À propos de ce poste Scientist, Biology chez Alector
As a Scientist on our Biology team, you will design and execute in vitro studies and analytical assays that help us evaluate potential therapeutics for neurodegenerative diseases. You will work with advanced cellular models, process in vivo and in vitro samples, and generate high-quality data that inform pharmacokinetics/pharmacodynamics (PK/PD), efficacy, safety, proof-of-concept (POC), and mechanism-of-action (MOA) studies.
You’ll collaborate closely with colleagues across Biology, ADPE, and Preclinical teams to advance our programs. We value scientific curiosity, thoughtful experimentation, and the ability to adapt as our science and priorities evolve.
Key Goals and Accountabilities
-
Advance our therapeutic programs! Design and execute in vitro pharmacology studies using iPSC-derived cellular models, including induced neurons, induced microglia, and co-culture and triple-culture systems.
-
Build disease-relevant models! Develop and optimize cellular models of neurodegenerative disease, including Alzheimer’s disease, to enable POC and MOA studies.
-
Generate decision-driving data! Collect and process cell lysates, media, rodent brain, and other biological samples and perform downstream biochemical and cellular analyses.
-
Turn experiments into shared insights! Analyze, interpret, document, and communicate results while maintaining accurate experimental records, protocols, and data in our electronic lab notebook.
-
Accelerate how we do science! Collaborate across Biology, ADPE, and Preclinical teams while identifying opportunities to integrate innovative technologies, especially AI, to expedite programs, improve scientific workflows, and save valuable resources.
Required Qualifications
-
PhD in Neuroscience, Immunology, Biology, or a related scientific discipline.
-
Hands-on experience with cell culture, including iPSC-derived and/or primary rodent neuronal models.
-
Experience with biochemical and cellular techniques such as immunoblotting, ELISA, MSD, immunocytochemistry, flow cytometry/FACS, or immunohistochemistry.
-
Demonstrated ability to analyze and interpret experimental data and clearly communicate scientific findings.
-
You are an active user of large language models (LLMs) and have a strong interest in evolving AI technologies and how they can improve scientific research and productivity.
Preferred Qualifications
-
Experience working in a biotechnology or pharmaceutical research environment.
-
Experience developing or optimizing cellular models of neurodegenerative disease.
-
Familiarity with confocal microscopy and neurohistology techniques.
