Director, Operations

Harvard Hillel

Location: On Site, Harvard Hillel  |  Cambridge, MA

Employment Status: Exempt salaried staff member

Reporting: Jason Rubenstein, Executive Director 

Salary Range: $100,000 - $120,000

Role Overview

The mission of Harvard Hillel is to be a Jewish home, both physical and virtual, on the Harvard University campus. Harvard Hillel welcomes all students to experience the variety of Jewish identity, tradition, practice, values, culture, and community and to inspire and enable connections on campus and beyond. Harvard Hillel students find meaningful connections and friendship while engaging in unique opportunities to make Jewish thought and culture integral in the life of the University.

The Director, Operations (Director) reports to the Harvard Hillel executive director who has been in the role less than two years. As a team, you will engage effectively with internal and external constituent groups around operational excellence at Harvard Hillel. The Director will move easily between strategic decision-making, governance requirements, and the everyday tactical coordination and planning that brings operational priorities to fruition. The Director serves as an empathetic and collaborative leader and coach, where operational excellence and a positive engagement around organizational culture is as important as rigorous monitoring of systems and process.

The Director’s role will ensure effective and consistent financial integrity and compliance of this 501(c)(3) institution. Working closely with the executive director, chief of staff, and other stakeholders, the Director will oversee the planning, coordination, and tracking of institutional annual goals against budget. The Director will serve as a trusted advisor and thought partner to the executive director and staff on organizational priorities, strategic goal setting, and effective project coordination in relation to designing and meeting budget goals.

Key to the success of the Director’s role is to add capacity to the executive director to support the transformation of the institution and its future. In year one, the Director will actively engage with colleagues and outsourced providers to modernize financial budgeting systems, tracking and reporting. Over time, a successful Director in this role will help reshape Harvard Hillel—its building and its operations, to move the organization forward.

Anticipated accountabilities are outlined below. The Director will be expected to actively surface and collaboratively projects to design and address anomalies to ensure work moves forward effectively and efficiently.

What You’ll Do

Annual Planning & Financial Management

• Accounting, Banking, Benefits, Insurances, Payroll: accountability for ensuring an annual cycle, with relevant systems, tracking, and reporting designed and implemented to record and reflect on the overall fiscal health of the organization.
  • Lead annual budget cycle: engaging with budget holders and other colleagues to establish and coordinate an effective budget planning process and reporting tools to support budget holders’ ability to manage and track their budgets and cashflow. At minimum, monthly and quarterly budget reviews, cash flow management and reporting, and ad-hoc tracking and issue resolution as needed. Ensure organizational priorities are visible, clear, and actionable in relation to budget monitoring and tracking. Lead communications in relation to annual budget cycle process and the obligations of contributors. Serve as a trusted colleague and coach around budget management, accountability, and tracking in relation to finance and budgets.
  • Lead annual cycle of audited financial statements and filings: engage with external providers to oversee and actively manage the timely scheduling and delivery of an annual audit; delivery of a 990, and to meet an annual schedule of filing obligations.
  • Annual Insurances: engage with a broker and others to manage insurance obligations for this 501(c)(3) organization.
  • Departmental planning and analyses: In year one, redesign financial planning, budgeting, tracking, and reporting systems, with analysis tools that are right-sized for the institution, in preparation for a capital project to renovate the historic Rosovsky building and to support the institution's journey to scale.

Board of Directors Operations

• Working closely with the chief of staff and executive director, and Board committees, plan and coordinate audit, finance, and risk related committees and reporting to meet timely Board reporting and meetings. Serve as the staff liaison for finance, audit, and risk related committee meetings and discussions.
• Support committee development, structures, and governance principles and processes to ensure the organization’s ByLaws support and drive compliance and governance decision-making in relation to financial risk.

Fiscal Sponsorships Management

• In close coordination with the Director of Programs and others, actively manage student-led initiatives related to financial controls, guidance on policy, procurement, and expenditures and timely payments of events for student-led projects.

Policy Design and Management

• Actively review and manage organizational policies in relation to both risk management and business continuity, balancing the organization’s values and core programming, to facilitate a smooth-running institution in service of students and other stakeholders.
• Schedule routine policy review cycles to ensure the organization is up to date with best practices and technologies to function with operational excellence.

Human Resources

• Work closely with payroll providers and benefits brokers to manage an annual benefits cycle of enrollments and benefits assessments, actively engaging and communicating with staff through a benefits review cycle.
• Actively engage with the chief of staff to design and implement an annual cycle of health and safety protocols specific to this institution. Working closely with the chief of staff and executive director, actively track and monitor engagement in mandatory trainings for Boston, MA.
• Work in close partnership as needed on staff disciplinary activities, including investigations, performance management support, hiring and termination, holding personnel records and record keeping for related human resources materials.

Facilities

• Oversee the planning of budgets and coordination support needs for buildings owned or rented by Harvard Hillel.
• Oversee the health and safety, security, and business continuity planning around onsite activities, in close partnership with the manager of facilities and operations and the executive director.
• Oversee onsite programmatic activities and events in close liaison with the Director of Program and Facilities Manager, ensuring smooth running of event scheduling, planning, and logistics.
• Oversee management and coordination of facilities technologies serve onsite programming through facilities.
• Identify and manage cost-savings opportunities for services provided by Harvard University and others.

Minimum Qualifications

• 10+ years of experience as a CFO with an Operations portfolio, Finance & Operations Manager, or similar role in a nonprofit or community engagement organization.
• High comfort in Microsoft Office tools, QBO, Bill.com, other financial management platforms.
• Bachelor’s Degree or equivalent.

Knowledge, Skills and Abilities 

• 8+ years of progressive experience in nonprofit or mission-driven leadership roles.
• Commitment to the organization’s mission and respectful of Jewish values.
• Demonstrated success in strategic planning and execution, operational systems and tracking, and Board governance. People-center systems thinker, with strong success operationalizing strategies into trackable, measurable action plans.
• Strong financial, project management, and institutional administration skills.
• Exceptional written, verbal, and interpersonal skills.
• Highly effective manager of people, projects, and budgets.
• Adaptable, sound judgment, diplomatic, and respectful of holding sensitive information.
• Ability to successfully balance high emotional intelligence with result-driven project management and serving as an empathetic culture carrier who models collaborative leadership and teamwork.
• Open and willing to engage in conversations about religion, and to learn about Judaism and Israel in a way that inspires stakeholders to invest in our work.
• Highly collaborative problem-solver with curiosity to engage across teams both inside and outside of Hillel to successfully manage competing priorities.
• A self-starter, adept at project management tools and practices, time-management and effective communications both verbally and in writing.
• Highly comfort working effectively both independently and in teams to meet goals and deadlines.

Benefits

• A comprehensive benefits package, including health insurance, retirement plan, Life, AD&D and Long-Term Disability (LTD) insurances, Flexible Spending accounts, generous vacation/sick time, and parental leave.
• A unique opportunity to develop and promote a vibrant, pluralistic Jewish community at Harvard Hillel.

Harvard Hillel is affiliated with Hillel International. Hillel International enriches the lives of Jewish students so they may enrich the Jewish people and the world, and envisions a world where every student is inspired to make an enduring commitment to Jewish life, learning and Israel.

Director, Finance & Administration

Harvard Hillel

Location: On Site, Harvard Hillel  |  Cambridge, MA

Employment Status: Exempt salaried staff member

Reporting: Jason Rubenstein, Executive Director 

Salary Range: $100,000 - $120,000

Role Overview

The mission of Harvard Hillel is to be a Jewish home, both physical and virtual, on the Harvard University campus. Harvard Hillel welcomes all students to experience the variety of Jewish identity, tradition, practice, values, culture, and community and to inspire and enable connections on campus and beyond. Harvard Hillel students find meaningful connections and friendship while engaging in unique opportunities to make Jewish thought and culture integral in the life of the University.

The Director, Finance & Administration (Director) reports to the Harvard Hillel executive director who has been in the role less than two years. As a team, you will engage effectively with internal and external constituent groups around operational excellence at Harvard Hillel. The Director will move easily between strategic decision-making, governance requirements, and the everyday tactical coordination and planning that brings operational priorities to fruition. The Director serves as an empathetic and collaborative leader and coach, where operational excellence and a positive engagement around organizational culture is as important as rigorous monitoring of systems and process.

The Director’s role will ensure effective and consistent financial integrity and compliance of this 501(c)(3) institution. Working closely with the executive director, chief of staff, and other stakeholders, the Director will oversee the planning, coordination, and tracking of institutional annual goals against budget. The Director will serve as a trusted advisor and thought partner to the executive director and staff on organizational priorities, strategic goal setting, and effective project coordination in relation to designing and meeting budget goals.

Key to the success of the Director’s role is to add capacity to the executive director to support the transformation of the institution and its future. In year one, the Director will actively engage with colleagues and outsourced providers to modernize financial budgeting systems, tracking and reporting. Over time, a successful Director in this role will help reshape Harvard Hillel—its building and its operations, to move the organization forward.

Anticipated accountabilities are outlined below. The Director will be expected to actively surface and collaboratively projects to design and address anomalies to ensure work moves forward effectively and efficiently.

What You’ll Do

Annual Planning & Financial Management

• Accounting, Banking, Benefits, Insurances, Payroll: accountability for ensuring an annual cycle, with relevant systems, tracking, and reporting designed and implemented to record and reflect on the overall fiscal health of the organization.
  • Lead annual budget cycle: engaging with budget holders and other colleagues to establish and coordinate an effective budget planning process and reporting tools to support budget holders’ ability to manage and track their budgets and cashflow. At minimum, monthly and quarterly budget reviews, cash flow management and reporting, and ad-hoc tracking and issue resolution as needed. Ensure organizational priorities are visible, clear, and actionable in relation to budget monitoring and tracking. Lead communications in relation to annual budget cycle process and the obligations of contributors. Serve as a trusted colleague and coach around budget management, accountability, and tracking in relation to finance and budgets.
  • Lead annual cycle of audited financial statements and filings: engage with external providers to oversee and actively manage the timely scheduling and delivery of an annual audit; delivery of a 990, and to meet an annual schedule of filing obligations.
  • Annual Insurances: engage with a broker and others to manage insurance obligations for this 501(c)(3) organization.
  • Departmental planning and analyses: In year one, redesign financial planning, budgeting, tracking, and reporting systems, with analysis tools that are right-sized for the institution, in preparation for a capital project to renovate the historic Rosovsky building and to support the institution's journey to scale.

Board of Directors Operations

• Working closely with the chief of staff and executive director, and Board committees, plan and coordinate audit, finance, and risk related committees and reporting to meet timely Board reporting and meetings. Serve as the staff liaison for finance, audit, and risk related committee meetings and discussions.
• Support committee development, structures, and governance principles and processes to ensure the organization’s ByLaws support and drive compliance and governance decision-making in relation to financial risk.

Fiscal Sponsorships Management

• In close coordination with the Director of Programs and others, actively manage student-led initiatives related to financial controls, guidance on policy, procurement, and expenditures and timely payments of events for student-led projects.

Policy Design and Management

• Actively review and manage organizational policies in relation to both risk management and business continuity, balancing the organization’s values and core programming, to facilitate a smooth-running institution in service of students and other stakeholders.
• Schedule routine policy review cycles to ensure the organization is up to date with best practices and technologies to function with operational excellence.

Human Resources

• Work closely with payroll providers and benefits brokers to manage an annual benefits cycle of enrollments and benefits assessments, actively engaging and communicating with staff through a benefits review cycle.
• Actively engage with the chief of staff to design and implement an annual cycle of health and safety protocols specific to this institution. Working closely with the chief of staff and executive director, actively track and monitor engagement in mandatory trainings for Boston, MA.
• Work in close partnership as needed on staff disciplinary activities, including investigations, performance management support, hiring and termination, holding personnel records and record keeping for related human resources materials.

Facilities

• Oversee the planning of budgets and coordination support needs for buildings owned or rented by Harvard Hillel.
• Oversee the health and safety, security, and business continuity planning around onsite activities, in close partnership with the manager of facilities and operations and the executive director.
• Oversee onsite programmatic activities and events in close liaison with the Director of Program and Facilities Manager, ensuring smooth running of event scheduling, planning, and logistics.
• Oversee management and coordination of facilities technologies serve onsite programming through facilities.
• Identify and manage cost-savings opportunities for services provided by Harvard University and others.

Minimum Qualifications

• 10+ years of experience as a CFO with an Operations portfolio, Finance & Operations Manager, or similar role in a nonprofit or community engagement organization.
• High comfort in Microsoft Office tools, QBO, Bill.com, other financial management platforms.
• Bachelor’s Degree or equivalent.

Knowledge, Skills and Abilities 

• 8+ years of progressive experience in nonprofit or mission-driven leadership roles.
• Commitment to the organization’s mission and respectful of Jewish values.
• Demonstrated success in strategic planning and execution, operational systems and tracking, and Board governance. People-center systems thinker, with strong success operationalizing strategies into trackable, measurable action plans.
• Strong financial, project management, and institutional administration skills.
• Exceptional written, verbal, and interpersonal skills.
• Highly effective manager of people, projects, and budgets.
• Adaptable, sound judgment, diplomatic, and respectful of holding sensitive information.
• Ability to successfully balance high emotional intelligence with result-driven project management and serving as an empathetic culture carrier who models collaborative leadership and teamwork.
• Open and willing to engage in conversations about religion, and to learn about Judaism and Israel in a way that inspires stakeholders to invest in our work.
• Highly collaborative problem-solver with curiosity to engage across teams both inside and outside of Hillel to successfully manage competing priorities.
• A self-starter, adept at project management tools and practices, time-management and effective communications both verbally and in writing.
• Highly comfort working effectively both independently and in teams to meet goals and deadlines.

Benefits

• A comprehensive benefits package, including health insurance, retirement plan, Life, AD&D and Long-Term Disability (LTD) insurances, Flexible Spending accounts, generous vacation/sick time, and parental leave.
• A unique opportunity to develop and promote a vibrant, pluralistic Jewish community at Harvard Hillel.

Harvard Hillel is affiliated with Hillel International. Hillel International enriches the lives of Jewish students so they may enrich the Jewish people and the world, and envisions a world where every student is inspired to make an enduring commitment to Jewish life, learning and Israel.

About Us:

The wholesale distribution industry is ready for a revolution, and Proton is leading the charge. The world relies on distributors to sell nearly every physical product, but despite its massive contribution to the global economy, this industry has been left behind in terms of technology. Proton is changing that. With AI-powered sales software, we’re breaking through the complexity of selling millions of products and making it easier for distributors to anticipate customer needs. Our mission is to bring the distribution industry into the modern age and the results speak for themselves. Distributors using Proton see 10x ROI, faster new hire ramp-up, and happier sales teams.

In 2022, we raised a $20M Series A backed by Felicis Ventures (investors in Twitch, Shopify, Opendoor, and many others) and Battery Ventures. This year, we’re laser-focused on driving customer growth. If you’re excited about the opportunity to wear multiple hats, and continuously learn and experiment, now’s the time to join the Proton team.

The Role:

Why you should apply:

Proton is at an inflection point. We started as a CRM for distributors, and now we’re expanding into a multi-product platform. More products to take to market. More problems to solve. More opportunity for a product marketer to make a real impact. We’re looking for a strategic product marketer who knows how to turn product into pipeline. You’ll own go-to-market for new capabilities, sharpen our positioning in a competitive space, and arm Sales with stories that win.You’ll report to our Head of Marketing and work closely with Product, Sales, and our CEO. From day one, you’ll be executing on the core pillars of product marketing—positioning, messaging, enablement, and launches.We move fast, bias hard toward action, and stay close to the customer. If you want real ownership and the chance to directly shape how a startup makes the leap from product to platform, this is the role. 

Comp: $160k-$200k

Note: We care more about drive than a perfect résumé. Maybe you’re running content, sitting in customer success, or doing something else entirely — and you’ve been itching to break into product marketing. If you’re hungry to learn, curious about customers, and not afraid to hustle, apply anyway.

What you’ll own and run with:

• Positioning & messaging: Develop sharp, no-nonsense messaging that explains what Proton does, why it matters, and how we’re different.
• Product launches: Work with Product to ensure every feature and add-on we release—ranging from major launches to minor enhancements—has a clear plan for success.
• Enablement: Create talk tracks, collateral, and resources that help Sales confidently explain and sell what we offer.
• Customer insights: Get inside the minds of our buyers. Talk to customers, shadow users, and listen to discovery calls to understand their challenges, needs, and how they describe their problems. Use these insights to refine messaging and inform our marketing strategy.
• Competitive intelligence: Track market shifts and competitor activity to inform messaging and differentiation.
• Collaborate across teams: Be the go-to expert on our customers—key personas, their pain points, and what makes them tick. Partner with Product, CX, and Sales to make sure everyone is aligned and equipped to deliver on Proton’s potential.
• AI leverage: Figure out how AI can make you better at your job—whether it’s scaling customer insights, accelerating launches, or uncovering competitive angles.

Who you are:

• 3–5 years of product marketing experience in B2B SaaS
• You thrive in the unknown. Ambiguity doesn’t stress you out—it motivates you.
• A knack for building go-to-market strategies that make new product features and releases resonate with customers.
• Bias for action—you dive in, figure things out, and make progress, even when it’s your first time tackling something.
• The ability to write clear, concise product copy and craft stories that connect features to real customer problems and outcomes.
• Strong communication skills—you can take something complex and explain it simply, without oversimplifying.
• A head for numbers—you know how to track what’s working, optimize what’s not, and use data to drive decisions.
• You’re organized and can juggle multiple projects without dropping the ball.

Benefits:

• Competitive salary, quarterly performance bonuses, and meaningful equity
• Company-sponsored 401(k) program
• Health, dental, and vision insurance
• Unlimited PTO (and we mean it—we want you to take time off)
• Professional development (get that book, take that course, attend that conference)
• Encouragement to explore and adopt new AI tools that make your work faster and smarter
• Incredible training and career growth opportunities
• A friendly, inclusive, human-first team culture with a strong mix of hustle, productivity, and fun

Why Join Us?

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

The Vice President, Medical Affairs Oncology is a member of the Development Leadership Team reporting to the Chief Medical Officer. This senior executive leader is accountable for the end-to-end design and execution of the Medical Affairs strategy across Parabilis portfolio, including Scientific Communications, Medical Education, Evidence Generation, Key Opinion Leader (KOL) Engagement, Publication Planning, and Medical Information. This role ensures scientific excellence and cross-functional integration across all development programs and builds a scalable Medical Affairs organization capable of supporting global, multi-indication growth.

Key Responsibilities:

Strategic Leadership

• Define and execute the Medical Affairs Oncology strategy aligned with the clinical development roadmap and portfolio priorities.
• Serve as a core member of the Development Leadership Team and contribute to broader
• Development governance and portfolio decision-making.
• Support portfolio-level medical prioritization, lifecycle planning, and cross-indication strategy.

KOL Engagement & Medical Education

• Build and sustain relationships with leading KOLs, academic medical centers, and cooperative groups relevant to Parabilis’ pipeline.
• Design and oversee Medical Education programs that advance understanding of Parabilis’ science, novel mechanisms, and unmet need across tumor types.

Evidence Generation & Publication Strategy

• Lead the development and execution of a robust evidence generation strategy, including investigator-initiated studies, real-world evidence, and health outcomes research
• Oversee development and execution of a comprehensive publication plan aligned with clinical milestones and regulatory timelines
• Build global medical affairs infrastructure to support multi-program, multi-regional growth
• Drive Medical Affairs KPIs and impact metrics in support of portfolio strategy and commercial readiness

Scientific Communications & Medical Information

• Lead scientific communications strategy to accurately and compellingly convey the differentiated profile of Parabilis’ Helicon™ platform and pipeline assets
• Oversee Medical Information function, ensuring timely, accurate, and compliant responses to healthcare professional inquiries
• Oversee the creation of high-quality medical education materials, slide decks, and scientific exchange resources
• Establish scalable medical affairs infrastructure to support launch readiness across tumor types and geographies

Patient Advocacy and Patient Support

• Building trusted partnerships with advocacy organizations across Parabilis' specific tumor types
• Integrating the patient voice into MA strategy, trial design, and evidence generation
• Collaborating with patient communities on disease awareness and education
• Developing patient support programs to improve access, adherence, and trial participation ensuring all patients’ engagement is conducted with ethical rigor and full compliance

Cross-functional Partnership & Commercial Readiness

• Partner closely with Clinical Development, Regulatory Affairs, and New Product Planning to ensure scientific and medical alignment across the development and pre-commercialization continuum
• Support payer strategies by contributing to value dossiers, HEOR data packages

Compliance & Medical Governance

• Lead development and continuous improvement of Medical Affairs SOPs, governance frameworks, and compliance systems
• Ensure all Medical Affairs activities are executed in accordance with applicable regulations, industry codes, and Parabilis’ internal policies

Organizational Leadership

• Build and mentor a high-performing Medical Affairs Oncology team with deep scientific expertise and strong cross-functional collaboration skills
• Establish clear accountability, performance metrics, and a culture of scientific rigor and integrity
• Foster a culture of collaboration, scientific curiosity, and patient-centricity across the Medical Affairs team

What you’ll need to be successful:

• MD required; PharmD or PhD in a relevant biomedical discipline may be considered with commensurate experience
• 15+ years of progressive biopharmaceutical industry experience, with a minimum of 8 years in Medical Affairs with deep scientific expertise in oncology
• Demonstrated success building and leading Medical Affairs organizations, including KOL engagement, evidence generation, and scientific communications
• Experience standing up Medical Affairs capabilities in high-growth, clinical-stage biotech or pharmaceutical environments
• Strong scientific credibility, executive leadership presence, and ability to engage effectively with both internal and external stakeholders
• High emotional intelligence and track record of cross-functional influence across Development, Commercial, and Regulatory functions

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $360,000-$410,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com

The Position

Reporting to our Co-CEO’s, the SVP of Program Leadership & Development will drive the advancement of our clinical-stage pipeline. This individual will be responsible for end-to-end leadership of one or more key development programs translating scientific innovation into clinical, regulatory, and commercial success.

The SVP of Program Leadership & Development will play a critical role in shaping program strategy, guiding cross-functional execution, and maximizing asset value from early development through late-stage trials and potential regulatory approval.

This role will serve as a core member of the Senior Leadership Team, partnering closely with Clinical Operations, Medical, Regulatory, Biometrics, CMC, Commercial and other functional leaders to drive the successful execution of Amylyx’s development portfolio.

In a lean and evolving biotech environment, this individual will operate both as an enterprise leader and a hands-on program leader, directly supporting key assets while building a scalable program leadership organization over time.

The Opportunity

This is a unique opportunity to shape and define how program leadership is executed within a growing biotech organization at a critical inflection point.

Build a New Function from the Ground Up - design and implement a modern program leadership model, including the evolution from traditional program management to a strategic Program Lead and Program Manager structure.

Operate as a True Peer to Clinical and Medical Leadership - serve as an equal partner to senior leaders across Clinical Operations, Medical, and Regulatory, helping shape asset strategy and execution.

Drive Impact Across the Full Development Lifecycle - lead programs spanning early-phase IND-enabling work through Phase 3 and potential NDA submission, with direct impact on key value-driving milestones.

Balance Strategy and Execution in a Lean Environment - play a dual role as both a strategic leader and hands-on program leader, directly influencing outcomes while building for future scale.

Shape Organizational Culture and Ways of Working - establish a highly collaborative, accountable, and transparent operating model that strengthens alignment across functions and reduces organizational friction.

Scale with the Portfolio - build and develop a high-performing team over time, aligned to the growth of the pipeline and key clinical milestones.

Responsibilities

Strategic Program Leadership

• Partner with Clinical Operations and Medical leadership to define and execute development strategies and plans across programs
• Drive program-level decision-making, including risk assessment, trade-offs, and prioritization
• Ensure alignment between asset strategy, clinical execution, and regulatory pathways
• Present program updates, risks, and opportunities to Executive Leadership and Board of Directors

Cross-Functional Integration & Alignment

• Serve as the central integrator across Medical, Clinical Operations, Regulatory, Biometrics, CMC, Commercial and other key functions
• Drive clarity of roles, decision-making, and accountability across program teams
• Proactively identify and resolve cross-functional misalignment, gaps, and competing priorities

Hands-On Program Execution

• Directly serve as Program Lead for one or more key assets, particularly in the early phase of the role
• Lead cross-functional team meetings, execution planning, and milestone delivery
• Translate strategic objectives into clear, aligned execution plans

Build & Scale Program Leadership

• Design and implement a program leadership model, including Program Leads and Program Managers
• Hire, develop, and lead program leadership talent over time as the organization grows
• Establish best practices, governance frameworks, and ways of working that enable scalability

Portfolio & Executive Contribution

• Contribute to portfolio prioritization, resource allocation, and strategic planning discussions at the leadership level
• Provide clear, actionable insights and recommendations to executive leadership
• Support the evolution of Amylyx’s development organization as it scales toward key clinical and regulatory milestones

Required Qualifications

• Advanced degree (PhD, MD, PharmD, or MD) in a relevant scientific discipline preferred; equivalent experience in drug development and program leadership will also be considered
• 20+ years of experience in the pharmaceutical or biotechnology industry, including significant experience leading cross-functional drug development programs
• Lead integrated clinical development plans (CDPs)
• Overseen protocol design, endpoints, and trial execution
• Demonstrated success in regulatory interactions (FDA, EMA)
• Significant experience leading cross-functional drug development programs, ideally spanning early development through late-stage clinical and/or regulatory milestones
• Demonstrated success in regulatory interactions (FDA, EMA)
• Prior experience serving as a Program Lead, Development Team Leader (DTL), Asset Team Lead or equivalent role, with accountability for cross-functional program execution
• Demonstrated ability to partner with Clinical Operations, Medical, and Regulatory leaders as a peer, influencing strategy and execution
• Experience operating in a biotech or similarly lean, fast-paced environment, with comfort navigating ambiguity and evolving priorities
• Proven track record of building or scaling teams and/or functions within a matrixed organization
• Strong leadership and collaboration skills, with the ability to align diverse stakeholders and drive decision-making in complex environments
• Hands-on, execution-oriented leadership style, with willingness to engage directly in program delivery when needed
• Excellent communication and interpersonal skills, with the ability to bridge scientific, clinical, and business perspectives

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations candidates must be able to attend meetings at our office in Cambridge, MA on a regular basis.  Preference will be given to candidates who reside in the New England region and can be in person on an as needed basis. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• When working remotely, you must have access to a work setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

About Alltrna 

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.

Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics. 

For more information, visit www.alltrna.com

Sr. Director Program Management & Business Operations

Position Summary:

Alltrna is seeking a talented and highly motivated Sr. Director Program Management and Business Operations, reporting to the President & CFO.  The successful candidate is a proven leader with extensive experience in leading research and early drug development program teams from research through the clinic with a particular initial focus on IND enabling and early/mid-stage clinical development. The candidate will be a member of the Company’s Leadership Team and will serve as Chief of Staff to the team to drive collaboration, cross-functional clarity, alignment and execution on key priorities and initiatives required to meet the goals of the organization.

Key Responsibilities:

Program Management:

• Work closely with the Chief Medical Officer to lead the program team for the Company’s lead program, AP003, and future programs instilling a culture of scientific rigor, open debate, collaborative teamwork, sense of urgency and accountability
• Possess a comprehensive understanding of the drug discovery process to guide program teams to define the key scientific questions, program strategy and objectives, translating these into optimal deliverables, cross-functional plans, timelines and budgets
• Identify bottlenecks, risks, issues and proactively develop appropriate mitigation proposals with input from team members
• Ensure all key decisions are identified and properly assessed as to their impact and alternative scenarios developed and evaluated, where appropriate
• Work closely with finance and functional teams to develop the operational plans to support program activities with realistic timelines, budget, and resource planning and monitor performance against plans
• Interface with and drive collaboration between the various functional teams and with the Leadership Team on program-related matters.
• Be the key accountable person for communicating matters related to the programs to management including strategy, work product, updates and issues; producing the one “source of truth” for program-related topics and timelines
• Point person for alliance management and coordination, as needed
• Lead and/or manage strategic or platform development projects as required and collaborate with Chief Scientific Officer and Research Leadership Team to coordinate relevant content for quarterly business review meetings

Operations:

• Collaborate with Leadership Team in development of strategic plans, company goals, long-range planning assumptions, portfolio-level reports and analyses to support business processes and strategic discussions
• Develop and deliver impactful presentations that effectively distill complex issues to the critical points and lead to increased understanding and optimized strategic planning & decision-making

• Prepare strategic communications utilizing a clear understanding of the business strategy and issues; develop and maintain consistent, relevant content for use in executive-level communications and to further organizational and business goals

• Lead the Scientific Communications process, working with the Scientific Communications Committee

• Manage schedule, agenda, and content for Leadership Team, Board of Directors and Town Hall meetings

• Proactively seek opportunities for organizational improvements (e.g. team structure, processes, communication, etc.)

Other:

• Support CEO / LT with partnership discussions and negotiations, including background research, preparation of presentation materials, supporting diligence activities, participating in analysis of terms, etc.
• Assist in mapping competitive landscape and proactively identify potential and emerging competitive threats and opportunities
• Promote strategic discussions on external trends, competitor strategies, and potential disruptors, and translate these into strategic choices/ recommendations
• Collect insights and intelligence from a variety of sources including literature searches, reviewing analyst research, KOL and patient group interactions, etc.

Key Competencies:

• This is a highly visible leadership role that requires exceptional interpersonal and communication skills, creative thinking, and early drug development experience that allows one to recognize opportunities/challenges and modify strategy accordingly
• The individual will need to have self-confidence and poise to manage complicated programs and projects with multiple stakeholders

• The individual will need a sense of urgency and can-do attitude to develop therapies for patients with significant unmet medical needs

Minimum Qualifications:

• BS/MS Degree in a scientific discipline, ideally life science or chemistry.
• At least 15 years relevant experience in pharma or biotech drug discovery and development, as well as a comprehensive understanding of drug discovery (preclinical and clinical).
• 10+ years of Program Management experience, preferably in early-stage drug discovery and development.
• Experience in the development of advanced therapies to treat rare genetic disease is a plus
• Demonstrated experience leading cross-functional teams; strong interpersonal and communication skills
• Scientific curiosity and passion for discovering new, innovative medicines.
• Openness to embrace new technologies and digital approaches in drug discovery
• Proven track record in driving successful, collaborative drug discovery teams.

The salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

About Alltrna 

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.

Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics. 

For more information, visit www.alltrna.com

Sr. Director Program Management & Business Operations

Position Summary:

Alltrna is seeking a talented and highly motivated Sr. Director Program Management and Business Operations, reporting to the President & CFO.  The successful candidate is a proven leader with extensive experience in leading research and early drug development program teams from research through the clinic with a particular initial focus on IND enabling and early/mid-stage clinical development. The candidate will be a member of the Company’s Leadership Team and will serve as Chief of Staff to the team to drive collaboration, cross-functional clarity, alignment and execution on key priorities and initiatives required to meet the goals of the organization.

Key Responsibilities:

Program Management:

• Work closely with the Chief Medical Officer to lead the program team for the Company’s lead program, AP003, and future programs instilling a culture of scientific rigor, open debate, collaborative teamwork, sense of urgency and accountability
• Possess a comprehensive understanding of the drug discovery process to guide program teams to define the key scientific questions, program strategy and objectives, translating these into optimal deliverables, cross-functional plans, timelines and budgets
• Identify bottlenecks, risks, issues and proactively develop appropriate mitigation proposals with input from team members
• Ensure all key decisions are identified and properly assessed as to their impact and alternative scenarios developed and evaluated, where appropriate
• Work closely with finance and functional teams to develop the operational plans to support program activities with realistic timelines, budget, and resource planning and monitor performance against plans
• Interface with and drive collaboration between the various functional teams and with the Leadership Team on program-related matters.
• Be the key accountable person for communicating matters related to the programs to management including strategy, work product, updates and issues; producing the one “source of truth” for program-related topics and timelines
• Point person for alliance management and coordination, as needed
• Lead and/or manage strategic or platform development projects as required and collaborate with Chief Scientific Officer and Research Leadership Team to coordinate relevant content for quarterly business review meetings

Operations:

• Collaborate with Leadership Team in development of strategic plans, company goals, long-range planning assumptions, portfolio-level reports and analyses to support business processes and strategic discussions
• Develop and deliver impactful presentations that effectively distill complex issues to the critical points and lead to increased understanding and optimized strategic planning & decision-making

• Prepare strategic communications utilizing a clear understanding of the business strategy and issues; develop and maintain consistent, relevant content for use in executive-level communications and to further organizational and business goals

• Lead the Scientific Communications process, working with the Scientific Communications Committee

• Manage schedule, agenda, and content for Leadership Team, Board of Directors and Town Hall meetings

• Proactively seek opportunities for organizational improvements (e.g. team structure, processes, communication, etc.)

Other:

• Support CEO / LT with partnership discussions and negotiations, including background research, preparation of presentation materials, supporting diligence activities, participating in analysis of terms, etc.
• Assist in mapping competitive landscape and proactively identify potential and emerging competitive threats and opportunities
• Promote strategic discussions on external trends, competitor strategies, and potential disruptors, and translate these into strategic choices/ recommendations
• Collect insights and intelligence from a variety of sources including literature searches, reviewing analyst research, KOL and patient group interactions, etc.

Key Competencies:

• This is a highly visible leadership role that requires exceptional interpersonal and communication skills, creative thinking, and early drug development experience that allows one to recognize opportunities/challenges and modify strategy accordingly
• The individual will need to have self-confidence and poise to manage complicated programs and projects with multiple stakeholders

• The individual will need a sense of urgency and can-do attitude to develop therapies for patients with significant unmet medical needs

Minimum Qualifications:

• BS/MS Degree in a scientific discipline, ideally life science or chemistry.
• At least 15 years relevant experience in pharma or biotech drug discovery and development, as well as a comprehensive understanding of drug discovery (preclinical and clinical).
• 10+ years of Program Management experience, preferably in early-stage drug discovery and development.
• Experience in the development of advanced therapies to treat rare genetic disease is a plus
• Demonstrated experience leading cross-functional teams; strong interpersonal and communication skills
• Scientific curiosity and passion for discovering new, innovative medicines.
• Openness to embrace new technologies and digital approaches in drug discovery
• Proven track record in driving successful, collaborative drug discovery teams.

The salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond. 

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet.

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company’s annual list of the World’s Most Innovative Companies.

Position Overview

Flagship Pioneering is seeking an experienced and strategic Vice President or Senior Vice President, Total Rewards and People Operations to lead the design, management, and evolution of Total Rewards programs and key people infrastructure across our ecosystem. The scope of this role spans compensation, executive compensation, equity, benefits, people operations, and people analytics for Flagship and its portfolio of companies.

This is a highly visible leadership role requiring deep expertise in compensation strategy and private-company equity, as well as the ability to operate effectively across a complex, fast-paced, and highly matrixed environment. The ideal candidate will bring strong executive presence, sound judgment, and the ability to translate business strategy into scalable people programs that support growth, innovation, and organizational effectiveness.

This leader will oversee an established team across Compensation, Benefits, People Operations, and People Analytics, and will be expected to shape a modern, market-relevant Total Rewards philosophy, refine equity and incentive structures, advance benefits strategy, and drive people insights that support executive decision-making.

Key Responsibilities

Total Rewards Strategy and Leadership

• Lead the strategy, design, and ongoing evolution of Flagship’s global Total Rewards philosophy across compensation, executive compensation, equity, benefits, and other reward programs. 
• Serve as the principal architect of rewards strategy, recommending program direction to senior leadership and ensuring alignment with business priorities, talent strategy, and financial objectives. 
• Develop and refine salary structures, incentive frameworks, equity guidelines, and market positioning approaches across a global footprint. 
• Oversee job architecture and leveling governance in support of internal equity, talent management, and scalable compensation decision-making. 
• Guide annual compensation planning processes, including merit, bonus, promotion, and other pay actions, in partnership with HR, Finance, and business leadership. 
• Partner closely with Talent Acquisition and HR Business Partners on executive and broad-based offer strategy, market competitiveness, and internal equity. 
• Lead the continued evolution of executive compensation and broad-based equity strategy across Flagship and applicable portfolio companies. 

Equity and Incentive Design

• Provide strategic leadership for complex equity and long-term incentive programs, including private-company equity structures and alternative long-term incentive constructs. 
• Oversee equity strategy, governance, and operational execution through the team, ensuring strong program design and scalable administration. 
• Partner with senior leadership on the design and refinement of incentive and ownership frameworks that support attraction, retention, and long-term value creation. 
• Bring familiarity with innovative and non-traditional compensation approaches, including profits interests, carried interest, and related long-term incentive structures. 

Benefits Strategy

• Lead benefits strategy across health and welfare, retirement, leave, and ancillary programs, ensuring programs remain competitive, sustainable, and aligned with organizational values and workforce needs. 
• Partner with the Benefits leader and external advisors to evaluate plan design, funding, market trends, vendor performance, and evolving regulatory requirements. 
• Support harmonization and modernization of benefits strategy where appropriate across a diverse and growing ecosystem. 

People Operations

• Oversee key People Operations functions, including onboarding, offboarding, employee lifecycle processes, policy administration, compliance workflows, service delivery, and operational process excellence. 
• Ensure people processes are scalable, well-governed, and designed to support a high-quality employee and manager experience. 
• Partner effectively across HR, Payroll, IT, Legal, and Finance to improve operational efficiency and strengthen people-related infrastructure. 
• Provide leadership on HR compliance, as well as compensation- and benefits-related compliance considerations, in partnership with internal and external experts as appropriate. 

People Analytics

• Lead the People Analytics agenda, with an emphasis on generating insights that support executive decision-making across workforce planning, hiring, retention, compensation, and organizational effectiveness. 
• Oversee dashboards, reporting, and analytical frameworks that inform leaders including the CEO and CFO. 
• Translate data and analysis into actionable recommendations in partnership with HR Business Partners and business leaders. 
• Advance a thoughtful, increasingly sophisticated analytics capability that supports better people decisions across Flagship and the broader ecosystem. 

Portfolio Company Partnership

• Advise and support portfolio company leaders on Total Rewards strategy, with involvement calibrated to company stage, maturity, and business need. 
• Tailor rewards frameworks and guidance for a range of company stages while maintaining sound governance and alignment with broader talent and value creation goals. 
• Present recommendations and insights to portfolio company leadership and boards as needed. 

Leadership and Team Development

• Lead, develop, and inspire a multi-functional team spanning Compensation, Benefits, People Operations, and People Analytics. 
• Foster strong collaboration across functional teams and help continue building a high-performing, service-oriented, and strategically focused organization.
• Manage external consultants, brokers, survey providers, and other key vendors in support of rewards strategy and operational excellence. 

Qualifications

• 15+ years of progressive experience in Total Rewards, with significant depth in compensation strategy and experience leading broad, multi-functional teams. 
• Deep expertise in compensation design, market benchmarking, executive compensation, incentive strategy, and private-company equity. 
• Strong familiarity with alternative long-term incentive structures, including profits interests, carried interest, and other innovative ownership or reward constructs. 
• Experience leading or advising on benefits strategy, including health and welfare, retirement, leave, and ancillary offerings. 
• Experience overseeing or partnering closely with People Operations and People Analytics functions in complex organizations. 
• Demonstrated success operating in high-growth, founder-led, venture-backed, private equity, or similarly dynamic business environments. 
• Experience supporting global workforces and navigating matrixed organizations with multiple stakeholders and business models. 
• Strong executive presence with the ability to influence senior leaders, present compelling recommendations, and operate as a trusted advisor. 
• Proven ability to translate data and market insights into practical, business-relevant decisions and action plans. 
• Experience working with boards, founders, and senior executive stakeholders preferred. 
• Prior life sciences or biotechnology experience preferred, but not required. 

Why Join Flagship Pioneering?

This is a rare opportunity to play a critical role in shaping how a highly innovative organization rewards, supports, and scales exceptional talent. As Senior Vice President, Total Rewards and People Operations, you will operate at the intersection of business strategy, organizational design, and cutting-edge science, helping to build and evolve the people infrastructure that supports transformative work in human health and sustainability.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-NM1

The salary range for this role is $300,000 - $400,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond. 

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet.
Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company’s annual list of the World’s Most Innovative Companies.

Position Overview

Flagship Pioneering has a new and exciting opportunity for a high-energy, detail-oriented Corporate Paralegal to join its fast-paced, dynamic legal team. This role will report to the Senior Corporate Paralegal and work closely with members of the legal team to support Flagship’s corporate legal function across its growing portfolio of companies.

The Corporate Paralegal will assist with a range of corporate matters, including financings, corporate governance, equity compensation, and general corporate maintenance for Flagship and its cutting-edge, high-growth companies. This includes providing support on a variety of transactions and day-to-day corporate activities across both private and public companies—such as preparing and organizing documentation for financings; supporting equity compensation processes; and maintaining corporate records and governance materials. This role will also have touchpoints in the Finance, Human Resources, Communications and Flagship Labs groups.

Key Responsibilities

Board Governance Support

• Assist in preparation of board and stockholder consents
• Maintain board records, minutes, and governance documentation
• Support recurring board cycles across portfolio companies
• Track and organize signature pages; prepare closing binders

Equity Administration

• Support equity grant processing and updates in Carta or similar platforms 
• Assist with coordination across HR and Finance on equity-related matters 
• Respond to routine equity-related inquiries 

Corporate Maintenance & Entity Management

• Maintain and track corporate records, minute books, and entity documentation 
• Support entity formations, dissolutions, and ongoing maintenance
• Track officer and director information across entities 
• Assist with international entity management 

Process & Infrastructure Support

• Support development of governance processes and templates
• Assist with compliance initiatives and cross-functional projects
• Contribute to building scalable governance infrastructure
• Assist with the design and development of AI agentic support for routine corporate matters
• Provide backup and surge support to other paralegals on the Flagship legal team

Key Qualifications and Skills

• Bachelor’s degree required
• 2–5 years of corporate paralegal experience (law firm and/or in-house)
• Experience with governance, entity management, or equity administration preferred

• Comfortable working in an entrepreneurial environment with compressed timelines and evolving priorities.
• Strong priority-setting, organizational and communication skills
• Exceptional attention to detail and are highly organized
• Ability to prioritize and manage multiple deadlines in a fast-paced, high-volume environment with competing demands.
• Excellent written and verbal communication skills.
• Willingness to use and adopt AI tools (ChatGPT, Claude, GC AI) to enhance legal workflows, as well as core legal and business platforms (iManage, SharePoint, Carta, Microsoft Office). 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies:  Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.  The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.   Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-NM1

The salary range for this role is $88,000 - $121,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Who We Are

Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond. 

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet.

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company’s annual list of the World’s Most Innovative Companies.

About the Role

Flagship's GRC program has matured from build to operate. We have a functioning GRC system of record in Jira, active compliance tracks across HITRUST, NIST 800-171, ISO 27001, and SOC 2, and a TPRM workflow in production. What we need now is a hands-on practitioner who can execute against that infrastructure — someone who is as comfortable running a vendor risk assessment in Jira as they are prepping evidence packages for an audit. This is not a policy-writing or director-level role. It is a technical execution role for someone who gets things done.

What You'll Do

• Own day-to-day execution of the GRC system of record in Jira — maintaining control records, updating compliance status, logging implementation and auditor notes, and keeping the SOR current across all active frameworks
• Run TPRM assessments end-to-end: intake, questionnaire review, risk scoring, CISO decision documentation, and post-approval tracking
• Coordinate audit evidence collection and control testing activities across HITRUST, ISO 27001, SOC 2, and NIST 800-171 frameworks, working directly with the external audit firm
• Maintain the compliance calendar and drive sprint-by-sprint execution against framework deadlines
• Manage sub-processor and DPA tracking for portfolio company privacy programs, including gap identification and remediation follow-up
• Support DSR and privacy program operations, including data inventory maintenance and deletion workflow tracking
• Build and maintain GRC automation using AI tools (Claude, Jira automation, Zapier) to reduce manual burden on recurring compliance tasks
• Produce clear, accurate reporting on compliance posture for the CISO and cross-functional stakeholders

What We're Looking For

• 3–6 years of hands-on GRC experience, ideally in a fast-moving tech or life sciences environment
• Direct experience working in Jira as a compliance or GRC tool — not just a project management tool; you should understand issue types, custom fields, bulk operations, and reporting
• Working knowledge of at least two of: HITRUST CSF, ISO 27001, NIST 800-171/CMMC, SOC 2, HIPAA
• Experience running vendor risk assessments — intake to decision — not just filling out questionnaires
• Comfort with AI-assisted work: you should already be using tools like Claude or ChatGPT to accelerate your GRC work, not learning to do so for the first time
• Strong written communication — you'll be producing evidence narratives, audit responses, and control documentation that external auditors and regulators will read
• Ability to operate with high autonomy; the CISO will provide direction but not day-to-day supervision

Nice to Have

• CISA, CRISC, CISM, or equivalent certification
• Experience with privacy program operations (CCPA, GDPR, DSR workflows)
• Familiarity with Drata, Vanta, or similar compliance automation platforms
• Experience supporting a portfolio company or multi-entity compliance program

Why This Role

You'll own a real compliance program, not support someone else's. The CISO is your direct partner, not a distant approver. You'll use modern tools — Jira, Claude, Zapier — to do GRC work that most teams still do in spreadsheets. And you'll have visibility into a genuinely diverse security environment spanning drug discovery AI, clinical platforms, and life sciences infrastructure.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. 

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. 

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. 

#LI-NM1 

The salary range for this role is $88,000 - $121,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Your Impact at LILA

Lila Sciences is the world’s first scientific superintelligence platform and autonomous lab for life, chemistry, and materials science.  We are pioneering a new age of boundless discovery by building the capabilities to apply AI to every aspect of the scientific method.  We are introducing scientific superintelligence to solve humankind's greatest challenges, enabling scientists to bring forth solutions in human health, climate, and sustainability at a pace and scale never experienced before.

As a Head of Software Product you will serve as the primary architect of our software product strategy. You will lead the development of our “Agentic Superscience” software—the foundational platform designed to reinvent the scientific method through AI. Reporting directly to the Chief Revenue & Product Officer, you will be responsible for transforming complex scientific workflows into a scalable, world-class software ecosystem. You will set the roadmap, build the processes, and the culture necessary to deliver Lila’s most critical competitive advantage. As a member of the leadership team, you will play a critical role in shaping the culture, technical strategy, and therapeutic impact of our software.

What You'll Be Building

• The Agentic Platform: Lead the roadmap and build of our foundational software platform that enables AI agents to conduct, analyze, and iterate on complex materials, chemistry, and biology experiments.
• A Cross-Functional Engine: Create the integrated framework that allows Software, ML, and Wet-lab teams to work in a continuous, high-performance loop.
• Customer-Centric Interfaces: Deliver reliable, intuitive interfaces and high-performance endpoints that make scientific superintelligence accessible to diverse users.
• Operational Excellence: Own the product lifecycle from discovery to delivery. Implement robust frameworks for prioritization that balance rapid innovation with enterprise-grade reliability.
• The Product Org & Executive Voice: You will build the frameworks for high-level communication, serving as the authoritative voice for the software product and providing the strategic insights that will influence Lila’s overall trajectory.

What You’ll Need to Succeed

• 15+ years of experience in Product Management, with a track record of shipping complex, multidisciplinary software systems (0-to-1 and scaling phases) using a modern tech stack.
• Experience building software with AI at its core and must be AI-native.
• Deep understanding of the scientific method, either via schooling in a scientific domain or from experience building software for scientists
• Demonstrated experience building and leading large, high-performing teams in fast-paced, high-stakes environments.
• A drive for impact against mission goals, with a high degree of comfort in the ambiguity of a ‘founding’ environment.
• Capable of communicating technical and scientific concepts to any audience, from engineers to investors.

Bonus Points For

• Experience with automated or self-driving labs.
• Experience building complex agentic AI strategies.

Your Impact at LILA

As Lila scales its AI Science Factories globally, the VP of Engineering will create and sustain an engineering model for a unified, scalable platform for autonomous experimentation. This role will be responsible for defining and implementing that platform across hardware, automation, and systems engineering. This executive will own strategy, execution, and talent across Lila’s systems, hardware, and automation engineering. The role sits on the senior leadership team, reports directly to the Chief Autonomous Science Officer, and interfaces directly with Robotics, Software, Operations, and Science teams.

The VP Engineering will bring deep technical experience in automation of lab science, a track record of building and leading multi-disciplinary engineering organizations, mentorship practices that foster career development of engineers at all levels, and the judgment to balance near-term delivery with long-term platform development. This is a hands-on leadership role in a fast-moving environment, requiring brilliance and dynamism to realize autonomous experimentation across materials science, chemistry, and life science. The role requires engineering innovations to achieve an unprecedented depth of AI integration in lab science, which combined with aggressive scaling of Lila’s AI Science Factories (AISFs) will produce the highest degree of scientific intelligence on earth.

What You'll Be Building

• Set the engineering roadmap for ASP Engineering, including objectives, risks, and platform priorities via collaboration with the Robotics, Software, Science, and Product teams.
• Define and drive a unified platform architecture across hardware, automation, and systems engineering, reducing one-off designs and enabling repeatable system deployment across sites
• Establish system-level ownership of architecture, interfaces, and requirements to ensure consistent integration across all engineering domains
• Implement efficient processes for lifecycle, design controls, safety and compliance, change management, and deployment of autonomous laboratories to support rapid scaling without compromising system consistency
• Develop a repeatable deployment model for standing up global AI Science Factory sites with predictable performance and reliability
• Create a culture of mentorship that supports execution of the roadmap while fostering career development of engineers
• Partner with Robotics and Software to build, industrialize, and scale all-of-science autonomous labs with a focus on reliability, throughput, and quality
• Integrate AI into the engineering lifecycle to bolster engineering speed and quality, decision making, and continuous improvement
• Collaborate with Talent Acquisition to establish hiring practices that accelerate identification and onboarding of brilliant, culturally-aligned engineers
• Partner with AI Research, Software, Product, and Science to align platform capabilities with scientific and commercial priorities
• Develop and communicate clear prioritization frameworks across engineering initiatives; translate organizational feedback into actionable systems and process improvements
• Represent Engineering with executive stakeholders and external partners; communicate tradeoffs, progress, and impact clearly
• Partnering with external integrators, OEMs, and contractors to expand engineering capacity

What You’ll Need to Succeed

• 15+ years building lab automation systems
• 10+ years leading managers and multi-disciplinary teams at scale
• Proven track record scaling automated labs or manufacturing-like lab operations, including instrument and robot integration, scheduling and orchestration, reliability engineering, and capacity planning
• Demonstrated experience integrating AI/ML into engineering, operations, and/or research environments
• Experience building and standardizing complex engineering systems from early-stage, project-based environments into scalable, repeatable platforms
• Demonstrated ability to balance rapid experimentation with the introduction of structure required for scale
• Technical expertise across lab automation, controls/SCADA, and science instrumentation, including integration and co-development of robotics and software/data/compute platforms
• Strong people and org leadership: recruiting and developing exceptional managers and ICs; building inclusive, high-ownership cultures that scale
• Excellence in retaining cultural and technical excellence across multiple sites of lab automation innovation and build-outs

Bonus Points For

• Multi-domain engineering excellence (mechanical, controls, electrical, systems) and cross-discipline engineering fluency (robotics, software, computer)
• Experience defining interface standards across hardware, robotics, and software systems
• Experience standing up lifecycle management (e.g., PLM-lite, change control, commissioning frameworks) in fast-moving environments
• Multi-domain science fluency (materials science, chemistry, life science)
• 10+ years experience integrating LIMS, orchestration, schedulers, and reliability and observability pipelines in lab automation
• Experience managing stage-gate transitions from R&D to scaled operations across multiple sites

Your Impact at LILA

We’re seeking a Vice President / Head of Marketing focused on accelerating commercial growth and strategic partnerships. This role fuels pipeline, enables revenue, and increases partner-driven adoption across priority industry segments. Reporting line is flexible and can sit under our Chief Communication and works directly with the CEO/Founder, with day-to-day collaboration across Sales, Partnerships, Revenue, Product, and Scientific leadership. You will define and execute marketing motions that translate frontier science and technical capabilities into enterprise-ready programs that open doors, build trust, and close.

What You'll Be Building

Drive commercial demand and pipeline

• Build and run an integrated demand engine targeting senior scientific and business buyers (R&D leadership, innovation executives, technical decision-makers).
• Develop account-based marketing programs for enterprise and strategic accounts.
• Plan and optimize channel mix across digital, field events, executive programs, and partner-led efforts.
• Own reporting and iteration loops that connect marketing activity to pipeline outcomes.

Enable partnerships and ecosystem growth

• Create go-to-market motions with partners that generate qualified introductions and joint opportunities.
• Develop partner-facing materials, co-marketing kits, and joint event strategies.
• Identify and cultivate ecosystems that matter to LILA’s commercial expansion (scientific communities, industry networks, and mission-aligned institutions).

Build segment-specific positioning and sales enablement

• Translate LILA’s technical platform into clear, differentiated value propositions for priority verticals.
• Partner with Commercial leadership to define ICPs, buyer personas, and qualification narratives.
• Deliver sales enablement: pitch narratives, technical collateral, case studies, ROI framing, objection handling, and competitive context.
• Support longer enterprise sales cycles with the right proof points at each stage.

Produce content that supports revenue and credibility

• Develop high-leverage content (technical briefs, case studies, webinars, white papers, executive narratives).
• Package customer and partner outcomes into reusable assets that accelerate trust and decision-making.
• Ensure marketing outputs are consistent with LILA’s brand and narrative, in close coordination with Corporate Communications.

What success looks like (first 6–12 months)

• Clear commercial messaging and a repeatable set of sales assets for core segments.
• A measurable pipeline contribution engine tied to specific commercial targets.
• Partner co-marketing motions that produce qualified opportunities.
• A content and events strategy that materially improves credibility with enterprise scientific buyers.

What You’ll Need to Succeed

• 10+ years in B2B marketing, with senior leadership experience in high-consideration enterprise or technical markets.
• Track record of driving pipeline and revenue outcomes (demand gen, ABM, field marketing, partner marketing).
• Strong product/segment marketing instincts for complex technical products (AI, deep tech, SaaS, biotech, industrial tech).
• Ability to work fluently with technical teams and translate technical truth into buyer-relevant value.
• Experience building functions and operating systems from early stage to scale.
• Strong analytical and operational discipline, with comfort owning metrics and performance reviews.
• Collaborative leadership style with a high degree of ownership.

Bonus Points For

• Experience in vendor/partner ecosystems, or experience scaling marketing in AI-for-science contexts.
• Background in academic or research-domain communications, or with PhD communities.

Position Overview:

The Vice President, Compliance is a strategic leader responsible for designing, implementing, and continuously improving the company’s Corporate Compliance Program to oversee promotional materials, field training, and HCP/patient programs. As an objective advisor, the Vice President, Compliance ensures the organization operates with integrity and in compliance with all applicable laws, regulations, and internal policies. Reporting to the Chief Legal Officer, the Vice President, Compliance partners with executive leadership, the legal and compliance function, the Audit Committee of the Board of Directors, and employees at all levels to foster a culture of ethical conduct and accountability.

Beam is transitioning to a commercial stage company, and this position plays a critical role in developing a culture of compliance.  Additionally, ex vivo cell therapy and in vivo gene therapy have unique commercial and operational needs that require a strategic leader to collaborate with commercial, medical, and manufacturing to build a commercial process that delivers for patients compliantly.

Key Responsibilities:

• Develop, execute, and evolve a comprehensive compliance strategy and program focusing on healthcare compliance and aligning with business objectives and legal requirements that meets the unique needs of cell and gene therapy.
• Provide proactive strategic advice to the business to help drive commercial success and ensure compliance with applicable laws and company policies, including federal and state anti-kickback and false claims laws; U.S. and other country anticorruption laws; the federal Food, Drug and Cosmetic Act; and federal and state transparency laws.
• Serve as Chair of the Beam Compliance Committee and as Data Privacy Officer.
• Provide regular updates on the Compliance Program to executive leadership and the Audit Committee of the Board of Directors.
• Review business strategy plans and business development opportunities for compliance risks and advise the business on how to mitigate those risks.
• Develop and maintain trusting relationships with key client groups, such as commercial and clinical, and serve as a trusted and strategic advisor and resource.
• Act as a compliance champion to reinforce a culture of integrity and raise awareness of compliance as a collective responsibility of all company personnel.
• Champion open communication by ensuring employees feel empowered to raise concerns without fear of retaliation.
• Oversee ongoing education initiatives to enhance understanding of the Code of Business Conduct & Ethics, Beam policies and procedures, and emerging compliance risks, and seeking opportunities for continuous learning across the organization.
• Continuously assess the effectiveness of the compliance program through data-driven audits, risk assessments, and performance metrics. Identify gaps and support the design and tracking of corrective actions to strengthen compliance controls.
• Manage and conduct compliance investigations, working with internal business partners to identify appropriate corrective and preventive actions.
• Stay ahead of regulatory and industry code changes and industry and enforcement trends impacting compliance areas and proactively advise leadership on potential impacts and necessary adaptations.
• Serve as a trusted advisor to the Board of Directors, Chief Legal Officer, executive leadership team, and other functions, providing actionable guidance on compliance matters and risk mitigation.
• Engage with outside counsel, regulatory agencies, and industry groups to understand and benchmark the best practices and ensure the compliance regime meets or exceeds industry standards.

Qualifications:

• Bachelor’s degree required, Juris Doctorate or advanced degree a plus.
• Cell and gene therapy experience a must.
• Relevant experience (typically 7 years or more, or equivalent combination of education, training, and experience) with a deep understanding of compliance issues confronting the pharmaceutical/biotech industry.
• Demonstrated knowledge and understanding of the requirements for effective compliance programs as set forth in the OIG Compliance Program Guidance for Pharmaceutical Manufacturers and the U.S. Sentencing Guidelines.
• Demonstrated effectiveness operating in complex organizational and regulatory environments and experience with Code implementation (PhRMA, EFPIA, IFPMA)
• Demonstrated knowledge and understanding of the legal and regulatory framework affecting the pharmaceutical industry including sales and marketing, OIG and other industry guidance documents, regulations on the promotion of marketed products, clinical trial regulations, patient privacy and issues arising under the False Claims Act, anti-bribery/anti-corruption laws, and other related laws.
• Business focused and solution oriented.
• Excellent written, oral and presentation skills.
• Proven ability to work with all levels of management.
• Strong problem-solving and analytical skills.
• Self-motivated and able to perform role independently, with a minimum level of supervision.
• Demonstrated ability to partner effectively with others in addressing complex issues.
• Strong influencing skills and sound business judgment.
• Ability to appropriately prioritize issues.
• Outstanding attention to detail.

Who We Are

Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.  

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.  

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. 

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

Position Summary:

The Director of Financial Reporting, Planning and Analysis (FP&A) is a core player in creating, growing, and building Flagship Pioneering early-stage companies. You will join the FP&A team in Flagship Labs Finance, primarily focusing on a set of NewCos or recent GrowthCos. You will be an instrumental player responsible for driving the annual planning cycle across the Flagship Lab companies, providing business insights to our leaders to measure progress on company performance and enhancing companywide financial reports, including enhanced analytics, finance modeling, cash flow management and consolidated reporting. This position provides an opportunity for professional growth and exposure to multiple Flagship-funded companies.

Key Responsibilities:

• Establish and maintain the financial models that inform and enable capital allocation in a dynamic business planning environment
• Work with Pioneering Business Units (PBU) leaders, their CFO/Heads of Finance, corporate teams, and the companies to develop and maintain the long-term value creation model 
• Partner with the PBU Controllers to support planning that is aligned with GL reporting structure and support functional and program costing 
• Responsible for all aspects of management reporting and analysis for operating and capital expenses, cash flow analysis and funding requirements for multiple business scenarios
• Partner with HR to reliably track and report actual and projected headcount, including open reqs and progress against hiring plans and budgets
• Provide analytical support and modeling for business development deals
• Provide financial analysis to support critical portfolio and business decisions such as evaluation of indication selection, commercial opportunity analysis, make vs buy, etc. 
• Compile relevant financial information and presentations for internal (BOD, management) and external (lender, investors, partners) stakeholders, including meaningful data visualization as needed

Qualifications:

• 10+ years’ experience in FP&A roles in the biotech/pharmaceutical industry, preferably a high growth environment. Candidates with experience in MedTech and AgTech will be considered
• Experience with public companies preferred.  A combination with small private/start-up experience will be an advantage to thrive in a fast-growing and rapidly changing environment, comfortable with ambiguity
• Expertise building relationships with various stakeholders and working with senior leaders
• Direct experience with data manipulation and visualization tools is a plus (e.g., Power BI)
• Master’s degree in accounting or finance. MBA or CPA is a plus

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-NM1

The salary range for this role is $172,000 - $236,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Who We Are

Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.  

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.  

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. 

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

About the Role

The Information Security team has strong detection and response capability and a maturing compliance program. This is a greenfield opportunity to build Flagship’s cloud security and application security engineering practice in earnest — with the CISO and Director of Security Engineering as your strategic partners and a well-resourced program behind you. You’ll define how cloud posture management, SSDLC security, and cloud-side DLP get done at Flagship — in deep partnership with the Infrastructure & Operations team, who are your primary counterparts for cloud architecture, network, and endpoint infrastructure. What makes this role distinctive is the expectation that you’ll build AI-augmented workflows from the start — using LLMs and agentic tooling to handle the routine 80% so your expertise stays focused on the 20% that actually requires human judgment. If you want to own a practice area rather than execute someone else’s playbook, this is that role. You'll own the technical execution of cloud security and AppSec across Flagship and its portfolio, working directly with engineering teams to embed security into their pipelines, not just review them after the fact.

What You'll Own

• Cloud security posture management: own remediation execution against Wiz findings in close partnership with Infrastructure & Operations — building shared remediation playbooks, coordinating finding resolution across AWS environments, and ensuring security controls are implemented consistently with I&O’s infrastructure standards
• CI/CD and SSDLC security: design and implement security guardrails in engineering pipelines — SAST, secrets scanning, IaC security, container scanning — working directly with portfolio engineering teams, and building AI-powered pipeline security automation (e.g., LLM-assisted code review, automated fix suggestions for SAST findings) that reduces developer friction and scales security coverage beyond what manual review allows
• Cloud-side DLP enforcement: build and operationalize data loss prevention controls at the cloud and application layer, not just policy definition
• Cloud identity and access: own technical execution on Entra/Azure AD conditional access, BYOD policy enforcement, and cloud identity governance in partnership with Infrastructure & Operations, who manage the underlying directory and endpoint infrastructure
• Detection engineering (cloud layer): write and tune cloud-side detection rules and contribute to alert fidelity improvements in partnership with the SOC
• AI platform security: contribute to security architecture reviews and guardrail design for AI-powered portfolio products, including Bedrock and EKS-based platforms
• Serve as the embedded security engineering partner for portfolio company engineering teams — not a reviewer at the end of the process, but a collaborator throughout it
• Design and maintain AI-augmented workflows across all functional areas you own — using LLMs, agentic tooling, and automation to multiply your own capacity. You'll be expected to treat AI as a core part of your engineering toolkit, not an experiment: building prompt-driven triage pipelines, automating remediation drafting, and continuously identifying where human judgment is the bottleneck versus where it's being wasted on pattern-matchable work.

What We're Looking For

• 5+ years in cloud security, application security, or a closely related security engineering discipline
• Deep hands-on experience with AWS security services (Security Hub, GuardDuty, IAM, SCPs, CloudTrail) and cloud posture tooling — Wiz experience strongly preferred
• Practical AppSec experience: you've integrated SAST/DAST/SCA tooling into CI/CD pipelines and worked directly with developers to resolve findings, not just filed tickets
• Experience with cloud identity platforms — Entra ID / Azure AD, including conditional access policy design and enforcement
• Ability to write infrastructure-as-code and scripting to automate security controls (Python, Terraform, or equivalent), including comfort working with LLM APIs, prompt engineering, and agentic orchestration frameworks
• Demonstrated experience building AI-augmented security workflows — you've used LLMs, agentic frameworks, or AI-assisted tooling to automate security tasks at scale, not just experimented with ChatGPT. You should be able to articulate which security problems are well-suited to AI automation and which aren't.
• Strong enough communication skills to be credible with engineering leadership and portfolio company CTOs — you’ll be in technical design reviews, not just security reviews Proven ability to build trusted working relationships with Infrastructure & Operations teams — you approach I&O as a partner, not a gatekeeper, and can influence security outcomes through collaboration rather than mandate
• Comfort operating as a self-directed practitioner in a lean team; this role requires you to set your own execution priorities within a defined strategic direction

Nice to Have

• Experience securing ML/AI platforms — Bedrock, SageMaker, or comparable environments
• AWS Security Specialty, GWEB, OSCP, or equivalent certification
• Experience in a portfolio company or multi-entity security model
• Familiarity with HIPAA technical safeguard requirements and PHI data flows in cloud environments
• Experience designing or operating agentic AI workflows for security operations
• Container and Kubernetes security experience (EKS, image scanning, network policy)

Why This Role

This is a net-new capability role on a small team — you won't be executing someone else's existing playbook, you'll be building the cloud and AppSec program from a solid foundation. You’ll work directly with the CISO and collaborate closely with the Director of Security Engineering. Flagship's portfolio spans some of the most technically ambitious biology and AI work happening anywhere, and the security work reflects that complexity. If you want a role where the scope is real, the autonomy is genuine, and you have the freedom to build an AI-augmented security practice — this is it.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. 

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship. 

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. 

#LI-NM1 

The salary range for this role is $148,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Quotient is seeking a hands-on, highly experienced Vice President of Finance who has experience working in a private biotech company with both pre-clinical and clinical programs. The ideal candidate will have strong finance expertise, experience with technical and operational accounting, proven experience as a leader, and a demonstrated ability to build innovative finance teams and systems. This individual must be comfortable working independently in a resource-constrained environment while building out the finance function and also providing strategic financial guidance to the executive team.

The Vice President of Finance will be responsible for overseeing all aspects of accounting, financial operations, and compliance while contributing meaningfully to corporate strategy and long-term planning. This is a key leadership role within the company and is the primary steward of financial strategy, discipline, systems, and governance.

Responsibilities: 

• Initially serve as the company’s controller, overseeing all accounting operations, financial reporting, and internal controls; ensure compliance with GAAP and all applicable regulations, manage monthly, quarterly and annual close processes as well as tax and regulatory filings, and initiate/lead financial statement audits
• Partner with the CFO and leadership team to develop and refine the company’s financial strategy and long term operating plan; provide scenario modeling, budgets, forecasts, long range planning models and capital allocation recommendations, and support fundraising activities, investor relations and board-level financial reporting
• Implement and maintain innovative and scalable accounting and financial systems, processes and tools; oversee cash flow management, including tracking of R&D expenses, collaboration budgets and operational spend, and lead implementation of accounting and finance systems independent from the Flagship ecosystem
• Plan and build out a small internal finance team, fostering growth and accountability; develop and oversee launch of finance function independent of Flagship support, oversee and coordinate work of external vendors, including auditors, accounting consultants, tax advisors and payroll providers, ensuring vendors meet performance expectations, budgets and timelines

Qualifications:

Essential

• 15+ years of progressive finance and accounting experience, including senior leadership roles 
• Proven track record in a private life sciences/biotech company with both clinical and pre-clinical programs
• Strong understanding of GAAP and biotech-specific accounting issues, including R&D accruals and clinical trial accounting
• Experience leading budgeting, financial reporting and long range planning processes
• Experience building teams and system transitions/implementations
• Experience managing direct reports and external vendors
• Demonstrated ability to work independently in a fast-paced, entrepreneurial environment

Desirable

• CPA or MBA strongly preferred 
• Experience supporting fundraising activities (venture capital, crossover, IPO readiness)
• Understanding of and interest in utilizing AI and automation for finance 
• Familiarity with biopharma collaboration accounting and reporting as well as cost modeling for clinical development and pre-clinical programs

Values and Behaviors:

• Encourage respectful disagreement and cultivate open-minded, ego-free interactions to continuously push each other towards excellence
• Seek out diverse perspectives; practice active listening and genuine curiosity to ensure all contributions are valued, regardless of source
• Recognize the impact of your behavior, language and attitudes, and strive for balanced, meaningful exchanges that enhance mutual growth and understanding in all interactions
• Use a company-first mindset to guide decision-making; prioritize team over individual success
• Take calculated risks and challenge convention in the quest for exceptional outcomes

About Quotient:

Quotient Therapeutics is a privately-held, early stage company developing breakthrough medicines informed by natural somatic genetic diversity present in patients. Through our work in somatic genomics, we are forging a new status quo for biopharma research and development across a broad pipeline of internal and partnered programs.  

The company was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS).

Quotient Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies:

Quotient Therapeutics (“Quotient”) and Flagship Pioneering (“FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Quotient, FSP or their employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $250,000 - $350,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Quotient Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Quotient Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

The salary range for this role is $360,000 - $415,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

The salary range for this role is $360,000 - $415,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

The Recovery Adjuster is responsible for handling Recovery files of small to moderate severity and complexity, for all lines of business including Auto, Property, Commercial and Liability files. The adjuster will be responsible for investigating, reviewing, evaluating, negotiating and settling Recovery files for all business lines.  

The adjuster will be expected to demonstrate strong judgment and analytical skills in order to maximize recovery results and provide superior customer service while adhering to Gore Mutual’s internal policy and procedures while ensuring accurate reserving is in place and the anticipated Subrogation recovery is updated accordingly in the file.  Files may be pursued through inter-company arbitration or litigation.  

In addition to maximizing recoveries, the adjuster will also manage and guide their files on controlling expenses by ensuring accuracy and consistency in invoices received and paid accordingly. 

What you will do: 

HANDLE LOW TO MODERATE COMPLEXITY RECOVERY FILES:

• Review, investigate and assess new claims as they are referred and ensure that required expert vendors are involved in a timely manner.  
• Ensure that responsible parties are placed on notice and send the Demand and Subrogation documents to the responsible parties.  
• Engage legal counsel as soon as the need is identified and when appropriate. 
• Ensure that legal limitation dates are protected where we intend to pursue recovery or are still investigating, while also ensuring our clients are kept apprised of recovery efforts.  
• This role will also require that they prepare detailed reports for the Recovery Team Leader or Specialist for settlement authority requests and abandonment requests. 

ATTEND SETTLEMENT CONFERENCES, MEDIATIONS, PRE-TRIALS, TRIALS:

• Attend settlement conferences, mediation, pre-trials, and trials as required with our legal counsel.  
• Provide settlement instructions to legal counsel in pro-active efforts to resolve files in a timely manner using Alternative Dispute Resolution such as mediation/arbitration when possible.   
• Prepare files for pre-arbitration officer for inter-company arbitration process and attend hearings when possible and where pre-arbitration does not resolve the matter. 

PROVIDE DIRECTION TO CLAIMS HANDLERS ON RECOGNITION AND SUPPORT FOR RECOVERY:

• Collaborate with and provide direction to front line staff based on the claim circumstances around what evidence is required to enhance our chances of a successful recovery.   
• Ensure evidence is secured and/or retained and that the initial subrogation investigation is addressed. 

CONTROL RECOVERY EXPENSES:

• Review all invoices received for accuracy and legitimacy, issue payment accordingly.   
• Obtain budgets from recovery vendors prior to engaging their services to ensure it makes economic sense to pursue the recovery.  
• Ensure the expense of investigating and pursuing the recovery claim is not more than 35% of the value of the potential recovery amount. 

NEGOTIATE SETTLEMENT OF RECOVERY FILES:

• Negotiate directly with responsible parties, their insurers or other representatives to arrive at the highest possible settlement amount, in a timely manner.  
• Ensure releases are properly worded before signing on behalf of Gore Mutual and that the Insured’s interests and Gore’s interests are protected. 
• Ensure that Recovery payments are received within a timely manner and the insured’s deductible is reimbursed accordingly if applicable. 

What you need to Succeed:

• College or University degree preferred
• 1-3 years Auto Claims, Property Claims, or Casualty Claims experience required
• 1-3 years of Subrogation experience preferred
• CIP designation or in-progress preferred 

Hybrid: We are a hybrid company and work 2 days per week in-office. This role has the flexibility to attend either our Cambridge or Toronto office, with one day per quarter required in our Cambridge office.

The expected base salary range for this position is $52,500 - $86,500. Depending on your relevant experience, skills, qualifications, market conditions and business needs, base compensation may vary. You have the potential to earn more through Gore Mutual’s discretionary bonus program which gives you an opportunity to increase your total compensation, provided the business meets its performance targets and you meet your individual goals.

Please note: This range reflects the expected base salary for this role but may not represent the full compensation range for all experience and skill levels. During the recruitment process, we will discuss and consider how your unique qualifications align with the broader range for this position.

 Gore Mutual is proud to offer a comprehensive total rewards package which includes extended health and dental benefits, disability insurance, retirement plan matching, paid time off, recognition and perk programs.

The Position

The Vice President of Clinical Pharmacology will provide leadership and support to the clinical pharmacology team and be accountable for the overall strategy for determining the PK, PD, and immunogenicity properties of all drugs and drug candidates in development and, as applicable, through commercialization. As the clinical pharmacology expert within the company, you have experience and expertise in matrixed leadership and team management, and will lead, develop, and educate through cross-functional teams. In addition, there will be opportunities to contribute to diligence assessments. Reporting directly to the SVP, Head of Clinical Development, you will have high visibility at leadership levels, including with the Chief Medical Officer. You can efficiently and effectively synthesize internal and external data to produce a clinical pharmacology strategy.

Responsibilities

• Serve as the clinical pharmacologist for the company across all clinical programs, providing strategic and scientific input from preclinical development through Phase 3 trials
• Lead the Clinical Pharmacology team accountability for the clinical pharmacology strategy for Amylyx' development portfolio from pre-IND through and post approval, including design and implementation of program specific clinical pharmacology studies, data analysis, internal decision points, and external regulatory interactions
• Integrate clinical pharmacology knowledge with a broad understanding of and collaboration with related disciplines such as clinical, statistics, regulatory, nonclinical ADME, toxicology to support and impact development decisions
• Ensure appropriate PK, PD and PK/PD data analyses (including population PK, PK/PD modeling and simulation) are conducted for each study/program.
• Collaborates with toxicologist and preclinical pharmacology scientists to design, analyze, interpret, and report preclinical PK and translational PK/PD studies to support candidate selection and IND filing, including human PK prediction to support starting dose and dose escalation schemes for first-in-human studies
• Ensure adherence to agreed timelines and budgets to insure prompt and accurate execution of deliverables from clinical pharmacology studies and programs
• Serves as the clinical Pharmacology expert across study and program teams
• Develops and implements new clinical pharmacology approaches to processes and clinical studies that impact development programs
• Contributes to program strategy, study design, protocol preparation, study execution, data review/analysis, study reports and regulatory document preparation
• Works closely with research and development teams and provides input into assay development, CRO selection and CRO management. Leads method development, method qualification, method validation activities as SME and sponsor monitor, as assigned. 
• Represents nonclinical and clinical pharmacology during meetings and discussions with regulatory authorities
• Creates or guides nonclinical and clinical pharmacology summary documents
• Reviews literature and peer-reviewed publications to keep apprised of global regulatory developments in clinical pharmacology; Authors/ reviews manuscripts for submission to peer-reviewed journals

Required Qualifications

• PhD, PharmD, MD, or equivalent training in pharmacokinetics, pharmaceutical sciences, or related disciplines
• Minimum 12 years of experience within the pharmaceutical and biotechnology industry with 5+ years' direct experience in Clinical Pharmacology
• Experience in an array of molecules including biologics, small molecules and gene therapy
• Demonstrated experience in writing, presenting, and discussing clinical pharmacology with regulatory authorities as well as other external and internal stakeholders
• Strong analytical skills and ability to interpret complex clinical data sets as well as deep understanding of individual patient data coupled with excellent written and verbal communication skills
• Ability to work in cross-functional teams and manage multiple projects, engaging subject matter experts across functions to drive the execution of programs
• Strong technical proficiency in PK analysis (NCA and PopPK)
• Ability to work with an elevated level of integrity, accuracy, and attention to detail, while executing corporate objectives and goals
• Entrepreneurial, enjoys working in a fast-paced, small-company environment

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.