree experience in pharmaceutical analytical method development and validations.  
• Proficient in data analysis including raw data review and interpreting results.  
• Strong writing and documentation skills (cGMP, protocols, reports, OOS investigations, lab notebooks) 
• Proficient with Microsoft Office Suite (Word, Excel, Outlook) 
• Familiar with using QMS systems (i.e., Empower, Master Control) 
  

Preferred Qualifications

• Experience: prefer 5+ years’ work experience with BS degree experience in pharmaceutical analytical method development and validations.  
• Experience in HPLC, Dissolution, UV-Vis, GC, Cleaning Validations, Empower, and compendial (USP, FCC, EP) testing preferred. 

Work Environment & Culture 

PBI-Gordon Companies offers a collaborative, employee-owned environment where accountability, partnership, and continuous improvement are valued. Team members are encouraged to contribute ideas, develop professionally, and grow their careers alongside the business. 

Equal Opportunity Employer 

PBI-Gordon Companies is an Equal Opportunity Employer. We value diversity and are committed to creating an inclusive environment for all employees. 

Ready to Apply? 

If you're passionate about pharmaceutical analytical method development and validation, data analysis and technical writing, and working in a cGMP-regulated environment, we'd love to hear from you.

Apply today to join an employee-owned company committed to scientific excellence, collaboration, and shared success.

The Opportunity:

General Purpose 

The Senior Director, Head Pharmacist/Responsible Pharmacist guarantees the pharmaceutical responsibility of the laboratory as “exploitant” (see definition of the “exploitant”, Article R.5124-2, 3 ° of the French Public Health Code) and assumes the role of "Responsible Pharmacist" as described in Article R.5124-36 of the Public Health Code. Responsibilities include:

• Organize and supervise all pharmaceutical operations of the company or organization, including manufacturing, advertising, information, pharmacovigilance, batch monitoring and withdrawal, distribution, import and export of the drugs, products, objects or articles concerned, as well as the corresponding storage operations.

• Ensure that transport conditions guarantee the proper preservation, integrity and safety of these medicines, products, objects or articles.

• Acknowledge the files related to marketing authorization applications submitted by Corporate or organization and any other application related to the activities they organize and supervise.

• Participate in the development of research and study programs.

• Imperson authority over delegate and deputy pharmacists; approve their hiring and be consulted on their dismissal, except in the case of an army pharmacist-chemist.

• Appoint interim delegate pharmacists.

• Inform the other directors of the company or organization of any obstacle or limitation to the exercise of these powers.

• Implement all necessary means to comply with the obligations set out in articles R. 5124-48 and R. 5124-48-1;

• In the case of medicinal products intended to be marketed in the territory, he(she) ensures that the safety measures referred to in article R. 5121-138-1 have been affixed to the packaging in accordance with the conditions set out in articles R. 5121-138-1 to R. 5121-138-4;

• Notify the Agence nationale de sécurité du médicament et des produits de santé (ANSM : French National Agency for the Safety of Medicines and Health Products) of any launching on the national market of a medicinal product which is considered to be falsified within the provisions of article L. 5111-3, and for which they are responsible for the manufacture, exploitation and distribution.

They organize the quality system within the laboratory in accordance with French laws and regulations (good distribution practices, good pharmacovigilance practices, good manufacturing practices) and laboratory requirements.

They also support the transversal activities carried out by the marketing, medical, compliance and market access departments.

The Senior Director, Head Pharmacist/Responsible Pharmacist, France takes part in the deliberations of the management, administrative, executive or supervisory bodies, or those of any other body with an executive function, of the company or organization, when these deliberations concern or may affect the performance of the tasks falling under his/her responsibility as described above.

The RP is responsible for ensuring compliance with professional ethics and all regulations issued in the interests of public health. He/she must also ensure that the responsibilities of pharmacists and staff under his/her authority are clearly defined.

In accordance with articles L. 5121-14-3, R. 5121-152 and L. 5121-164 of the French Public Health Code, the RP ensures that pharmacovigilance cases are reviewed and processed within the appropriate timeframes.

In accordance with article L5121-9-2 of the French Public Health Code, the RP immediately informs the French National Agency for the Safety of Medicines and Health Products of any prohibition or restriction imposed by the competent authority of any country in which the medicinal product for human use is marketed, and of any other new information likely to influence the evaluation of the benefits and risks of the medicinal product for human use or the product concerned.

In addition, the Responsible Pharmacist also has knowledge of :

• the role of professional bodies and organizations that regulate those who supply medical products to the public.

• the ANSM's role in handling controlled drugs.

• the role of the European Medicines Agency (EMA) and the use of EUDRAGMDP.

• the Directive on Falsified Medicines.

• the principles and guidelines of good manufacturing practice, and how GMP/GDP principles maintain product quality throughout the distribution chain.

Responsibilities

In the performance of the duties, the Employee is responsible for the following tasks in French territory:

Regulatory Affairs:

• Submission and obtaining the opening authorization application for the “Exploitant” pharmaceutical establishment.

• Filling and submission of the annual facility master file (once a year).

• Relationships with the Health competent authority – the French Agency for the Safety of Medicines and Health Products (ANSM).

• Participation in the management of early access programs.

• Monitoring of drug marketing (declaration to the health authority of the date of initial marketing, reporting of prohibition or restriction decisions or any information likely to influence the benefit/risk assessment).

• Validation of the Advertising and Medical Information process.

• Participation in pharmaceutical document archiving management.

• Implementation of the Regulatory Intelligence process.

• Supervision of pharmaceutical contracts (head office and outsourced activities).

Quality Assurance/Supply Chain:

• Regular audits of internal pharmaceutical activities (distribution, medical information, promotion processes, claims, pharmacovigilance processes, etc.).

• Implementation of a risk management approach (document management, claims, audits, continuous improvement, premises, suppliers, shortages, etc.) and business continuity plan.

• Implementation of change control management process following regulatory approvals (marketing authorization, variations, risk management plan, etc.).

• Participation in audits and inspections by authorities (ANSM, etc.).

• Follow-up of batch release for distribution in France and tracking/traceability.

• Management of batch recalls with the marketing authorization holder, the health authority and distribution stakeholders.

• Management of shortages with the health authority.

• Storage and distribution management.

• Management of quality complaints.

• Implementation of procedures (SOP).

• Implementation of compliance with the French Charter of Promotional Information and its Guidance.

• Implementing quality compliance:

• Planning, execution and follow-up of audits.

• Implementation of KPIs (definition, collection and analysis of KPIs for key pharmaceutical activities).

Pharmacovigilance and drug safety management:

• Implementation of the local pharmacovigilance process.

• Nomination of local Qualified Persons responsible for Pharmacovigilance.

• Interaction with European Qualified Person responsible for Pharmacovigilance (QPPV); Global Patient Safety Department (GPS)and PV database.

• Procedures and data management.

• Report to Competent authorities.

• Collection, registration, assessment, report and follow-up of adverse events.

• Screening of local scientific and medical literature for pharmacovigilance relevant information.

• Local Signal detection.

• Review and validation of Periodic Safety Update Report (PSUR).

• Reconciliation of shared PV data.

• Implementation of key performance indicators (KPI).

• Monitoring of product good use and off-label use, and declaration to competent authorities if applicable.

Medical information management:

• Implementation of medical information process in collaboration with the Medical information department (data management, standard responses, access to literature database).

• Collection, registration and response to medical information requests.

• Reconciliation of shared medical information data.

• Implementation of KPI.

Advertising and promotional information:

Promotional and non-promotional material review and approval.

Review and submission to Health authority of promotional material.

Approval and dissemination of the positive list.

Logistical management of material with traceability (withdrawal, archiving, etc.).

Personnel training:

• Implementation of a local training process for pharmaceutical and compliance processes.

• Review and validation of training material for commercial and medical teams.

• Validation of integration and ongoing staff training plans, and monitoring of training plans.

• Ensuring that all staff are trained in Good Practices, their own tasks, product identification, risks of drug falsification and specific training for products requiring more rigorous handling.

• Competency assessment and empowerment of key personnel.

Participation to Compliance management:

• Participation to implementation of French law about anti-bribery, transparency and compliance of interaction with HCPs and HCOs.

• Participation to legal review of agreements with healthcare professionals, hospitals, organizations, etc.

Management of the Pharmaceutical Affairs Department in France

• Team leadership, development and management;

• Recruitment, training and development of team members;

• Follow-up of team objectives.

The above list of tasks is not exhaustive.

Required Skills, Experience and Education:

• Doctor in pharmacy and able to be registered as Responsible Pharmacist.

• Specialization in regulatory affairs and quality.

• Minimum 15 years of proven experience in leadership roles within the biopharmaceutical industry in the field of oncology.

• Fluency in both verbal and written French and English.

• Proven leadership and people management capabilities; demonstrated success in small but fast growing, entrepreneurial commercial environment.

• High capacity of social competence for teamwork, coaching and situational leadership.

• Proven track record shaping and executing country strategy and influencing policy at a senior industry level.

• In-depth knowledge of the French pharmaceutical market and regulatory environment.

• Ability to create and nurture a strong culture of collaboration and authenticity to extend and replicate the RevMed culture.

• Proven success in building effective relationships with internal stakeholders, regional authorities, and vendors.

• Highly organized and motivated individual possessing excellent communication, presentation and interpersonal skills.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com. 

#LI-Remote #LI-LO1

CHEMIST (STARLINK PCB)

SpaceX is developing a low-latency, broadband internet system to meet the needs of consumers worldwide. Enabled by a constellation of low Earth orbit satellites, Starlink will provide fast, reliable internet to populations with little or no connectivity, including those in rural communities and places where existing services are too expensive or unreliable. We are looking for talented, creative, and driven technicians to drive manufacturing output and yield.  You will have ownership of one or more process areas and will have the opportunity to directly impact Starlink’s products.  You will have frequent interaction with engineering teams and leadership and will participate in developing and validating new equipment, processes, and technologies. The success of Starlink depends on the quality, reliability, cost, manufacturability, throughput, security, and user experience of the products that you will manufacture.

As a PCB Chemical Lab Technician, you will be working in a chemical and materials lab supporting printed circuit board manufacturing in the Starlink factory. This is a versatile and highly skilled, hands-on lab role that will involve performing chemical analysis and additions, as well as executing reliability test methods, while meeting goals for output and quality. The ideal candidate is comfortable working in an analytical lab setting within a manufacturing environment and is motivated by Starlink’s mission to provide high-speed, low latency connectivity across the globe.

RESPONSIBILITIES

• Execute test methods and perform chemical analysis to support state-of-the-art PCB production lines
• Work with engineers to develop and document test procedures
• Recommend improvements to lab processes and work with engineers to develop, implement, and refine processes with a specific focus on reducing cost and downtime and increasing yield
• Provide feedback on failure modes and support engineering to drive root cause of yield limiters
• Execute start-up and shutdown procedures for lab equipment
• Track schedule for and perform preventive maintenance and calibration of equipment and instruments
• Perform first level troubleshooting, provide feedback, and work with maintenance and engineering teams to drive root cause of equipment downtime
• Ensure lab equipment is maintained and calibrated
• Clean chemical processing equipment and tools
• Maintain inventory of consumables
• Safely handle chemicals (including transporting and loading) and chemical handling equipment
• Collect, segregate, and transport waste from generation points to the hazardous waste storage area
• Read, interpret, and follow technical documents
• Ensure 5S standards are upheld by maintaining a clean and organized work area
• Cross train on microsection analysis

BASIC QUALIFICATIONS:

• High school diploma or equivalency certification
• 1+ years hands-on chemical testing or Associate's degree 

PREFERRED SKILLS AND EXPERIENCE:

• Bachelor's or Associate's degree in a STEM field
• Strong desire to expand technical knowledge
• Experience in a wet chemistry lab performing titrations, photometry, atomic absorption spectroscopy, or similar tests
• Experience performing electrochemical analyses (i.e., CVS)
• Previous experience performing PCB fabrication quality analyses
• Familiarity with PCB failure modes (IPC-A-600, IPC-6012)
• Experience working with LIMS software
• Experience handling flammable, toxic, corrosive, or hazardous chemicals
• Strong interpersonal, verbal, and written communication skills to work closely with engineering, other technicians, and cross-functional teams
• Ability to identify and maintain priorities for tasks and projects while staying organized
• Ability to rapidly change roles/responsibilities while working independently in a high-paced, challenging work environment with minimal oversight

ADDITIONAL REQUIREMENTS:

• Must be open to work all shifts, overtime and/or weekends as needed
• Due to the nature of production line bring-up, the work schedule will evolve
  • Will start as 5 AM - 5 PM (Monday - Thursday) 
  • Final permanent schedule: B-Shift: 5 AM - 5 PM (Thursday - Saturday and every other Wednesday)
• Must be able to lift up to of 25 lbs. unassisted
• Must be able to walk and stand for long periods of time
• Must be comfortable working in a production environment with extensive use of hazardous chemicals such as acids, alkalis, and solvents
• Must be able to wear appropriate PPE for lab and electro-chemical manufacturing environment
• Must be comfortable with climbing up and down ladders, grasping, standing, lifting, bending, pulling, pushing, stooping, stretching, carrying, crawling, and maneuvering in tight spaces

Your Impact at LILA

The Scientist I/II, Organic Chemistry will develop, execute, and optimize modern chemical transformations that support Discovery Chemistry efforts across Lila’s platform, with a focus on the rapid synthesis of small molecules and structurally diverse chemical matter. This role is intended for an experimental organic chemist who combines strong foundations in synthetic chemistry with hands-on experience in high-throughput experimentation (HTE), reaction workup, and analytical characterization.

Working closely with Discovery Chemistry, analytical chemistry, automation, screening, and AI/computational teams, this scientist will help build and apply efficient chemistry workflows that accelerate molecular design–make–test–analyze cycles. The Scientist II will contribute to reaction development, analog generation, and route execution using modern organic chemistry approaches that are compatible with scalable, data-rich, and increasingly automated discovery environments.

This role is ideal for a chemist excited by solving synthetic problems at the interface of reaction innovation, high-throughput experimentation, process efficiency, and analytical insight, and who is motivated to help shape next-generation discovery workflows beyond traditional bench chemistry.

What You'll Be Building

• Design, execute, and optimize chemical transformations relevant to Discovery Chemistry programs, with emphasis on the rapid synthesis of small molecules and analog series.
• Apply modern synthetic organic chemistry to enable efficient exploration of structurally diverse and medicinally relevant chemical space.
• Plan and perform multi-step synthesis, reaction optimization, workup, purification, and compound characterization in support of molecular discovery campaigns.
• Design and execute HTE workflows for reaction screening, condition optimization, reagent evaluation, and rapid assessment of transformation scope.
• Develop robust approaches for reaction setup, reaction workup, sample preparation, and analytical readout to support fast and information-rich experimentation.
• Use analytical tools such as chromatography, NMR, and related methods to assess reaction performance, characterize products, and guide synthetic decisions.
• Contribute to the development of practical and scalable chemistry workflows that integrate reaction discovery, reaction optimization, and downstream compound generation.
• Partner closely with Discovery Chemistry scientists to translate molecular design concepts into executable synthetic strategies and experimentally tractable reaction plans.
• Collaborate with analytical chemistry and automation teams to build workflows that connect reaction execution with streamlined workup, purification, and data generation.
• Support the adaptation of synthetic workflows to parallel, automated, or robotics-enabled platforms where appropriate.
• Interpret reaction and analytical data rigorously, identify bottlenecks, and propose solutions to improve efficiency, robustness, and reproducibility.

What You’ll Need to Succeed

• PhD in Organic Chemistry, Medicinal Chemistry, or a closely related discipline with relevant postdoctoral and/or industry experience.
• Strong expertise in synthetic organic chemistry, including design and execution of multi-step synthesis and development of chemical transformations relevant to small molecule discovery.
• Hands-on experience with HTE for reaction screening, optimization, or scope evaluation.
• Experience with reaction workup, sample preparation, purification, and analytical characterization in fast-paced synthetic workflows.
• Strong working knowledge of analytical methods commonly used to support organic synthesis.
• Demonstrated ability to troubleshoot challenging reactions and independently solve synthetic and experimental problems.
• Strong understanding of how reaction design, execution, workup, and analysis fit together in efficient discovery workflows.
• Ability to work effectively in interdisciplinary environments spanning chemistry, analytics, automation, and computational sciences.
• Strong organizational, documentation, and communication skills, with commitment to scientific rigor and reproducibility.

Bonus Points For

• Experience supporting Discovery Chemistry or medicinal chemistry programs in biotech, pharma, or advanced research environments.
• Familiarity with modern reaction classes relevant to small molecule discovery, including coupling chemistry, heterocycle synthesis, late-stage functionalization, and rapid analog generation.
• Experience with parallel synthesis or robotics-enabled chemistry workflows.
• Exposure to data-rich, AI-enabled, or platform-based R&D environments.
• Collaborative mindset and enthusiasm for building modern chemistry capabilities that go beyond traditional bench-scale synthesis.

The Impact You’ll Make

We are seeking an experienced Senior Scientist in Automation/Medicinal Chemistry to accelerate our internal and partnership drug discovery portfolio. This role, bridging AI-enabled design and cutting-edge automated synthesis, is central to our mission. 

Operating our Milton Park site, you will take ownership for delivery of compounds through our state-of-the-art Automation Studio and, by collaborating closely with drug designers, drive impactful outcomes for drug discovery programs within our pipeline.

You will have a track record of leadership from the lab, and combine deep medicinal and synthetic chemistry expertise with a commitment to modernizing the drug discovery process. A self-starter who can lead effectively from the bench and operate strategically.

In this role, you will:

• Design, prioritise, and tactically execute synthetic routes for small‑molecule targets, strategically using our Chemistry Automation Platform, our well-equipped traditional synthesis laboratories and CRO support to meet project goals on tight timelines.
• Build a strong collaborative partnership with computational and medicinal chemists to use the full capabilities of both the Centaur Chemist (design) and Chemistry Automation (synthesis) platforms including optimising methodologies, workflows, and best practices. 
• Adapt core synthetic medicinal chemistry tactics onto the automation platform by collaborating with software developers and module owners, validating feasibility, defining safe and scalable conditions, and documenting processes clearly for reuse.
• Act as primary medicinal chemist supporting a drug discovery project accountable for deliverables and ensuring successful outcomes, working with a senior project lead for program‑level strategy.

The Team You’ll Join 

You’ll join the Milton Park based Chemistry Automation group, a multidisciplinary team of chemists and automation specialists who partner closely with discovery and platform teams across Recursion. The group operates a state-of-the-art Chemistry Automation Platform supported by well-equipped synthesis and spectroscopy laboratories, that combines automated synthesis and purification, high-throughput experimentation, and integrated analytical workflows to deliver high-quality small-molecule synthesis for our discovery portfolio.

You will work closely with the drug design groups as part of the wider chemistry function, and be embedded into a program team tasked with advancing internal or partnership drug discovery programs leveraging the Recursion platform. 

The Experience You’ll Need

• Ph.D. in Organic or Medicinal Chemistry, or a BSc/MSc degree with equivalent industry experience. In addition, significant relevant industry experience and evidence of impact.
• Proven ability to design, prioritize, and tactically execute small molecule drug discovery, including expertise in route design, optimising challenging reaction conditions and prosecuting medicinal chemistry with automated synthesis.
• Experience in the application of automation in synthesis in an industrial setting (e.g. use of liquid handling or powder dispensing for library synthesis, HTE for reaction optimisation, flow chemistry) with enthusiasm to work directly with automated systems.
• Excellent interpersonal and communication skills, both written and verbal, with ability to influence and work cross-functionally to ensure alignment on priorities, facilitating collaboration. 
• Fluency in modern medicinal and computational chemistry software tools such as workflow builders, basic cheminformatics packages, structure based design and data visualisation tools.

Working Location & Compensation:

This is a lab-based role in our Milton Park site. Employees are expected to work on-site 100% of the time, with occasional flexibility.

At Recursion, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role, the estimated current annual base range for this role is £70,400 to £93,500. You will also be eligible for an annual bonus and equity compensation, as well as a comprehensive benefits package. 

#LI-DB1

The Impact You’ll Make

We are growing our chemistry team at Recursion and are seeking a Research Synthetic Chemist to join our Automated Chemistry group. We are looking for an individual that thrives in a dynamic and collaborative team environment and successfully adopts new technologies and workflows to accelerate drug discovery.

You will independently convert synthesis requests into structured experimental plans for our state-of-the-art Chemistry Automation platform. You will collaborate with other scientists and automation specialists with our chemistry team to meet project deadlines by providing hands-on experimental support and take ownership of your experimental work to deliver compounds and reaction data. 

With structured training and drawing on previous experience of lab automation or methodology development, you will develop deep familiarity with the Chemistry Automation Platform and workflow software, and be able to propose, develop and translate new methodologies onto the automated platform in collaboration with senior chemists and automation engineers. 

In this role, you will:

• Execute synthetic routes by seamlessly integrating traditional laboratory techniques with our automated chemistry platforms to deliver high-quality compounds independently for drug discovery projects.
• Translate synthetic methods to the automation platform utilising critical thinking and your technical knowledge of chemical reactivity and methodology development. 
• Learn how to diagnose and resolve chemical or procedural issues within our automated workflows seeking assistance from automation specialists where needed.
• Collaborate with teams at the interface of automated chemistry, medicinal chemistry, software and hardware engineering to develop our platform and tools to better serve patients
• Champion a culture of laboratory excellence by taking a proactive approach to HSE (Health, Safety, and Environment) standards and maintaining a high-performance lab environment. 

The Team You’ll Join 

As a core member of Recursion’s Automated Chemistry team, you will join a multidisciplinary group of highly skilled scientists and engineers. This team operates at the technological cutting edge, focusing on the application of automation and advanced cheminformatics tools to synthetic organic chemistry in support of our medicinal chemistry programmes.

The Experience You’ll Need

• A PhD in Synthetic Organic Chemistry or BS/MSc degree in Chemistry (with equivalent experience) and experience of performing synthetic organic chemistry in an industrial setting.
• Adept at safely planning and executing chemical synthesis for medicinal chemistry or equivalent applications delivering high quality contributions in an independent manner.
• Demonstrable experience of adopting computational tools, new software or lab automation with a positive impact on throughput or data quality.
• Strong communication skills, ensuring clear and concise information exchange with peers and key stakeholders.

Preferred

• Exposure to automation in synthesis (e.g., liquid handling, HTE, powder dispensing, parallel synthesis, or flow), even if not yet the primary focus of your role.
• Experience supporting library expansions or direct-to-biology in a medicinal chemistry or discovery context.

Working Location & Compensation:

This position is based at our office located in Milton Park (Bell Labs), UK. We operate a hybrid environment, but this lab‑based role requires the majority of time onsite to perform hands‑on experimental work and collaborate directly with the Automation Chemistry team. Specific onsite expectations can be discussed during the hiring process.

At Recursion, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role, the estimated current annual base range for this role is £52,000 to £70,400. You will also be eligible for an annual bonus and equity compensation, as well as a comprehensive benefits package. 

#LI-DB1

The Impact You’ll Make

At Recursion, we are reimagining drug discovery through a powerful synthesis of AI, automation, and deep scientific expertise. In this role, you will be the bridge between complex chemical data and the strategic systems that power our discovery programs. Your primary focus will be building the tools and infrastructure that support our computational designers and medicinal chemists in making data-driven decisions for the next steps in discovery programs. You will expose analytics that help us further automate the platform by closing the Design-Make-Test-Learn (DMTL) loop to accelerate the design process.

You will have high-level ownership of our analytical ecosystem—including the Spotfire library, data schemas, and automation services—transforming complex datasets into directed platform improvements. You will be at the center of our DMTL loop, creating the tools that empower our scientists to design novel, high-quality drug candidates with unparalleled speed and precision. Your work will directly accelerate our portfolio, drive our partnerships, and contribute to our mission of decoding biology to radically improve lives.

In this role, you will:

• Build and maintain integrated project dashboards that serve as a core resource for design teams by syncing assay results with cross-functional portfolio data.
• Code and manage robust repositories for Spotfire automation and BigQuery integration to streamline the flow of data across the discovery lifecycle.
• Design and evolve metrics and predictive modeling workflows that inform "next-best" design recommendations and track project progress through the discovery lifecycle.
• Create automated reporting pipelines to proactively surface critical signals, ensuring project teams can take timely action on new scientific data.
• Collaborate cross-functionally to translate strategic objectives into scalable analytical tools, using adoption metrics to prioritize features that deliver the greatest impact.
• Define and analyze metrics for product success, tool adoption, and scientific impact to ensure teams are focused on critical priorities for accelerating drug discovery.
• Identify and innovate on gaps in analytics maturity, taking responsibility for implementing solutions that modernize how our scientists interact with data.
• Contribute to the development of Agentic AI systems that leverage our data infrastructure to automate and enhance the understanding of Structure-Activity Relationships (SAR).

The Team You’ll Join 

You will be a core member of the Design Workflow team, an interdisciplinary group responsible for the end-to-end development and operation of our molecular design platform. We are the orchestration engine for the Hit-to-Lead (H2L) and Lead Optimization (LO) phases of drug discovery. Our team embodies a “Build & Operate” philosophy, intentionally integrating the development of the Recursion OS with its direct application in advancing our portfolio.

The Experience You’ll Need

• Expert-level proficiency in TIBCO Spotfire development, including experience managing automation services and measuring tool adoption through action logs.
• Advanced engineering foundation in Python, BigQuery, and Prefect, with a track record of maintaining production-level repositories via Git.
• Experience in a major cloud provider (Google Cloud Platform preferred) to support scalable data infrastructure.
• Scientific domain knowledge of the drug discovery lifecycle and the specific data products required to support end-to-end chemist workflows.
• Proven ability to synthesize data from multiple domains—such as lab informatics, chemistry, and portfolio management—into clear, execution-ready recommendations.
• Exceptional systems-thinking and communication skills, with the ability to deconstruct complex scientific workflows and identify key leverage points.
• Practical experience with AI/ML frameworks applied to drug discovery and the development of agentic systems to automate complex scientific reasoning and SAR analysis.
• Degree in a relevant field (Chemistry, Cheminformatics, Engineering, or Computer Science) with significant professional experience in a biotech or pharmaceutical R&D setting.

Working Location & Compensation:

This is an office-based, hybrid role in our London office. Employees are expected to work in the office at least 50% of the time.

At Recursion, we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role, the estimated current annual base range for this role is £75,900 - £101,900. You will also be eligible for an annual bonus and equity compensation, as well as a comprehensive benefits package. 

#LI-EP1

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an experienced medicinal chemist with chemical biology training to be a founding member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include: supervising synthetic efforts with our CROs, performing and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Applicant must be able to work fluently at the interface of chemistry and biology.
• Top-notch written and oral communication skills.

• Strong experience with:
  • Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
  • Contributing to hit-to-lead and lead optimization studies
  • Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK
  • Applicant must have experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistry
    

• Nice to have:
  • Proficiency in HTS and phenotypic assay development
  • Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
  • Computational or molecular dynamics drug discovery experience
  • DEL experience
  • Experience managing others, especially synthetic chemistry CRO teams
  • Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. 
• Reading budget! We will buy you books. 📚
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio

Summary of Position

This individual supports various departments within Imbibe by providing analytical chemistry support to the Research & Development, Quality Control, and Operations teams.  Their focus will be on GC operations, capability improvements, and building critical databases for ongoing production.

Essential Job Duties

• Primarily responsible for the execution of methods for the analysis of raw materials, flavors, and finished goods. Execute methods for the analysis of food and flavor-related samples using chromatography (GC/MS, UHPLC), solvent extraction, headspace extraction, SPME, etc.
• Perform analytical testing of volatile and non-volatile components in foods, beverages, flavors, extracts, and essences.
• Performs analysis of raw materials used in the manufacture of flavors for both their purity and for an identification and internal library mapping.
• Train in method development for the analysis of food and flavor-related samples using chromatography (GC/MS, UHPLC), solvent extraction, headspace extraction, SPME, etc.
• Learn chromatographic methods for use in identifying and quantifying flavor materials.
• Provide detailed, well-reviewed volatile analysis results using Agilent Chemstation and Excel reporting.
• Engage with other departments, both within and outside of R&D, to promote existing capabilities as well as determine areas for improvement.
• Performs routine and non-routine maintenance, troubleshoots, and resolves equipment malfunctions as they arise on analytical chromatography equipment while providing support to ensure that analytical laboratory equipment is maintained in proper working order.
• Coordinates maintenance from outside vendors as needed.
• Work with Senior Analytical Chemist to coordinate and improve flavor analysis methods within R&D and QC.
• Coordinate testing methodologies between internal lab, customer labs and/or third-party labs.
• Manage day-to-day laboratory operations: workflow for all analysis, ordering of supplies, lab organization, safety, and cleanliness.
• Performs all duties following established laboratory procedures and establishes and documents new procedures as necessary.
• Possesses excellent presentation and communication skills, effectively translating analytical results into business drivers.
• Conduct independent research to keep abreast of scientific advances in the areas of analytical and flavor chemistry.

Minimum Qualifications

• S. degree in chemistry, biochemistry, or related field
• 0-2 years of experience with quantitative chemical analysis and creating analytical methodologies.
• Familiar with laboratory experimentation and data analysis skills
• This position requires the handling of food grade chemicals and ingredients for food and beverage with strong odors.
• This position requires the use of personal protective equipment and clothing, including but not limited to lab coats, safety glasses, gloves, face masks, respirators, ear protection, etc.
• Must be able to sit, stand, or remain in a stationary position for extended periods of time.
• May occasionally need to move, lift, or transport containers of ingredients weighing up to 50 lbs.
• Exposure to food and beverage product tastings which may include allergens.

Preferred Qualifications

• Experience with the following equipment and software:
  • GC/MS (GC 6890 MS 5975 With a Gerstel MPS2 Autosampler, Agilent 7890B GC with 5977B MSD and Gerstel Pro 3 Autosampler)
  • U-HPLC (UPLC H-Class Waters with Empower 3 Software)
  • Agilent Chemstation

Working Conditions

• This is a full-time laboratory position
• Typical office setting for most desk work and paperwork including use of standard office equipment.
• Typical food/beverage laboratory and pilot plant setting for all hands-on development work including the use of standard laboratory equipment.

About the Computational Drug Design Team

We are building a dynamic team of Computational Chemists in Cambridge, MA within the Drug Design and Medical Research function. We drive the computational chemistry strategy for our internal portfolio and collaboration projects. Crucially, we partner closely with our AI/ML colleagues, using our domain expertise to augment the Isomorphic Labs Drug Design Engine and leverage its power to accelerate drug design. We foster a supportive, learning-focused environment where every member is valued, and continuous professional development is a priority.

Your Impact

As part of our expansion to Cambridge, MA, we are seeking an experienced and strategic Head of Computational Drug Design to join our foundational Drug Design team. This is a pivotal role for a motivated scientific leader eager to shape the future of drug discovery at the intersection of computational chemistry and artificial intelligence. This role requires a unique blend of deep scientific expertise and the ability to lead both technical projects and high-performing teams, whilst contributing to or leading active drug discovery programs.

You will provide scientific leadership and strategic direction for the Computational Drug Design team, responsible for delivery and guidance of projects to clinical candidate nomination. Additionally, you will oversee and mentor a team of talented Computational Drug Designers, fostering their scientific growth and career development. Working alongside world-leading AI Scientists, you will play a critical role in establishing principles for embedding AI/ML into modern computational chemistry workflows, ensuring seamless integration across ML, Biology, and Chemistry teams.  You will partner with our Head of Chemistry, Drug Design to champion the drug discovery pipeline, overseeing external collaborations (with CROs) and lead programs to deliver critical go/no-go milestones. Critical to this role will be the ability to build highly effective and efficient connectivity with Medicinal Chemistry, Biology and Pre-Clinical Development teams to accelerate pace to the clinic. If you are a skilled Computational Chemist with leadership experience and a passion for applying cutting-edge technology to complex scientific challenges, this role offers an unparalleled opportunity for impact and growth.

What you will do 

• Apply your knowledge and track record of modern drug design and discovery principles to deliver our Drug Design portfolio. 
• Provide direct line management for a growing team of Computational Chemists. Set clear goals, provide regular feedback, support their professional development, and foster a collaborative and high-performance team environment.
• Provide strategic input and technical direction to our AI/ML platform teams. 
• Collaborate both internally and with third party organisations, interacting within multidisciplinary teams, to support data-driven delivery of high quality scientific solutions to complex technical problems. 
• Represent the company externally, interacting with existing and prospective collaborators and Contract Research Organizations (CROs). 
• Prepare detailed scientific proposals and reports to support new and ongoing programs. 
• Embrace and champion our culture of inclusion and continuous professional development.

Skills and Qualifications

Essential:

• PhD in Computational Chemistry, Medicinal Chemistry, Synthetic Chemistry, or a related scientific field, or equivalent industrial experience.
• Solid foundation in computational chemistry with a minimum of 10+ years previous industrial experience within a pharma/biotech/CRO setting.
• Proven experience leading computational chemistry strategy and execution for multiple drug discovery programs and target classes, and managing high-performing scientific teams.
• Prior experience of leading drug discovery programs, from hit finding to lead optimisation and candidate selection.
• Strong expertise in virtual screening, ligand and structure-based drug design using physics-based and ideally AI/ML methods.
• Proven track record of developing models using ML or deep learning methods.
• Expertise in writing and implementing Python scripts for analysis and tool development, and/or utilising pipelining tools to support cheminformatics and design workflows.
• Genuine passion and enthusiasm for applying AI/ML to drug design and how this can transform the field.
• Demonstrated success managing external collaborations (industry/CROs) and working effectively in cross-functional environments.
• Growth mindset, adaptability, and eagerness to learn new concepts and techniques.

Nice to Have:

• Prior experience leveraging machine learning and generative AI methods for hit finding (e.g. ultra-large virtual screening and active learning), molecular design and lead optimisation
• Strong knowledge of drug design principles, including ADMET and DMPK.
• Knowledge of modalities such as PROTACs, molecular glues, PPI inhibitors or ADCs.
• A track record of authorship of relevant scientific manuscripts.

About the Medicinal Drug Design Team

We are building a dynamic team of Medicinal Chemists in Cambridge, MA, to transform how drugs are designed. By partnering deeply with our AI/ML colleagues, we are doing more than just leveraging the Isomorphic Labs Drug Design Engine - we are actively shaping it. We use our domain expertise to challenge and refine our algorithms, creating a powerful symbiotic relationship that drives our internal and collaborative portfolios. Our team work closely together in a supportive environment, where everyone is valued for their medicinal chemistry expertise and experience they bring to the group. We have a strong growth mindset and prioritise continued development and learning.

Your impact 

As part of our expansion to Cambridge, MA, we are seeking an experienced and strategic Head of Chemistry, Drug Design to join our foundational Drug Design team. This is a pivotal role for a motivated scientific leader who is eager to shape the future of drug discovery at the intersection of medicinal chemistry and artificial intelligence. This role requires a unique blend of deep scientific expertise and the ability to lead both technical projects and high-performing teams, whilst contributing to or leading active drug discovery programs.

You will provide scientific leadership and strategic direction for the Medicinal Drug Design team, responsible for delivery and guidance of projects to clinical candidate nomination. Additionally, you will oversee and mentor a team of talented Medicinal Chemists, fostering their scientific growth and career development. Working alongside world-leading AI/ML Scientists, you will play a critical role in driving project success, enhancing our AI platform through expert feedback, and building a high-performing team. Critical to this role will be the ability to build highly effective and efficient connectivity with Computational Drug Design, Biology and Pre-Clinical Development teams to accelerate pace to the clinic. If you are a skilled Medicinal Chemist with leadership experience and a passion for applying cutting-edge technology to complex scientific challenges, this role offers an unparalleled opportunity for impact and growth.

What you will do 

• Apply your knowledge and track record of modern drug design & discovery principles to deliver our Drug Design portfolio. 
• Provide direct line management for a growing team of Medicinal Chemists. Set clear goals, provide regular feedback, support their professional development, and foster a collaborative and high-performance team environment.
• Provide strategic input and technical direction to our AI/ML platform teams. 
• Collaborate both internally and with third party organisations, interacting within multidisciplinary teams, to support data-driven delivery of high quality scientific solutions to complex technical problems. 
• Represent the company externally, interacting with existing and prospective collaborators and Contract Research Organizations (CROs). 
• Effectively manage CRO resource and monitor KPIs to maintain delivery. 
• Prepare detailed scientific proposals and reports to support new and ongoing programs. 
• Embrace and champion our culture of inclusion and continuous professional development. 

Skills and qualifications 

Essential:

• PhD in Synthetic Organic Chemistry, Medicinal Chemistry or a related technical field, or equivalent industrial experience.
• Solid foundation in medicinal chemistry with a minimum of 10+ years previous industrial experience within a pharma/biotech/CRO setting. 
• Proven track record of leading medicinal chemistry efforts on drug discovery projects, demonstrating significant contributions to project progression (ideally from Hit Identification through to Lead Optimization/Candidate Nomination, with familiarity of optimization of Drug Metabolism and Pharmacokinetics (DMPK).
• Demonstrated experience in line management, mentorship, and developing scientific talent.
• Excellent strategic thinking, problem-solving, and decision-making capabilities applied to complex drug discovery challenges.
• Strong strategic thinking, problem-solving, and decision-making capabilities applied to complex drug discovery challenges.
• Experience of working with and closely managing CRO resource. 
• Strong track record of scientific achievement, evidenced by publications, patents, and presentations.
• Genuine passion for drug discovery and enthusiasm for the potential of AI/ML to transform the field.

Nice to have:

• Experience of successful application of fragment-based drug design approaches. 

Who We Are:

Cogent Biosciences is a publicly traded biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent’s lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has exhibited promising initial data across all three trials: APEX in AdvSM, SUMMIT in NonAdvSM, and PEAK in GIST, including an encouraging safety profile across 600+ patients in single-agent and combination dosing. 

The Role: 

We are seeking an Experienced Computational Chemist who thrives at the intersection of molecular modeling, data‑driven decision making, and innovative drug design. In this role, you will directly influence discovery programs by generating actionable structure‑based insights, developing predictive models, and partnering with multidisciplinary teams to guide molecular design from hits to optimized leads. This is a full-time, on-site position based at our R&D facility in Boulder, Colorado.

Responsibilities:

Vast is looking for a Senior Polymer Chemist, reporting to the Non-Metallic Materials & Processes Lead, to support the development of the systems that will be required for the design and build of artificial-gravity human-rated space stations. 

This role supports toxicity and contamination control for Haven-1, ensuring a safe and healthy environment for crew members in orbit. 

This will be a full-time, exempt position located in our Long Beach location. 

Responsibilities: 

• Conduct research on advanced polymer materials-including composites, coatings, and elastomers- with a focus on chemical stability, thermal decomposition, and outgassing/off-gassing behavior under aerospace-relevant conditions
• Operate and maintain analytical instrumentation, including SIFT-MS, TGA, FTIR, and TGA-FTIR
• Calibrate, validate, and optimize performance of analytical instruments; ensure high reliability and data integrity
• Troubleshoot and resolve equipment issues; liaise with vendors, technical support, stakeholders as needed
• Develop, refine, and validate methods for evolved gas analysis (EGA) and real-time volatile detection, including off-gas testing protocols using SIFT-MS
• Collaborate with cross-functional teams, including materials, thermal, and systems engineers, to integrate findings into broader design and testing efforts
• Ensure compliance with internal quality standards, industry best practices, and regulatory requirements related to materials and chemical analysis

Minimum Qualifications:

• Bachelor’s degree in Polymer Chemistry, Analytical Chemistry, or a related field
• 3+ years of industrial or research experience in polymer characterization and analytical method development
• Hands-on experience operating and maintaining TGA, FTIR, GC-MS, HPLC-MS, and SIFT-MS or CIMS instrumentation
• Strong foundation in thermal analysis and gas-phase chemical detection

Preferred Skills & Experience:

• Masters degree or PhD in Polymer Chemistry or Analytical Chemistry preferred 
• Expertise in SIFT-MS, TGA-FTIR, or TGA-MS data acquisition, method development, and result interpretation
• Advanced knowledge of polymer degradation mechanisms and desorption processes
• Experience validating analytical protocols and conducting method development for off-gassing and thermal stability testing
• Familiarity with NASA-STD-6001B for flammability, off-gassing, and material selection of non-metallic materials
• Familiarity with MAPTIS for material screening, evaluation, and compliance
• Strong data analysis skills, including statistical modeling and use of Design of Experiments (DoE)
• Exceptional problem-solving skills and attention to detail
• Proven ability to communicate complex technical findings clearly, both verbally and in writing
• Experience in a fast-paced, multidisciplinary environment, ideally in aerospace, defense, or other highly regulated industries
• Experience with identifying and investigating chemical ionization mechanisms (e.g., proton/electron transfer, adduct formation, dissociative electron transfer, hydride association) relevant to polymer off-gassing and degradation

Additional Requirements:

• Ability to travel up to 10% of the time
• Willingness to work evenings and/or weekends to support critical mission milestones
• Ability to lift up to 25 lbs unassisted
• Specific certifications, as appropriate

About the Role >>> Senior Scientist, Medicinal Chemistry 

As the Senior Scientist, Medicinal Chemistry reporting to the Associate Director of Medicinal Chemistry, you will design and synthesize novel small molecules as part of ongoing research program hit-to-lead and lead optimization efforts. You will have the opportunity for strong scientific collaboration with the internal medicinal chemistry team and will provide scientific oversight of external resources involved in the design and synthesis of novel small molecule drug candidates.  You may lead the organic chemistry function within multidisciplinary project teams to help advance drug discovery projects from inception to the clinic in support of our mission to deliver novel medicines to the cancer patients who need them.  

 This role is based out of our San Francisco Bay Area Laboratory and will require 5% travel. 

 Your work will primarily encompass: 

• Performing hit-to-lead and lead optimization by designing and synthesizing novel small molecules. 
• Supporting and guiding external chemistry resources by designing synthetic strategies, prioritizing targets, and proposing creative solutions to chemistry problems. 
• Advancing novel small molecule hits and lead compounds into clinical candidates by leveraging structure-based drug design, and/or multi-parameter lead optimization. 
• Effectively communicating scientific results and progress. 

And will also include: 

• Collaborating with internal biology and pharmacology teams, CROs, and consultants, including DMPK scientists and CADD experts. 
• Communicating project results and progress to key internal stakeholders. 
• Developing internal talent by providing positive mentorship while fostering a culture of collegiality, accountability, and scientific rigor. 
• Partnering with internal colleagues and external collaborators in cross-functional teams to ensure efficient progression of new compounds through assay workflows. 
• Assisting in writing scientific manuscripts/posters in support of Olema’s publication strategy. 
• Active participation in laboratory safety and environmental initiatives. 

Ideal Candidate Profile >>>  

A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role. 

Knowledge: 

• Ph.D. in Organic or Medicinal Chemistry. 
• Strong knowledge of state-of-the-art synthetic organic chemistry methodology and possess outstanding synthetic trouble-shooting skills. 
• Working knowledge of structure-based drug design as demonstrated by publications or patents. 

Experience: 

• Minimum of 5 years as a medicinal chemist in the pharmaceutical or biotechnology industry. 
• Proven experience collaboration with and supporting external medicinal chemistry FTEs. 
• Demonstrated proficiency in computational modeling software and cheminformatics tools (e.g., Maestro, MOE) 
• Experience with chemical databases such as Dotmatics a plus. 
• Protein Degrader experience a plus. 

Attributes: 

• Have impeccable professional ethics, integrity, and judgment. 
• Self-motivated and enthusiastic; fast learner who can identify project challenges and expeditiously change course as required in a fast-paced organization.  
• Teamwork and collaboration; balances team and individual responsibilities; gives and welcomes feedback; puts success of team above own interests; supports everyone's efforts to succeed; shares expertise with others. 
• Be a “difference maker” in terms of ones’ professionalism and contributions. 
• Strong verbal and scientific writing skills to effectively share information with a wide range of internal and external audiences.

The base pay range for this position is expected to be $160,000-$170,000 annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.

#LI-MT1

WHO WE ARE

          We are a company where people matter. 

          We are family driven. 

          We are financially strong.

          And we are looking for problem-solvers to join our growing team.  

OPPORTUNITY

The primary purpose of this position is to perform required quality control analysis of incoming, manufactured, and outgoing material. Provide technical support to production and sales and ensure all Quality Assurance/Quality Control practices and procedures are followed. This position will uphold the Hydrite “Standards of Excellence” through continuous commitment to customer satisfaction, both internal and external.

SCHEDULE FOR THIS POSITION IS FRIDAY-SUNDAY 5:00am-5:30pm

PRIMARY RESPONSIBILITES 

• Uphold Hydrite’s Standard of Excellence through a continuous commitment to maintain quality facilities and provide quality products and services to internal and external customers.
• Perform required quality control analysis of incoming, manufactured and outgoing materials with authority to make acceptance, production adjustments or rejection decisions.
• Maintain records accurately, neatly, legibly and completely.
• Perform daily laboratory activities to help meet production requirements.
• Perform instrument maintenance, calibrations, quality control checks, solutions preparations and standardization.
• Assist in addressing customer product complaints and returns through investigation and analysis and process laboratory portion of paperwork. Suggest corrective action.
• Assure timely technical support to production in regards to manufacturing adjustments and quality issues.
• Assure timely response of material acceptance/rejection decisions.
• Maintain a clean and neat laboratory at all times; clean glassware.
• Communicate to supervisor concerns about laboratory practices, operational problems, quality trends, etc.
• Perform and complete analysis, projects, analytical developments and revisions of quality policies as assigned by supervisor.
• Promote complete customer satisfaction through quality and service to both external and internal customers
• Perform all duties outlined in relevant SOPs and all other duties to be assigned.
• Participate in RCRA, regulatory, health & safety and process training activities as required. Review changes/additions with your supervisor. Must be RCRA compliant.
• Perform administrative duties which includes the generation, distribution and filing of Certificates of Analysis.
• Maintain analytical capabilities.
• Must manage any wastes in accordance with applicable SOPs, including labeling, storage, and profiling.
• Works with other staff members to maintain workload balances. Provide backup support as necessary.
• Supports effective communication with all Hydrite departments where responsibilities overlap to ensure success of the branch team.

REPORTING STRUCTURE

• This position reports to the QC Manager

EXPERIENCE AND EDUCATIONAL CRITERIA

• A Bachelor’s Degree or equivalent is required; preferably in a science related field.
• Must possess good laboratory analytical skills.
• Must have good presentation and interpersonal skills, including ability to communicate in English.
• Able to apply advanced math skills and use involved problem solving.
• Must be self-motivated and initiate continuous improvement.
• Ability to perform multiple tasks.
• Must have communication and interpersonal skills, along with the ability to read, write, and speak English

PHYSICAL REQUIREMENTS 

• Able to stand six to seven hours a day.
• Ability to wear a respirator for up to 4 hours a day without restrictions. Please refer to the SOP for facial hair guidelines.
• Able to perform tasks requiring good manual dexterity.
• Able to lift 50 pounds.
• Bend, twist, and squat on occasion.
• Climb ladders or stairs multiple times per day.
• Due to safety concerns, the wearing of contact lenses is prohibited.
• Must meet DOT vision requirements

JOB EXPECTATIONS 

• Uphold Hydrite’s Standard of Excellence through a continuous commitment to maintain quality facilities and provide quality products and services to internal and external customers.
• Participate in RCRA, regulatory, health & safety and process training activities as required.  Review changes/additions with your supervisor.  Must be RCRA compliant.
• Regular attendance is essential.
• Perform all duties outlined in relevant SOPs and all other duties to be assigned.
• Work with other staff members to maintain workload balances.  Provide back-up support as necessary.
• Support effective communication with all Hydrite departments where responsibilities overlap to ensure success of the branch team.

BENEFITS

Benefits and perks include 401k and profit sharing, medical/dental/vision/life insurance, paid time off, tuition reimbursement, adoption assistance, legal services insurance, scholarship awards for children of employees, summer picnic, community giving events, free family wellness coaching including nutritionist and fitness coach.

WHY HYDRITE?  

Watch this Why Hydrite video to find out:  https://vimeo.com/201673899

WANT TO STAY CONNECTED?  FIND US ON SOCIAL MEDIA

• LinkedIn: linkedin.com/company/hydrite-chemical-co-
• Facebook: facebook.com/hydrite
• YouTube:https://www.youtube.com/watch?v=Bs_493NR8RI

Learn more about Hydrite on our website: www.hydrite.com/careers

Privacy Notice for California Residents: https://www.hydrite.com/Legal/Privacy-Notice-for-Employees.htm

****Must reside in or be willing to relocate to the U.K.******

PsiQuantum’s mission is to build the first useful quantum computers—machines capable of delivering the breakthroughs the field has long promised. Since our founding in 2016, our singular focus has been to build and deploy million-qubit, fault-tolerant quantum systems. 

Quantum computers harness the laws of quantum mechanics to solve problems that even the most advanced supercomputers or AI systems will never reach. Their impact will span energy, pharmaceuticals, finance, agriculture, transportation, materials, and other foundational industries. 

Our architecture and approach is based on silicon photonics. By leveraging the advanced semiconductor manufacturing industry—including partners like GlobalFoundries—we use the same high-volume processes that already produce billions of chips for telecom and consumer electronics. Photonics offers natural advantages for scale: photons don’t feel heat, are immune to electromagnetic interference, and integrate with existing cryogenic cooling and standard fiber-optic infrastructure. 

In 2024, PsiQuantum announced government-funded projects to support the build-out of our first utility-scale quantum computers in Brisbane, Australia, and Chicago, Illinois. These initiatives reflect a growing recognition that quantum computing will be strategically and economically defining—and that now is the time to scale. 

PsiQuantum also develops the algorithms and software needed to make these systems commercially valuable. Our application, software, and industry teams work directly with leading Fortune 500 companies—including Lockheed Martin, Mercedes-Benz, Boehringer Ingelheim, and Mitsubishi Chemical—to prepare quantum solutions for real-world impact. 

Quantum computing is not an extension of classical computing. It represents a fundamental shift—and a path to mastering challenges that cannot be solved any other way. The potential is enormous, and we have a clear path to make it real. 

Come join us. 

Job Summary:

Want to be at the forefront of using theoretical and computational chemistry, physics, and materials science to maximize the impact of quantum algorithms and fault tolerant quantum computing (FTQC) in generating exact and useful quantum data for a wide range of industrial applications? As a Computational Quantum Chemist, you will develop and apply advanced electronic-structure and quantum-chemistry methods at the interface of quantum computing and molecular and materials modeling. You will work within an interdisciplinary research team to advance methodologies for correlated electronic systems and embedding, with an emphasis on enabling and evaluating quantum-computing-based workflows.

Within PsiQuantum’s Application Development team, you will integrate and develop computational chemistry approaches alongside emerging quantum algorithms and high-performance computing (HPC), collaborating closely with quantum algorithm researchers and domain experts. Your work will connect quantum-computed atomic and molecular properties with higher-level materials and chemical behavior through rigorous computational modeling. These efforts will support innovations in applied fields such as energy materials, superconductors, batteries, drug design, and catalysis, among others.

This role offers the opportunity to conduct publishable research, build robust computational workflows, and contribute to interdisciplinary efforts across computational chemistry, materials science, and quantum computing.

Responsibilities:

• Conduct theoretical and computational research in electronic-structure theory and quantum chemistry, including literature analysis, method development, and problem solving.
• Design, develop, and evaluate computational workflows that integrate established electronic-structure methods with emerging quantum-computing-based approaches.
• Collaborate with quantum algorithm researchers to identify and assess areas where quantum computing can provide value for electronic-structure and materials-chemistry problems.
• Apply expertise in conventional (non-quantum-computing) algorithms to support the development, benchmarking, and validation of quantum algorithms.
• Develop computational workflows that combine best-in-class classical approaches (e.g., HPC and GPU acceleration) with FTQC for quantum chemistry and materials modeling.
• Serve as a subject matter expert in computational quantum chemistry and electronic-structure methods, staying current with relevant literature, tools, and methodologies.
• Participate in scientific collaboration and technical discussions across teams to support shared research objectives.
• Document research progress and contribute to internal reports, technical documentation, and publications.

Experience/Qualifications:

• Ph.D. in computational or theoretical chemistry, physics, or a closely related field with a strong emphasis on electronic-structure and computational chemistry methodology development.
• Strong foundational knowledge in electronic-structure theory, including density functional theory (DFT) and/or wave function-based quantum chemistry methods, with experience applying these approaches to molecular or materials systems.
• Experience working in high-performance computing (HPC) environments for electronic-structure or atomistic simulations.
• Ability to work effectively in a collaborative, interdisciplinary research environment spanning physics, chemistry, materials science, machine learning, and quantum computing.
• Proficiency in scientific programming and algorithm development, with experience in either Python, Fortran, or C++.
• Strong track record of peer-reviewed publications. 

Preferred:

• Experience with advanced electronic-structure or quantum-chemistry method development, including extensions or improvements to existing theoretical frameworks (e.g., DFT functional development).
• Deep understanding of or hands-on experience with machine learning and data-driven techniques applied to electronic structure, quantum chemistry, or materials modeling problems.
• Experience with quantum embedding or multiscale electronic-structure approaches for treating strongly correlated or localized electronic effects.
• Experience constructing or working with localized orbital representations, effective subspaces, or reduced electronic models derived from first-principles calculations.
• Advanced knowledge and hands-on experience with multireference or strongly correlated electronic-structure methods, such as coupled-cluster, configuration interaction, tensor-network, or related approaches.
• Experience applying or evaluating quantum-computing algorithms for electronic-structure, chemistry, or materials-science applications.
• Experience with GPU-accelerated method development or performance optimization for scientific computing applications.
• Experience developing, extending, or contributing to large-scale scientific software for electronic-structure, quantum chemistry, or materials modeling.

PsiQuantum provides equal employment opportunity for all applicants and employees. PsiQuantum does not unlawfully discriminate on the basis of race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), gender identity, gender expression, national origin, ancestry, citizenship, age, physical or mental disability, military or veteran status, marital status, domestic partner status, sexual orientation, genetic information, or any other basis protected by applicable laws.

Note: PsiQuantum will only reach out to you using an official PsiQuantum email address and will never ask you for bank account information as part of the interview process. Please report any suspicious activity to recruiting@psiquantum.com.

We are not accepting unsolicited resumes from employment agencies.

We’re seeking a Computational Chemist to join us in our mission to improve human health and quality of life through the development, distribution, and application of advanced computational methods!

Our drug discovery group of over 60 scientists includes designers, modelers, computational chemists, medicinal chemists, crystallographers, biochemists, and biologists with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers, as well as a large scale computer infrastructure. Four of the programs we’ve worked on in the past seven years have progressed into the clinic; two are still progressing through trials and two have been approved by the FDA.  

Who will love this job:

• A structure-based drug designer who has experience in two of the following molecular modeling areas: virtual ligand screening, computationally-driven lead optimization, machine learning, molecular dynamics, quantum mechanics, cheminformatics, ADMET/QSPR 
• An excellent communicator who’s been exposed to one or more other disciplines of relevance to drug discovery, such as synthetic organic chemistry, pharmacology, toxicology, formulation, biochemistry, physical chemistry, or analytical chemistry
• A team player who enjoys working in interdisciplinary environments and has some background in programming/scripting and/or chemically-aware databases
• A pharma/biotech veteran

What you’ll do:

• Support active drug discovery projects as a computational chemist/modeler
• Work closely with internal software development teams to improve our drug discovery technologies

What you should have:

• PhD in computational chemistry, organic chemistry, or physical chemistry, preferably with postdoctoral experience or 1 to 5 years industry experience

Pay and perks:

Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have regular catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time. Our Office Management team also plans a myriad of fun company-wide events. Schrödinger is honored to have been included in Newsweek's list of America's 100 Most Loved Workplaces. 

Estimated base salary range: $120,000 - $165,000. Actual compensation package is dependent on a number of factors, including, for example, experience, education, degrees held, market data, and business needs. If you have any questions regarding the compensation for this role, do not hesitate to reach out to a member of our Strategic Growth team.

Sound exciting? Apply today and join us!

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.

Quantum computing holds the promise of humanity’s mastery over the natural world, but only if we can build a real quantum computer. PsiQuantum is on a mission to build the first real, useful quantum computers, capable of delivering the world-changing applications that the technology has long promised.  We know that means we will need to build a system with roughly 1 million qubits that supports fault tolerant error correction within a scalable architecture, and a data center footprint.

By harnessing the laws of quantum physics, quantum computers can provide exponential performance increases over today’s most powerful supercomputers, offering the potential for extraordinary advances across a broad range of industries including climate, energy, healthcare, pharmaceuticals, finance, agriculture, transportation, materials design, and many more.

PsiQuantum has determined the fastest path to delivering a useful quantum computer, years earlier than the rest of the industry. Our architecture is based on silicon photonics which gives us the ability to produce our components at Tier-1 semiconductor fabs such as GlobalFoundries where we leverage high-volume semiconductor manufacturing processes, the same processes that are already producing billions of chips for telecom and consumer electronics applications. We also benefit from the quantum mechanics reality that photons don’t feel heat or electromagnetic interference, allowing us to take advantage of existing cryogenic cooling systems and industry standard fiber connectivity.

In 2024, PsiQuantum announced two government-funded projects to support the build-out of our first Quantum Data Centers and utility-scale quantum computers in Brisbane, Australia and Chicago, Illinois. Both projects are backed by nations that understand quantum computing’s potential impact and the need to scale this technology to unlock that potential. And we won’t just be building the hardware, but also the fault tolerant quantum applications that will provide industry-transforming results.

Quantum computing is not just an evolution of the decades-old advancement in compute power. It provides the key to mastering our future, not merely discovering it. The potential is enormous, and we have the plan to make it real. Come join us.

There’s much more work to be done and we are looking for exceptional talent to join us on this extraordinary journey!

Job Summary:

Are you eager to revolutionize life sciences using the transformative power of quantum computing? As a Quantum Life Sciences Chemist, you will lead efforts at the intersection of quantum computing, computational chemistry, and biology, solving critical challenges in drug design, biomolecular modeling, and biological systems simulation. By integrating quantum algorithms with established life sciences methodologies, you will pioneer new approaches to address complex problems in pharmaceuticals, biomaterials, and bioinformatics. Join our interdisciplinary team to advance quantum-enabled innovations and shape the future of life sciences.

At PsiQuantum’s Quantum Solutions team, your role will focus on bridging the gap between fault-tolerant quantum computing (FTQC) and established computational chemistry and life sciences tools. You will integrate these approaches with machine learning to explore novel workflows for quantum-informed drug discovery and biomolecular modeling. Your expertise in theoretical and computational chemistry will enable you to connect quantum-computed molecular insights with complex biological systems, driving advancements in drug design, biomaterials, and other critical areas within the life sciences.

This position requires a PhD in computational chemistry, biophysics, or a closely related field, preferably with postdoctoral research experience (although postdoc experience is not mandatory). We are looking for a curious, creative, and interdisciplinary thinker with a strong foundation in computational methodologies applicable to life sciences. The ideal candidate should be an avid reader of scientific literature, possess expert-level hands-on coding experience (e.g., Python, Fortran, C++), and have demonstrated skills in developing and applying computational techniques. Experience contributing to scientific software or modeling workflows is a plus. While prior knowledge of quantum information and fault-tolerant quantum computing is highly preferred, it is not required.

Responsibilities:

• Conduct innovative research, literature analysis, problem solving, and quantum workflow design in the areas of quantum-informed biomolecular modeling, drug discovery, and computational chemistry.
• Collaborate with quantum algorithm experts to identify areas where quantum computing can have the greatest impact in computational chemistry, biology, and life sciences.
• Contribute expertise in conventional (non-quantum-computing) algorithms to the development of in-house quantum algorithms. Serve as a technical lead in customer projects by collaborating with customers’ teams to integrate quantum computing-produced computational outputs into conventional life sciences workflows.
• Serve as a liaison between partner teams and PsiQuantum’s quantum information experts for innovative algorithm selection, development, and prioritization relevant to life sciences.
• Develop computational workflows that combine best-in-class conventional approaches (e.g., through high-performance computing (HPC)) with the breakthrough computational abilities of FTQC to reshape how quantum workflows are designed for life sciences applications.
• Serve as a subject matter expert in computational quantum chemistry and biomolecular modeling for PsiQuantum’s Quantum Solutions team, staying updated on recent academic literature, trends, and tools in life sciences.
• Foster collaboration across teams to maximize the impact of quantum algorithms and quantum computing-generated data in life sciences applications.
• Help shape external-facing materials that champion the applications of FTQC in the pharmaceutical, biotechnology, and life sciences industries (for key opinion leaders, media, and partners).
• Build and maintain external partnerships and collaborations on the topic, which can include meetings, group problem-solving sessions, or drafting research proposals, among others.
• Create organized internal reports and thoroughly document progress on assigned tasks.

Experience/Qualifications:

Required:

• Ph.D. in computational chemistry, biophysics, bioinformatics, or a closely related field, with a strong focus on computational methodology development, and 0 to 6 years of post-PhD (postdoctoral or industrial) experience.
• Hands-on experience with modeling and simulation of biological systems, such as protein-ligand interactions, enzymatic reactions, or biomolecular dynamics.
• Enthusiasm for working in a collaborative, interdisciplinary, and dynamic team environment.
• Expert-level Python coding skills with experience in scientific libraries relevant to life sciences.
• Proven ability to stay updated on recent academic literature and trends in computational chemistry and biomolecular modeling.

Preferred:

• Strong foundational knowledge of quantum chemistry methods (e.g., DFT, coupled cluster theory, or wavefunction-based approaches) and molecular simulation techniques as applied to biomolecular systems.
• Experience with free energy perturbation (FEP), molecular docking, or similar computational techniques for drug discovery.
• Experience with machine learning (ML) techniques in computational drug discovery, biomolecular modeling, or structural biology.
• Experience with coding GPU-accelerated molecular simulations.
• Familiarity with hybrid quantum-classical methodologies, such as QM/MM, applied to biomolecular systems.
• Knowledge of quantum embedding theories (e.g., DMET, embedded correlated wavefunctions) and their application to large, complex biomolecular systems.
• Hands-on experience with quantum computing or quantum algorithms, especially as applied to biological or chemical systems.
• General understanding of light-matter interactions or electronic excitations relevant to biological or chemical systems, such as energy transfer or photochemical processes.
• Familiarity with advanced quantum mechanical methods (e.g., CASCI, CASSCF) and their relevance to modeling enzymatic reactions or metal-containing biomolecules.
• Demonstrated scientific communication skills through peer-reviewed publications, conference presentations, or collaboration with industry partners.
• Expert-level C++ or Fortran coding skills.

PsiQuantum provides equal employment opportunity for all applicants and employees. PsiQuantum does not unlawfully discriminate on the basis of race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), gender identity, gender expression, national origin, ancestry, citizenship, age, physical or mental disability, military or veteran status, marital status, domestic partner status, sexual orientation, genetic information, or any other basis protected by applicable laws.

Note: PsiQuantum will only reach out to you using an official PsiQuantum email address and will never ask you for bank account information as part of the interview process. Please report any suspicious activity to recruiting@psiquantum.com.

We are not accepting unsolicited resumes from employment agencies.

About the Medicinal Drug Design team

We are a dynamic team of Medicinal Chemists transforming how drugs are designed. By partnering deeply with our AI/ML colleagues, we are doing more than just leveraging the Isomorphic Labs drug design engine - we are actively shaping it. We use our domain expertise to challenge and refine our algorithms, creating a powerful symbiotic relationship that drives our internal and collaborative portfolios. Our team closely together in a supportive environment, where everyone is valued for their medicinal chemistry expertise and experience they bring to the group. We have a strong growth mindset and prioritise continued development and learning.

We are looking for a Team Leader, Medicinal Drug Design to champion this cross-disciplinary approach, fostering a supportive team culture where continuous learning and the adoption of next-generation tools are the standard, not the exception. This is a pivotal role for an experienced and motivated scientific leader eager to shape the future of drug discovery at the intersection of medicinal chemistry and artificial intelligence.

Your impact 

You will be responsible for line managing and mentoring a small team of talented and high-performing Medicinal Chemists, fostering their scientific growth and career development. Additionally, you will provide scientific leadership and strategic direction for key drug discovery projects, guiding them from initiation towards clinical candidate selection. Working alongside world-leading AI/ML scientists, you will play a critical role in driving project success, enhancing our AI platform through your technical expertise.

If you are a skilled Medicinal Chemist with leadership experience and a passion for applying cutting-edge technology to complex scientific challenges, this role offers an unparalleled opportunity for impact and growth.

What you will do

• Provide line management for a team of 2-4 Medicinal Chemists. Set clear goals, provide regular feedback, support their professional development, and foster a collaborative and high-performance team environment.
• Invent new medicines. Rapidly drive drug discovery programs to value inflection points by deploying your knowledge of modern discovery principles and synthetic organic chemistry, taking ownership as either a Medicinal Chemistry Lead or overall Project Lead.
• Collaborate cross-functionally to support the data-driven delivery of high quality scientific solutions to complex technical problems.
• Represent the company externally, interacting with existing and prospective collaborators and Contract Research Organisations (CROs).
• Provide strategic input and technical direction to our AI/ML platform teams.
• Effectively manage CRO resource and monitor KPIs to maintain delivery.
• Generate intellectual property positions and capture the value derived from IsoLabs’ investment.
• Prepare detailed scientific proposals and reports to support new and ongoing programs. 
• Embrace and champion our culture of inclusion and continuous professional development.
  
  

Skills and qualifications 

Essential:

• PhD in Medicinal Chemistry, Synthetic Organic Chemistry, or a related technical field, or equivalent industrial experience.
• 8+ years’ professional experience in a Medicinal Chemistry role, operating within a biotech, pharma or CRO setting.
• Proven track record of leading medicinal chemistry efforts on drug discovery projects, demonstrating significant contributions to project progression (ideally from hit identification through to lead optimisation/candidate nomination), with familiarity of optimisation of DMPK.
• Experience of contributing to structure-based drug design problems. 
• Experience of leading a high-performing scientific team, mentoring and empowering them to thrive in their roles.
• Excellent strategic thinking, problem-solving, and decision-making capabilities applied to complex drug discovery challenges.
• Experience of working with and closely managing CRO resources. 
• Strong track record of scientific achievements, evidenced by publications, patents, and presentations.
• A genuine passion for drug discovery and enthusiasm for the potential of AI/ML to transform the field.
• Excellent communication (written and verbal) and interpersonal skills, with an ability to work effectively in a cross-functional, collaborative team environment.
• Track record of creative problem solving with a strong growth mindset, adaptability, and eagerness to learn new concepts and techniques.

Nice to have:

• Experience of successful application of fragment-based drug design approaches. 

About the Medicinal Drug Design Team

We are a dynamic team of Medicinal Chemists transforming how drugs are designed. By partnering deeply with our AI/ML colleagues, we are doing more than just leveraging the Isomorphic Labs drug design engine - we are actively shaping it. We use our domain expertise to challenge and refine our algorithms, creating a powerful symbiotic relationship that drives our internal and collaborative portfolios. Our team work closely together in a supportive environment, where everyone is valued for their medicinal chemistry expertise and experience they bring to the group. We have a strong growth mindset and prioritise continued development and learning.

Your impact 

As part of the ongoing expansion of our Drug Design and Medical Research function, we are hiring Medicinal Drug Design Leads. You will work as a Chemistry Lead, delivering scientific expertise and strategic direction to fulfil milestone objectives on our portfolio projects. You will support the business alongside world leading AI/ML Drug Design Platform teams, and will work collaboratively to drive improvements in the platform and apply these to impactful drug design projects. Please note that this is a scientific leadership role, where you will take an active hands-on role as an individual contributor rather than being a people manager, although you will support and mentor junior colleagues.

If you are a skilled Medicinal Chemist with a passion for applying cutting-edge technology to complex scientific challenges, this role offers an unparalleled opportunity for impact and growth.

What you will do 

• Invent new medicines. Rapidly drive drug discovery programs to value inflection points by deploying your knowledge of modern discovery principles and synthetic organic chemistry, taking ownership as a Medicinal Chemistry Lead.
• Collaborate cross-functionally to support the data-driven delivery of high quality scientific solutions to complex technical problems.
• Represent the company externally, interacting with existing and prospective collaborators and Contract Research Organisations (CROs).
• Provide strategic input and technical direction to our AI/ML platform teams.
• Effectively manage CRO resource and monitor KPIs to maintain delivery.
• Prepare detailed scientific proposals and reports to support new and ongoing programs. 
• Embrace and champion our culture of inclusion and continuous professional development.

Skills and qualifications 

Essential:

• PhD in Medicinal Chemistry, Synthetic Organic Chemistry, or a related technical field, or equivalent industrial experience.
• 5+ years’ professional experience in a Medicinal Chemistry role, operating within a biotech, pharma or CRO setting.
• Proven track record of leading medicinal chemistry efforts on drug discovery projects, demonstrating significant contributions to project progression (ideally from hit identification through to lead optimisation/candidate nomination), with familiarity of optimisation of DMPK.
• Experience of contributing to structure-based drug design problems. 
• Excellent strategic thinking, problem-solving, and decision-making capabilities applied to complex drug discovery challenges.
• Experience of working with and closely managing CRO resources. 
• Strong track record of scientific achievements, evidenced by publications, patents, and presentations.
• A genuine passion for drug discovery and enthusiasm for the potential of AI/ML to transform the field.
• Excellent communication (written and verbal) and interpersonal skills, with an ability to work effectively in a cross-functional, collaborative team environment.
• Track record of creative problem solving with a strong growth mindset, adaptability, and eagerness to learn new concepts and techniques.

Nice to have:

• Experience of successful application of fragment-based drug design approaches.

Treeline Biosciences, a clinical-stage biotechnology company advancing precision medicines, is seeking an experienced small molecule process chemist to drive the development, scale-up, and commercial readiness of our small molecule, clinical-stage portfolio. This role centers around close collaboration with the medicinal chemistry team within the discovery portfolio. Additionally, the role is critical to ensuring clinical supply and commercial readiness for identified programs and ensuring that drug substance manufacturing processes meet quality, regulatory, safety, scalability, and scalability expectations. 

About the Position

Senior Scientist / Principal Scientist – Process Chemistry (Discovery Process Research)

Position Overview

We are seeking an experienced synthetic chemist to join our Process Chemistry (Discovery Process Research) team supporting drug discovery programs. This role focuses on route invention, reaction development, and scalable synthesis of key intermediates and drug candidates.

The scientist will lead from the bench within our project-based research and development organization, designing and executing synthetic strategies that enable discovery programs. The successful candidate will collaborate with cross-functional teams, including Medicinal Chemistry, DMPK, Toxicology, Drug Product, and Analytical Sciences to develop practical routes that support SAR exploration and deliver material for biological and early toxicology studies. The role emphasizes modern synthetic methodologies, efficient route design, and early scalability assessment.

Scientific Impact

• Enable drug discovery through innovative synthetic strategy. Develop creative and efficient routes that accelerate SAR exploration, enable rapid evaluation of new chemical matter, and deliver material for early toxicology studies.
• Solve complex synthetic challenges. Apply modern synthetic methodologies to access structurally complex molecules and support emerging therapeutic modalities.
• Translate discovery chemistry into scalable processes. Design practical routes that support both rapid compound synthesis and early-stage scale-up.
• Advance cross-disciplinary drug discovery. Partner closely with discovery scientists to translate synthetic innovation into therapeutic progress.

Responsibilities

• Collaborate with medicinal chemistry partners to support candidate selection and developability assessments.  Advise and assist with sourcing scaffolds and intermediates as appropriate. 
• Design and execute route scouting and synthetic strategies for drug candidates and key intermediates.
• Design and optimize chemical transformations and scalable synthetic routes to enable efficient and robust processes for discovery and early development programs.
• Enable rapid compound synthesis and methodologies to support SAR campaigns and discovery timelines.
• Apply modern synthetic technologies to address complex synthetic challenges.
• Support multi-gram to kilogram-scale synthesis for biological and toxicology studies.
• Manage external partners and cultivate strong, collaborative relationships to support program objectives.
• Contribute to early CMC understanding, including impurity identification and process considerations.
• Communicate results through technical reports, documentation, and presentations.
• May be involved with preparations for the first GMP synthesis of a clincial candidate for Phase 1 trials.
• Ability to travel up to 10% to support program needs, including on-site support at manufacturing plants and partner collaboration.

Qualifications

• Ph.D. in Organic Chemistry or related discipline with 3–8+ years of relevant industry or postdoctoral experience; M.S. with 6–10+ years of industry experience also considered.
• Strong expertise in synthetic organic chemistry, reaction development, and route design.
• Experience with complex molecule synthesis and route optimization.
• Familiarity with scale-up considerations and impurity control in chemical processes.
• Ability to work effectively within cross-functional discovery teams.
• Experience working with and managing external CDMO partners. 
• Strong written and verbal communication skills.
• Strong project leadership skills with the ability to manage complex timelines, multiple stakeholders, and evolving program priorities. 
• Strong communication and collaboration skills with a proven ability to work cross-functionally in a fast-paced, science-driven environment. 
• High level of personal integrity, commitment to excellence and to our patients 

Desired Experience

• Experience with modern synthetic methodologies and technologies (e.g., catalysis, flow chemistry, photochemistry, high-throughput experimentation, as well as other techniques).
• Experience enabling synthesis of structurally complex drug candidates or emerging modalities.
• Demonstrated creative problem solving in synthetic chemistry.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in San Diego is $166,380 to $189,533. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through RingCentral, Skype or Telegram.
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulations are changing the way we develop new drugs. At 1910 , we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, data science, and software engineering to develop drugs for previously undruggable targets. 

Role Description 

• Own computational theoretical chemistry programs across therapeutic modalities, disease targets, and indications 

• Ensure effective collaboration with the Biology, and Medicinal Chemistry teams by providing key computational chemistry insights to aid in the Hit-to-Lead and Lead Optimization phases of drug discovery operations  

• Ensure effective collaboration with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discovery as well as the incorporation of those models into drug discovery operations 

• Teach key computational chemistry principles to your cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology 

• Partner to improve 1910’s existing process for progressing from computational hit to experimental hit to lead to drug candidate 

• Co-author provisional patents and peer-reviewed research papers  

• Validate a cellular hit in a clinically relevant animal model of disease 

• Update provisional patents with the animal model data 

• Nominate a lead candidate for progression into IND-enabling studies 

• Attend and present research at conferences and events related to computational modeling in drug discovery 

Qualifications 

• Ph.D. in computational chemistry or related discipline 

• In-depth knowledge and hands-on experience with quantum chemical (QC) methods, including semi-empirical and density functional theory (DFT) approaches, molecular dynamics (MD) simulations, including both standard MD and enhanced sampling techniques such as metadynamics, umbrella sampling, and replica exchange MD, free energy simulations such as FEP and TI, and QM/MM methodologies for small and large molecular systems 

• Strong understanding of key concepts, including potential energy surfaces (PES), intermolecular and intramolecular forces/interactions, force fields, molecular properties, thermodynamic properties, solvation models (implicit/explicit), and conformational sampling 

• Proficiency in analyzing molecular properties such as solvation free energy, dipole moments, vibrational frequencies, electrostatic potential, charge distribution, and more 

• Deep knowledge of implicit and explicit solvent models, with extensive experience modeling solvent effects on molecular systems and chemical reactions in various environments 

• Extensive experience in using and troubleshooting software tools for QC calculations (e.g., ORCA, xTB, CREST, etc.), MD simulations (e.g., GROMACS, OpenMM, etc.), Drug Design Development Packages (e.g., EG, Schrodinger, MOE, CRESSET) 

• Experience working with HPC Clusters and cloud-based services like (e.g., Microsoft AZURE, AWS) 

• Ability to optimize computational simulation protocols for efficient resource usage 

• Proven experience working with small organic molecules and large biomolecular systems (e.g., peptides, proteins, etc.) for property prediction, conformational analysis, and structure-activity relationships (SAR) 

• Hands-on experience with Python and Bash scripting for automating workflows and data analysis 

• Familiarity with cheminformatics toolkits such as RDKit for molecular property prediction and data management 

• Basic knowledge of machine learning (ML) techniques applied to molecular property prediction, virtual screening, and related tasks 

• Strong desire to collaborate with AI scientists, data scientists, medicinal chemists, and biologists to interpret computational results and guide experimental design 

• Clear and effective communication of complex scientific ideas through reports, presentations, and publications 

Nice to Haves 

• Relevant industry experience via internship and co-op 

• Publication records in computational chemistry related to drug discovery 

#LI-Onsite

Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulation are changing the way we develop new drugs. At 1910 , we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, data science, and software engineering to develop drugs for previously undruggable targets. 

Role Description 

• Own computational chemistry programs across therapeutic modalities, disease targets, and indications 

• Ensure effective collaboration with the Biology and Medicinal Chemistry teams by providing key computational chemistry insights to aid in the Hit-to-Lead and Lead Optimization phases of drug discovery operations  

• Ensure effective collaboration with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discovery as well as the incorporation of those models into drug discovery operations 

• Teach key computational chemistry principles to your cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology 

• Partner to improve 1910’s existing process for progressing from computational hit to experimental hit to lead to drug candidate 

• Co-author provisional patents and peer-reviewed research papers 

• Progress a virtual hit to a biochemical/cellular hit 

• Validate a cellular hit in a clinically relevant animal model of disease 

• Update provisional patents with the animal model data 

• Nominate a lead candidate for progression into IND-enabling studies 

• Attend and present research at conferences and events related to computational modeling in drug discovery 

Qualifications  

• Ph.D. in computational chemistry or related discipline 

• 2 years of relevant industry experience within drug discovery or biotechnology 

• Played a key role in advancing a drug discovery program from early research phases to clinical development 

• In-depth knowledge and hands-on experience with quantum chemical (QC) methods, including semi-empirical and density functional theory (DFT) approaches, molecular dynamics (MD) simulations, including both standard MD and enhanced sampling techniques such as metadynamics, umbrella sampling, and replica exchange MD, free energy simulations such as FEP and TI, and QM/MM methodologies for small and large molecular systems 

• Strong understanding of key concepts, including potential energy surfaces (PES), intermolecular and intramolecular forces/interactions, force fields, molecular properties, thermodynamic properties, solvation models (implicit/explicit), and conformational sampling 

• Proficiency in analyzing molecular properties such as solvation free energy, dipole moments, vibrational frequencies, electrostatic potential, charge distribution, and more. 

• Deep knowledge of implicit and explicit solvent models, with extensive experience modeling solvent effects on molecular systems and chemical reactions in various environments 

• Extensive experience in using and troubleshooting software tools for QC calculations (e.g., ORCA, xTB, CREST, etc.), MD simulations (e.g., GROMACS, OpenMM, etc.), Drug Design Development Packages (e.g., EG, Schrodinger, MOE, CRESSET) 

• Experience working with HPC Clusters and cloud-based services like (e.g., Microsoft AZURE, AWS) 

• Ability to optimize computational simulation protocols for efficient resource usage 

• Proven experience working with small organic molecules and large biomolecular systems (e.g., peptides, proteins, etc.) for property prediction, conformational analysis, and structure-activity relationships (SAR) 

• Hands-on experience with Python and Bash scripting for automating workflows and data analysis 

• Familiarity with cheminformatics toolkits such as RDKit for molecular property prediction and data management 

• Basic knowledge of machine learning (ML) techniques applied to molecular property prediction, virtual screening, and related tasks 

• Strong desire to collaborate with AI scientists, data scientists, medicinal chemists, and biologists to interpret computational results and guide experimental design 

• Clear and effective communication of complex scientific ideas through reports, presentations, and publications 

Nice to Haves 

• Publications in computational chemistry related to drug discovery 

#LI-Onsite

Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulation are changing the way we develop new drugs. At 1910 , we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, data science, and software engineering to develop drugs for previously undruggable targets. 

Role description  

• Own computational chemistry programs across therapeutic modalities, disease targets, and indications 

• Ensure effective collaboration with the Biology and Medicinal Chemistry teams by providing key computational chemistry insights to aid in the Hit-to-Lead and Lead Optimization phases of drug discovery operations  

• Ensure effective collaboration with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discovery as well as the incorporation of those models into drug discovery operations 

• Teach key computational chemistry principles to your cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology 

• Manage day-to-day operations of the Computational Theoretical Chemistry Team, mentor junior staff, and represent the team in senior leadership meetings 

• Partner to improve 1910’s existing process for progressing from computational hit to experimental hit to lead to drug candidate 

• Co-author provisional patents and peer-reviewed research papers 

• Progress a virtual hit to a biochemical/cellular hit 

• Validate a cellular hit in a clinically relevant animal model of disease 

• Update provisional patents with the animal model data 

• Nominate a lead candidate for progression into IND-enabling studies 

• Attend and present research at conferences and events related to computational modeling in drug discovery 

Qualifications  

• Ph.D. in computational chemistry or related discipline 

• 3+ years of relevant industry experience within drug discovery or biotechnology 

• Played a key role in advancing a drug discovery program from early research phases to clinical development. 

• In-depth knowledge and hands-on experience with quantum chemical (QC) methods, including semi-empirical and density functional theory (DFT) approaches, molecular dynamics (MD) simulations, including both standard MD and enhanced sampling techniques such as metadynamics, umbrella sampling, and replica exchange MD, free energy simulations such as FEP and TI, and QM/MM methodologies for small and large molecular systems 

• Strong understanding of key concepts, including potential energy surfaces (PES), intermolecular and intramolecular forces/interactions, force fields, molecular properties, thermodynamic properties, solvation models (implicit/explicit), and conformational sampling 

• Proficiency in analyzing molecular properties such as solvation free energy, dipole moments, vibrational frequencies, electrostatic potential, charge distribution, and more. 

• Deep knowledge of implicit and explicit solvent models, with extensive experience modeling solvent effects on molecular systems and chemical reactions in various environments 

• Extensive experience in using and troubleshooting software tools for QC calculations (e.g., ORCA, xTB, CREST, etc.), MD simulations (e.g., GROMACS, OpenMM, etc.), Drug Design Development Packages (e.g., EG, Schrodinger, MOE, CRESSET) 

• Experience working with HPC Clusters and cloud-based services like (e.g., Microsoft AZURE, AWS) 

• Ability to optimize computational simulation protocols for efficient resource usage 

• Proven experience working with small organic molecules and large biomolecular systems (e.g., peptides, proteins, etc.) for property prediction, conformational analysis, and structure-activity relationships (SAR) 

• Hands-on experience with Python and Bash scripting for automating workflows and data analysis 

• Familiarity with cheminformatics toolkits such as RDKit for molecular property prediction and data management 

• Basic knowledge of machine learning (ML) techniques applied to molecular property prediction, virtual screening, and related tasks 

• Strong desire to collaborate with AI scientists, data scientists, medicinal chemists, and biologists to interpret computational results and guide experimental design 

• Clear and effective communication of complex scientific ideas through reports, presentations, and publications 

Nice to Haves 

• Publications in computational chemistry related to drug discovery 

 #LI-Onsite

Zeteo Tech, Inc, a venture backed company developing solution for Medical and Biodefense applications, is seeking a motivated chemist to join our team. The ideal candidate should be interested in working in an entrepreneurial environment developing game changing solutions to healthcare and national security challenges. You will use your expertise to conduct chemical and physical laboratory tests to assist scientists in development of tools to detect and identify biological organisms and materials.

Duties:

• Conduct chemical experiments, tests, and analyses using techniques such as MALDI-TOF mass spectrometry, gas chromatography mass spectrometry, and microscopy
• Conduct chemical and physical laboratory tests to assist scientists in refining MALDI-TOF MS equipment
• Compile and interpret results of tests and analyses
• Provide technical support and assistance to our team of biologists, chemists, and engineers
• Prepare chemical solutions for products and processes following standardized formulas, or create experimental formulas
• Maintain, clean, and sterilize laboratory instruments and equipment
• Write technical reports or prepare graphs and charts to document experimental results

Qualifications:

• Bachelor's degree, chemistry preferred
• 1 – 5 years of working experience in the field
• Knowledge of and experience with wet bench chemistry procedures
• Ability to analyze data and accurately document and record results
• Attention to detail and problem-solving skills
• Ability to be a team player
• Eligibility requirements include U.S. citizenship or permanent resident

What we can offer you in compensation:

• Competitive salary
• Comprehensive medical and dental insurance, with 100% premiums paid for employees
• 401k plan with company match
• Equity position in Zeteo Tech
• Paid vacation, sick time, and holidays
• Laptop for work use
• Experience in a venture backed startup

Zeteo Tech, Inc. is an Equal Opportunity Employer and will not discriminate against any applicant for employment on the basis of race, age, religion, sex, veterans, individuals with disabilities, sexual orientation, or gender identity.