Senior Scientist, Delivery Technologies

CSL's organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we're building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide.

Could you be our next Senior Scientist, Delivery Technologies?

Work Environment:

This position is based in Waltham, MA and is an onsite role 5 days each week. CSL is not providing relocation assistance or visa sponsorship.

You will report to the Principal Scientist, Delivery Technologies

The successful candidate will provide scientific expertise in the design, formulation, characterization, and optimization of delivery technologies to support drug discovery efforts across multiple functions and external collaborations. This role requires strong expertise in lipid nanoparticle (LNP) formulation, extra-hepatic targeted delivery approaches, siRNA-conjugates to enable tissue- and cell-specific delivery, and extensive knowledge in translational drug delivery sciences.

Key Responsibilities

• Contribute and support CSL’s novel modalities portfolio and pipeline
• Participate in external due diligence, assessing delivery system suitability for various modalities, technical feasibility, and risk
• Lead the design, formulation, and characterization of LNPs containing siRNA, mRNA, gene-editing cargoes, and other nucleic acid modalities
• Design and execute Design of Experiment (DOE) principles in formulation screening
• Work on medium to high throughput formulation preparation
• Optimize formulation parameters, lipid composition, manufacturing processes, and excipient systems to enhance stability and biological performance
• Develop and characterize targeted delivery strategies (t-LNP) utilizing receptor-mediated uptake mechanisms, targeting ligands, and tissue-specific delivery approaches
• Lead efforts related to the design and evaluation of ligand-siRNA conjugates for extrahepatic delivery
• Evaluate delivery performance through in vitro and in vivo studies, including cellular uptake, endosomal escape, biodistribution, and target engagement
• Serve as a subject matter expert in delivery approaches and LNP process development,  and provide technical delivery-related support across research, development, and manufacturing activities
• Apply mechanistic insights into critical process parameters and product attributes through hypothesis-driven experimentation, robust data analysis, and problem-solving
• Provide scientific guidance and mentorship to team members and collaborate closely with Analytical Biochemistry and Molecular Biology teams

Minimum Qualifications:

• PhD with 5+ years or MS with 7+ years of relevant experience in Pharmaceutical Sciences, Nanomedicine, Biomedical Engineering, Chemistry, Chemical Engineering, Drug Delivery, in the pharmaceutical industry
• Demonstrated ability to independently lead scientific projects and experience working in cross-functional research environments
• Strong track record in LNP formulation and optimization
• Expertise in nanoparticle characterization techniques including particle size, encapsulation efficiency, and stability assessment
• Expertise in in vitro and in vivo evaluation of RNA-based delivery systems
• Understanding of cellular uptake mechanisms, intracellular trafficking, and endosomal escape
• Demonstrated experience with targeted LNPs and extrahepatic delivery platforms
• Experimental design, statistical analysis, and data interpretation
• Preferred: Knowledge of medicinal chemistry principles related to ionizable lipid design, structure-activity relationships (SAR), ligand optimization and linker chemistry

The minimum and maximum base salary range that CSL expects to pay for this position at the Waltham, MA USA work location at the time of this posting is $126,000/yr - $157,000/yr. Individual base salary for a successful candidate is determined by qualifications, skill level, experience, competencies and other relevant factors. In addition to base salary, total compensation for this role may also include incentive compensation and equity.

About CSL Behring

CSL Behring is a global biotherapeutics leader driven by our promise to save lives. Focused on serving patients’ needs by using the latest technologies, we discover, develop and deliver innovative therapies for people living with conditions in the immunology, hematology, cardiovascular and metabolic, respiratory, and transplant therapeutic areas. We use three strategic scientific platforms of plasma fractionation, recombinant protein technology, and cell and gene therapy to support continued innovation and continually refine ways in which products can address unmet medical needs and help patients lead full lives.

CSL Behring operates one of the world’s largest plasma collection networks, CSL Plasma. Our parent company, CSL, headquartered in Melbourne, Australia, employs 32,000 people, and delivers its lifesaving therapies to people in more than 100 countries.

To learn more about CSL, CSL Behring, CSL Seqirus and CSL Vifor  visit https://www.csl.com/ and CSL Plasma at https://www.cslplasma.com/.

Our Benefits

For more information on CSL benefits visit How CSL Supports Your Well-being | CSL.

You Belong at CSL

At CSL, Inclusion and Belonging is at the core of our mission and who we are. It fuels our innovation day in and day out. By celebrating our differences and creating a culture of curiosity and empathy, we are able to better understand and connect with our patients and donors, foster strong relationships with our stakeholders, and sustain a diverse workforce that will move our company and industry into the future.

 To learn more about inclusion and belonging visit https://www.csl.com/careers/inclusion-and-belonging

Equal Opportunity Employer

CSL is an Equal Opportunity Employer. If you are an individual with a disability and need a reasonable accommodation for any part of the application process, please visit https://www.csl.com/accessibility-statement.