Research Associate – Antibody Characterization (onsite in Quincy, MA)

We are seeking a motivated individual to join our team and expand our antibody characterization department. Using state-of-the-art technologies and workflows, this Research Associate would work with the Antibody Characterization team to ensure project-specific deliverables are met across a diverse panel of discovery campaigns and contract services. The role would involve wet-lab experimental design, execution, and data analysis for multiple custom antibody development projects, incorporating various biologics assay formats

What you will be doing

• Performing titer testing, screening, and antibody validation by high-throughput multicolor flow cytometry and ELISA
• Running and troubleshooting cell-based functional assays
• Performing mammalian cell culture, including thaw, maintenance, expansion, cryopreservation, and QC of a wide variety of adherent and suspension cell lines
• Developing, running, and troubleshooting antibody characterization experiments using advanced label-free analytical techniques (e.g., BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning
• Sample handling, sample inventory tracking, and assisting with automation integration into the department
• Concurrently execute multiple antibody discovery projects requiring wet lab activities, data analysis, report generation, and preparation of deliverables adhering to project timelines
• Record and communicate experimental details, draft reports, and deliver data with a high level of integrity and ethics

What You’ll Bring to the Team

• Bachelor's degree in molecular biology, biochemistry, or a related discipline, and a minimum of 2 years of related experience; or a master’s degree without experience; or equivalent work experience.
• Excellent aseptic technique and experience with mammalian adherent and suspension cell culture are required
• Flow cytometry experience is required
• Ability to troubleshoot scientific processes
• Ability to work independently, but also collaborate and effectively communicate within and across departmental team
  Exceptional written and verbal communication skills
• Highly organized, detail oriented and able to operate in a fast-paced and growing environment
• Industry experience strongly preferred.
• Understanding of antibody discovery, preferably focusing on assay development and protein characterization, is preferred
• Previous experience with Carterra, Octet, Hamilton, and/or iQue instruments nice to have 
• Direct experience with ELISA preferred

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

Manager, Antibody Characterization (onsite in Quincy, MA)

JOB DESCRIPTION 

This is a management position that provides support for bioanalytical characterization for a variety of therapeutic antibody candidates. This role oversees our Antibody Characterization team and is responsible for managing, optimizing, and troubleshooting a range of workflows, including immunoassays, affinity analysis, functional assays, and target binding characterization.

ESSENTIAL FUNCTIONS

• Lead, manage, and develop a team of scientists and research associates in our Antibody Characterization department.
• Provide technical guidance (assay development, analysis, and data reporting) in a range of areas, including high-throughput ELISA, flow cytometry, kinetic assays (BLI and SPR), advanced/custom characterization, and functional screening.
• Serve as an end-to-end technical lead for a variety of in vivo antibody discovery programs and contract services, contributing to scientific planning and feasibility review during project scoping.
• Review, critically analyze, and present data to customers to facilitate antibody lead selection for a variety of concurrent antibody discovery programs.
• Work closely with the Project Management team to communicate timelines and deliverables to internal and external stakeholders and customers.
• Work closely with all scientific departments and senior management to ensure excellent management of all activities and effective communication.
• Promote operational and scientific excellence by driving continuous process improvement.
• Stay up to date with recent developments in antibody discovery methods and technologies, and help guide the advancement of our laboratory capabilities in alignment with strategic company goals.
• Spend approximately 30-50% of your time performing wet-lab benchwork alongside the team.

POSITION QUALIFICATIONS

• PhD in a related technical field with 3+ years of management experience in biopharmaceutical analytical development, or MS with 5+ years of experience, including 3+ years of management experience.
• Expert knowledge of biologics characterization assays: extensive hands-on experience required in ELISA, flow cytometry, and SPR/BLI with Carterra and Sartorius Octet.
• Very strong track record of developing, executing, and analyzing common assay formats for biologics discovery, such as high-throughput screening, epitope binning, ligand blocking analysis, affinity analysis, and cell-based functional assays.
• Able to independently manage and prioritize tasks in a fast-paced environment that hinges on overlapping projects and sensitive workflow timelines.
• Advanced understanding of in vivo antibody discovery concepts.
• Proven ability to assess, interpret, and present complex scientific data effectively and with a high level of integrity and ethics.
• Proven management skills for both projects and people, with a strong track record of building trust and developing teams at a variety of levels.
• Exceptional written and verbal communication skills, including customer-facing communication.
• Highly organized and detail-oriented with a focused, problem-solving mentality to address projects and logistics.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.