tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate chemical biologist to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an experienced chemical biologist with medicinal chemistry training to be a founding member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include: supervising synthetic efforts with our CROs, designing, performing, and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• PhD in Chemical Biology, Medicinal Chemistry, Pharmacology, or related field.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Able to work fluently at the interface of chemistry and biology.
• Top-notch written and oral communication skills.

• Strong experience with:
  • Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
  • Contributing to hit-to-lead and lead optimization studies
  • Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK
  • Experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen)

• Nice to have:
  • Proficiency in HTS and phenotypic assay development
  • Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
  • Computational or molecular dynamics drug discovery experience
  • DEL experience
  • Experience managing others, especially synthetic chemistry CRO teams
  • Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. 
• Reading budget! We will buy you books. 📚
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an experienced medicinal chemist with chemical biology training to be a founding member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include: supervising synthetic efforts with our CROs, performing and analyzing in cellulo assays, designing and optimizing first-in-class bifunctional molecules, collaborating with our Drug Discovery and IP team on patent applications, providing input for mechanistic studies on lead drug molecules, and spearheading forays into new disease areas.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Applicant must be able to work fluently at the interface of chemistry and biology.
• Top-notch written and oral communication skills.

• Strong experience with:
  • Designing, synthesizing, and optimizing induced proximity medicines (e.g. PROTACs or other IPMs)
  • Contributing to hit-to-lead and lead optimization studies
  • Med-chem optimizations: SAR, PK/PD, strong understanding of DMPK
  • Applicant must have experience with chemical biology techniques such as mammalian cell culture and cell-based assays (e.g., cytotoxicity assays, transfections, stable cell line generation, co-immunoprecipitation), PPI assays (e.g., BRET, APEX/BioID, AlphaScreen), or strong experience in computational chemistry
    

• Nice to have:
  • Proficiency in HTS and phenotypic assay development
  • Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
  • Computational or molecular dynamics drug discovery experience
  • DEL experience
  • Experience managing others, especially synthetic chemistry CRO teams
  • Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. 
• Reading budget! We will buy you books. 📚
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate Lab Technician / Operations Manager to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an experienced Laboratory Technician / Operations Manager to support our Biology and Platform teams. In this position, you will work at the intersection of lab operations, infrastructure management, and research and development. This job requires strong skills and demonstrable experience in all three areas: lab operations, management, and cell/molecular biology.

Your responsibilities will include 1) general lab management and technician duties: maintaining lab stocks, inventories and ordering, registering and preparing compounds stocks, preparing buffers/media, and receiving supplies; 2) operations: organizational and operational tasks, procurement, and equipment acquisition; and 3) biological research: assisting teams with maintaining cell lines and performing cell-based assays. You will either train or coordinate the training of new members on the different assays we use in our company. 

This is a full-time contract role with the potential to convert to a regular employee position based on performance.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• BS in Biology or related life sciences field, with a minimum of 2 years of experience in maintaining laboratory operations for a group of 10+ scientists. 
• Excellent attention to detail, exceptional organizational and problem-solving skills, top-notch written and interpersonal communication skills.
• Proactive mindset towards identifying and solving potential issues to ensure seamless operations. 
• Experience managing sample inventories, vendors, EHS compliance, and lab safety.
  
  
• Proficiency in:
  • Mammalian cell culture and passaging/seeding cells
  • Cell-based assays
  • Registration of inventory and compound stock preparation
  • Experience with HTS and phenotypic assay development
  • Plasmid design/cloning and PCR
    
    
• Nice to have:
  • Working knowledge of LIMS/database systems is highly desirable
  • Transient/stable protein expression and characterization, immunoprecipitation assays
  • Experience with flow cytometry/cell sorting
  • Any computational or programming skills would also be a bonus

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. 
• Reading budget! We will buy you books. 📚
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate cancer biologist to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an experienced cancer biologist to help lead our Biology Team. In this position, you will help lead and manage our Biology Team and work closely with our Platform Team in the development of our core drug discovery technology.  

Your responsibilities will include phenotypic assay development, establishing pre-clinical in vitro/in vivo studies, performing mechanistic studies on lead drug molecules, spearheading forays into new oncology indications, and grant writing. 

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• PhD in Cancer Biology, Cell Biology, or related field.  
• 5-7+ years of industry experience.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Exceptional leadership, interpersonal, and communication skills, with a track record of managing high-performing, multidisciplinary teams.
  
  
• Strong experience with:
  
  • Cellular and molecular biology, including cancer cell line work and associated assays, stable cell line generation (lentiviral and CRISPR-based systems), co-IP/pull-down assays, RNA-seq, global proteomics, flow cytometry, plasmid design/cloning etc.
  • Pre-clinical characterization and mechanistic elucidation of small-molecule drug candidates
  • Mechanistic studies of cancer cell signaling and PTM analysis
  • Phenotypic assay development for cancer drug discovery (low to high throughput)
  • Small molecule drug development campaigns (hit discovery, hit validation, dose-response studies, SAR and MOA studies)

• Proficiency in:  
  • Managing a team of exceptional scientists and research associates 
  • Target/indication selection
  • Animal models of cancer (GEMM, orthotopic, xenograft models), in vivo study design, and PK/PD interpretation
  • Managing CROs for in vitro and in vivo studies
  • Grant writing 

• Nice to have:
  • Experience navigating IND-enabling studies and working on teams that have successfully advanced research to the clinic
  • Experience working at the interface of cancer biology and chemistry  
  • Familiarity or experience with PROTAC/next-gen IPM technologies
  • Experience with PPI techniques (e.g., BRET, APEX/BioID, AlphaScreen etc.)

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. 
• Reading budget! We will buy you books. 📚
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking a first-rate research associate to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

The Position

We are seeking an experienced Research Associate to be a key member of our Platform/Drug Discovery Team. In this position, you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Your responsibilities will include: designing and executing experiments independently or in collaboration with senior researchers, contributing to the development and optimization of experimental protocols and assays, preparation and handling of biological samples including mammalian cell cultures, performing advanced laboratory techniques and methodologies, data analysis and interpretation under the guidance of senior researchers, and recording and organizing experimental data accurately and efficiently.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Qualifications & Nice-To-Haves

• BS or MS in Biology, Biochemistry, Molecular Biology, or a related field.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Top-notch written and oral communication skills.
  
  
• Proficiency in:
  • Mammalian cell culture, passaging/seeding cells, aseptic technique
  • Molecular biology/cloning, PCR, and other common biology techniques like western blotting, flow cytometry, microscopy, and biochemical assays
  • Assay development and optimization
  • Strong understanding of basic biological principles and laboratory techniques
  • Strong problem-solving skills and the ability to work independently as well as part of a team

•  Nice To Have:
  • 2+ years of post-degree experience
  • Experience with HTS and phenotypic cell-based assay development
  • Transient/stable protein expression and purification, immunoprecipitation assays
  • Experience working with CRISPR-Cas systems
  • Familiarity with data analysis software (e.g., Prism) and statistical tools
  • Familiarity with automatic, robotic dispensers, liquid handlers
  • Prior experience on teams that have successfully advanced research to the clinic

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. 
• Reading budget! We will buy you books. 📚
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio

Other Position(s)

Interested in working with us but don't see a position that fits? Send us your resume/CV by applying here, and we will add you to our talent pool and reach out once we find a good fit!

tl;dr

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.

We are seeking first-rate scientists to help us pioneer this uncharted frontier of drug discovery.

Our Story

A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.

General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).

Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.

About You

High Agency. Initiative, independence, and self-accountability are some of our most valued traits.

Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.

Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.

Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.

Benefits

• Strong equity incentives. We are looking for candidates who will bring a strong sense of ownership to drive their project areas forward, and we believe that you deserve to be compensated accordingly.
• Top tier medical, dental, and vision coverage + One Medical membership.
• 401(k) retirement plans.
• Education and health/fitness incentive programs.
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days. 
• Reading budget! We will buy you books. 📚
• Located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

About Us

Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴

Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.

Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.

Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.

Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)

More info at jobs.generalproximity.bio