23andMe sits on one of the largest and most scientifically rich genetic datasets in the world. We're looking for a Senior Software Engineer to help build and operate the systems that make that data meaningful — powering everything from ancestry features and DNA relatives to health insights and machine learning pipelines that serve millions of customers.

Our Engineering team is based in the San Francisco Bay Area, CA, and this position will follow our hybrid work model.

Who We Are

We are a group of individuals passionate about genetic discovery. 23andMe Research Institute is a nonprofit medical research organization that enables people everywhere to access their genetic information, learn about themselves, and participate in the world's largest crowdsourced research initiative. The Institute aims to be the world's most significant contributor to scientific advancement, uniting people with the common goal of improving health and deepening our understanding of DNA — the code of life.

What You'll Do

• Design, build, and operate the backend services and data stores that turn raw genetic data into customer-facing results at scale

• Leverage AI tooling to automate testing, accelerate feature delivery, and ship with confidence through robust CI/CD pipelines

• Partner with product, science, and engineering teams to translate requirements into reliable, scalable systems

• Build AI-powered data pipelines that deliver personalized health and ancestry insights directly to customers

• Debug production incidents and get services back online: you'll own what you ship

What You’ll Bring

• B.S. in Computer Science or equivalent; 4+ years of industry experience

• Deep, hands-on Python: libraries, services, data pipelines

• Infrastructure as code experience, ideally in Terraform on AWS, containerized in Docker

• Hands-on experience working with CI/CD deployment pipelines and testing frameworks

• Experience operating distributed systems at scale: debugging, observability, performance tuning

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What We Offer

A small, high-trust team with real ownership, autonomy, and direct impact on one of the most scientifically rich datasets in the world. You'll work at the intersection of software engineering and cutting-edge genetic research without needing to be a scientist yourself. Our R&D and bioinformatics teams own the science; your job is to make it production-ready and scalable, supported by some of the sharpest minds in genomics who are excited to bring you up to speed. We're an AI-friendly team that actively uses coding tools like Claude Code to help engineers do their best work. You'll ship multiple times per week, work with some of the sharpest minds in genomics, and build systems that matter to millions of people.

About Us

23andMe, headquartered in California, is a leading consumer genetics and research company. The company’s mission is to help people access, understand, and benefit from the human genome. 23andMe has pioneered direct access to genetic information as the only company with multiple FDA authorizations for genetic health risk reports. The company has created the world’s largest crowdsourced platform for genetic research, with 80 percent of its customers electing to participate. 23andMe research participants consent to research conducted by 23andMe which is overseen by an independent third-party Institutional Review Board (IRB) regulated under the 'Common Rule' (45 CFR part 46). More information is available at www.23andme.com/research.

At 23andMe, we value a diverse, inclusive workforce and we provide equal employment opportunity for all applicants and employees. All qualified applicants for employment will be considered without regard to an individual’s race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.  If you are unable to submit your application because of incompatible assistive technology or a disability, please contact us at [email protected]. 23andMe will reasonably accommodate qualified individuals with disabilities to the extent required by applicable law.

Please note: 23andMe does not accept agency resumes and we are not responsible for any fees related to unsolicited resumes. Thank you.

Pay Transparency

23andMe takes a market-based approach to pay, and amounts will vary depending on your geographic location. The salary range reflected here is for a candidate based in the San Francisco Bay Area.  The successful candidate’s starting pay will be determined based on job-related skills, experience, qualifications, work location, and market conditions. These ranges may be modified in the future.

San Francisco Bay Area Base Pay Range

$160,000-$200,000