Research Associate – Antibody Characterization (onsite in Quincy, MA)

We are seeking a motivated individual to join our team and expand our antibody characterization department. Using state-of-the-art technologies and workflows, this Research Associate would work with the Antibody Characterization team to ensure project-specific deliverables are met across a diverse panel of discovery campaigns and contract services. The role would involve wet-lab experimental design, execution, and data analysis for multiple custom antibody development projects, incorporating various biologics assay formats

What you will be doing

• Performing titer testing, screening, and antibody validation by high-throughput multicolor flow cytometry and ELISA
• Running and troubleshooting cell-based functional assays
• Performing mammalian cell culture, including thaw, maintenance, expansion, cryopreservation, and QC of a wide variety of adherent and suspension cell lines
• Developing, running, and troubleshooting antibody characterization experiments using advanced label-free analytical techniques (e.g., BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning
• Sample handling, sample inventory tracking, and assisting with automation integration into the department
• Concurrently execute multiple antibody discovery projects requiring wet lab activities, data analysis, report generation, and preparation of deliverables adhering to project timelines
• Record and communicate experimental details, draft reports, and deliver data with a high level of integrity and ethics

What You’ll Bring to the Team

• Bachelor's degree in molecular biology, biochemistry, or a related discipline, and a minimum of 2 years of related experience; or a master’s degree without experience; or equivalent work experience.
• Excellent aseptic technique and experience with mammalian adherent and suspension cell culture are required
• Flow cytometry experience is required
• Ability to troubleshoot scientific processes
• Ability to work independently, but also collaborate and effectively communicate within and across departmental team
  Exceptional written and verbal communication skills
• Highly organized, detail oriented and able to operate in a fast-paced and growing environment
• Industry experience strongly preferred.
• Understanding of antibody discovery, preferably focusing on assay development and protein characterization, is preferred
• Previous experience with Carterra, Octet, Hamilton, and/or iQue instruments nice to have 
• Direct experience with ELISA preferred

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

Manager, Antibody Characterization (onsite in Quincy, MA)

JOB DESCRIPTION 

This is a management position that provides support for bioanalytical characterization for a variety of therapeutic antibody candidates. This role oversees our Antibody Characterization team and is responsible for managing, optimizing, and troubleshooting a range of workflows, including immunoassays, affinity analysis, functional assays, and target binding characterization.

ESSENTIAL FUNCTIONS

• Lead, manage, and develop a team of scientists and research associates in our Antibody Characterization department.
• Provide technical guidance (assay development, analysis, and data reporting) in a range of areas, including high-throughput ELISA, flow cytometry, kinetic assays (BLI and SPR), advanced/custom characterization, and functional screening.
• Serve as an end-to-end technical lead for a variety of in vivo antibody discovery programs and contract services, contributing to scientific planning and feasibility review during project scoping.
• Review, critically analyze, and present data to customers to facilitate antibody lead selection for a variety of concurrent antibody discovery programs.
• Work closely with the Project Management team to communicate timelines and deliverables to internal and external stakeholders and customers.
• Work closely with all scientific departments and senior management to ensure excellent management of all activities and effective communication.
• Promote operational and scientific excellence by driving continuous process improvement.
• Stay up to date with recent developments in antibody discovery methods and technologies, and help guide the advancement of our laboratory capabilities in alignment with strategic company goals.
• Spend approximately 30-50% of your time performing wet-lab benchwork alongside the team.

POSITION QUALIFICATIONS

• PhD in a related technical field with 3+ years of management experience in biopharmaceutical analytical development, or MS with 5+ years of experience, including 3+ years of management experience.
• Expert knowledge of biologics characterization assays: extensive hands-on experience required in ELISA, flow cytometry, and SPR/BLI with Carterra and Sartorius Octet.
• Very strong track record of developing, executing, and analyzing common assay formats for biologics discovery, such as high-throughput screening, epitope binning, ligand blocking analysis, affinity analysis, and cell-based functional assays.
• Able to independently manage and prioritize tasks in a fast-paced environment that hinges on overlapping projects and sensitive workflow timelines.
• Advanced understanding of in vivo antibody discovery concepts.
• Proven ability to assess, interpret, and present complex scientific data effectively and with a high level of integrity and ethics.
• Proven management skills for both projects and people, with a strong track record of building trust and developing teams at a variety of levels.
• Exceptional written and verbal communication skills, including customer-facing communication.
• Highly organized and detail-oriented with a focused, problem-solving mentality to address projects and logistics.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

Sr. Director, Customer Relationship Management 

Job Description

We are seeking an experienced and highly motivated executive to lead the strategic development, implementation, and optimization of our Customer Relationship Management systems. Based primarily on the Salesforce platform, we seek an expert with deep, demonstrated experience in a technical (Pharma/Biotech/Med Device/Semiconductor) commercial space. Our CRM systems play a special role in our entire mind-to-molecule software stack, whereby research scientists and commercial partners are able to turn cutting edge ideas into therapeutics, diagnostics, and research tools that benefit health and the environment. The Sr. Director will serve as the strategist for all things CRM, with a mission to maximize customer lifetime value, drive commercial excellence, and ensure compliance in a highly regulated environment. The Sr. Director will lead a team of professionals, primarily Salesforce administrators, configuration specialists, and software developers, who in close collaboration with our Sales Operations and Global Support teams will build and maintain an easy to use, scalable and compliant CRM enterprise software ecosystem.

• The Sr. Director will define the vision, developing and executing a multi-year CRM roadmap aligned with our commercial and customer experience goals.
• The Sr. Director will drive adoption, leading the effort to maximize the use of the Salesforce platform across Sales, Marketing, and Service teams.
• The Sr. Director will measure success by defining, tracking, and reporting key CRM performance indicators to executive leadership, including customer retention, pipeline health, and user proficiency.
• The Sr. Director will own the platform, acting as the ultimate subject matter expert for the CRM ecosystem, overseeing all implementation, configuration, and governance.
• The Sr. Director will direct projects, counseling project managers leading all major CRM-related projects, including new Salesforce MarketingCloud rollouts, enterprise integrations (ERP, Marketing Automation), and system enhancements.
• The Sr. Director will own data integrity, establishing rigorous data governance policies to ensure the integrity, quality, and compliance of all customer data within the platform.
• The Sr. Director will ensure all CRM strategy and technology strictly adhere to relevant regulatory requirements (e.g., HIPAA, GDPR, GxP, and data privacy) for the pharmaceutical/med device sector.
• The Sr. Director will lead, mentor, and grow a high-performing team of CRM analysts and developers, fostering a culture of technical excellence and collaboration.

Key Responsibilities

• Strategic Leadership & Architecture: In collaboration with our Platform Team and our technical platform architects, define and execute the long-term architectural roadmap for our CRM, ensuring scalability, maintainability, and alignment with industry best practices.
• Technical Team Management: Lead, mentor, and develop a high-performing team of CRM admins, software developers, analysts, and specialists, fostering a culture of continuous improvement, technical excellence, robust software development practices, and regulatory compliance.
• Software Development & Implementation: Oversee the full Software Development Life Cycle (SDLC) for our CRM, including detailed requirements gathering, system design, coding standards, development, rigorous testing, validation, deployment, and post-go-live support.
• System Optimization & Support: Drive continuous improvement and feature enhancement of existing CRM functionalities, identify opportunities for process automation, and advanced data utilization and forecasting. Ensure robust system performance, availability, and audit readiness through proactive monitoring and maintenance.
• Cross-Functional Collaboration: Partner closely with the platform architecture and infrastructure teams, Sales, Sales Operations, Global Support, Manufacturing Operations, Quality Assurance, Process Development, and Regulatory Affairs teams to define CRM requirements, design seamless integrations with other enterprise systems (e.g., ERP, eCommerce), and ensure compliant data flow across the biomanufacturing ecosystem.
• Data Integrity & Reporting: Architect and ensure the accuracy, integrity, traceability, and security of all data within the CRM, critical for regulatory submissions and audit trails. Develop and implement robust reporting, analytics, and data visualization capabilities to support operational decision-making and quality reviews.
• Compliance & Validation: Ensure our CRM solutions comply with relevant regulations (e.g., SOX, HIPAA, GDPR, GxP, and data privacy), and internal quality standards. Oversee and execute comprehensive computer system validation activities specifically tailored for custom software.
• Vendor & Internal Resource Management: Manage relationships with any external software development contractors or technology partners, ensuring effective collaboration, adherence to standards, and delivery of services. Optimize the utilization of internal development resources.
• Budget Management: Develop and manage the CRM budget, optimizing resource allocation for both internal development and external services, and demonstrating ROI for CRM investments.
• Change Management: Lead change management efforts related to CRM development, implementations, and upgrades, ensuring user adoption, effective user training programs, and adherence to change control procedures for custom software releases.

Qualifications

• Masters degree or higher in Business, Marketing, Information Technology, Computer Science, Software Engineering, Electrical Engineering, BioEngineering, Structural Biology, Chemistry, or a related technical field.
• 12+ years of progressive experience in CRM, Commercial Operations, software development and technical leadership, with 5+ years in a leadership/Director-level role managing an enterprise CRM platform.
• Expert-level proficiency in the Salesforce platform (Sales Cloud, Service Cloud, Experience Cloud, etc.) as a system owner or strategic consultant.
• Proven track record of successfully implementing and/or managing Salesforce within the Life Science/Healthcare industry (Pharma, Biotech, or Med Device).
• Active Salesforce Administrator or Consultant certification (e.g., Sales Cloud Consultant, Platform App Builder).
• Proven leadership experience, with at least 5 years managing and developing a team of software developers and technical professionals.

Preferred Qualifications

• Experience with Veeva CRM or Salesforce Health Cloud.
• Additional Salesforce certifications (e.g., Advanced Administrator).
• Experience integrating Marketing Automation (e.g., Marketing Cloud/Pardot) with Salesforce.
• Experience with specific biopharmaceutical manufacturing processes or modalities (e.g., cell and gene therapy, mAbs, vaccines).
• Familiarity with Industry 4.0 concepts, IoT, and advanced manufacturing technologies in a biotech context.
• Certifications in project management (PMP), Agile methodologies, or relevant software architecture certifications.
• Experience with cloud platforms (e.g., AWS, Azure, GCP) and DevOps practices.
• Direct experience participating in regulatory audits (e.g., FDA inspections, SOX) specifically related to custom software and validations.
• Experience with data analytics tools and methodologies for monitoring and quality control in biotech.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

Scientist - Tech Transfer ( Onsite in Wilsonville, OR)

Job Description

We are seeking a Scientist to join our Tech Transfer team, focused on advancing and scaling synthetic biology workflows across DNA-based and mammalian cell culture systems. This role sits at the interface of R&D and production, where you will drive the successful transfer of new products and processes into high-throughput manufacturing environments.

You will play a key role in developing, optimizing, and troubleshooting workflows spanning molecular biology and mammalian cell culture systems, ensuring processes are robust, scalable, and production-ready. This includes hands-on experimental work, cross-functional collaboration, and enabling operational teams through training, technical guidance, and documentation.

This is a highly collaborative role partnering with teams across operations, automation engineering, and bioinformatics to translate innovation into reliable production processes. A key component of this work will be designing processes with automation in mind, enabling deployment across a diverse suite of liquid handling platforms to support scalable and standardized manufacturing.

We are looking for someone who combines strong experimental rigor with practical problem-solving, and who is equally comfortable working at the bench and thinking strategically about process improvement. Experience across both DNA technologies (e.g., NGS, cloning) and mammalian cell culture/protein expression systems is highly valued.

If you enjoy working in a fast-paced, multidisciplinary environment where you can directly impact how products are built and delivered at scale, this role offers broad exposure to cutting-edge synthetic biology platforms and technologies.

Key Responsibilities

• Design and execute experiments to develop, optimize, and scale production workflows for synthetic biology products, including DNA and mammalian cell-based protein expression systems
• Drive process improvements by analyzing complex datasets and translating findings into actionable changes across workflows
• Lead technical transfer of new products and processes into production, ensuring robustness, reproducibility, and scalability
• Author and maintain technical documentation, including SOPs, validation protocols, and training materials to support manufacturing teams
• Act as a technical subject matter expert, representing R&D/PD in cross-functional meetings and contributing to project strategy and decision-making
• Collaborate cross-functionally with operations, automation, and bioinformatics teams to troubleshoot issues and implement solutions
• Apply scientific literature and domain expertise to inform experimental design, process development, and strategic direction
• Maintain clear and accurate documentation of experimental work and results using electronic lab notebooks
• Mentor and train team members and operators on newly developed processes and workflows
•  

Qualifications And Required Skills

• PhD in Molecular Biology, Biochemistry, or related field; or Master’s with 2–5+ years of industry experience; or Bachelor’s with 5+ years of relevant experience
• Strong foundation in molecular biology techniques, including DNA/RNA purification, PCR/qPCR, and molecular cloning
• Hands-on experience developing and optimizing mammalian cell culture systems for protein expression (e.g., HEK, CHO)
• Experience designing expression constructs and optimizing systems for yield, solubility, and activity across host platforms
• Proven ability to develop and optimize upstream and downstream workflows, including transfection and protein purification strategies
• Demonstrated experience in experimental design, data analysis, troubleshooting, and method development in complex biological systems
• Strong attention to detail and ability to translate experimental outcomes into scalable process improvements
• Solid scientific judgment and ability to independently drive technical decisions

Preferred Skills

• Experience with next-generation sequencing (NGS) workflows, library preparation, and/or data analysis
• Familiarity with high-throughput workflows and laboratory automation systems (e.g., liquid handlers)
• Programming or data analysis experience (e.g., Python, SQL, JSON) for handling large datasets
• Proven ability to manage multiple priorities in a fast-paced environment
• Strong collaboration and communication skills, with experience working across multidisciplinary teams
• Experience mentoring, training, or onboarding team members
• Demonstrated problem-solving skills and a proactive, solution-oriented mindset
• Self-motivated with a commitment to continuous learning and staying current with scientific advancements

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we serve people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals, and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this Oregon-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.