Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

The Director of Formulation Development will assist in the development of late-stage oral drug product development and commercial manufacturing strategies to support Kymera’s small molecule pipeline from Phase 2/3 through commercialization.

This is an opportunity to join a fast-paced, innovative biotech environment where bold ideas and collaboration drive breakthroughs. As a member of the CMC team, you will develop and implement robust, scalable manufacturing processes for late-stage manufacturing and eventual commercialization.

The ideal candidate will bring deep expertise in oral solid dose formulation development and manufacturing within a GMP environment, strong project leadership capabilities, and a passion for working in a dynamic, mission-driven culture focused on delivering life-changing medicines. This role will work cross-functionally with CMC, Regulatory, Quality and external partners to deliver high-quality drug products aligned with program timelines.

• Drive late-stage drug product activities, including registration and validation campaigns, and commercial readiness for solid oral dosage forms.
• Define and execute phase-appropriate activities to support Phase 3 and NDA submissions
• Oversee formulation robustness, process characterization, and control strategy development in alignment with QbD principles.
• Provide technical and strategic oversight of CDMOs, including development, scale-up, technology transfer, and clinical batch production to ensure reliable supply.
• Collaborate with Analytical Development to ensure late-stage method readiness, validation, and stability strategies to support shelf-life assignments.
• Partner with Regulatory Affairs to author and review CMC sections for global filings, including responses to health authority questions and inspections.
• Review and approve master and executed batch records. Ensure compliance with GMP requirements and lead or support deviation investigations, CAPAs, and change control processes.
• Provide technical leadership in troubleshooting manufacturing issues.

Skills and experience you’ll bring:

• D. in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, or related field with 10+ years of industry experience, or M.S. with 15+ years of relevant experience.
• Demonstrated expertise in late-stage small molecule formulation development and manufacturing for oral solid dosage forms.
• Proven track record of advancing compounds through Phase 3, regulatory approval, process validation and commercialization.
• Deep technical expertise in oral solid dosage form manufacturing and process development, spanning unit operations such as tableting, encapsulation, coating, granulation, spray drying, hot-melt extrusion, and milling.
• Strong experience with CDMO oversight, technology transfer, and commercial supply management.
• Working knowledge of global regulatory CMC requirements, including NDA preparation and inspection readiness.
• Experience working in cross-functional CMC teams, strong knowledge of process and analytical development and a working knowledge of other areas of drug development
• Excellent leadership, communication, and cross-functional influencing skills.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $195,000 – $275,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

The Associate Director will act as a Quality subject matter expert for Good Manufacturing Practices (GMP) activities. The individual will be responsible for material disposition; will provide Quality oversight for technical transfers, stability assessments, manufacturing, analytical and distribution activities performed at external suppliers. In addition, the individual will ensure compliance with regulations and Kymera policies and procedures.

• Provide quality oversight of contract organizations associated with the manufacturing and distribution of Drug Substances, Drug Products, and Finished Goods.
• Collaborate with manufacturing and distribution colleagues to (i) review manufacturing batch records, protocols, reports, and specifications, and (ii) perform disposition of critical intermediates, drug substances/drug products, and finished goods.
• Partner closely with CMC analytical colleagues to (i) review test methods, SOPs, analytical data summaries, validation and stability protocols, and technical reports (ii) oversee specification control and shelf life management.
• Ensure that product quality-related issues, including deviations/OOSs/OOTs and product complaints, are appropriately investigated and resolved.
• Collaborate cross-functionally and develop strong relationships with internal and external partners.
• Support the preparation and review of regulatory filing submissions (IND/IMPD/NDA)
• Help develop and implement phase-appropriate SOPs and policies. Ensure compliance with relevant regulatory requirements such as FDA, EMA, and ICH guidelines.
• Manage the qualification and performance monitoring of external GMP suppliers and maintain Quality Agreements with them.
• Develop and track quality metrics to measure performance and identify trends.
• Present quality assessments to the Material Review Board and Quality Management Review Board.
• Provide support for late-stage manufacturing and commercialization readiness activities.

Skills and experience you’ll bring:

• 8 + years of experience in pharmaceutical manufacturing or laboratory settings, including at least 4 years in a GMP quality assurance role. Experience in a small-molecule manufacturing environment is preferred.
• Experience providing Quality oversight of outsourced late-phase GMP manufacturing activities, including process validation and commercial readiness.
• Excellent communication and interpersonal skills.
• Experience working in a CMC team setting as a Quality representative.
• Work independently and manage multiple projects within the established timelines and objectives.
• Strong problem-solving ability to evaluate quality matters and make risk-based decisions.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $160,000 – $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

As an Associate Director of Drug Substance Development, you will serve as the accountable Drug Substance lead for one or more development programs, owning DS strategy, execution, and delivery from late discovery through clinical development.

• Use scientific, data-drive, and risk-based approaches to clinical and commercial route and process innovation and development, guided by safety and green chemistry principles.
• Provide technical leadership and decision‑making oversight for outsourced Drug Substance development activities at CROs and CDMOs, ensuring quality, timelines, and scientific rigor.
• Serve as the Drug Substance technology lead for internal and external knowledge transfers, including authoring transfer strategies, defining success criteria, and supporting manufacturing execution.
• Collaborate with Drug Product and Analytical colleagues to ensure the Drug Substance physical attributes are understood, controlled, and are appropriate for Drug Product manufacturing.
• Ensure stage appropriate data is generated and documented; serve as contributing author and technical reviewer of Drug Substance sections of regulatory filings.
• Collaborate effectively with internal and external stakeholders to deliver on program objectives.

Skills and experience you’ll bring:

• Ph.D. in Chemistry or Chemical Engineering with at least 7 years’ or B.S./ M.S. in Chemistry or Chemical Engineering with at least 12 years’ experience in Drug Substance Development.
• Experience with:
  • Bringing small molecule assets from late discovery through mid-phase clinical trials.
  • Serving as the Drug Substance lead on fully integrated Chemistry, Manufacturing, and Control (CMC) teams.
  • Directing CRO and CDMO partners.
  • Writing and reviewing Drug Substance related technical documents.
• Deep understanding of small molecule drug development; understand how CMC disciplines integrate and partner with associated functional areas such as Quality, Non-clinical Safety, Clinical, Regulatory, and Intellectual Property Protection.
• In-depth familiarity with phase based GMPs and manufacturing compliance requirements, regulatory guidelines and expectations.
• Willingness and ability to work hands-on and with a sense of urgency in a fast-paced, agile environment.
• Demonstrated ability to make sound, risk‑based scientific and business decisions in ambiguous, fast‑paced development environments.
• Ability to conduct, manage, and communicate risk assessments.

Preferable Experience:

• Ability to develop data driven crystallization processes based on an understanding and application of fundamental principles.
• Experience using statistical and modelling software applicable to Drug Substance Development and Manufacturing to support process understanding and decision making.
• Design and execution of process characterization with cross-functional colleagues, utilizing Quality by Design principles.
• Comfortable stepping into hands‑on problem solving when needed to unblock programs, while maintaining focus on strategic and technical leadership.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $160,000 – $240,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.

Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll make an impact:

As the Principal Scientist, Analytical Development, you will contribute to CMC activities supporting mid and late phase clinical development of Kymera’s small-molecule protein degraders. You will use your scientific expertise to support all CMC analytical development activities, in partnership with CDMOs.

• Execute development and validation of critical analytical methods, including achiral and chiral HPLC, GC, IC, dissolution, and methods for quantification of potentially mutagenic impurities (PMIs) and nitrosamine impurities
• Ensure analytical methods, control strategies, and specifications are robust and validated to support Phase 3 clinical studies, registration, process performance qualification (PPQ), and eventual commercial manufacture
• Characterize drug substance and drug product-related impurities
• Design and monitor ICH stability programs for drug substance and drug product
• Manage day-to-day analytical development and testing activities at CDMOs and contract test labs to ensure that projects remain on track
• Contribute to implementing and operating analytical capabilities in Kymera’s internal lab
• Partner closely with CMC colleagues and QA to (i) write or review test methods, SOPs, analytical data summaries (CoT/CoA), protocols, and technical reports, (ii) critically review, trend, and interpret analytical testing results, and (iii) support investigation of nonconformances (OOS/OOT results, deviations, etc.)
• Communicate and present analytical data in CMC meetings and other cross-functional settings
• Collaborate effectively with internal and external stakeholders to deliver on program objectives
• Participate in authoring and reviewing analytical sections of late phase regulatory submissions (e.g., IND, NDA, MAA).
• Support health authority interactions, including responses to agency questions related to analytical methods and controls.
• Ensure analytical approaches meet global regulatory expectations and inspection readiness standards

Skills and experience you’ll bring:

• PhD in Analytical Chemistry or related life sciences field is preferred, but not required, with 7+ years of experience in CMC analytical development
• Demonstrated late phase analytical development experience in drug substance and drug product (oral solid dosage experience required)
• Experience in developing impurity control strategies, including potentially mutagenic impurities (PMIs) and nitrosamine impurities
• In-depth expertise in late phase test method development, method validation/transfer, and characterization of small-molecule drugs
• Broad analytics expertise with widely employed techniques – HPLC (UV, RID, ELSD, CAD), GC, MS, NMR, XRPD, DSC/TGA, KF, particle size analysis, and dissolution
• Knowledgeable of compendial testing methods (USP/EP) used for DS and DP testing
• Capable of designing, implementing, and managing cGMP stability studies for DS and DP at external labs
• Strong working knowledge of GLP, cGMP, and ICH requirements
• Prior experience writing analytical sections in NDA/MAA filings a plus
• Experience providing technical guidance to CDMOs and contract test labs
• Experience working cross-functionally among project teams, including internal groups and external CDMOs
• Problem-solving mindset, highly organized and detail-oriented, and excellent oral and written communication skills

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Compensation

• Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.
• The anticipated base salary range for this role is $145,000 – $215,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.
• Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.