About Every Cure:   

Every Cure is an AI-driven nonprofit, biotech organization on a mission to save and improve lives by repurposing existing medicines for diseases with significant unmet need. We are working to create a world where every drug is used to treat every disease it possibly can, so that no patient suffers when an existing treatment could help them. We are filling a gap left by the current biomedical system, which doesn’t systematically pursue new uses for old drugs. Through artificial intelligence technologies, collaboration with healthcare professionals, and patient advocacy, Every Cure is dedicated to unlocking the full potential of existing medicines to treat every disease and every patient we possibly can. Inspired by Every Cure’s co-founders' work repurposing drugs for Castleman disease and other rare diseases, Every Cure is advancing repurposed treatments for neglected diseases and has been featured in The New Yorker,  New York Times, USA Today, Good Morning America and other news media. Led by a talented leadership team and an outstanding Board of Directors, Every Cure is supported through funding from leading philanthropic organizations like Chan Zuckerberg Initiative, TED’s Audacious Project, and ARPA-H. 

 Our approach:  

• AI-Powered Identification: We use advanced artificial intelligence to analyze the world’s biomedical knowledge and identify FDA-approved drugs that can be repurposed for untreated conditions. This cutting-edge technology enables us to explore new therapeutic possibilities efficiently.  
• Open-Source Commitment: We are dedicated to making our predictive pipeline open-source, fostering collaboration and transparency within the scientific community and unlocking the potential for discovering new treatments.  
• High-Impact Focus: We prioritize drug repurposing opportunities that will relieve the most suffering and have the greatest impact possible.  
• Rigorous Validation: Promising opportunities are thoroughly validated through laboratory and clinical studies to confirm their efficacy and safety before advancing to broader application.  
• Strategic Marketing and Access: We disseminate information about effective repurposed treatments through multiple channels and are committed to ensuring that new cures are accessible to all patients.

Applicants must reside in the state specified at the top of this job posting. Residency in that state is a requirement for consideration and must be maintained for the duration of employment.

The Head of Clinical Development leads Every Cure’s clinical research and development function, serving as both strategic architect and working clinical lead on priority programs. They manage a diverse portfolio of drug repurposing initiatives including Every Cure-sponsored interventional trials (with full sponsor IND accountability and REMS complexity where applicable), collaborative investigator-sponsored trials, and Every Cure-led patient registries, natural history studies, and other real-world studies. They collaborate directly with computational and data science teams to translate AI-driven repurposing hypotheses into clinically testable programs and represent the organization to external partners and stakeholders. This role owns sponsor compliance under ICH E6(R3) including maintenance of the clinical QMS and SOP infrastructure regardless of CRO engagement  and oversees regulatory strategy and dissemination. The HCD supports Every Cure’s CSO and engages directly with external stakeholders including CROs, clinical trial technology vendors, academic investigators, patient advocacy organizations, the IRB of record, and FDA. The HCD helps build and lead a lean internal clinical development team, modeling the working-leader norm expected in a small, mission-driven organization.

How you will make an impact: 

Strategic Leadership of Clinical Development and Medical Affairs

• Set the direction for Every Cure’s clinical research and development, ensuring alignment with the organization’s mission to repurpose FDA-approved drugs for high-impact unmet needs, while personally leading or co-leading priority programs.
• Lead the execution of organizational goals through operational planning and cross-functional integration, personally owning project timelines, quality standards, and accountability metrics for priority programs rather than delegating all execution.
• Provide expert counsel to the CSO, President and Scientific Advisory Council on medical strategy, program development, and organizational growth.

Research and Clinical Development Oversight

• Design, author, and review key study documents (protocols, statistical analysis plans, informed consent documents, clinical study reports, investigator brochures) for Every Cure-sponsored clinical trials, patient registries, natural history studies, and real-world evidence assessments. Own study design decisions end-to-end, from scientific rationale through data integrity and analysis.
• Serve as sponsor medical lead and/or medical monitor on Every Cure-sponsored IND-holding studies (delegating per-study where appropriate), ensuring all research activities are ethically sound, methodologically rigorous, and regulatory compliant under FDA 21 CFR Part 312, ICH E6(R3), and ICH E9 principles.
• Translate complex medical findings into strategic decisions regarding program continuation, optimization, or sunsetting, based on efficacy, feasibility, and patient impact.
• Responsible for compliance and oversight of the Human Subjects Research program at Every Cure, including IRB (Advarra) submissions and amendments, sponsor safety reporting (IND safety reports, DSURs), SAE adjudication, signal detection, and REMS program participation where applicable (e.g., lenalidomide).

Portfolio Strategy and Program Management

• Partner on strategic prioritization and dynamic management of Every Cure’s diverse portfolio of drug repurposing opportunities, applying a risk-adjusted, impact-oriented lens to maximize outcomes.
• Direct the progression of programs through clinical and dissemination stages, using insights from AI models and external scientific inputs. Personally lead CRO and clinical technology vendor selection, contracting input, and ongoing governance (joint steering committees, KPIs, oversight plans) for highest-priority programs.
• Develop and manage resource allocation frameworks across disease areas and therapeutic modalities, ensuring optimal investment of time, talent, and funding toward the most promising interventions.

Leadership and Team Development

• Build, mentor, and lead a lean, high-performing team of clinical research and medical professionals united around a shared vision of maximizing patient impact through drug repurposing, modeling a working-leader norm in which senior leaders contribute directly alongside their teams.
• Define roles, responsibilities, and performance standards for the clinical team while fostering a culture of excellence, integrity, psychological safety, and cross-functional collaboration.
• Promote continuous learning and growth through coaching, training programs, and development opportunities that build both individual capability and team effectiveness.

Stakeholder Engagement, Compliance, and Dissemination

• Act as medical spokesperson and lead regulatory interface for Every Cure in public, scientific, and regulatory forums (including FDA pre-IND and Type B/C meetings), promoting the organization’s mission and sharing results from preclinical and clinical programs.
• Cultivate and manage partnerships with CROs, patient advocacy groups, academic institutions, and regulatory agencies to ensure successful execution and wide-scale impact of therapeutic programs.
• Guide the regulatory approval and post-study dissemination strategies to ensure timely and effective translation of research into therapies accessible to patients, including peer-reviewed publications, policy briefs, and healthcare provider outreach.
• Partner with the Impact lead to provide input and perspective on dissemination and to engage with key stakeholders to ensure medicines reach patients.

What you bring to the team:

Education 

• MD or MD/PhD preferred; PhD DO, or PharmD acceptable

Work Experience (Two-Tier: Head of / VP)

• Minimum for Head of Clinical Development: 8+ years of clinical development experience post-MD (or equivalent), including service as clinical lead on at least one sponsor-held Phase 2 trial from protocol through database lock.
• Demonstrated leadership experience recruiting, mentoring, and managing cross-functional clinical teams, with explicit willingness and proven ability to work hands-on alongside direct reports in a small-organization setting.
• Expertise in drug development, clinical trial design (including interventional trials in rare or ultra-rare populations), and clinical decision-making.
• Sponsor-side experience running Phase 2 trials (distinct from CRO or academic investigator experience).
• Experience working across more than one therapeutic research area.
• Experience with small-sample trial designs and natural history or registry data.
• Proven leadership in driving strategic initiatives and cross-functional collaboration to advance scientific and organizational goals.

Preferred for Vice President designation:

• 12+ years of clinical development experience, including prior functional leadership at a sponsor (Executive Director, Head of, or VP level); multiple sponsor-held INDs led through Phase 2 or beyond; direct experience with REMS programs, risk-based monitoring, or similarly complex regulatory programs; and prior responsibility for building or scaling a clinical QMS under ICH E6(R3) or predecessor standards.

Skills 

• Proficiency in clinical research, real-world evidence assessments, evidence generation, patient registry design, clinical trial execution, and sponsor-side pharmacovigilance.
• Working knowledge of FDA IND regulations (21 CFR Part 312), ICH E6(R3) Good Clinical Practice, ICH E9 statistical principles, 21 CFR Part 11 for electronic records, and REMS program requirements; familiarity with EU CTR a plus.
• Exceptional communication and presentation abilities.
• Demonstrated ability to foster and sustain a collaborative, cross-functional culture grounded in shared organizational mission and values.
• Able to partner effectively with computational and data science teams and critically evaluate AI/ML-driven repurposing hypotheses for clinical translatability.
• Strategic thinker with a focus on urgency, efficiency, and impact.
• Passionate about Every Cure’s mission and values.
• Highly adaptable, thriving in a fast-paced, start-up environment.
• Explicit willingness to be hands-on: comfort authoring and reviewing key clinical documents (protocols, SOPs, CSRs), directly managing vendor/CRO relationships, and working alongside junior staff rather than exclusively through delegation. Candidates seeking a purely oversight or figurehead role are not a fit for this position.

Compensations & Benefits: 

• Your paycheck: Competitive salary based on experience, ranging from $250,000 - $275,000 annually. 
• Health and wellness: Comprehensive plans with medical, dental, and vision coverage, plus a Flexible Spending Account (FSA) for eligible healthcare expenses. 
• Future nest egg: A 403(b)-retirement plan with an employer match of 3.5% helps you save for your future. 
• Relax and recharge: Generous time off, including paid time off and paid holidays. 
• We have you covered: Comprehensive paid leave for family and medical needs, ensuring you have the support you need during important times. 

This role is based in Cambridge, MA, with an expectation of minimum 3 days per week in office.  

Every Cure is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We provide equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, genetics, or any other characteristic protected by federal, state, or local laws.

Your Impact at LILA

We are seeking a highly organized and proactive Administrative Coordinator to provide operational and administrative support to our Government Affairs team in Washington, D.C. This role is the operational backbone of the team and ensuring the Government Affairs office can focus on its core efforts. The ideal candidate is a self-starter who thrives in a fast-paced, politically dynamic environment and exercises sound judgment and discretion at all times. This role requires 5 days a week in office in Washington, DC.

What You'll Be Building

GA Team Support 

• Manage scheduling for government affairs team, including scheduling meetings with Members of Congress, agency officials, and coalition partners
• Coordinate domestic and international travel logistics, including flights, hotels, ground transportation, and itineraries
• Prepare and process expense reports, invoices, and reimbursements in a timely manner
• Draft, proofread, and edit correspondence, briefing materials, talking points, and internal memos
• Anticipate executive needs and proactively handle administrative matters with minimal direction

Office Management

• Oversee day-to-day office operations, serving as the primary point of contact for building management, vendors, and service providers
• Manage office supply inventory, equipment maintenance, and facilities needs
• Onboard new team members, including coordinating workspace setup, badge access, and IT provisioning
• Maintain organized filing systems for legislative documents, regulatory filings, lobbying disclosures, and compliance records
• Coordinate with IT support to troubleshoot technology issues and manage software subscriptions

Legislative & Government Affairs Support 

• Assist with the preparation and timely filing of lobbying disclosure reports (LDA filings) in coordination with compliance counsel
• Maintain and update contact databases for congressional offices, agency contacts, and external stakeholders
• Coordinate logistics for Capitol Hill meetings, fly-ins, briefings, receptions, and fundraising events with external consultants
• Support the preparation of leave-behinds, one-pagers, and materials for Congressional meetings

Events & Stakeholder Coordination

• Plan and execute team events, including staff retreats, coalition meetings, roundtables, and receptions
• Manage coordination including invitations, RSVPs, catering, AV setup, and venue coordination
• Liaise with external partners, trade associations, and consulting firms on joint events and initiatives

What You’ll Need to Succeed

• 3–5 years of experience in an executive assistant, office manager, or administrative role, preferably in public service, government affairs, lobbying, law, or public policy environment
• Strong familiarity with the Washington, D.C. political landscape, including how Congress and federal agencies operate
• Exceptional organizational skills with the ability to manage multiple priorities under tight deadlines
• Outstanding written and verbal communication skills
• High degree of professionalism, discretion, and judgment when handling sensitive or confidential information
• Proficiency in Microsoft Office Suite (Outlook, Word, Excel, PowerPoint) and collaboration tools (e.g., Teams, Zoom, Slack)
• Ability to travel up to 10% of the calendar year, including international travel
• Ability to be in office 5 days a week in Washington, DC

Preferred

• Experience supporting C-suite executives or senior government officials
• Familiarity with Lobbying Disclosure Act (LDA) compliance and reporting requirements
  • Experience with stakeholder or contact management platforms (e.g., Quorum, Fireside, Salesforce)
  • Familiarity with political giving processes, including PAC administration, contribution tracking, and FEC reporting requirements
• Bachelor's degree in political science, public policy, communications, business, or a related field

Bonus Points For

• Discretion & Professionalism — Handles sensitive political and organizational information with the utmost confidentiality
• Proactive Problem-Solving — Anticipates issues and resolves them before they escalate
• Attention to Detail — Produces accurate, polished work products consistently
• Adaptability — Remains calm and effective in a dynamic, high-stakes environment
• Relationship Management — Builds trusted relationships with internal stakeholders, congressional staff, and external partners

About Flagship Pioneering

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. 

Position Summary:

We are seeking a dynamic individual to join the Communications and Public Affairs team to lead the development and execution of communications and brand strategies for a set of companies within Flagship Pioneering’s portfolio. The successful candidate will be a seasoned biotech corporate communications leader who is able to thrive in a fast-paced, start-up environment. This is an exciting opportunity to help shape the growth trajectory for breakthrough life sciences and technology companies in the human health, agriculture, and AI sectors.

This full-time position reports to the Vice President of Communications and requires in-office presence 4 days per week in Cambridge, MA.

Responsibilities include:

• Counsel to Flagship’s company founders and early company leadership, providing strategic guidance to emergent Flagship companies (Flagship NewCos) as they develop brand, voice, foundational messaging and overall communication strategies. 
• Lead brand development/visual identity and website design and development for NewCos, working with and overseeing outside agencies.
• Design and execute bespoke, integrated communications strategies for company launches, including all written materials, media engagement, and all social media elements. Identify and oversee PR agency support, as needed.
• Design and lead execution of communications strategies for both NewCos and a set of more mature companies (Flagship GrowthCos), including milestone announcements, internal comms, social and digital media, speaking opportunities, and issues management, partnering closely with company leadership.

Other

• Work collaboratively with other Communications & Public Affairs team members.
• Participate in weekly Communications & Public Affairs team meetings and collaborate with team members as needed to support broader team priorities that span events, government relations, digital, internal communications, and media relations.
• Manage external resources such as design and agency partners.

Qualifications

• Bachelor’s degree. Advanced degree in a related life sciences field is preferred.
• Extensive leadership-level experience in a public relations agency or corporate communications environment. Experience in pharma and/or biotech, as well as some experience with/exposure to financial and transaction communications. 
• Experience working within and across multiple highly complex organizations, while understanding and addressing the needs of both.  
• Exceptional research, writing, editing, verbal and interpersonal communication skills.
• Proven media relations track record, as well as the ability to see industry trends and craft insights into effective media relations pitches. Knowledge of and existing relationships with media outside the sphere of traditional media outlets.
• Strong diplomatic and persuasive skills.
• High degree of professional versatility and hands-on capability with a willingness to meet challenges head-on.
• Experience leading in a complex environment that requires skillful engagement of multiple stakeholders and successful, resourceful, and creative navigation of ambiguity.
• Must have the proven ability to advise senior leaders effectively.
• Must have superior interpersonal and organizational skills, along with a demonstrated ability to think strategically and critically and consistently exercise sound judgment. 
• Proven track record of coordinating multiple programs simultaneously, moving projects forward, and developing and implementing creative, solution-oriented strategies while anticipating future demands and opportunities.

The ideal candidate will also have:

• An aptitude for translating complex science into accessible and compelling narratives
• Experience building and leading effective communications campaigns for companies operating at the intersection of technology and science
• Creative mindset with a passion for innovative and impactful communications strategies
• A team player mentality and approach

#LI-NM1

The salary range for this role is $204,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

Join Cartwheel to help tackle the student mental health crisis!

Cartwheel is an early-stage company building a new kind of mental health program for kids that puts schools at the center. We see our role as supporting school staff who see kids every single day. Instead of going around them, we collaborate with them. This means: 

• Earlier intervention
• Higher student and family engagement in care
• Better coordination among the trusted adults in a student’s life 

Kids shouldn't just aspire to get out of bed and drag themselves to class. They should be able to experience joy. They deserve to envision and build a life they’re excited to live. If you join Cartwheel, you’ll help make this vision a reality for millions of students across the country. We’re backed by top investors including A Street Ventures, Menlo Ventures, Reach Capital, General Catalyst, BoxGroup, and Able Partners, and we're looking for mission-driven teammates to join our team.

ABOUT THE ROLE

In 3 years, Cartwheel has grown to serve more than 325 school districts in 16 states, making us the nation’s largest mental health provider that collaborates with K-12 schools. With billions of dollars in new state and federal investments in youth mental health coming in 2026, we are supplementing our district-level sales motion with statewide partnerships with Governor’s offices, education departments, and health agencies.

As the Enterprise Customer Success Manager, you will be Cartwheel's primary point of contact with the state agency, responsible for turning a signed contract into a high-impact, expanding program. That means building the implementation plan, coordinating execution across Cartwheel's internal teams, keeping agency staff informed and confident, and clearing whatever is in the way of delivering exceptional impact. Throughout the contract period, you’ll partner closely with our Government Relations teams, which will own executive and legislative relationships and the contract renewal process.

Role type: W2, Full-Time, Salaried position
Salary range: $143,000 – $187,000 OTE (10% variable pay included) plus competitive equity package
Location: Remote
Target Start: June 2026

WHAT YOU'LL DO

Own the state agency relationship

• Be the primary Cartwheel contact for agency program directors, behavioral health leads, and operational staff — the people responsible for implementing the partnership. 
• Build a deep understanding of agency priorities, constraints, and decision-making so you can navigate complexity and keep things moving
• Develop and maintain a comprehensive contact map across agency implementers, influencers, and financial buyers — and build productive relationships across each layer
• Lead regular agency check-ins covering progress, milestone tracking, and issue resolution
• Navigate agency political dynamics, policy constraints, and interagency complexity
• Develop success stories as implementation matures to support renewal and expansion

Drive implementation

• Build and own the implementation plan for your state(s): What needs to happen, in what order, by when, and who is responsible
• Develop a district prioritization framework: Where to start, how to sequence expansion, how to pace growth against contract timelines
• Own and track the metrics that matter — utilization, district activation, contract milestone attainment — and surface risks early before they become problems
• Coordinate across internal Cartwheel teams to ensure we meet all of our impact goals and milestones. For example:
• Partner with the Government Relations team on renewal readiness and ensure they have an excellent value story to share with executive and legislative buyers
• Ensure district-level sellers and CSMs are effectively onboarding districts
• Coordinate with Operations to clear compliance, credentialing, and regulatory hurdles that slow implementation down

• Engage state-level professional associations (superintendent associations, state education agencies) to support district activation and strengthen Cartwheel's presence

Keep leadership and the team aligned

• Maintain clear, multi-quarter visibility into contract health and district-level risk
• Report out on contract health to Senior Leadership and share insights on how to improve our approach to state implementations, product innovation, or other key insights
• Identify expansion opportunities (new districts, expanded services, adjacent agency relationships) and surface them to Government Relations and internal teams to pursue

WHAT WE’RE LOOKING FOR

Required

• 7–10+ years in customer success, strategic account management, or a closely related post-sale role, with meaningful experience in government or public sector
• You're an exceptional communicator — able to translate operational complexity into clear reporting for agency partners and internal leadership
• You've built trusted relationships with state or government agency staff. Not just executives, but program officers and operational leads
• You've managed complex, multi-stakeholder account plans and can connect the dots between day-to-day execution and long-term contract health
• You understand the revenue implications of implementation decisions and take ownership of retention outcomes
• You can navigate political and bureaucratic dynamics without losing momentum
• You are comfortable interpreting data on your own and communicating insights
• You're highly organized and comfortable building structure in an environment that doesn't have all the answers yet

Preferred

• Experience in K–12 education, healthcare, or direct service businesses
• Familiarity with braided funding models (state contracts, Medicaid, grants, district fees)
• Background working alongside or within Government Relations or public affairs functions
• Experience with state procurement processes and compliance relevant to public sector
• Familiarity with ChurnZero, Gainsight, Salesforce, or HubSpot

Travel

This role requires regular travel — approximately 40% — to support state agency relationships, district engagement, and key implementation milestones, concentrated in your assigned state(s).

Please apply even if you don't meet all of the criteria. If your past experience doesn't perfectly match the job description, but you bring other relevant experience or skills, we'd still love to hear from you. You may be a great fit!

WHY YOU’LL LOVE CARTWHEEL

Our hope is that Cartwheel will be your best career decision! In addition to tackling one of the biggest challenges of our time, at a company well-positioned to do so, you'll have:

• Mission-oriented and inclusive colleagues who will go to bat for you
• Competitive compensation
• Generous PPO medical, vision, and dental/ortho coverage
• Life Insurance
• Generous paid time off, including company closure from Christmas-New Years (12/25-1/1)
• Paid holidays and sick leave
• Paid parental leave
• 401K with employer match
• Meaningful equity ownership stake in Cartwheel
• Flexible and remote role with regular in-person retreats
• Annual learning stipend
• Laptop