Job Description

General Summary:

Vertex is seeking a talented individual to join our Analytical Development group in Boston, MA.  As a member of an industry leading CMC team, this individual will help advance transformative medicines treating the underlying cause of serious diseases by conducting analytical chemistry activities for small molecule development programs. Responsibilities include characterization and stability assessment of drug substances, spray-dried dispersions, and drug products, as well as contributing scientifically to the resolution of broader drug development challenges in collaboration with other R&D functions. Expertise with laboratory techniques commonly used in the analysis of pharmaceutical products, including liquid chromatography (LC), is desired. 

Key Duties and Responsibilities:

• Analytical testing and data review, as well as collation, interpretation, and presentation of complex data along with recommendations to guide project decisions and new research activities
• Independently designing and performing technically challenging experiments in a resourceful manner with a high degree of reliability and attention to details
• Solving complex problems to support crucial project goals, as well as innovation of research methodology to address important questions enabling the advancement of development programs
• Supporting method validation activities, including designing validation protocols that follow ICH and FDA guidelines and address critical factors that may not be mandated by the guidelines but are essential for validating the methods for their intended use
• Representing Analytical Development on cross functional pharmaceutical development teams
• Prioritizing studies, considering feasibility, timelines, and project impact
• Troubleshooting and maintain general lab equipment, including LCs
• Maintaining accurate records of experiments and results in an electronic laboratory notebook in a timely manner
• Working collaboratively cross-functionally and within the team to achieve program goals
• Complying with applicable SOPs
• May supervise or mentor junior staff

Knowledge and Skills:

• Understanding of the drug development process, including chemical and formulation development
• Skilled in HPLC, GC, KF, and broad knowledge of other techniques used in pharmaceutical analysis
• Good understanding of GMP is preferred. Hands-on GMP experience, as well as experience developing GMP friendly methods is a plus
• The ability to work successfully in both a team/matrix environment as well as independently is required
• The ability to work in a fast-paced environment, manage priorities, and maintain timelines for multiple activities are required
• Excellent written and verbal communication skills are essential

Education and Experience:

• A BS, Master’s degree or Ph.D. in the life or physical sciences with a preference for a concentration in analytical chemistry
• Minimum experience: Ph.D. with 0-3 years or MS with 3+ years or BS with 6+ years of relevant analytical development experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.  

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]