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The Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. As a biomedical research organization and philanthropy, HHMI supports a vibrant community of academic researchers, educators, students, and professionals. Together, we’re unlocking the fundamentals of biology and building an open, inclusive future for science.

We have an outstanding opportunity for a Postdoctoral Scientist to join Dr. Mustafa Aydogan’s lab team at Columbia University in New York City. The Aydogan lab investigates the molecular and cellular mechanisms that govern time control in animal development and developmental metabolism. In particular, they focus on the emerging concept of autonomous clocks. More information about the lab and their work can be found by visiting https://aydoganlab.com/.

This position is expected to begin after October 1, 2025 in concurrence with Dr. Aydogan’s upcoming appointment as a Freeman Hrabowski Scholar.

About the Postdoctoral Scientist role:

In collaboration with Dr. Halil Aydin’s lab at New York University focusing on structural biology and biochemistry, the Postdoctoral Scientist will dissect the molecular basis of a cellular clock governing the onset of cytoplasmic division (cytokinesis) independently of the nucleus and mitotic CDK/Cyclin complexes. To that end, they will use in vitro and in vivo reconstitution assays, which will provide a platform to investigate the mechanistic basis of protein-protein and protein-lipid interactions that regulate this putative molecular clock. In this project, they will take a multi-disciplinary approach that integrates biochemistry, biophysics and cell biology techniques, which will be combined with structure determination by Cryo-EM.

This role is an ideal fit for a passionate, creative, and collaborative biochemist ready to gain further professional training while bringing passion for scientific discovery and enthusiasm for developing innovative methodologies. The ideal candidate thrives on collaboration, demonstrates strong communication skills, and is committed to professional growth and development.

What we provide:

• A collaborative, intellectually curious lab environment that values innovation, creativity, scientific rigor, balance, and teamwork.

• Generous and stable research funding from HHMI.

• Joining the vibrant Columbia research community.

• Mentorship to help you thrive scientifically and prepare for the next step of your career.

• Opportunities to mentor the next generation of scientists.

• Opportunities to attend scientific workshops and conferences.

• Collaboration with a biochemistry-focused partner lab at NYU.

• A competitive compensation package with comprehensive health and wellness benefits.

• Full access to HHMI’s on-demand training courses and interactive skill-building seminars, led by members of our learning and organization development team.

What you’ll do:

• Lead a research project that focuses on protein biochemistry including cell fractionation, organelle and protein purification, in vitro / in vivo reconstitution, fluorescent live-microscopy, cell biology, and structural assays (including Cryo-EM) to discover the molecular basis of a biological clock.

• Develop new experimental approaches to advance your project and the lab’s overall research efforts.

• Mentor students and research assistants to strengthen your mentoring and lab leadership skills.

• Write scientific manuscripts describing research findings.

• Attend local and national meetings to present research findings, learn about the latest advances in the field, and develop a scientific network.

What you bring:

• A PhD in the life sciences is required. Focus on biochemistry, particularly protein biochemistry, is preferred.  

• Proven experience in independent research and strong wet lab skills, with the ability to design, execute, analyze, and publish your work.

• A strong publication record that showcases concrete research excellence, including at least one first author paper either published or in pre-print form from your PhD studies. This can also be with a co-first author, however you must be the leading first author.  

• A self-motivated mindset with the persistence to explore innovative research directions and address challenging scientific problems

• Strong problem-solving skills, with the ability to tackle challenges creatively.

• Excellent communication skills with the ability to present and discuss findings clearly in diverse settings.

• A flexible and adaptive approach, willing to learn new techniques, share expertise, and contribute to the collective success of the team.

• Excellent organizational and time management skills.

• Meticulous approach to work with a high level of attention to detail.

• Ability to work successfully within a collaborative and congenial environment.

• Strong commitment to research integrity.

Physical Requirements

Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).

Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:

This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act. #LI-NG1

Compensation and Benefits

Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more. 

Hiring Pay Range

Pay Type:

The posted range reflects HHMI’s good faith estimate of the anticipated hiring salary range for this role at the time of posting. Actual hiring compensation is determined by a candidate’s qualifications, experience, and internal equity.

HHMI is an Equal Opportunity Employer

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