At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

The Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Bioinformatics Scientist will be working alongside our collaboration teams, applying our cell-free solutions to large cancer patient cohorts and profiling patient response to therapy with our exome-scale solid tumor and cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products in immuno-oncology, cancer clinical trials, diagnostics, and therapeutics used by pharma, biotech, hospitals, and clinicians. 

Days onsite: Monday and Tuesday

Responsibilities:

• Plan, develop, and manage scientific collaborations, applying internally developed liquid biopsy and solid tumor products to detect somatic variants, neoantigens, and tumor escape mechanisms within high-profile and impactful partnerships

• Build upon our novel cell-free platforms and products, including our NeXT Personal MRD liquid biopsy platform 

• Work cross-functionally to translate collaborative findings into actively developed cutting-edge products

• Design and execute scientific projects and experiments focused on demonstrating the performance as well as research and clinical advantages our of cell-free platforms

• Modeling and analysis of large, complex genomics datasets using cutting-edge methods to generate biological and clinical insights

• Work with scientific teams to translate scientific findings into actively developed cutting-edge products

• Publish results and present at conferences in exciting areas, including cell-free DNA, cancer genomics, and immuno-oncology

Requirements:

• Advanced degree (Ph.D.) in bioinformatics, genomics, or a related field

• Experience managing, analyzing, and interpreting large impactful multi-participant projects

• Experience with cancer liquid biopsy analysis

• Experience with survival analysis

• Proficiency with at least one common programming language (e.g., Python, R)

• Experience with cancer genomics and variant detection

• Experience publishing and presenting scientific results

The hiring range for this position is $158,000 to $190,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

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