About the Role

We are seeking a highly motivated, proactive, strategic, and solution-focused Head of Clinical Operations. This hands-on position will lead and support all aspects of clinical trial operations including planning, implementation, execution, and management of clinical studies by overseeing day-to-day operations, including direct management of outside Clinical Research Organizations (CROs) for several clinical stage oncology assets. In this role, the Clinical Operations leader will manage multiple priorities in a fast-paced environment and enact quick problem solving to ensure the successful conduct of clinical trials and the timely delivery of high-quality data. This role will oversee early and late phase trials with an emphasis on proactivity and creative solutions to overcome regulatory and operational hurdles. The successful candidate will have experience, and interest in, working in a small, dynamic environment with broad responsibilities.

Responsibilities

• Develop and lead a team of clinical operations professionals to ensure high-quality execution of early and late phase clinical trials and the professional development of team members.
• Serve as subject matter expert in clinical operations, providing guidance and expertise to cross-functional teams, including clinical development, regulatory affairs, and data management.
• Provide operational expertise and strategic input to Clinical Development Plans and support the overall clinical strategy for clinical programs. 
• Proactively communicate study plans, progress, risks and mitigations with senior leaders.
• Develop, implement, and modify when needed a successful resource and outsourcing model to meet the evolving demands of an expanding clinical portfolio.
• Manage study site selection, qualification, initiation, and monitoring activities to ensure that clinical trials are conducted according to the study protocol and in compliance with regulatory requirements.
• Evaluate and negotiate budgets, oversee selection and provide oversight and management of CROs, consultants and vendors to ensure the effective and timely execution of clinical trials, with high quality (including inspection ready) and within agreed budget.
• Monitor progress of clinical activity and report on the progress of clinical trials including budget, timelines, enrollment, and data collection / review. 
• Participate in the creation, review, and finalization of clinical study-related documents such as protocols, protocol amendments, clinical study reports (CSRs), regulatory submissions and other publications as required.
• Coordinate the delivery of clinical trial supplies in collaboration with CRO and other company team members.
• Develop and maintain strong relationships with clinical investigators and study site staff to ensure site performance, patient enrollment, and data quality; perform periodic visits to sites and/or vendors to assess progress and compliance.
• Ensure clinical trials maintain an inspection readiness state throughout the lifecycle of the trial and provide subject matter expertise for regulatory inspections.
• Maintain knowledge across the clinical operations team of program specific therapeutic areas, current medical practice, and pharmaceutical regulations in order to ensure best practice across all activities and appropriate communication to study sites.
• Proactively implement process improvements and innovative approaches. Support the creation of clinical operations Standard Operating Procedures (SOPs), systems, and processes across the trials; ensures compliance with regulatory and other applicable standards and guidelines.

Qualifications:

• Bachelor’s degree (BA/BS) in a relevant scientific field (e.g. nursing, biology, biochemistry, or related areas); advanced degree preferred.
• At least 15 years of experience of successfully leading studies within clinical research operations. Experience with both small and large biotechnology companies is favorable.
• Experience in Phase I-III oncology clinical studies. Global experience preferred.
• Demonstrated expertise building and managing clinical operations teams.
• Excellent verbal and written skills, allowing for an open and effective dialogue throughout the company.
• Highly accountable for the results and outcomes of their responsibilities and understands the impact of their efforts, results, and attitudes on others.
• Experience with agency submissions and inspections, understands adherence to SOPs, ICH/GCP, and FDA and other health authorities’ regulations.
• Forward thinking mindset with ability to manage multiple projects, identify and resolve issues.
• Strong analytical, organizational, and time management skills with a track record of identifying and implementing novel solutions and problem-solving.
• Demonstrated agility and ability to navigate and be successful in a fast-paced, dynamic work environment.
• Proven hands-on leadership and communication skills (written and verbal).
• Team player who collaborates effectively with internal stakeholders as well as external contract organizations.
• Be a champion of a highly collaborative, transparent, data driven, “make it happen” culture.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown, MA is $319,333 - $375,665. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through Skype or Telegram.
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

About Treeline

Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing new medicines against difficult to drug targets in cancer and other life-threatening diseases. We are pursuing a uniquely integrated approach that applies modern and emerging tools in genomics, lead discovery, medicinal chemistry, and computation to reduce the time and risks of drug discovery.

About the role

We are seeking an experienced, enthusiastic, and highly motivated Scientist to join our Watertown, MA structural biology group to support the team’s delivery of high-quality scientific data that drive small molecule drug discovery. The successful candidate will have a critical role in supporting Treeline’s drug discovery programs by collaborating closely with the multi-disciplinary Lead Discovery organization across biophysics, mass spec, biochemistry, structural biology, and protein production, as well as the broader organization including biology, computational chemistry, and medicinal chemistry. The ideal candidate will take a lead on lab equipment operation/maintenance, execute on structural experiments, and effectively communicate results to colleagues within Lead Discovery and project teams.

Responsibilities

• Establish protein crystallization conditions for small molecule soaks/co-crystallization and solve high resolution crystal structures to drive structure-based drug design.
• Maintain day-to-day operation of the structural biology laboratory and equipment.
• Provide insights and guidance to build the capabilities of the structural biology platform.
• In collaboration with project teams, establish SAR to rapidly drive the hit finding, hit-to-lead, and lead optimization process.

Qualifications

• PhD in Structural Biology, Biophysics, Biochemistry, Chemistry, Chemical Biology or related discipline with 0+ years or BS/MS with 6+ years experience in biotech/pharma industry.
• Training in crystallographic workflow: screening, crystal harvesting, ligand complexing, data collection and processing, and structure refinement.
• Experience with a Linux cloud computation environment – knowledge of databases and Python/shell scripting is a plus.
• Ability to maintain and operate sensitive lab equipment, like liquid handlers, automated imagers, and microscopes.
• Ability to work efficiently and communicate detailed results within defined timelines and to collaborate in a multidisciplinary team.
• Experience with fragment screening or novel crystallographic workflows is a plus.
• Additional experience with protein purification, biophysical methods (SPR, DSF, MST, ITC), or other structural characterization technique (cryoEM/NMR/SAXS) is a plus.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $126,087 to $139,666. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through Skype or Telegram.
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

Scientist, NMR & Biophysics

About the Role

We are seeking a highly motivated Biophysics Scientist to join our Watertown team to deliver high-quality results and drive small molecule drug discovery. In this role, you will be a key contributor to our small‑molecule discovery engine, designing and executing biophysical strategies that identify high‑quality hits, elucidate mechanisms of action, and accelerate lead optimization. You will work at the center of multidisciplinary project teams, partnering closely with chemistry, biology, and lead discovery to advance programs toward development candidates. The successful candidate will design and implement new biophysical assays and hit ID approaches with a focus on ligand observed and protein observed NMR, along with other techniques such as SPR and DSF.  You will provide expert interpretation of biophysical results and use data analysis and visualization tools to integrate data with the broader set of data generated at Treeline to drive program decisions.

Responsibilities

• Design, develop, and execute biophysical assays to support hit identification, hit-to-lead, and lead optimization activities.
• Establish robust NMR assays to monitor small molecule binding
• Efficiently utilize a suite of biophysical and biochemical techniques to advance drug discovery
• Effectively analyze, interpret, and communicate biophysical data as a member of project teams.
• Employ biophysical methods to mechanistically deconvolute the molecular mechanism of action of small molecule hits.
• In collaboration with chemistry, biology, lead discovery, and medicine design, characterize and establish SAR to rapidly drive the hit-to-lead process.

Required Qualifications

• • PhD in Biophysics, Biochemistry, Chemistry, Chemical Biology or related discipline with 0+ years of relevant postdoctoral training or Masters with 6+ years.
  • Biotech/pharma experience with a demonstrated impact in hit identification, hit-to-lead, and lead optimization for small-molecule programs a plus.
  • Expertise in quantitative biophysical assay development, especially NMR for small‑molecule drug discovery. Hands-on experience characterizing protein–ligand interactions, using both ligand observed and protein observed experiments
  • Experience with programming (python) and implementing ML workflows a plus
  • Demonstrated ability to troubleshoot complex assays, work with challenging proteins, and deliver high‑quality, reproducible data.
  • Excellent communication, data visualization, and interpersonal skills, with a track record of effective collaboration on multidisciplinary teams.

Preferred Qualifications

• Experience with fragment-based lead discovery, covalent lead discovery, and/or DEL
• Experience with implementing ML workflows and programming
• Experience with 19F fragment-based NMR screening
• Theoretical and practical knowledge of an array of biophysical and biochemical methods with proven hands-on expertise applying biophysics for interaction analysis. Expertise with MST/SS, DSF, MS, SPR, TR-FRET and/or FP assays.
• Working knowledge of adjacent disciplines (biochemistry, structural biology, protein purification, biology, chemistry).
• Experience in working with challenging proteins.
• Experience working with CRO’s

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $126,087 to $139,666. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through RingCentral, Skype or Telegram. 
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

Treeline Biosciences, a clinical-stage biotechnology company advancing precision medicines, is seeking an experienced small molecule process chemist to drive the development, scale-up, and commercial readiness of our small molecule, clinical-stage portfolio. This role centers around close collaboration with the medicinal chemistry team within the discovery portfolio. Additionally, the role is critical to ensuring clinical supply and commercial readiness for identified programs and ensuring that drug substance manufacturing processes meet quality, regulatory, safety, scalability, and scalability expectations. 

About the Position

Senior Scientist / Principal Scientist – Process Chemistry (Discovery Process Research)

Position Overview

We are seeking an experienced synthetic chemist to join our Process Chemistry (Discovery Process Research) team supporting drug discovery programs. This role focuses on route invention, reaction development, and scalable synthesis of key intermediates and drug candidates.

The scientist will lead from the bench within our project-based research and development organization, designing and executing synthetic strategies that enable discovery programs. The successful candidate will collaborate with cross-functional teams, including Medicinal Chemistry, DMPK, Toxicology, Drug Product, and Analytical Sciences to develop practical routes that support SAR exploration and deliver material for biological and early toxicology studies. The role emphasizes modern synthetic methodologies, efficient route design, and early scalability assessment.

Scientific Impact

• Enable drug discovery through innovative synthetic strategy. Develop creative and efficient routes that accelerate SAR exploration, enable rapid evaluation of new chemical matter, and deliver material for early toxicology studies.
• Solve complex synthetic challenges. Apply modern synthetic methodologies to access structurally complex molecules and support emerging therapeutic modalities.
• Translate discovery chemistry into scalable processes. Design practical routes that support both rapid compound synthesis and early-stage scale-up.
• Advance cross-disciplinary drug discovery. Partner closely with discovery scientists to translate synthetic innovation into therapeutic progress.

Responsibilities

• Collaborate with medicinal chemistry partners to support candidate selection and developability assessments.  Advise and assist with sourcing scaffolds and intermediates as appropriate. 
• Design and execute route scouting and synthetic strategies for drug candidates and key intermediates.
• Design and optimize chemical transformations and scalable synthetic routes to enable efficient and robust processes for discovery and early development programs.
• Enable rapid compound synthesis and methodologies to support SAR campaigns and discovery timelines.
• Apply modern synthetic technologies to address complex synthetic challenges.
• Support multi-gram to kilogram-scale synthesis for biological and toxicology studies.
• Manage external partners and cultivate strong, collaborative relationships to support program objectives.
• Contribute to early CMC understanding, including impurity identification and process considerations.
• Communicate results through technical reports, documentation, and presentations.
• May be involved with preparations for the first GMP synthesis of a clincial candidate for Phase 1 trials.
• Ability to travel up to 10% to support program needs, including on-site support at manufacturing plants and partner collaboration.

Qualifications

• Ph.D. in Organic Chemistry or related discipline with 3–8+ years of relevant industry or postdoctoral experience; M.S. with 6–10+ years of industry experience also considered.
• Strong expertise in synthetic organic chemistry, reaction development, and route design.
• Experience with complex molecule synthesis and route optimization.
• Familiarity with scale-up considerations and impurity control in chemical processes.
• Ability to work effectively within cross-functional discovery teams.
• Experience working with and managing external CDMO partners. 
• Strong written and verbal communication skills.
• Strong project leadership skills with the ability to manage complex timelines, multiple stakeholders, and evolving program priorities. 
• Strong communication and collaboration skills with a proven ability to work cross-functionally in a fast-paced, science-driven environment. 
• High level of personal integrity, commitment to excellence and to our patients 

Desired Experience

• Experience with modern synthetic methodologies and technologies (e.g., catalysis, flow chemistry, photochemistry, high-throughput experimentation, as well as other techniques).
• Experience enabling synthesis of structurally complex drug candidates or emerging modalities.
• Demonstrated creative problem solving in synthetic chemistry.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in San Diego is $166,380 to $189,533. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through RingCentral, Skype or Telegram.
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.

Senior Scientist Biophysics

About the Role

We are seeking an experienced, self-starter, and highly motivated Biophysics Senior Scientists to join our San Diego team to deliver high-quality results and drive small molecule drug discovery. In this role, you will be a key contributor to our small‑molecule discovery engine, designing and executing biophysical strategies that identify high‑quality hits, elucidate mechanisms of action, and accelerate lead optimization. You will work at the center of multidisciplinary project teams, partnering closely with chemistry, biology, and lead discovery to advance programs toward development candidates. The successful candidate will propose, design, and implement new biophysical assays and hit ID approaches (ie. SPR, MST, DSF, NMR), characterize protein-small molecule and protein-protein interactions, and uncover mechanistic insights of our drug discovery targets and lead molecules. You will provide expert interpretation of biophysical results and use data analysis and visualization tools to integrate data with the broader set of data generated at Treeline to drive program decisions.

Responsibilities

• Propose, design, develop, and execute biophysical assays to support hit identification, hit-to-lead, and lead optimization activities.
• Establish robust SPR assays for small‑molecule interaction analysis, including hit triage, affinity/kinetic characterization, and mechanism-of-action studies.
• Efficiently utilize a suite of biophysical techniques to advance drug discovery: primarily SPR but also including DSF, DLS, and others through in-house and CRO capabilities.
• Employ biophysical methods to mechanistically deconvolute the molecular mechanism of action of small molecule hits.
• Effectively analyze, interpret, and communicate biophysical data as a subject matter expert and biophysics representative on project teams.
• In collaboration with chemistry, biology, lead discovery, and medicine design, characterize and establish SAR to rapidly drive the hit-to-lead process.
• Propose and evaluate new approaches and technologies.
• Provide scientific leadership, mentorship, and cross-functional partnership within a dynamic matrixed environment.

Required Qualifications

• PhD in Biophysics, Biochemistry, Chemistry, Chemical Biology or related discipline with 2-3 years of relevant postdoctoral training.
• 4+ years of biotech/pharma experience with a demonstrated impact in hit identification, hit-to-lead, and lead optimization for small-molecule programs.
• Expertise in quantitative biophysical assay development, especially SPR for small‑molecule drug discovery. Hands-on experience characterizing protein–ligand interactions, including affinity, kinetics, stoichiometry, and mechanism.
• Strong theoretical and practical knowledge of an array of biophysical methods with proven hands-on expertise applying biophysics for interaction analysis. Expertise with MST/SS, DSF, MS, or NMR are a plus.
• Demonstrated ability to troubleshoot complex assays, work with challenging proteins, and deliver high‑quality, reproducible data.
• Excellent communication, data visualization, and interpersonal skills, with a track record of effective collaboration on multidisciplinary teams.

Preferred Qualifications

• Ability to lead in a matrix environment, and for example, act as point of contact on project teams.
• Experience with fragment-based lead discovery, covalent lead discovery, and DEL are a plus.
• Strong hands-on biochemistry experience or expertise in enzymology.
• Working knowledge of adjacent disciplines (biochemistry, structural biology, protein purification, biology, chemistry).
• Experience in working with challenging proteins.
• Experience working with CROs.

This position is classified as exempt. The anticipated annual base salary range for candidates who will work in San Diego is $151,694 to $174,363. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, education, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.

Recruitment fraud statement

Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:

• Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.
• We do not conduct interviews through RingCentral, Skype or Telegram. 
• Our job openings are first posted to treeline.bio/careers. If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.
• You can find more information about job scams at consumer.ftc.gov/articles/job-scams.
• To report job scams, head to ReportFraud.ftc.gov.