POSITION SUMMARY

The VP, Program Leadership (Launch Products) is accountable for defining and driving the global strategy to maximize the long-term value of Mirum’s late-stage products. The Program Leader leads a cross-functional team spanning U.S. and International Commercial, Development, Regulatory, Medical Affairs, CMC/Technical Operations, Market Access, Finance, and other functions, ensuring alignment around a single integrated product vision and strategy.

The VP, Program Leadership (Launch Products) will initially provide leadership across Mirum’s commercial-stage portfolio, including LIVMARLI, ATEBRIOZ, CHOLBAM, and CTEXLI, identifying and prioritizing opportunities to maximize patient impact and product value globally.

The Program Leader operates as “Program CEO,” leading product strategy and execution, influencing executive leadership, and bringing together cross-functional leaders around a shared vision

JOB FUNCTIONS/RESPONSIBILITIES

Global Product Strategy and Value Maximization for Commercial Portfolio

• Define and execute the integrated global lifecycle strategy for assigned products, establishing the long-term vision and value-maximization plan, taking into account risks, tradeoffs, and value
• Identify and prioritize opportunities across geographies, indications, patient segments, formulations, evidence generation, regulatory pathways, and other lifecycle initiatives.
• Continuously reassess product strategy based on emerging clinical data, competitive developments, market dynamics, regulatory changes, product performance, and IP considerations.
• Lead the cross-functional Program Team, including representatives from U.S. and International Commercial, Development, Regulatory, Medical Affairs, CMC/Technical Operations, Market Access, Finance, Legal, and other relevant functions.
• Working closely with regional commercial leaders, evaluate geographic expansion opportunities and commercialization models, including direct entry, distributors, partnerships, and licensing.
• Lead the evaluation of new indications, expanded patient populations, label enhancements, combination strategies, and other development opportunities
• Drive cross-functional decision-making, ensuring key trade-offs and internal resource constraints are identified, evaluated, and resolved.
• Working closely with Finance and other cross-functional leaders, rationalize, get endorsement, and manage the Program Team budget, as part of the annual long-range planning exercise

Success Criteria

The successful Program Leader will:

• Lead through influence across senior cross-functional stakeholders and create accountability across organizational boundaries.
• Balance commercial opportunity with scientific, regulatory, operational, and financial considerations, making explicit strategic choices and trade-offs.
• Prioritize lifecycle opportunities and investments based on patient impact, strategic fit, value creation, probability of success, investment requirements, and organizational capacity.
• Develop and communicate business cases, investment recommendations, and strategic scenarios to executive leadership and governance committees to drive timely decisions and resource allocation.
• Translate complex information into clear recommendations and decisions.
• Maintain a global, long-term perspective while driving near-term execution
• Represent the program and Mirum externally, with thought leaders, prospective partners, and other stakeholders

QUALIFICATIONS

Education /Experience:

• 15+ years of experience in the biopharmaceutical industry, with significant experience in commercial strategy, marketing, new product planning, global commercialization, or related leadership roles; prior experience in rare disease and/or specialty pharmaceuticals preferred.
• Demonstrated success leading global product or lifecycle strategy for marketed and/or late-stage products, including responsibility for maximizing product value across indications, geographies, patient populations, and stages of the product lifecycle.
• Strong commercial foundation, with experience developing product strategy, positioning, forecasting, market development, launch planning, competitive strategy, and long-range commercial plans.
• Global mindset and demonstrated ability to incorporate the needs and perspectives of U.S. and international markets into product strategy and investment decisions.
• Significant experience leading senior cross-functional teams spanning Commercial, Development, Medical Affairs, Regulatory, Market Access, CMC/Technical Operations, Finance, and other functions, including leadership through influence without direct authority.
• Ability to operate as an enterprise product leader, integrating commercial, clinical, regulatory, medical, technical, and financial perspectives into a cohesive product strategy.
• Strong strategic and financial acumen, including experience developing business cases, evaluating investment alternatives, understanding product P&Ls and forecasts, and making resource-allocation recommendations.
• Track record of making effective decisions in situations involving complexity, uncertainty, competing priorities, and cross-functional trade-offs.
• Strong understanding of the global biopharmaceutical commercialization environment, including the interplay among clinical evidence, regulatory strategy, market access, pricing/reimbursement, competitive dynamics, and commercial execution
• Demonstrated ability to influence and align senior executives and functional leaders, constructively challenge assumptions, resolve differences, and drive teams toward clear decisions and execution.
• Excellent executive communication skills, with the ability to synthesize complex information into clear strategic choices and recommendations for executive leadership and governance bodies.
• Strong orientation toward patient impact and value creation, with the ability to balance near-term business performance with investments that maximize the long-term potential of a product.
• Bachelor’s degree required; MBA or other advanced degree preferred.

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