Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Contribute to the planning, implementation and execution of a global clinical trial
• Responsible for management of vendors to support clinical trial execution
• Plan, execute, and lead study-specific meetings (e.g., internal core team meetings, investigator meetings, etc), as needed
• Provide input for the design of the Informed Consent Form(s), eCRFs, monitoring conventions, edit checks, etc.
• Provide study-specific training and leadership to clinical research staff, CRO, CRAs, sites and other contract personnel.
• Manage study timelines and metrics to ensure completion of study deliverables
• Support site selection, qualification, initiation, and monitoring activities.
• Review monitoring reports to ensure quality and resolution of site-related issues.
• Ensure timely enrollment and data collection at clinical trial sites.
• Collaborate with the data management team to ensure data integrity and timely database lock.
• Review and analyze clinical trial data to identify trends and potential issues.
• Ensure tracking and review of protocol deviations and assess impact on study data
• Develop relationships with investigators and site staff
• Work closely with CRO and Medical Monitor to ensure safety and efficacy data appropriately summarized to facilitate review.
• Work closely with translational medicine team to ensure appropriate incorporation of bioanalytical sampling plan into clinical protocols and relevant data output of the trial is provided to functional groups for review.
• Maintain accurate and complete trial documentation.
• Proactively identify and resolve clinical project issues

Skills and experience you’ll bring:

• Bachelor of Science in Life Sciences and 3+ years (CTM)/5+ years (Sr. CTM) as a project/clinical trial manager in biotech/pharmaceutical industry.
• Experience working on large, global, complex Phase 2 clinical trial(s).
• Broad knowledge of regulatory and ICH GCP guidelines, HIPAA, Protection of Human Research Subjects.
• Strong project management skills with the ability to manage multiple trials simultaneously.
• Excellent problem-solving, leadership, and communication skills.
• Ability to work in a fast-paced, dynamic environment with cross-functional teams.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $115,000 – $200,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Contribute to the planning, implementation, and execution of global clinical trials.
• Plan, execute, and lead study-specific meetings (e.g., internal core team meetings, investigator meetings, etc), as needed.
• Provide input for the design of the Informed Consent Form(s), eCRFs, monitoring conventions, edit checks, etc.
• Provide study-specific training and leadership to clinical research staff, CRO, CRAs, sites and other contract personnel.
• Manage study timelines and metrics to ensure completion of study deliverables.
• Lead site feasibility and selection qualification, initiation, and oversight of outsourced monitoring activities.
• Review monitoring reports to ensure quality and resolution of site-related issues.
• Ensure timely enrollment and data collection at clinical trial sites.
• Collaborate with the data management team to ensure data integrity and timely database lock.
• Ensure tracking, review of protocol deviations, and assess impact on study data.
• Work closely with translational medicine team to ensure appropriate incorporation of bioanalytical sampling plan into clinical protocols and relevant data output of the trial is provided to functional groups for review.
• Partner with Operational Excellence and assigned Site Engagement Leads to help drive site engagement and bolster recruitment
• Serve as key counterpart of Clinical Outsourcing to build RFPs and support the selection of clinical vendors
• Oversee and contribute to Sponsor Oversight activities including but not limited to review of KPIs, KRIs, PDs, risks, Data Review Findings, etc. to assess the health of the study and proactively ensure mitigations are in place to achieve Kymera’s quality standards
• Contribute to clinical operations process improvement initiatives
• Maintain accurate and complete trial documentation.
• Proactively identify and resolve clinical project issues.
• This role may require up to 25% travel

Skills and experience you’ll bring:

• BS degree and 8+ years of experience in clinical operations in biotech/pharma. 5 years’ experience leading global clinical trials
• Inspection readiness experience preferred
• Experience working on large, global, complex phase 2b/3 or late stage trials. Respiratory or Immunology experience highly preferred.
• Broad knowledge of Global regulations and guidelines including CFR, ICH GCP, HIPAA, GDPR, and the Protection of Human Research Subjects.
• Strong project management skills with the ability to manage multiple trials simultaneously.
• Excellent problem-solving, leadership, and communication skills.
• Ability to work in a fast-paced, dynamic environment with cross-functional teams. 

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $160,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

The Senior Director, Clinical Operations is a leadership role responsible for overseeing and managing all aspects of clinical operations for the Phase 3 program of a high priority immunology program, KT-621.  This individual will be accountable for driving the cross-functional strategy and rigorous operational execution through regulatory approval.  This person possesses clinical operations expertise with a track record of success, working with peers and stakeholders. The Senior Director will be a leader in the organization who knows how to hire and manage a team internally, at our clinical sites, and with our vendors.

• Lead and oversee the strategic planning, implementation and execution of late stage clinical trials across a key immunology program in accordance with project timelines, budget, and quality standards (including ICH GCP and local regulations)
• Develop and manage comprehensive program project plans, including but not limited to, study protocols, clinical trial budgets, timelines, enrollment and risk mitigation strategies
• Collaborate cross functionally with internal teams, including Clinical Development, Regulatory Affairs, Biostatistics and Program Leadership to ensure alignment on clinical trial objectives and milestones
• Provide operational expertise and strategic input into the development of Clinical Development Plans (CDP), supporting the overall clinical strategy for the program
• Accountable for robust operational strategies for all studies in the Phase 3 program, ensuring consistency as needed, including country and site mix, PR&R and Site Engagement strategies, vendor strategy, risk based and site monitoring strategies, etc
• Serve as the point of contact for CROs and vendors, overseeing their performance and ensuring adherence to contractual agreements, timelines and quality standards
• Ensure compliance with regulatory requirements, ICH-GCP requirements, and company SOPs throughout all stages of clinical trial conduct
• Accountable for inspection readiness and provides appropriate guidance to Clinical Study Leads in support of inspection activities
• Contribute to the preparation and review of clinical study documents including the Investigator Brochure, Investigational New Drug Applications (IND), study protocols, clinical study reports, applicable sections of New Drug Applications (NDA) and or Marketing Authorization Application (MAA), updates to the IND, NDA and other safety reports
• Hire, train and develop the Clinical Operations KT-621Phase 3 team, fostering a culture of collaboration, accountability, continues improvement, and operational excellence

Skills and experience you’ll bring:

• BA/BS, preferably in a health-related field
• 12+ years of experience in clinical operations within the pharmaceutical or biotechnology industry
• Prior experience building and leading a high-performing clinical operations team
• Expertise in global regulatory and compliance requirements for clinical research, including but not limited to, US CRF, EU CTD and ICH GCP
• Ability to manage multiple competing priorities and adapt to changes in a high-pressure environment
• Strong communication, interpersonal, and problem solving skills
• Must be comfortable working in a fast-paced environment

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $235,000 - $330,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

The Director of Formulation Development will assist in the development of late-stage oral drug product development and commercial manufacturing strategies to support Kymera’s small molecule pipeline from Phase 2/3 through commercialization.

This is an opportunity to join a fast-paced, innovative biotech environment where bold ideas and collaboration drive breakthroughs. As a member of the CMC team, you will develop and implement robust, scalable manufacturing processes for late-stage manufacturing and eventual commercialization.

The ideal candidate will bring deep expertise in oral solid dose formulation development and manufacturing within a GMP environment, strong project leadership capabilities, and a passion for working in a dynamic, mission-driven culture focused on delivering life-changing medicines. This role will work cross-functionally with CMC, Regulatory, Quality and external partners to deliver high-quality drug products aligned with program timelines.

• Drive late-stage drug product activities, including registration and validation campaigns, and commercial readiness for solid oral dosage forms.
• Define and execute phase-appropriate activities to support Phase 3 and NDA submissions
• Oversee formulation robustness, process characterization, and control strategy development in alignment with QbD principles.
• Provide technical and strategic oversight of CDMOs, including development, scale-up, technology transfer, and clinical batch production to ensure reliable supply.
• Collaborate with Analytical Development to ensure late-stage method readiness, validation, and stability strategies to support shelf-life assignments.
• Partner with Regulatory Affairs to author and review CMC sections for global filings, including responses to health authority questions and inspections.
• Review and approve master and executed batch records. Ensure compliance with GMP requirements and lead or support deviation investigations, CAPAs, and change control processes.
• Provide technical leadership in troubleshooting manufacturing issues.

Skills and experience you’ll bring:

• D. in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, or related field with 10+ years of industry experience, or M.S. with 15+ years of relevant experience.
• Demonstrated expertise in late-stage small molecule formulation development and manufacturing for oral solid dosage forms.
• Proven track record of advancing compounds through Phase 3, regulatory approval, process validation and commercialization.
• Deep technical expertise in oral solid dosage form manufacturing and process development, spanning unit operations such as tableting, encapsulation, coating, granulation, spray drying, hot-melt extrusion, and milling.
• Strong experience with CDMO oversight, technology transfer, and commercial supply management.
• Working knowledge of global regulatory CMC requirements, including NDA preparation and inspection readiness.
• Experience working in cross-functional CMC teams, strong knowledge of process and analytical development and a working knowledge of other areas of drug development
• Excellent leadership, communication, and cross-functional influencing skills.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $195,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Develop quantitative cell-based assays to facilitate SAR and MOA studies for novel degraders.
• Perform various solution and plate-based assays to evaluate changes in biomarkers from primary human cells and animal models.
• Maintain good written records of laboratory procedures and communicate research findings in cross-functional project team meetings.
• Review literature and conference proceedings to identify emerging technologies/assays and execute exploratory efforts for internal validation.

Skills and experience you’ll bring:

• BS with 3+ years or MS with 1+ years of relevant lab experience in immunology, cell biology, or related field.
• Mammalian cell culture experience including both immortalized and primary human cells
• Proficiency with molecular and cell biology techniques including ELISA, MSD, AlphaLISA, western blot, and flow cytometry
• Independent mindset to execute experiments, analyze, and interpret results with minimal supervision while proactively seeking help and guidance.
• Excellent organizational, verbal, and written communication skills and familiarity with electronic laboratory notebooks (ELN).
• Previous experience in TPD is desirable but not required; innovative and growth mindset to execute and learn new things is essential.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $85,000 – $120,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

The Opportunity:

This is not a seat-warming role. The Executive Director, Talent Acquisition is a mission-critical hire - the person who will build and own Kymera's people engine through its most consequential growth phase yet.

You'll work directly with our SVP, People & Culture to architect workforce strategy for a company actively crossing the chasm from clinical to commercial readiness. You'll own the full talent acquisition function - strategy and execution - leading a high-performing team that is already delivering results. Your mandate: make it more proactive, more strategic, and more tightly connected to where the business is going.

The TA function has a very strong foundation, and your role will be to enable this team to continue to build a high- performing company with top talent.  Assess where we can create efficiencies, build value-add initiatives to maximize impact and create strategies that align with our long term build.

What You'll Own:

Workforce Planning & Strategic Leadership

Take clear, firm ownership of workforce planning - bringing rigor and proactivity to when, how, and who Kymera hires to deliver on its business objectives. Partner closely with People Partners to ensure alignment, while making sure the planning intelligence and hiring strategy is driven by Talent Acquisition.

• Own and lead the annual and rolling workforce planning process in close partnership with the SVP of People & Culture and senior business leaders
• Create proactive pipelining strategies for Kymera's most critical and hard-to-fill roles, including Medical Directors, late-stage clinical profiles, and senior leadership succession, well before vacancies become urgent
• Build forward-looking commercial hiring playbooks to ensure the team is positioned to move fast when commercialization demands it
• Develop trust-based partnerships across all functions and levels; engage directly with leaders to anticipate talent needs rather than react to them

Team Leadership & Execution

Lead a talented TA team with the leadership presence that connects the team's daily work to Kymera's broader ambitions. Stay close to the work yourself: this role owns requisitions and maintains first-hand visibility into candidate quality and experience.

• Manage, develop, and grow a strong, flexible TA team that scales to meet evolving hiring needs and organizational design requirements
• Create the leadership layer that bridges the TA function and executive leadership
• Evolve interview and assessment methodologies to support faster, more data-driven, and more equitable talent decisions
• Drive an exceptional candidate experience as a genuine extension of Kymera's culture, embodying our values of Pioneer, Collaborate & Belong

Analytics, Reporting & Systems

Build the intelligence layer that makes TA a strategic asset to the business, not just a function that fills roles.

• Establish an executive-ready analytics and reporting cadence: pipeline health, time-to-fill, capacity forecasts, offer acceptance, and demographic data
• Optimize talent systems including ATS and workflow automation to enhance candidate management and process efficiency
• Bring genuine curiosity to AI and automation tools; evaluate and pilot solutions that make the team meaningfully more effective

Employer Brand & Early-Talent Community

• Partner with Communications and People + Culture on employer branding and external communications, ensuring Kymera's story reaches the right talent at the right moments
• Launch co-op, internship, and student community programs in partnership with business leaders, building early-talent pipelines that match Kymera’s stage and trajectory

Skills and experience you’ll bring:

• 10+ years in talent acquisition, with 3+ years leading a TA function end-to-end
• Full-cycle recruiting experience in biotech or pharma, genuine passion for work and a high bar for talent
• Track record of proactively owning workforce planning, not just responding to requisitions, and translating business goals into talent strategy
• Demonstrated experience building pipelines for senior clinical, scientific, and leadership profiles (MDs, late-stage experts, succession planning)
• Experience building fit-for-purpose analytics, reporting cadences, and systems that drive better hiring decisions
• Strong executive communicator who can influence without authority and operate credibly with C-suite stakeholders
• Resilient self-starter who thrives in fast-paced, dynamic environments and looks at process and operations with a “right-sized” lens
• Genuinely curious about AI and automation and what it can do for TA; eager to explore and experiment

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $245,000 – $335,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Develop, optimize, and implement targeted proteomics analysis workflows, including automated enrichment strategies, to deliver precise, accurate, and sensitive protein measurements that inform drug discovery and development decisions.
• Collaborate cross-functionally to implement and qualify assays that drive pipeline decision-making.
• Communicate proactively with project teams and within the proteomics function to coordinate sample availability, align timelines, and ensure timely delivery of high-quality results.
• Manage and oversee activities at contract research organizations (CROs), including assay transfer, qualification, and performance monitoring, ensuring adherence to project specifications, timelines, and data quality standards.
• Perform targeted protein mass spectrometry (MS) assays using state-of-the-art LC-MS systems—including nano-LC and Orbitrap platforms—to determine pharmacodynamic (PD) effects, quantify biomarkers, and qualify assays for clinical studies.
• Prepare samples from a wide variety of biological matrices (cultured cells, tissues, plasma, biofluids) from both human and preclinical species using manual and automated bead-based workflows.
• Perform and interpret quantitative proteomics data analyses using software such as Skyline, MaxQuant, DIANN, and Spectronaut; generate clear, data-driven reports for cross-functional stakeholders.
• Maintain, qualify, and troubleshoot HPLC and MS instrument performance to ensure reliability and reproducibility.
• Present scientific results and strategic recommendations to internal project teams, senior leadership, and external collaborators in a clear, concise, and influential manner.

Skills and experience you’ll bring:

• PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with a minimum of 2 years of experience in targeted, mass spectrometry–based proteomics in an industry or startup biotech setting; or BS/MS with 8+ years of relevant experience.
• Broad expertise in targeted proteomics, including:
• Development and deployment of highly multiplexed and sensitive PRM or MRM stable isotope–labeled peptide assays using DDA and DIA data.
• Development of immunoaffinity enrichment methods to enhance MS sensitivity.
• Optimization of protein recovery from complex biological matrices (cells, tissues, plasma, biofluids) and various sample formulations (fresh, frozen, FFPE) across preclinical species.
• Operation, maintenance, and troubleshooting of nanoLC and Orbitrap MS instrumentation.
• Quantitative analysis and report generation using Skyline and related proteomics data tools.
• Demonstrated ability to independently analyze, interpret, and clearly communicate targeted proteomics data and conclusions to multidisciplinary teams.
• Proven success collaborating across functional areas and managing CRO relationships to deliver qualified assays that support drug discovery and clinical development.
• Strong organizational, problem-solving, and time-management skills with the ability to prioritize multiple projects to meet TPD drug discovery timelines.
• Excellent written and verbal communication skills, with the ability to convey complex scientific concepts to both technical and non-technical audiences.
• Familiarity with regulatory filings (e.g., IND) and qualification of MS assays for clinical applications preferred.
• Working knowledge of automated sample processing, including immunoaffinity capture MS assays, is a plus.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $115,000 – $200,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Partner closely with cross-functional stakeholders in Research and Development to support sourcing strategies that align with business needs and financial and operational objectives.
• Collaborate with Kymera’s functional relationship managers, Legal, and Finance to support the establishment and management of master service agreements (MSAs) and subsequent statements of work (SOWs).
• Build and maintain strong relationships with key vendors to support effective negotiations and positive business outcomes for Kymera.  Lead Supplier Relationship Management (SRM) efforts and establish contractual foundations with preferred terms.
• Lead negotiations of business and commercial terms with contract research organizations (CROs), contract manufacturing organizations (CMOs) and other strategic vendors, in alignment with internal stakeholder needs and company objectives.
• Identify and implement cost savings opportunities.  Deliver tangible business impact including hard savings and cost avoidance.
• Contribute to the development, implementation, and continuous improvement of strategic sourcing processes across the organization.
• Lead and own request for proposal (RFP) processes, bid evaluations, and vendor selection activities.
• Conduct vendor diligence and support the selection of primary and secondary suppliers.
• Help establish preferred commercial terms, discounts, and sourcing strategies across key categories and vendor networks.
• Track sourcing activities, contract status, and vendor performance metrics to help inform decision-making and ensure operational effectiveness.

Skills and experience you’ll bring:

• 6+ years of experience in sourcing, procurement, supplier management, outsourcing, or strategic negotiations within the biotech or pharmaceutical industry.
• Experience supporting sourcing initiatives across multiple R&D functions, including areas such as Clinical, Translational Medicine, Research, and/or CMC.
• Demonstrated ability to partner effectively with internal stakeholders and deliver high-quality customer service in a fast-paced environment.
• Experience supporting or leading contract negotiations, including commercial terms, with CROs, CMOs and other external service providers.
• Strong analytical and problem-solving skills, with the ability to synthesize complex information and communicate clearly to a range of stakeholders.
• Highly organized, with strong project management skills and the ability to manage multiple priorities simultaneously.
• Effective influencing skills and the ability to work cross-functionally to drive alignment and outcomes.
• Agile learner with the ability to quickly adapt to new tools, systems, and business needs.
• Strong interpersonal skills with the ability to build and maintain productive relationships with external vendors, partners, and internal collaborators.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $145,000 – $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Contribute to the creation, design, and execution of Kymera’s clinical development strategy, collaborating with cross-functional teams (Biometrics, Regulatory, Clinical Operations) and external advisors.
• Provide scientific leadership from clinical trial design and protocol development, ensuring operational feasibility, data quality, and participant/site engagement.
• Ensure patient safety and data accuracy and integrity by conducting medical and clinical data reviews, monitoring protocol adherence, and managing protocol deviations.
• Collaborate across functions to ensure timely, high-quality study delivery and successful execution of clinical programs.
• Lead or contribute to creating essential documents such as Investigator’s Brochures and safety updates and serve as subject matter expert for regulatory submissions and interactions with regulatory authorities.
• Drive improvement and innovation of clinical development practices and maintain consistency across studies.
• Engage with KOLs, academic collaborators, and external experts to guide program direction.
• Mentor and grow high-performing teams in a fast-paced, entrepreneurial environment.
• Stay current on disease biology, therapeutic practices, and drug mechanisms of action, providing insights into the competitive landscape and strategic development pathways.
• Contribute to the preparation of scientific materials for conferences, publications, and presentations, supporting internal and external communication.

Skills and experience you’ll bring:

• A Bachelor’s Degree is required, with an advanced degree in life sciences or healthcare (PhD, MD, PharmD, MSc or equivalent) preferred. Significant experience in late-stage drug development is highly desirable.
• 10+ years of experience in clinical trial planning, startup, execution, reporting, and publishing within the biotech/pharma industry. Experience in immunology, inflammation, or related therapeutic areas is a plus.
• Proven leadership in clinical strategy, development and execution of innovative clinical development plans.
• Demonstrated expertise in protocol development, study report and investigator brochure (IB) authoring, and preparing regulatory submissions.
• Proven track record of successfully collaborating with medical monitors, development operations, and clinical investigators.
• Thorough knowledge of relevant regulatory guidelines, including GCP, ICH, and FDA standards, as well as a strong understanding of Quality practices within GCP.
• Highly analytical and organized, with strong critical thinking skills and a history of innovative problem-solving.
• Experience managing multiple tasks and priorities, especially under tight deadlines, with a keen attention to detail.
• Ability to work independently, in multi-disciplinary teams, and with external partners, demonstrating strong interpersonal skills.
• Exceptional communication skills, both written and verbal, with the ability to convey complex information clearly to diverse audiences.
• Strong influencing abilities, with a history of resolving complex issues in creative and effective ways, and the capability to lead cross-functional teams.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $235,000 – $330,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

The Senior Clinical Trial Associate (Sr. CTA) is responsible for supporting the Clinical Operations Team in the successful delivery of clinical trials in accordance with applicable regulations, within agreed timelines and budget. They are responsible for coordination, logistics, tracking, and administrative tasks in support of clinical trials from protocol concept through clinical study report.

• Collaborates with internal teams to support execution of Kymera-sponsored clinical trials
• Assists with clinical operations oversight, including but not limited to, review of Monitoring Visit Reports, Study Plans and Essential Document Packets, etc.
• Maintains eTMF in a state of inspection readiness through ongoing QC, reconciliation, and audit/inspection support to ensure compliance with GCP and regulatory requirements.
• Ensures study issues and decision-related correspondence is maintained through the duration of the trial.
• Maintains the Action Decision Issue Log and tracks actions to completion.
• May contribute to development and review of study documents, including informed consent forms and study templates.
• Performs reconciliations and tracking activities.
• Manages a trial vendor with oversight.
• Assists in the routing, tracking, and coordination of Site and CRO/Vendor Confidential Disclosure Agreements (CDAs) and other contracts with Clinical Operations, Legal, and Finance departments.
• Leads eTMF archiving and coordinate file transfer and reconciliation with CROs at study closeout.
• Maintains internal SharePoint site (folder creation, filing)
• Drafts internal agendas and keeps meeting minutes; manages external partners in their execution of agendas and minutes.
• Assists with logistics coordination for investigator meetings and external vendor meetings.
• Participates in functional initiatives, including SOP development and review, staff training, and system/process improvement.
• Develops and maintains strong, collaborative relationships with multiple cross-functional team members and external vendors.
• Participate in co-monitoring visits as needed.

Skills and experience you’ll bring:

• BS/BA degree; preference for a degree in a scientific or health related field
• 3+ years of experience in clinical trial execution, with at least one year of experience on the sponsor side.
• Knowledge and understanding of the International Conference on Harmonization (ICH) and Good Clinical Practice (GCP) Guidelines.
• Excellent communication (verbal and written), organizational, and problem-solving skills.
• Experience building and managing external contract research relationships.                                                                                                                                                                              

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $90,000 – $155,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Working closely with program teams towards addressing key biology and chemistry questions
• Develop and optimize sample preparation and mass spectrometry methods for deep quantitative analysis of cell and tissue total proteomes as well as post-translational modifications.
• Perform maintenance, quality control and troubleshooting of instruments, including HPLCs and mass spectrometers
• Establish robust nLC-MS-based data acquisition and analysis workflows
• Provide documentation, analysis, interpretation and presentation of experimental data in a clear and concise manner
• Present scientific results and strategic recommendations to internal project teams, senior leadership, and external collaborators in a clear, concise, and influential manner.
• Stay up to date on proteomics methods and technologies
• Proactively recognize and solve technical and scientific issues to ensure high quality proteomics data is generated for the progression of drug discovery projects.

Skills and experience you’ll bring:

• PhD in Biochemistry, Biology, Chemical Biology, or a related discipline, with 3+ years of quantitative mass spectrometry-based proteomics experience, or 7+ years of industry experience in proteomics.
• Extensive hands-on experience in proteomics is required including:
• Demonstrated ability to independently troubleshoot, analyze, and interpret proteomics data with attention to detail, to recommend and execute next steps.
• High level of proficiency in a variety of quantitative proteomics techniques including DIA, label-free quantification and peptide fragmentation methods.
• Maintaining and troubleshooting HPLCs and mass spectrometers.
• Developing methods and performing nano LC-MS/MS experiments using Orbitrap Astral or Orbitrap Exploris 480 mass spectrometers.
• Experience in computational analysis and downstream statistical analysis software packages, such as DIANN, Perseus, R or Python, to address key program questions.
• Ability to work in an agile, fast-paced, team-oriented environment.
• Lead from the lab for activities include hit validation, lead optimization, target validation, and small molecule mechanism of action studies
• Experience with PTM analysis (phosphorylation and ubiquitination), protein interaction analysis, and targeted proteomics are a plus.
• Experience in low abundance protein isolation from complex biological samples including cells, tissue and biofluids and affinity enrichment to selectively enrich sub-proteomes and experience with automation and liquid handling systems are a plus.
• Experience in mapping protein-protein interactions by mass spectrometry with pulldown approaches, proximity labeling and XL-MS are a plus
• Tissue culture experience with suspension and adherent cell lines is a plus

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $90,000 – $200,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Define and implement the long-term vision for Clinical Operations Excellence, ensuring alignment with corporate objectives and regulatory standards.
• Partner with senior leaders in Clinical Development, Quality, Regulatory, and other functions to harmonize processes and elevate trial execution.
• Lead the design and deployment of scalable, standardized processes, tools, and KPIs across clinical operations.
• Oversee operational performance dashboards, risk management frameworks, and trial health reporting to ensure proactive issue identification and resolution.
• Champion continuous improvement initiatives that enhance trial efficiency, cost-effectiveness, and speed-to-market.
• Partner with Quality Assurance to ensure inspection readiness and adherence to compliance frameworks.
• Develop and implement frameworks to ensure adherence to regulatory requirements and Good Clinical Practice (GCP) guidelines. Ensure adherence to global regulatory requirements, ICH-GCP, and company SOPs.
• Develop training programs and support change management initiatives to embed best practices.
• Drive continuous process improvements to enhance operational efficiency, quality, and effectiveness in clinical oversight.

Skills and experience you’ll bring:

• 10+ years of experience in the biotech/pharmaceutical industry with direct experience in project management within Clinical Operations
• Proven track record in process improvement, clinical trial execution, and operational strategy.
• Experience with planning, management, and oversight of activities and deliverables within Clinical Operations
• Strong understanding of clinical trial management, ICH-GCP, and regulatory compliance
• Proven track record of managing multiple projects and/or programs concurrently
• Excellent analytical, problem-solving, and organizational skills.
• Strong communication and interpersonal skills with the ability to influence cross-functional stakeholders.
• Demonstrated ability to lead change and foster a culture of continuous improvement.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $195,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

As the Lead Statistician, you will spearhead the statistical efforts of one or more clinical programs, playing a key role in the clinical development plan, regulatory submissions, and overall data strategy. This role requires strategic involvement in program teams, authorship of statistical sections in study documents, and direct oversight of outsourced statistical functions.

• Act as the lead statistician of a clinical program, leading statistical efforts and representing biometrics functions on program teams. Make strategic contributions to the clinical development plan.
• Serve as the biostatistical lead for regulatory submissions and inspections, ensuring compliance with global regulatory standards.
• Contribute to the development of clinical protocols by authoring the statistical methods section and reviewing other sections for statistical accuracy.
• Develop and review statistical analysis plans for individual studies and integrated summaries of safety/efficacy (ISS/ISE). Create and edit statistical outputs shells.
• Provide statistical input during CRF design to ensure alignment with study objectives and analyze requirements. Oversee and quality control results from statistical programmers or CROs.
• Contribute to clinical study reports by authoring statistical sections and interpreting study results. Support the preparation of scientific publications and presentations.
• Manage relationships with CROs to ensure high-quality statistical outputs and compliance with study requirements.
• May manage direct reports, as needed, providing guidance and professional development.

Skills and experience you’ll bring:

• Advanced degree in Statistics or related field with minimum 6 years of clinical trial experience in a biotechnology or pharma company.
• Extensive knowledge of statistical methods for clinical trials and deep familiarity with FDA, EMA, and ICH guidelines.
• Expertise in SAS required; R or Python is advantageous. Experience with trial design software such as EAST or nQuery.
• Strong communication skills necessary for effective collaboration with cross-functional teams. Ability to communicate statistics to non-statisticians effectively; influence and ensure adoption of robust statistical methods.
• Exceptional ability to manage multiple priorities in a fast-paced environment.
• A strong passion for innovation in Biostatistics and continuous improvement in processes.
• Strong analytical and problem-solving abilities.
• Positive attitude and a collaborative spirit.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $195,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

The Associate Director will act as a Quality subject matter expert for Good Manufacturing Practices (GMP) activities. The individual will be responsible for material disposition; will provide Quality oversight for technical transfers, stability assessments, manufacturing, analytical and distribution activities performed at external suppliers. In addition, the individual will ensure compliance with regulations and Kymera policies and procedures.

• Provide quality oversight of contract organizations associated with the manufacturing and distribution of Drug Substances, Drug Products, and Finished Goods.
• Collaborate with manufacturing and distribution colleagues to (i) review manufacturing batch records, protocols, reports, and specifications, and (ii) perform disposition of critical intermediates, drug substances/drug products, and finished goods.
• Partner closely with CMC analytical colleagues to (i) review test methods, SOPs, analytical data summaries, validation and stability protocols, and technical reports (ii) oversee specification control and shelf life management.
• Ensure that product quality-related issues, including deviations/OOSs/OOTs and product complaints, are appropriately investigated and resolved.
• Collaborate cross-functionally and develop strong relationships with internal and external partners.
• Support the preparation and review of regulatory filing submissions (IND/IMPD/NDA)
• Help develop and implement phase-appropriate SOPs and policies. Ensure compliance with relevant regulatory requirements such as FDA, EMA, and ICH guidelines.
• Manage the qualification and performance monitoring of external GMP suppliers and maintain Quality Agreements with them.
• Develop and track quality metrics to measure performance and identify trends.
• Present quality assessments to the Material Review Board and Quality Management Review Board.
• Provide support for late-stage manufacturing and commercialization readiness activities.

Skills and experience you’ll bring:

• 8 + years of experience in pharmaceutical manufacturing or laboratory settings, including at least 4 years in a GMP quality assurance role. Experience in a small-molecule manufacturing environment is preferred.
• Experience providing Quality oversight of outsourced late-phase GMP manufacturing activities, including process validation and commercial readiness.
• Excellent communication and interpersonal skills.
• Experience working in a CMC team setting as a Quality representative.
• Work independently and manage multiple projects within the established timelines and objectives.
• Strong problem-solving ability to evaluate quality matters and make risk-based decisions.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $160,000 – $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Serve as the study level Clinical Scientist in immunology, actively participating in study team meetings, vendor meetings, and data/safety monitoring committees.
• Support the design of clinical trial protocols and amendments, ensuring scientific integrity and alignment with regulatory standards. Collaborate with Translational Medicine to integrate biomarker testing and with Clinical Pharmacology to integrate pharmacokinetic sampling into trial protocols.
• Prepare and review essential documents such as medical monitoring plans, statistical analysis plans, informed consent forms, case report forms and clinical study reports.
• Support study execution as scientific subject matter expert.
• Conduct clinical data reviews, including safety monitoring activities, to ensure patient safety and data accuracy and integrity.
• Data review, cleaning, and monitoring utilizing data visualization tools, and protocol deviations review to analyze trends, identify risks and implement mitigation strategies.
• Support IRB and regulatory submissions and query responses.
• Present data and information to external investigators and internal stakeholders, contributing to meetings with governance bodies and regulatory authorities.
• Work within a matrix environment, collaborating with medical directors, regulatory affairs, translational medicine, clinical operations, data management, biostatistics, and other departments to drive clinical development programs forward.

Skills and experience you’ll bring:

• Bachelor’s or advanced degree (MSc, PharmD, MD, PhD) in Life Sciences or related field.
• 4+ years in pharmaceutical clinical drug development, with experience in global clinical trials and program execution.
• Experience in immunological diseases (e.g. Systemic Lupus Erythematosus, Inflammatory Bowel Disease), with an understanding of disease biology and treatment landscapes.
• In-depth understanding of clinical development processes, regulatory requirements, and guidelines (FDA, EMEA, ICH, GCP).
• Strong critical-thinking, problem-solving abilities and excellent medical writing skills.                                                                                                                                                                            

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $160,000 – $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Contribute to the execution of clinical trial protocols in Respiratory, working closely with the Clinical Science Study Lead to support high-quality and scientifically rigorous study conduct.
• Support day-to-day study activities, in collaboration with Clinical Operations, ensuring alignment with scientific, organizational, and regulatory standards.
• Conduct ongoing clinical data review and cleaning of clinical trial data to ensure data quality, integrity, and patient safety.
• Perform medical data monitoring, including review of safety data, listings, and outputs, and partner with Data Management and Medical Development to support escalation, query generation and resolution.
• Contribute to the identification, analysis, and interpretation of clinical data trends, communicating findings and escalating to the Clinical Science Study Lead as appropriate.
• Contribute to the development and review of study-related documents (e.g., protocols, amendments, clinical study reports).
• Support interactions with investigators, CROs, and vendors during study conduct.
• Collaborate within a matrix environment, collaborating with medical directors, regulatory affairs, translational medicine, clinical operations, data management, biostatistics, and other departments to drive clinical development programs forward.

Skills and experience you’ll bring:

• Bachelor’s or advanced degree (MSc, PharmD, MD, PhD) in Life Sciences or related field.
• 2+ years in pharmaceutical clinical drug development, with experience in global clinical trials and program execution.
• Experience in immunological diseases (e.g. asthma), with an understanding of disease biology and treatment landscapes is a plus.
• In-depth understanding of clinical development processes, regulatory requirements, and guidelines (FDA, EMEA, ICH, GCP).
• Strong critical-thinking, problem-solving abilities and excellent medical writing skills.                                                                                                                                                                    

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $145,000 – $215,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Contribute to the execution of clinical trial protocols in Immunology, working closely with the Clinical Science Study Lead to support high-quality and scientifically rigorous study conduct.
• Support day-to-day study activities, in collaboration with Clinical Operations, ensuring alignment with scientific, organizational, and regulatory standards.
• Conduct ongoing clinical data review and cleaning of clinical trial data to ensure data quality, integrity, and patient safety.
• Perform medical data monitoring, including review of safety data, listings, and outputs, and partner with Data Management and Medical Development to support escalation, query generation and resolution.
• Contribute to the identification, analysis, and interpretation of clinical data trends, communicating findings and escalating to the Clinical Science Study Lead as appropriate.
• Contribute to the development and review of study-related documents (e.g., protocols, amendments, clinical study reports).
• Support interactions with investigators, CROs, and vendors during study conduct.
• Collaborate within a matrix environment, collaborating with medical directors, regulatory affairs, translational medicine, clinical operations, data management, biostatistics, and other departments to drive clinical development programs forward.

Skills and experience you’ll bring:

• Bachelor’s or advanced degree (MSc, PharmD, MD, PhD) in Life Sciences or related field.
• 2+ years in pharmaceutical clinical drug development, with experience in global clinical trials and program execution.
• Experience in immunological diseases (e.g. lupus), with an understanding of disease biology and treatment landscapes is a plus.
• In-depth understanding of clinical development processes, regulatory requirements, and guidelines (FDA, EMEA, ICH, GCP).
• Strong critical-thinking, problem-solving abilities and excellent medical writing skills.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $145,000 – $215,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Develop and execute innovative strategies to expedite development cycles, focusing on efficient design and execution of Phase 2 and Phase 3 programs. Experience with pediatric development is a plus.
• Act as a clinical leader, engaging with academic advisors, principal investigators, patient groups, regulatory authorities, and industry collaborators.
• Utilize specialized knowledge in pulmonology, immunology and/or dermatology fields to support and enhance the clinical portfolio.
• Collaborate with regulatory leaders to develop and execute submission strategies, overseeing the creation and quality of clinical content for protocols, INDs, and regulatory reports, and ensuring the highest standards for all clinical documents and regulatory responses.
• Serve as Medical Monitor and sponsor representative with CROs, PIs, core laboratories and other organizations involved in clinical trials.
• Ensure timely execution of studies within the pulmonology, immunology, and/or dermatology portfolio.
• Develop and implement publication strategies and actively contribute to key presentations.

Skills and experience you’ll bring:

• Advanced degree in medicine (e.g., M.D. or D.O. or equivalent). Clinical training in Pulmonary & Critical Care Medicine (board certified or eligible) or Dermatology is preferred.
• Clinical pediatric experience and/or Industry pediatric development experience is a plus
• 2+ years of Industry experience, with a focus on late clinical development; strong academic backgrounds with less experience may also be considered.
• Experience in inflammatory and immunological therapeutic areas is preferred; pulmonary/respiratory and/or dermatology experience is advantageous.
• Proven expertise in leading late-stage clinical trials, including protocol design, study start-up, team management, data analysis, and medical monitoring.
• Experience with New Drug Applications (NDA) and pediatric label expansion is a plus.
• Demonstrated capability as a clinical development representative on cross-functional drug development teams.
• Thorough understanding of all phases of drug development.
• Exceptional communication skills with the ability to effectively present and engage a wide range of stakeholders

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $260,000 – $315,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

As an Associate Director of Drug Substance Development, you will serve as the accountable Drug Substance lead for one or more development programs, owning DS strategy, execution, and delivery from late discovery through clinical development.

• Use scientific, data-drive, and risk-based approaches to clinical and commercial route and process innovation and development, guided by safety and green chemistry principles.
• Provide technical leadership and decision‑making oversight for outsourced Drug Substance development activities at CROs and CDMOs, ensuring quality, timelines, and scientific rigor.
• Serve as the Drug Substance technology lead for internal and external knowledge transfers, including authoring transfer strategies, defining success criteria, and supporting manufacturing execution.
• Collaborate with Drug Product and Analytical colleagues to ensure the Drug Substance physical attributes are understood, controlled, and are appropriate for Drug Product manufacturing.
• Ensure stage appropriate data is generated and documented; serve as contributing author and technical reviewer of Drug Substance sections of regulatory filings.
• Collaborate effectively with internal and external stakeholders to deliver on program objectives.

Skills and experience you’ll bring:

• Ph.D. in Chemistry or Chemical Engineering with at least 7 years’ or B.S./ M.S. in Chemistry or Chemical Engineering with at least 12 years’ experience in Drug Substance Development.
• Experience with:
  • Bringing small molecule assets from late discovery through mid-phase clinical trials.
  • Serving as the Drug Substance lead on fully integrated Chemistry, Manufacturing, and Control (CMC) teams.
  • Directing CRO and CDMO partners.
  • Writing and reviewing Drug Substance related technical documents.
• Deep understanding of small molecule drug development; understand how CMC disciplines integrate and partner with associated functional areas such as Quality, Non-clinical Safety, Clinical, Regulatory, and Intellectual Property Protection.
• In-depth familiarity with phase based GMPs and manufacturing compliance requirements, regulatory guidelines and expectations.
• Willingness and ability to work hands-on and with a sense of urgency in a fast-paced, agile environment.
• Demonstrated ability to make sound, risk‑based scientific and business decisions in ambiguous, fast‑paced development environments.
• Ability to conduct, manage, and communicate risk assessments.

Preferable Experience:

• Ability to develop data driven crystallization processes based on an understanding and application of fundamental principles.
• Experience using statistical and modelling software applicable to Drug Substance Development and Manufacturing to support process understanding and decision making.
• Design and execution of process characterization with cross-functional colleagues, utilizing Quality by Design principles.
• Comfortable stepping into hands‑on problem solving when needed to unblock programs, while maintaining focus on strategic and technical leadership.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $160,000 – $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

The Associate Director, GCP Quality is responsible for developing, implementing, and maintaining the Good Clinical Practice (GCP) Quality framework to support Kymera’s global clinical development programs. This role provides independent quality oversight of clinical trials, CROs, and vendors, ensuring compliance with ICH GCP, global regulatory requirements, and internal quality standards.

The individual will play a key role in operational study team GCP support, audit management, risk-based quality management, continuous improvement initiatives and inspection readiness, as the organization advances toward late-stage development and commercialization.

• Provide GCP quality oversight of Kymera’s global clinical trials to ensure compliance with ICH E6 (R2/R3), FDA, EMA, and applicable regional regulations
• Provide Quality oversight and investigation support for vendor and internal Quality Issues and CAPA management
• Support risk-based quality management system (RBQM) through assessment, characterization and escalation of quality risks
• Lead qualification and ongoing oversight of CROs and clinical vendors, via review of vendor quality documentation and audit responses
• Ensure appropriate quality agreements are in place and monitor vendor performance metrics and risk indicators
• Execute on Kymera’s GCP audit strategy for investigator sites and internal processes, through effective CAPA management
• Contribute to development and maintenance of GCP-related SOPs and policies in alignment with Kymera’s QMS
• Support a GCP training program across clinical development and promote a culture of quality

Skills and experience you’ll bring:

• Bachelor’s degree in life sciences or related field required. Advanced degree (MS, PharmD, PhD) preferred.
• 8+ years of experience in GCP Quality, Clinical QA, or Clinical Operations with strong QA focus in a sponsor organization
• Experience supporting regulatory inspections is a plus
• Deep knowledge of ICH GCP (E6 R2/R3), with strong understanding of sponsor oversight obligations
• Experience with risk-based monitoring and RBQM frameworks, TMF systems and electronic platforms
• Working knowledge of global regulatory requirements and strong understanding of data integrity principles.
• Strong communication and influencing skills and ability to work cross-functionally in a fast-paced biotech environment
• Strong problem solving and operational execution skills

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $160,000 – $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Act as Lead Data Manager, overseeing all deliverables of activities outsourced to DM CRO for multiple studies
• Interact and manage relationships with other functional areas to ensure high quality data management activities
• Oversight of data collection tools (EDC, DTAs, EDC integrations) and essential documents (DMP, UAT Documents, data edit specifications, annotated case books and data entry guidelines)
• Participate in User Acceptance Testing Activities for the applicable Data Collection Tools
• Perform Quality Control for the data completeness and accuracy.
• Participate in and support data cleaning, query generation and resolution and review of medical coding as needed.
• Responsible for adhering to the Data Management timelines and budget.
• Provide technical expertise to help in the use of technologies for Data Management and the clinical study team.
• Contribute to the development of lessons learned and best practices as well as help develop SOPs and internal working procedures and process improvement initiatives.
• Contribute to the establishment of systems and tools to help ensure clinical data security and integrity.

Skills and experience you’ll bring:

• 8+ years’ experience in clinical data management in biotechnology or pharmaceutical industry, with outsourced CRO oversight experience
• 5+ years managing vendor relationships/partnerships in a global environment.
• Must have advanced knowledge of Data Management processes and systems
• Solid understanding of CDISC standards required
• Data Visualization Tool experience preferred.
• Experience using standardized medical terminology, including but not limited to MedDRA and WHODrug.
• Excellent interpersonal, communication, and organizational skills with the ability to work independently and in a study team environment.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $145,000 – $215,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

The Vice President, Program Management is a strategic and operational leader responsible for leading Kymera’s Program Management / Office function from early discovery through development and commercialization. 

• Ensures all Kymera programs have strong PM support and ownership to achieve optimized program strategies, plans, milestones, and value inflection points.
• Defines and implements best PM practices, tools, systems, risk assessment, and standards for program execution across research, development and eventually commercialization
• Ensures company stage-gate governance processes, program strategy and data review meetings are effectively organized and supported, to ensure disciplined decision-making.
• Supports and drives major company wide scaling and/or improvement initiatives such as stage-gated readiness programs
• Manage/mentors high-performing Program Managers.
• As needed, takes on hands-on PM role to support program teams to ensure integrated development plans are aligned, realistic, and strategically sound.
• Supports enterprise portfolio planning, prioritization, and resource allocation processes.
• Ensures development of best-in-class performance metrics across the portfolio, bringing in creative and innovative approaches to achieve excellence
• Contributes to alliance governance and cross-company program coordination when applicable.

Skills and experience you’ll bring:

• Advanced degree (PhD, MD, PharmD, or equivalent) and 15+ years of experience in biotech/pharma, with significant experience in drug development.
• 8+ years in program management or cross-functional leadership roles.
• Demonstrated success leading complex, cross-functional programs through major development milestones (IND, Phase 1–3, NDA/BLA, etc., as applicable).
• Strong understanding of regulatory, clinical, CMC, and commercial considerations.
• Alliance management or partnered program experience.
• Portfolio governance design and implementation experience.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $315,000 – $395,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

• Serve as clinical study team Subject Matter Expert for eCOA, IRT, Data Visualization and other clinical data systems.
• Lead clinical technologies including planning, execution, and delivery of the clinical data activities on eCOA, IRT and other clinical technologies, implementing standard procedures to initiate best practices and lead data management flow.
• Support the establishment of an overall clinical systems roadmap.
• Partners with cross-functional team members (e.g., Clinical Operations, Clinical Science, Clinical Data Management, Tech Ops/Clin Supplies, QA, IT, Procurement) to gather relevant study requirements to create the system design, provide subject matter expertise, and ensure expert and on-time system delivery and implementation as well as data quality standards are met.
• Responsible for user acceptance testing oversight and documentation, including UAT test case creation, facilitating signatures on documentation, and study risk and impact assessments.
• Oversee data imports and integrations from multiple systems and ensure quality.
• Responsible for facilitation of clinical system technical support, data changes, data issue resolution; working with cross-functional stakeholders including Clinical Data Management, IT, Clinical Operations and Biostatistics in order to achieve goals.
• Monitor and improve data collection processes; partner to identify how to standardize data across multiple systems; provide recommendations for enriched reporting and data standards; support standardization of internal data infrastructure.
• As Business Owner, ensure processes, tools, documents, and training materials related to clinical systems are developed and implemented, as needed.
• Act as technical SME for contracting and budget management activities including establishing initial Scope of Work (SOW) and Change Orders in partnership with Strategic Sourcing, as applicable.

Skills and experience you’ll bring:

• 10+ years of progressive experience in a Systems Management role with a Sponsor/CRO company is required.
• Ability to work independently with a high level of attention and act with initiative to address issues.
• Experience overseeing IRT/RTSM and eCOA/ePRO systems is required.
• Experience with user requirement specifications/user test scripts with clinical data systems is required.
• Experience authoring/reviewing procedures (SOPs, WIs) in a GCP environment is required.
• Experience in clinical trial conduct. Hands-on Data Management experience of EDC, eCOA and IRT.
• Effectively negotiates and influences to solve high impact challenges
• Strong leadership and project management skills, and is able demonstrate flexibility and agility working within a multi-functional, global matrix.
• Must have excellent communication skills (verbal and written), and good interpersonal/group skills.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $195,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

As the Principal Scientist, Analytical Development, you will contribute to CMC activities supporting mid and late phase clinical development of Kymera’s small-molecule protein degraders. You will use your scientific expertise to support all CMC analytical development activities, in partnership with CDMOs.

• Execute development and validation of critical analytical methods, including achiral and chiral HPLC, GC, IC, dissolution, and methods for quantification of potentially mutagenic impurities (PMIs) and nitrosamine impurities
• Ensure analytical methods, control strategies, and specifications are robust and validated to support Phase 3 clinical studies, registration, process performance qualification (PPQ), and eventual commercial manufacture
• Characterize drug substance and drug product-related impurities
• Design and monitor ICH stability programs for drug substance and drug product
• Manage day-to-day analytical development and testing activities at CDMOs and contract test labs to ensure that projects remain on track
• Contribute to implementing and operating analytical capabilities in Kymera’s internal lab
• Partner closely with CMC colleagues and QA to (i) write or review test methods, SOPs, analytical data summaries (CoT/CoA), protocols, and technical reports, (ii) critically review, trend, and interpret analytical testing results, and (iii) support investigation of nonconformances (OOS/OOT results, deviations, etc.)
• Communicate and present analytical data in CMC meetings and other cross-functional settings
• Collaborate effectively with internal and external stakeholders to deliver on program objectives
• Participate in authoring and reviewing analytical sections of late phase regulatory submissions (e.g., IND, NDA, MAA).
• Support health authority interactions, including responses to agency questions related to analytical methods and controls.
• Ensure analytical approaches meet global regulatory expectations and inspection readiness standards

Skills and experience you’ll bring:

• PhD in Analytical Chemistry or related life sciences field is preferred, but not required, with 7+ years of experience in CMC analytical development
• Demonstrated late phase analytical development experience in drug substance and drug product (oral solid dosage experience required)
• Experience in developing impurity control strategies, including potentially mutagenic impurities (PMIs) and nitrosamine impurities
• In-depth expertise in late phase test method development, method validation/transfer, and characterization of small-molecule drugs
• Broad analytics expertise with widely employed techniques – HPLC (UV, RID, ELSD, CAD), GC, MS, NMR, XRPD, DSC/TGA, KF, particle size analysis, and dissolution
• Knowledgeable of compendial testing methods (USP/EP) used for DS and DP testing
• Capable of designing, implementing, and managing cGMP stability studies for DS and DP at external labs
• Strong working knowledge of GLP, cGMP, and ICH requirements
• Prior experience writing analytical sections in NDA/MAA filings a plus
• Experience providing technical guidance to CDMOs and contract test labs
• Experience working cross-functionally among project teams, including internal groups and external CDMOs
• Problem-solving mindset, highly organized and detail-oriented, and excellent oral and written communication skills

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $145,000 – $215,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.