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The Department of Microbiology and Immunology is seeking a highly motivated and technically skilled Research Scientist to lead cancer immunotherapy-based research program focused on the ways to improve T-cell homing into solid tumors. The ideal candidate will have strong background in immunology and expertise in T-cell biology including primary cell culture, expansion, manipulation and phenotyping and adoptive transfers into mice analyzing specific phenotypes.  Research activities will include development and validation of methods for viral transduction of T-cells for ectopic expression of homing molecules including chemokine receptors.  The position requires independent experimental design, data processing, statistical analysis, interpretation of complex datasets, and preparation of technical reports, manuscripts, grant applications, and presentations. The candidate will be expected to present findings at laboratory meetings, scientific conferences, and other professional venues.

Essential Duties and Responsibilities

• Design and implement experimental strategies to enhance T-cell homing to solid tumors.
• Develop methods for viral transduction of murine and human T-cells
• Maintain and manage complex genetically altered mice that develop spontaneous tumors such as ApcMin mice in various backgrounds including leukotriene B4 receptor BLT1-null mice and Rag-KO mice.
• Execute implantable tumor models in diverse mouse backgrounds and analyze tumor phenotypes in mouse models
• Characterize human T-cells including cancer patient derived cells and lentiviral transduction and phenotype analysis.
• Train graduate students, postdocs, and staff in proper instrument use.

Preferred Qualifications

• PhD, MD, DVM, or a related doctoral degree with 4–6 years of experience in Immunology, with specific knowledge of T-cell function, regulation or related biomedical research fields.
• Expertise in culture, manipulation and invivo analysis of function.
• Preference will be given to applicants with a strong publication record and demonstrated success in collaborative research.
• Experience in multiomics, and translational biomedical research is desirable.

Competencies

• Excellent communication and scientific writing skills, a strong commitment to research excellence, and the ability to work collaboratively while mentoring students and laboratory personnel.
• Training, operation of laboratory instruments, developing T-cell phenotype analysis methods, troubleshooting, handling and training in new technologies.
• Organization Skills, Project Management Skills, Analytical skills, Critical thinking, work ethics, excellent Interpersonal skills and ability to work in the team.

Compensation will be commensurate to candidate experience.

Equal Employment Opportunity

The University of Louisville is an Equal Employment Opportunity employer. The University strives to provide equal employment opportunity on the basis of merit and without unlawful discrimination on the basis of race, sex, age, color, national origin, ethnicity, creed, religion, disability, genetic information, sexual orientation, gender, gender identity or expression, veteran status, marital status, or pregnancy. In accordance with the Rehabilitation Act of 1973 and the Vietnam Era Veteran Readjustment Act of 1974, the University prohibits job discrimination of individuals with disabilities, Vietnam era veterans, qualified special disabled veterans, recently separated veterans, and other protected veterans. The University acknowledges its obligations to ensure affirmative steps are taken to ensure equal employment opportunities for all employees and applicants for employment. It is the policy of the University that no employee or applicant for employment be subject to unlawful discrimination in terms of recruitment, hiring, promotion, contract, contract renewal, tenure, compensation, benefits, and/or working conditions. No employee or applicant for employment is required to endorse or condemn a specific ideology, political viewpoint, or social viewpoint to be eligible for hiring, contract renewal, tenure, or promotion.

Consistent with applicable law, demographic information is collected for aggregate reporting requirements. Demographic information provided through this application is not available to hiring managers/committees and is not considered in hiring or employment decisions.

Assistance and Accommodations

Computers are available for application submission at the Human Resources Department located at 2315 South First Street Walk, Room 02C - Louisville, Kentucky 40292.

If you require assistance or accommodation with our online application process, please contact us by email at [email protected] or by phone 502-852-6258.