The Opportunity

This Real World Evidence (RWE)/Health Economics (HEOR) Contractor role supports the RWE/HEOR Senior Director in leading RWE execution for pipeline assets. The role is fun and flexible with a mix of both study execution and data analytics. This person will be accountable for developing and delivering components of the evidence generation plan (including RWE and economic value evidence), and driving high-quality deliverables that inform internal decision-making during product development, pre-launch readiness, and lifecycle planning. The role is anchored to 1–2 priority pipeline assets/indications.

This is a remote role based with flexible hours. We are currently seeking an individual with 20-30 hours of weekly availability with potential to increase hours in late 2026/2027.

Responsibilities

• Evidence strategy and planning: Maintain US RWE & HEOR plans for 1–2 priority pipeline assets/indications, aligned to US medical, payer, and access needs; translate strategy into actionable workplans, timelines, and resourcing proposals.
• Study leadership (RWE/HEOR): Own day-to-day leadership for assigned real-world evidence and health outcomes studies (e.g., real-world evidence studies, cost-effectiveness/budget impact analyses, burden of illness, treatment patterns, patient-focused outcomes) including design and execution in partnership with internal functions and external vendors.
• Scientific communication and quality: Draft/review project specifications, protocols, statistical analysis plans, study reports, abstracts, posters, and manuscripts; ensure adherence to SOPs and high scientific/operational quality.
• Analytic execution and statistics: Execute ad hoc analyses in clinical trial, claims and PCOR data as needed for ad hoc and protocol/SAP driven analyses. This may include feasibility or full protocol execution.
• Governance, compliance, and capability building: Complete required training, adhere to company/department SOPs, and contribute to continuous improvement of processes that enable efficient planning, execution, and dissemination of RWE & HEOR deliverables.

Required Qualifications

• Master’s degree or PhD in epidemiology, health economics and outcomes research, public health, biostatistics, or related discipline.
• At least 1+ years of experience in the pharmaceutical industry and/or managed care, hospital, academic, or healthcare consulting environment with exposure to HEOR/RWE strategy and application
• Proficiency with SAS and/or R for statistical programming. Preference for experience in clinical trials OR claims data.
• Expertise in RWE and study designs/methods evidenced by publications and/or contributing to study concept sheets and protocols, reviewing/authoring key sections of statistical analysis plans and study reports, and ensuring publication/disclosure readiness in accordance with ICJME criteria
• Strong communication and presentation skills, demonstrated by developing and presenting clear, decision-oriented materials (e.g., evidence strategy slides, executive readouts) and summarizing outcomes/next steps for senior audiences

Preferred Qualifications

• Demonstrated success developing and executing health outcomes research plans and delivering high-quality data generation outputs.
• Experience managing real-world data sources and vendors (e.g., claims, EHR, registries) and translating findings into actionable insights and value messages.
• Demonstrated ability to influence without authority in a matrix environment, evidenced by aligning cross-functional stakeholders on objectives/trade-offs, documenting decisions, and driving actions to closure.
• Experience in PCOR implementation and validation

Work Location and Condition

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location

Orthodox Rabbi

Harvard Hillel

Role Overview

Harvard Hillel is looking for a dynamic Orthodox Rabbi to foster a warm, inspiring Jewish community for students, faculty, and staff. The ideal candidate makes Jewish tradition exciting and meaningful through teaching, mentorship, and pastoral care, and is deeply aligned with the religious values, practices, and spiritual aspirations of our students. In addition to high level guidance, the Orthodox Rabbi engages with students on a day to day basis, building relationships and supporting their Jewish journeys. Within Harvard’s pluralistic Jewish community, the Orthodox Rabbi is a committed and inspiring exemplar of Torah and mitzvot, drawing on the depth and wisdom of Judaism to enrich the entire Jewish community and broader campus life. He collaborates closely with Hillel staff and student leaders to plan, develop, and execute programs that bring the community together while supporting student leaders in taking on increasing responsibility for their community, their own experiences and spiritual growth, and that of their peers.

This role is 10 months/year with June and July off.

What You’ll Do

• Advise the Orthodox Student Minyan: Serve as the student minyan advisor, providing shiurim, drashot, chavrutot, and organizational support. Act as a halakhic and hashkafic guide to Orthodox students, and the local Orthodox minyan as needed. 
• Teach Torah: Teach Torah in ways that are textually ambitious, intellectually sophisticated, inviting of questions, and responsive to students’ interests. In classes and informal settings, you’ll regularly facilitate complex conversations characterized by humility, curiosity, and respect for multiple perspectives. Beyond group settings, you will learn regularly in chavruta with multiple students.
• Welcome students in your home: Host students regularly for Shabbat and holiday meals, cultivating a sense of home and close-knit community for students away from their families.
• Create a warm Shabbat and Chag Environment: Support students and the rabbinic team in making Shabbatot and Chaggim times of connection and holiness, including at least one off-site Shabbaton for the Orthodox community.
• Provide pastoral care and mentorship: Build substantial relationships with a wide swath (> 100) undergraduate and graduate students through pastoral care, chavruta learning, teaching, and mentorship. Maintain a consistent, visible, and accessible presence in students’ daily lives, and work to make sure every Jewish student feels invited into and curious about deeper Jewish learning and practice, by modeling a grounded openness to their thoughts and experiences.
• Contribute to a pluralistic community: Grounded in Orthodox practice and identity, you will bring together elements of Harvard’s diverse Jewish community. This includes engaging respectfully and curiously with students’ and colleagues’ religious and moral commitments even and especially when they differ from your own. Beyond the Jewish community, you will participate in campus conversations and gatherings, including joining the Harvard Chaplains’ community.
• Be an exemplar of good middot: Unfailingly relate to students and colleagues with a warm, caring, and approachable demeanor. When questions or conflicts arise, you’ll approach them with energy and a commitment to working out solutions together with others - and will consistently try to take up others’ perspectives.
• Collaborate with the Hillel team: Join the student-facing programming team, collaborating closely with colleagues to plan and execute programs. All staff share responsibility for student engagement and bringing ideas to fruition, making their differences into points of connection and mutual appreciation. The Orthodox Rabbi reports to the Senior Director of Student Life and Executive Director and partners with the broader team to advance shared goals.
• Partner beyond Harvard: Serve as Harvard Hillel’s liaison to the Orthodox Minyan at Harvard Hillel, supporting scheduling, financial coordination, and student participation in the broader Cambridge Orthodox community. Maintain relationships with Jewish day schools and other pipelines to attract prospective students.

What You’ll Bring to the Job

• A commitment to and passion for creating Jewish community and inspiring students to grow in Torah, shmirat mitzvot, and participation in Jewish life.
• Appreciation for the value of a broader pluralistic Jewish community, and a desire to build bridges with other Jews.
• A warm, engaging, and approachable personality. 
• Experience in engagement and building meaningful pastoral relationships
• Facility in program design and implementation. 
• Relevant work experience in experiential Jewish education within Orthodox communities, Hillel, youth movements, or camp.
• A talmid hakham with strong textual knowledge and fluency, demonstrating deep familiarity with Torah, from traditional texts to contemporary Jewish wisdom, and the ability to engage students in the tradition of Jewish learning through learner centered pedagogy.
• Facility leading complex conversations that are intellectually serious and personally sensitive.
• A warm and welcoming home in which to host Shabbat experiences.
• Confidence initiating, running, and evaluating programs.
• A deep personal concern for the success of this work.
• A willingness to admit what you don’t know and excitement to learn in those areas
• Creative problem-solving, proactive communication, and the capacity to collaborate in teams both inside and outside of Hillel.
• Curiosity about… everything. You are hungry to learn and ask insightful questions before offering solutions. In this community, we are all learners, even the educators among us.
• Membership in good standing in a rabbinic alumni association with established ethical guidelines.
• BA and Orthodox rabbinic ordination.

What You’ll Receive

• Competitive salary range of $100,000-$110,000 for 10 months a year of employment.
• A network of students, parents, and university partners who will inspire you and become lifelong professional resources and partners.
• Opportunities for professional development, mentoring, and Jewish study.
• Colleagues and support from across the Hillel movement.
• Travel opportunities, both domestic and international.
• Stipends for Shabbat hosting experiences.
• A comprehensive benefits package, including health insurance, Tax Deferred Retirement Plan, Life, AD&D, and Long Term Disability insurances, Flexible Spending Plan, generous vacation/sick time, and parental leave.
• Plenty of Hillel and university swag.

About Harvard Hillel

Harvard Hillel is the Jewish center of the world’s greatest university. Home to 500 Jewish undergraduates and 1,800 Jewish graduate students, Harvard Hillel’s mission is to train a generation of Jewish students to lead a divided Jewish community in an uncertain future - by helping mentoring them as they create an inspiring, life-shaping community of meaning with and for one another during their years as students. Cambridge, Massachusetts is a rapidly growing observant Jewish community with synagogues, independent minyanim, an eruv, kosher restaurants, and hundreds of observant Jews. Students, young professionals, young couples, and families call "Camberville" home. We also have many Jewish resources including mikva’ot across the river in Brookline, Brighton, and Newton.

Harvard Hillel is affiliated with Hillel International. Hillel International enriches the lives of Jewish students so they may enrich the Jewish people and the world, and envisions a world where every student is inspired to make an enduring commitment to Jewish life, learning and Israel.

The Opportunity

The Director Clinical Science will be a key member of the Clinical Development team with responsibilities to provide scientific support for ongoing activities. This role will report to a Medical Director and will collaborate cross functionally with R&D, program management, clinical operations, biostatistics, and data management. The selected candidate will support and drive key development activities for clinical studies and overall execution of program Clinical Development Plans (CDP).

Responsibilities

• Collaborates with the clinical development team in review, analysis, and interpretation of study results.
• Provides scientific support on ongoing Phase I to III clinical trials and contributes to the planning and design of upcoming clinical studies.
• Performs monitoring and review of study data including labs, safety data, and patient eligibility.
• Authors and/or reviews clinical trial-related documents including protocols, CRF, informed consent, protocol deviations, monitoring plans and regulatory documents, etc.
• Contributes to regulatory documents including CSRs, Investigator’s Brochures, and Clinical sections of INDs, CTAs.
• Interacts with external medical/scientific advisors, thought leaders and clinical investigators in the therapeutic areas as well as with internal management and drug development staff to prepare/revise/maintain and efficiently execute the clinical development plan.

Required Qualifications

• Advanced degree (M.D., Ph.D., Pharm.D., Master’s Degree in Science/Medical-related field).
• MD, PhD or PharmD with 3+ years Clinical Research, Pharmaceutical, or CRO experience, OR Master’s degree with 8+ years of relevant experience.
• Knowledge of Phase 1-3 drug development.
• Knowledge of clinical trial implementation and sponsor/site interactions for clinical trials.
• Prior experience working within neurology or neurodegenerative indications.
• Well-versed in relevant applications of GCP (Good Clinical Practice), ICH, FDA, EMEA and other relevant guidelines and regulations.
• Strong, collaborative team-player.
• Excellent attention to detail and communication skills.

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

We are seeking an energetic, highly organized and detail-oriented individual to fill a full-time, Payroll Specialist role. The ideal candidate is an enthusiastic self-starter who is motivated to set and  achieve goals and take initiative within the workplace. They are organized, professional  and demonstrate excellent attention to detail. The successful candidate will be critical in reducing manual processing risks, ensuring regulatory compliance, systems automatizations and day-to-day payroll operations. This position will give you the opportunity  to grow your payroll and accounting knowledge and experience.  This role plays a key part in ensuring the accuracy and efficiency of our financial operations and will support broader financial reporting and compliance initiatives.

Key Responsibilities

• Process and finalize payroll runs (Semi-Monthly, Bi-Weekly, Weekly, and specialized off-cycle runs) for all employees using our primary payroll platforms, Rippling and ADP.
• Verify all timecards, wage computation, statutory deductions, benefits deductions, garnishments, and employee changes for accuracy and compliance.
• Manage end-to-end processing, including reconciling final payroll previews and submitting funding requests.
• Serve as the primary subject matter expert for payroll and HRIS systems including Rippling, ADP, and BambooHR.

• Prepare payroll-related General Ledger (GL) entries into the NetSuite accounting system, ensuring accurate cost center allocations.
• Reconcile payroll accounts on a monthly basis.
• Monitor and reconcile bank account transactions related to payroll disbursements.

• Ensure timely and accurate processing of all federal, state, and local tax remittances, including quarterly and year-end reporting (W-2s, 1099s, 941a reports).
• Manage new state registrations for employees and quarterly Workers' Compensation (WC) tax reporting.
• Administer 401K contribution processing. 
• Support the annual 401K audit..
• Respond to and resolve employee inquiries regarding pay, deductions, and tax forms, reducing the administrative burden on the Accounting Manager.

Required Qualifications

• Education: Associate’s degree in Accounting, Finance, or a related field; Bachelor’s degree preferred.
• Experience: 2+ years of dedicated payroll processing experience, ideally managing high-frequency (monthly, bi-weekly, weekly) and multi-state payroll.
• System Proficiency: Proven, hands-on expertise with major systems including ADP, Rippling, Fidelity 401K, NetSuite, and advanced Microsoft Excel skills.
• Skills: Exceptional attention to detail, strong analytical and problem-solving skills, and ability to handle confidential information with discretion.

Preferred Qualifications

• Familiarity with ADP, Rippling, Bamboo, NetSuite.
• Professional certification (e.g., Fundamental Payroll Certification (FPC) or Certified Payroll Professional (CPP)).
• WorkDay Experience

Montai Therapeutics, Inc., is based in Cambridge, Massachusetts and was founded in 2019 by Flagship Labs, the innovation branch of Flagship Pioneering, which is a venture capital firm that invests in biotechnology, life sciences, health and sustainability companies. The Company is a privately held company focusing on its CONECTA^TM platform to identify new small molecule medicines known as Anthromolecule^TM therapeutics for chronic diseases. 

Montai is seeking an experienced and talented accounting professional to join a first-in-category organization. The Senior Accountant will be an instrumental player in the month end close, will be responsible developing and implementing new accounting policies and procedures to scale within the organization, provide business insights to our leaders to measure progress on company performance, and assist with enhancing companywide financial reports, including enhanced analytics, cash flow management and consolidated reporting. This role will report to the Controller.

Key Responsibilities:

• Perform and assist with month-end and quarter end close accounting tasks including preparation of journal entries ensuring compliance with US GAAP
• Conduct monthly and quarterly account reconciliations to ensure accurate reporting and ledger maintenance
• Review of P&L accounts to resolve classification issues
• Ensure that reconciliations, supporting schedules and analysis are completed on a timely basis and in accordance with the monthly closing schedule
• Partner with Controller to develop and update annual budget and monthly forecasts
• Preparation and assistance with month end analytical review of actual versus budget/forecast
• Provide Ad-Hoc Reporting and Analysis
• Monitor and review new accounting pronouncements and implement where necessary
• Responsible for annual fixed asset observation and asset tracking
• Assists with internal and external reporting and, when applicable, with drafting and tie-out of the financial statements
• Ensures internal controls compliance for the responsible area, including implementing improvements to enhance the efficiency of current controls
• Supports the external audit firm in their annual audit
• Supports income tax provision and tax return process
• Assists with specific projects and initiatives unique to a fast-growing biotechnology start-up, such as system implementations, updates and business process improvements and other ad hoc projects

Qualifications:

• Bachelor’s degree in accounting is required
• CPA and 2-3 years of Big Four public accounting experience is preferred
• 1-2 years of biotechnology or life science industry experience preferred
• Substantial experience with GAAP financial reporting
• Extensive experience with Microsoft Excel and Word
• Detail-oriented personality
• Ability to manage multiple projects in a fast-paced environment
• Experience with NetSuite a plus
• Must have excellent analytical skills, with very strong attention to detail
• Ability to work both independently and in a collaborative team setting
• Flexibility and ability to adapt to changing conditions and different culture
• Ability to work within and meet all deadlines while executing on multiple deliverables
• Ability to identify errors and root causes of errors, develop workable solutions or alternatives
• Flexible, personable team-player, comfortable in a fast-paced, small company environment
• Proven ability to set and meet ambitious deadlines, handle numerous multifaceted financial matters and see projects through to conclusion
• Strong written and verbal communication skills and demonstrated ability to work collaboratively with both scientists and management
• Ability to distill complexity and to communicate decisively with sound judgment
• Ability to self-motivate and function independently, driven towards superior effort and performance and the desire to work in a very dynamic environment

Location: Hybrid role in Cambridge, MA

Montai is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

More About Flagship Pioneering

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-NM1

The salary range for this role is $88,000 - $121,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

Quotient is seeking a hands-on, highly experienced Vice President of Finance who has experience working in a private biotech company with both pre-clinical and clinical programs. The ideal candidate will have strong finance expertise, experience with technical and operational accounting, proven experience as a leader, and a demonstrated ability to build innovative finance teams and systems. This individual must be comfortable working independently in a resource-constrained environment while building out the finance function and also providing strategic financial guidance to the executive team.

The Vice President of Finance will be responsible for overseeing all aspects of accounting, financial operations, and compliance while contributing meaningfully to corporate strategy and long-term planning. This is a key leadership role within the company and is the primary steward of financial strategy, discipline, systems, and governance.

Responsibilities: 

• Initially serve as the company’s controller, overseeing all accounting operations, financial reporting, and internal controls; ensure compliance with GAAP and all applicable regulations, manage monthly, quarterly and annual close processes as well as tax and regulatory filings, and initiate/lead financial statement audits
• Partner with the CFO and leadership team to develop and refine the company’s financial strategy and long term operating plan; provide scenario modeling, budgets, forecasts, long range planning models and capital allocation recommendations, and support fundraising activities, investor relations and board-level financial reporting
• Implement and maintain innovative and scalable accounting and financial systems, processes and tools; oversee cash flow management, including tracking of R&D expenses, collaboration budgets and operational spend, and lead implementation of accounting and finance systems independent from the Flagship ecosystem
• Plan and build out a small internal finance team, fostering growth and accountability; develop and oversee launch of finance function independent of Flagship support, oversee and coordinate work of external vendors, including auditors, accounting consultants, tax advisors and payroll providers, ensuring vendors meet performance expectations, budgets and timelines

Qualifications:

Essential

• 15+ years of progressive finance and accounting experience, including senior leadership roles 
• Proven track record in a private life sciences/biotech company with both clinical and pre-clinical programs
• Strong understanding of GAAP and biotech-specific accounting issues, including R&D accruals and clinical trial accounting
• Experience leading budgeting, financial reporting and long range planning processes
• Experience building teams and system transitions/implementations
• Experience managing direct reports and external vendors
• Demonstrated ability to work independently in a fast-paced, entrepreneurial environment

Desirable

• CPA or MBA strongly preferred 
• Experience supporting fundraising activities (venture capital, crossover, IPO readiness)
• Understanding of and interest in utilizing AI and automation for finance 
• Familiarity with biopharma collaboration accounting and reporting as well as cost modeling for clinical development and pre-clinical programs

Values and Behaviors:

• Encourage respectful disagreement and cultivate open-minded, ego-free interactions to continuously push each other towards excellence
• Seek out diverse perspectives; practice active listening and genuine curiosity to ensure all contributions are valued, regardless of source
• Recognize the impact of your behavior, language and attitudes, and strive for balanced, meaningful exchanges that enhance mutual growth and understanding in all interactions
• Use a company-first mindset to guide decision-making; prioritize team over individual success
• Take calculated risks and challenge convention in the quest for exceptional outcomes

About Quotient:

Quotient Therapeutics is a privately-held, early stage company developing breakthrough medicines informed by natural somatic genetic diversity present in patients. Through our work in somatic genomics, we are forging a new status quo for biopharma research and development across a broad pipeline of internal and partnered programs.  

The company was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS).

Quotient Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies:

Quotient Therapeutics (“Quotient”) and Flagship Pioneering (“FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Quotient, FSP or their employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $250,000 - $350,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Quotient Therapeutics, Inc. currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Quotient Therapeutics, Inc.'s good faith estimate as of the date of publication and may be modified in the future.

Montai Therapeutics, Inc., is based in Cambridge, Massachusetts and was founded in 2019 by Flagship Labs, the innovation branch of Flagship Pioneering, which is a venture capital firm that invests in biotechnology, life sciences, health and sustainability companies. The Company is a privately held company focusing on its CONECTA^TM platform to identify new small molecule medicines known as Anthromolecule^TM therapeutics for chronic diseases. 

Montai is seeking an experienced and talented accounting professional to join a first-in-category organization. The Senior Accountant will be an instrumental player in the month end close, will be responsible developing and implementing new accounting policies and procedures to scale within the organization, provide business insights to our leaders to measure progress on company performance, and assist with enhancing companywide financial reports, including enhanced analytics, cash flow management and consolidated reporting. This role will report to the Controller.

Key Responsibilities:

• Perform and assist with month-end and quarter end close accounting tasks including preparation of journal entries ensuring compliance with US GAAP
• Conduct monthly and quarterly account reconciliations to ensure accurate reporting and ledger maintenance
• Review of P&L accounts to resolve classification issues
• Ensure that reconciliations, supporting schedules and analysis are completed on a timely basis and in accordance with the monthly closing schedule
• Partner with Controller to develop and update annual budget and monthly forecasts
• Preparation and assistance with month end analytical review of actual versus budget/forecast
• Provide Ad-Hoc Reporting and Analysis
• Monitor and review new accounting pronouncements and implement where necessary
• Responsible for annual fixed asset observation and asset tracking
• Assists with internal and external reporting and, when applicable, with drafting and tie-out of the financial statements
• Ensures internal controls compliance for the responsible area, including implementing improvements to enhance the efficiency of current controls
• Supports the external audit firm in their annual audit
• Supports income tax provision and tax return process
• Assists with specific projects and initiatives unique to a fast-growing biotechnology start-up, such as system implementations, updates and business process improvements and other ad hoc projects

Qualifications:

• Bachelor’s degree in accounting is required
• CPA and 2-3 years of Big Four public accounting experience is preferred
• 1-2 years of biotechnology or life science industry experience preferred
• Substantial experience with GAAP financial reporting
• Extensive experience with Microsoft Excel and Word
• Detail-oriented personality
• Ability to manage multiple projects in a fast-paced environment
• Experience with NetSuite a plus
• Must have excellent analytical skills, with very strong attention to detail
• Ability to work both independently and in a collaborative team setting
• Flexibility and ability to adapt to changing conditions and different culture
• Ability to work within and meet all deadlines while executing on multiple deliverables
• Ability to identify errors and root causes of errors, develop workable solutions or alternatives
• Flexible, personable team-player, comfortable in a fast-paced, small company environment
• Proven ability to set and meet ambitious deadlines, handle numerous multifaceted financial matters and see projects through to conclusion
• Strong written and verbal communication skills and demonstrated ability to work collaboratively with both scientists and management
• Ability to distill complexity and to communicate decisively with sound judgment
• Ability to self-motivate and function independently, driven towards superior effort and performance and the desire to work in a very dynamic environment

Location: Hybrid role in Cambridge, MA

Montai is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

More About Flagship Pioneering

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-NM1

The salary range for this role is $88,000 - $121,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Montai Therapeutics currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Montai Therapeutics's good faith estimate as of the date of publication and may be modified in the future.

The Opportunity

The Senior Director of Patient Services will play a critical role in shaping how Amylyx supports patients throughout their treatment journey. This leader will design, build, and launch a best-in-class patient support program for our lead product candidate, ensuring that it reflects a commitment to supporting patient access, community education, and operational excellence.

This individual will bring strategic vision and hands on leadership to create an integrated support program—from access and reimbursement solutions to patient education and continued on-treatment support. As a key leader in the commercial organization, this individual will partner with colleagues across market access, sales, and marketing, as well as cross functionally, to ensure a seamless and high impact customer experience that helps people start and continue treatment.

This is a unique opportunity to define a foundational capability at Amylyx and set a new standard for patient access support.

Responsibilities

Program Design

• Design a comprehensive, patient‑centered services model tailored to the unique needs of the communities we serve
• Define the strategic framework, service offerings, operational workflows, and end‑to‑end experience for patients, caregivers, and providers, ensuring alignment with the current market access landscape across reimbursement, technology, and delivery models
• Optimize the program by determining the appropriate balance of insourced versus outsourced services and planning for program evolution over time

 Operations Leadership

• Lead end‑to‑end patient support operations, including financial assistance, benefits verification, case management, adherence, nursing, and injection training
• Build, hire, and lead high‑performing internal and field‑based patient access and service operations teams
• Evaluate, contract, and manage third‑party service providers, ensuring strong governance, performance accountability, and alignment with business objectives
• Establish compliant oversight across hub services and all patient‑facing operations in close partnership with Legal, Compliance, and Medical Affairs
• Define KPIs, dashboards, and feedback loops to drive performance, transparency, and continuous improvement across service operations
• Serve as the operational lead for launch readiness and ongoing execution by identifying access barriers, leading cross‑functional issue resolution, and aligning with Commercial, Market Access, Sales, Medical Affairs, IT, and National Accounts teams

Required Qualifications

• Bachelor’s degree required, advanced degree in a related health or business field preferred
• 12+ years of experience in biopharmaceutical patient support services, including product launch and rare disease product access
• Proven track record designing, launching, and managing hub services, reimbursement support, and financial assistance programs
• Expertise in U.S. payer specialty drug coverage, reimbursement mechanics, and specialty pharmacy operations
• Proficiency in analytics and reporting for service programs and pharmacy data
• Knowledge of compliance and regulatory requirements for patient support programs
• Ability to communicate program objectives, launch plans, and performance effectively to internal stakeholders
• Proven people management experience, including hiring, coaching, and developing teams
• Demonstrated leadership of cross‑functional teams in fast‑paced, launch‑focused environments
• An unwavering dedication to patient access and empowering the teams responsible for delivering it

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

The Opportunity

The Senior Director, Market Insights is a highly visible, enterprise-level leadership role responsible for defining and driving the end-to-end insights strategy to support U.S. commercialization and global expansion. The Senior Director will serve as the strategic owner of the insights function, ensuring that market intelligence, analytics, and evidence generation are fully integrated into corporate decision-making across the product lifecycle.

Reporting into the Vice President, Commercial Operations, the Senior Director will act as a key advisor to commercial and executive leadership, shaping commercial strategy through forward-looking insights that inform launch readiness, lifecycle management and portfolio prioritization. This role requires the ability to operate at both a strategy and operational level, building scalable capabilities and frameworks to support a multi-asset, multi-market organization.

Responsibilities

• Define and own the enterprise-wide market insights strategy, aligning U.S. and ex-U.S. perspectives to support global commercialization and long-term portfolio growth, ensuring readiness across multiple markets and stakeholder groups
• Lead and execute market research projects influencing key decisions related to product launch strategy, lifecycle planning, new product planning, and as necessary, key market access strategies; ensure project deliverables are actionable, archived, and accessible
• Lead cross-functional integration of insight, ensuring alignment across Marketing, Medical, Market Access, Regulatory, R&D, and Executive Leadership to support decision-making
• Build and scale the market insight’s function, including defining operating models, processes, tools, and governance to support increasing organizational complexity
• Oversee and evolve global competitive intelligence strategy, ensuring proactive identification and ongoing communication of market shifts, competitive threats, and strategic opportunities
• Partner with Business Development (BD) colleagues to rapidly build market assessments, competitive landscape modeling, value creation theses, and financial modeling to facilitate executive decision-making
• Drive development of advanced analytics capabilities, including integration of primary research, real-world data, and secondary data sources into a cohesive insight ecosystem
• Establish KPIs and measurement frameworks (customer engagement, brand tracking, etc.) to evaluate commercial effectiveness and inform ongoing strategic adjustments
• Lead external partnerships and vendor strategy, including selection, governance, and optimization of research and analytics partners
• Develop and mentor future capabilities, including team build-out as the organization scales
• Lead insights efforts with a focus on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)

Required Qualifications

• Bachelor’s degree required; advanced degree (PhD, MD, PharmD, or MBA) preferred
• 12+years of experience in pharmaceutical or biotech market research, insights, or analytics, with increasing levels of responsibility
• Proven experience generating insights across the product lifecycle, including early-stage development, launch, and post-launch optimization
• Demonstrated expertise in competitive intelligence, including conference coverage and strategic synthesis of competitor activity
• Strong understanding of global market dynamics, including U.S. and ex-U.S. commercialization considerations
• Experience building or scaling capabilities, functions, or operating models
• Advanced analytical and strategic thinking skills, with the ability to translate complex data into actionable, enterprise-level decisions
• Exceptional communication and executive presence
• Experience in endocrinology is preferred
• Strong vendor management, budget oversight, and project management skills
• High degree of initiative, curiosity, and comfort with ambiguity in a fast-paced, mission-driven environment

Work Location and Conditions

** Preference will be given to candidates residing in the Boston area or elsewhere on the East Coast.

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

The Opportunity

The Associate Director, HCP Marketing will be a critical member of the Marketing team and will be responsible for leading the healthcare professional (HCP) engagement strategy to support the launch of avexitide for post-bariatric hypoglycemia (PBH). This role will focus on identifying, understanding and engaging key HCP segments, including thought leaders and early adopters, to build awareness of PBH and the role of avexitide in its treatment. This individual will partner closely with the sales force and field-facing teams, including Thought Leader Liaisons (TLLs), to ensure aligned, educational, and impactful engagement with the HCP community. Through the development of targeted promotional strategies and educational initiatives, this individual will help shape the HCP understanding of PBH, drive informed clinical dialogue and support successful product adoption at launch.

This is a unique opportunity for a strategic, collaborative, and results-oriented HCP marketer to build a high-impact engagement platform in a complex and underserved therapeutic area.

Responsibilities

• Lead the development and execution of the HCP marketing strategy to support the launch of avexitide in the U.S., with a focus on raising awareness and understanding of post-bariatric hypoglycemia (PBH) among key clinical audiences
• Identify and prioritize HCP targets, including early adopters, influencers, and thought leaders, to inform segmentation, messaging, engagement strategies, and opportunities for advisory boards and speaker programs
• Develop and deploy unbranded and branded educational materials and tools, speaker content and engagement tools across personal and non-personal channels to support HCP understanding of PBH and avexitide
• Partner closely with the sales force and TLLs to align on field strategies, deliver compelling resources and ensure consistent and aligned execution across U.S. regions
• Create field-facing resources, engagement tools and training (e.g., leave-behinds, visual aids, digital content, trainings, etc.) that support effective HCP conversations and reinforce key clinical messages
• Lead the planning and execution of HCP-focused conference and symposium activities, including booth presence, branded and unbranded materials, and sponsored programs in collaboration with cross-functional teams
• Drive the planning and execution of advisory boards and speaker program activities, including associated content development
• Oversee tracking of budget accruals, forecasts, and actuals, and ensure successful and timely completion of projects within budget
• Manage the end-to-end process for the development, review / approval, printing, and fulfillment of all HCP-facing materials
• Help manage external agencies and partners to ensure timely, high-quality deliverables that meet agreed-upon objectives, key performance indicators (KPIs), timelines, and budgets
• Ensure compliance with all Medical, Legal, and Regulatory (MLR) requirements in the development and deployment of HCP-facing materials
• Leverage customer and market insights, claims, and performance data to develop insight-driven marketing strategy and content, continuously optimize programs and identify opportunities for innovation

Required Qualifications

• Bachelor’s degree required
• 8+ years of pharmaceutical or biotech experience, with at least 3 years focused on HCP Marketing
• Proven success in developing and executing HCP engagement strategies
• Experience supporting field teams and partnering with Sales, Field Marketing and Thought Leader Liaison to drive brand messaging and education
• Demonstrated ability to translate complex clinical information into clear, compelling promotional messaging for HCP audiences
• Strong project management and organizational skills, with the ability to lead multiple high-priority initiatives simultaneously
• Effectively managing external partners, agencies and budgets
• Navigate Medical, Legal, and Regulatory (MLR) review and approval processes
• Strong communication, strategic thinking, relationship-building skills, and a results-oriented mindset

Preferred Requirements

• Advanced degree; PharmD preferred
• Experience in rare disease or product launch environments
• Familiarity in digital HCP engagement, thought leader strategy and clinically complex therapeutic areas

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

The Opportunity

The Senior Director, Trade & Channel Operations will be responsible for building Amylyx’s U.S. distribution and channel model from the ground up in preparation for a future commercial launch of our lead product candidate. This individual will architect the distribution strategy, create the operational infrastructure necessary for launch, and partner cross functionally to ensure Amylyx is fully prepared to commercialize with excellence. As a key member of the Market Access team, this role will influence launch readiness, customer service delivery, and ongoing performance across distribution partners.

Responsibilities

• Design and build Amylyx’s U.S. distribution model across specialty pharmacy, specialty distributor, and 3PL channels to support product launch
• Lead contracting strategy for specialty pharmacies and distributors, including negotiating distribution and service agreements, fee schedules, data requirements, and service levels
• Integrate distribution channels with service programs and field initiatives to enable a seamless customer experience
• Collaborate with Supply Chain and Finance to support 3PL operations, including order‑to‑cash processes, inventory management, data exchange, shipping, returns, and chargeback management
• Establish and manage noncommercial and free‑goods pharmacy operations
• Forecast and model channel performance, assess specialty pharmacy throughput, and provide recommendations to ensure timely, reliable patient access
• Develop distribution analytics including inventory visibility, service metrics, dispense data, time to therapy, and partner scorecards; lead specialty pharmacy QBRs
• Partner cross‑functionally with Supply Chain, Quality, Compliance, Legal, Finance, Patient Services, and Commercial Operations to ensure operational alignment and launch readiness
• Serve as a senior leader within Market Access, contributing to launch planning, forecasting, patient access workflows, and overall distribution strategy
• Continuously optimize post‑launch distribution operations by driving root‑cause remediation, vendor KPI management, and process improvements informed by field and service feedback.

Required Qualifications

• Bachelor’s degree required
• 12+ years of experience in biopharmaceutical trade and distribution, including leadership of specialty pharmacy and distributor channel networks
• Prior product launch experience in the US market
• Experience designing and implementing channel strategies for product launches
• Proven ability to assess, manage, and influence channel partner performance to contractual expectations
• Hands‑on experience with 3PL operations, serialization, state licensing, and compliant distribution processes
• Demonstrated strength in contract negotiation, vendor management, and commercial channel operations
• Deep understanding of payer reimbursement, hub/patient support integration, channel economics, and order‑to‑cash workflows
• Proven leadership experience, including managing large pharmaceutical vendors, with demonstrated people management skills
• Excellent communication, vendor management, analytical, and project execution capabilities

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

The Opportunity

The Clinical Data Management team at Amylyx Pharmaceuticals is seeking an Associate Director, Clinical Data Programmer. This individual will work collaboratively cross-functionally to provide hands-on data management support, programming support and technical leadership to develop, maintain, validate the clinical database, and run computer programs that access, visualize, and report clinical trial data, in accordance with various clinical plans, ICH guidelines, and applicable regulatory requirements. As an Associate Director of Clinical Data Programming, you will be required to program in the appropriate languages to create both textual and graphic displays that facilitate data cleaning and review.

Responsibilities

• Lead the study-specific design, development, and validation of study clinical data capture systems, ensuring data integrity, CDISC compliance and CRO oversight.
• Supports leading data management activities (i.e. DMP creation, CRF creation, edit checks creation, database lock), assisting with database setup, conduct and closeout phases.
• Performs UAT of systems and ensures appropriate plans and documentation are in place.
• Leads the development of SAS macros, data listings, summary tables and visualizations for supporting periodic and ad hoc data review.
• Manages external vendor compliance and quality checks.
• Supports Clinical Operations, Biostatistics and Data Management by providing data insight and solving technical data challenges.
• Ensures databases adherences to SOPs, 21CRF Part 11, ICH-GCP and CDISC Standards (CDASH/SDTM)
• Acts as a subject matter expert in leading technical initiatives and data management

Required Qualifications

• Bachelor’s degree or higher in Life Science or related discipline
• 8+ years of experience in clinical data management
• Extensive experience with clinical data systems (particularly Medidata Rave) and languages like SAS, R or Python
• Proven experience in clinical trial programming and database management
• Knowledge of Clinical Data Standards such as CDISC CDASH, and SDTM
• Provide strong support to Data Management
• Experience creating advanced interactive data visualizations from raw data using multi-languages and applications such as Using SAS, R, Python, RShiny, Power BI, Tableau, Spotfire etc.
• Ability to manage multiple projects simultaneously, to manage conflicting priorities, and to be flexible when priorities change.
• Excellent written and verbal communication skills and organizational and documentation skills.

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation.
• You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communicate via video conference, etc.) at your remote locatio

The Opportunity

We are seeking a Senior Director, Market Access Strategy to support a new product launch. This leader will own the creation of the payer value proposition, lead pricing strategy for launch, and prepare effective communications across payer, distribution channel, field access, and patient support teams.

As a key member of the Market Access leadership team, you will work cross functionally to drive strategies for all market access functions, oversee a post-launch marketing and pricing operations team, and effectively manage any vendors that support these initiatives.

Responsibilities

• Shape and lead the payer value story for Amylyx’s first launch product, translating clinical, economic, and real‑world evidence into a differentiated, evidence‑based value proposition that supports optimal access and reimbursement.
• Drive payer marketing and launch execution in close partnership with Medical Affairs, including development of PIE content, AMCP dossiers, and comprehensive launch education materials.
• Partner with Medical and Access leadership to define payer evidence requirements, identify data gaps, and execute strategies to address unmet needs across pre‑ and post‑launch phases.
• Develop and deploy access tools and communications that enable field access teams, patient support programs, and pharmacy partners to execute effectively and consistently.
• Establish a cross‑functional performance feedback loop across payer, field access, pharmacy, and services teams to rapidly identify access barriers and drive issue resolution.
• Build and oversee post‑launch pricing operations, including list price governance, price change management, pricing committee leadership, and close collaboration with Finance on gross‑to‑net management.
• Lead agencies and vendors, monitor payer and policy dynamics, and represent market access strategies including performance, risks, and opportunities—to internal stakeholders and senior leadership.

Required Qualifications

• Bachelor’s degree required
• 12+ years of experience in pharmaceutical market access, pricing, reimbursement strategy, and payer marketing
• Prior launch experience in US market
• Deep expertise in the U.S. payer, reimbursement, coverage, and coding landscape for specialty products under the pharmacy benefit
• Proven experience developing payer value propositions and payer‑facing materials
• Strong analytical skills using market access data sources (e.g., HUB, specialty pharmacy, and claims data)
• People leadership experience, including hiring, coaching, and developing teams
• Demonstrated experience with pricing strategy, contract modeling, and gross‑to‑net management
• Strong vendor management and contracting experience across agencies, consultants, analytics partners, and pricing operations vendors

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

The Opportunity

Amylyx is seeking a Senior Medical Director, Clinical Development to provide strategic and scientific leadership for one or more late-stage, pivotal programs with the potential to expand into additional indications and/or programs within the same molecule or across the portfolio. This individual will play a critical role in shaping the overall clinical development strategy and may lead multiple programs or key components of a broader development portfolio.

Reporting to the Senior VP of Clinical Development, you will be responsible for leading the design, execution, and interpretation of clinical studies and overseeing the development and implementation of Clinical Development Plans across assigned assets. You will provide strategic input into study design, endpoints, and regulatory strategy, ensuring alignment with the overall program and corporate objectives.

The successful candidate will collaborate with cross-functional teams in a matrix environment, influencing stakeholders across Research, Regulatory Affairs, Clinical Operations, and Commercial to ensure that clinical and scientific considerations are fully integrated into development plans. You will proactively identify and mitigate risks, guide decision-making through data-driven insights, and ensure the highest standards of scientific rigor and data integrity.

In this role, you will also serve as a key external representative, engaging with global medical experts, investigators, regulatory authorities, and alliance partners. You may lead or mentor a team of clinical scientists and physicians and contribute to broader organizational and portfolio-level initiatives.

Responsibilities

• Provides strategic medical leadership and oversight for assigned clinical programs, including late-stage and pivotal trials.
• Leads development and execution of Clinical Development Plans (CDPs), integrating clinical, scientific, regulatory, and commercial considerations.
• Drives study design, protocol development, and interpretation of complex clinical data to inform key program decisions.
• Serves as a core member of cross-functional program teams, influencing strategy and ensuring alignment across disciplines.
• Provides senior-level medical monitoring and guidance, ensuring patient safety, data integrity, and high-quality trial execution.
• Leads interactions with external stakeholders including key opinion leaders, investigators, regulatory agencies, and alliance partners.
• Oversees preparation of key program documents including protocols, investigator brochures, clinical study reports, regulatory submissions, and publications.
• Mentors and provides scientific guidance to junior team members, including Medical Directors and Clinical Scientists.
• Identifies and implements process improvements and best practices within Clinical Development.

Required Qualifications

• MD required
• Significant experience in late-stage clinical development and drug development in biotech/pharmaceutical industry; rare disease experience strongly preferred
• Typically 5+ years of experience leading clinical development programs with demonstrated impact on program strategy and execution
• Demonstrated ability to collaborate with cross-functional teams and influence without authority in a matrix environment
• Strong strategic thinking, problem-solving, and decision-making skills
• Proven ability to interpret complex clinical data and translate insights into actionable strategies
• Excellent communication and leadership skills, with experience interacting with senior stakeholders and external experts
• Experience mentoring or leading team members preferred
• Ability to travel internationally and domestically

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

The Position

The Vice President of Clinical Pharmacology will provide leadership and support to the clinical pharmacology team and be accountable for the overall strategy for determining the PK, PD, and immunogenicity properties of all drugs and drug candidates in development and, as applicable, through commercialization. As the clinical pharmacology expert within the company, you have experience and expertise in matrixed leadership and team management, and will lead, develop, and educate through cross-functional teams. In addition, there will be opportunities to contribute to diligence assessments. Reporting directly to the SVP, Head of Clinical Development, you will have high visibility at leadership levels, including with the Chief Medical Officer. You can efficiently and effectively synthesize internal and external data to produce a clinical pharmacology strategy.

Responsibilities

• Serve as the clinical pharmacologist for the company across all clinical programs, providing strategic and scientific input from preclinical development through Phase 3 trials
• Lead the Clinical Pharmacology team accountability for the clinical pharmacology strategy for Amylyx' development portfolio from pre-IND through and post approval, including design and implementation of program specific clinical pharmacology studies, data analysis, internal decision points, and external regulatory interactions
• Integrate clinical pharmacology knowledge with a broad understanding of and collaboration with related disciplines such as clinical, statistics, regulatory, nonclinical ADME, toxicology to support and impact development decisions
• Ensure appropriate PK, PD and PK/PD data analyses (including population PK, PK/PD modeling and simulation) are conducted for each study/program.
• Collaborates with toxicologist and preclinical pharmacology scientists to design, analyze, interpret, and report preclinical PK and translational PK/PD studies to support candidate selection and IND filing, including human PK prediction to support starting dose and dose escalation schemes for first-in-human studies
• Ensure adherence to agreed timelines and budgets to insure prompt and accurate execution of deliverables from clinical pharmacology studies and programs
• Serves as the clinical Pharmacology expert across study and program teams
• Develops and implements new clinical pharmacology approaches to processes and clinical studies that impact development programs
• Contributes to program strategy, study design, protocol preparation, study execution, data review/analysis, study reports and regulatory document preparation
• Works closely with research and development teams and provides input into assay development, CRO selection and CRO management. Leads method development, method qualification, method validation activities as SME and sponsor monitor, as assigned. 
• Represents nonclinical and clinical pharmacology during meetings and discussions with regulatory authorities
• Creates or guides nonclinical and clinical pharmacology summary documents
• Reviews literature and peer-reviewed publications to keep apprised of global regulatory developments in clinical pharmacology; Authors/ reviews manuscripts for submission to peer-reviewed journals

Required Qualifications

• PhD, PharmD, MD, or equivalent training in pharmacokinetics, pharmaceutical sciences, or related disciplines
• Minimum 12 years of experience within the pharmaceutical and biotechnology industry with 5+ years' direct experience in Clinical Pharmacology
• Experience in an array of molecules including biologics, small molecules and gene therapy
• Demonstrated experience in writing, presenting, and discussing clinical pharmacology with regulatory authorities as well as other external and internal stakeholders
• Strong analytical skills and ability to interpret complex clinical data sets as well as deep understanding of individual patient data coupled with excellent written and verbal communication skills
• Ability to work in cross-functional teams and manage multiple projects, engaging subject matter experts across functions to drive the execution of programs
• Strong technical proficiency in PK analysis (NCA and PopPK)
• Ability to work with an elevated level of integrity, accuracy, and attention to detail, while executing corporate objectives and goals
• Entrepreneurial, enjoys working in a fast-paced, small-company environment

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

The Opportunity

The Associate Director, Computer System Validation (CSV) & Quality Compliance provides enterprise‑level leadership, strategic direction, and governance for the validation, lifecycle management, and continuous compliance of GxP‑relevant computerized systems, with a strong emphasis on the Veeva Quality Suite. This role ensures that digital quality solutions and supporting systems meet global regulatory requirements (FDA, EMA, ICH, GAMP 5), maintain data integrity, and enable a sustainable, inspection‑ready state across the organization.

This person will partner closely with Quality, IT, Regulatory, Clinical, and business process owners to define system requirements, lead new system implementations and major enhancements, and drive harmonized, risk‑based validation practices. This role also oversees quality compliance processes such as Change Control, Deviations, CAPA, and continuous improvement, ensuring timely closure, trend analysis, and effective governance through leadership of key forums including Quality Management Review and cross‑functional compliance meetings.

Responsibilities

Strategic Leadership & Governance

• Develop, evolve, and steward the corporate CSV/CSA strategy, ensuring alignment with enterprise digital strategy and Quality Management System (QMS) objectives.
• Serve as the senior Quality authority for computerized systems validation, data integrity, and electronic system compliance.
• Oversee enterprise-wide governance programs, ensuring standardized, risk‑based approaches to system implementation and maintenance.
• Provide strategic guidance to senior leadership regarding system performance, risks, and compliance maturity.

Computer System Validation & Lifecycle Oversight

• Lead planning, execution, review, and approval of validation deliverables across GxP systems.
• Oversee system lifecycle activities including impact assessments, change management, periodic reviews, audit trails, user access reviews, and system retirement.
• Promote and reinforce CSA‑aligned, risk‑based validation practices to streamline compliance and maximize efficiency.
• Ensure documentation quality and consistent application of SDLC principles across projects.

Veeva Systems Expertise & Optimization

• Serve as the Quality SME for the Veeva Quality Suite, providing expert guidance on configuration, workflow optimization, and release readiness.
• Lead implementation, enhancement, and optimization of Veeva Vault modules and cross‑functional integrations.
• Drive automation and digitization initiatives that improve usability, compliance, and system performance.
• Partner with IT and Veeva administrators to maintain robust, compliant change control processes.

Quality & Regulatory Compliance

• Ensure all computerized systems maintain compliance with 21 CFR Part 11, EU Annex 11, GxP principles, and global data integrity expectations.
• Author, revise, and own Quality System policies and procedures related to electronic systems and validation.
• Represent Quality during internal audits, external regulatory inspections, and vendor assessments.
• Lead timely remediation, effectiveness checks, and continuous improvement initiatives.
• Provide oversight and trending for Quality Events related to system performance or compliance.

Required Qualifications

• Bachelor’s degree in a relevant scientific or technical discipline.
• 8+ years of experience in the life sciences industry with strong GxP system experience.
• Extensive leadership experience in cross functional implementation and validation of GxP computerized systems.
• Deep expertise with Veeva Vault Quality Suite (QMS, Docs, Training, etc.).
• Strong knowledge of global regulatory expectations and data integrity frameworks.
• Demonstrated ability to lead enterprise programs, influence stakeholders, and drive compliant decision making.

Preferred Qualifications

• Expertise with SaaS/cloud architectures and database compliance expectations.
• Understanding of clinical data collection technologies and supporting data processes.
• Familiarity with SDLC, Agile methodologies, CSV vs. CSA principles and automated testing platforms.
• Experience developing and interpreting Quality metrics such as KPIs and KQIs.
• Excellent communication skills with the ability to collaborate, negotiate, and influence at all organizational levels.

Work Location and Conditions

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii, Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested, which may include travel by air, driving or public transportation.
• You must have access to work in setting that meets all requirements of the role (including privacy, reliable internet access, phone, ability to communication via video conference, etc.) at your remote location.

*This job listing is open indefinitely, so if we are not currently hiring at a studio location near you, we will be sure to keep your information on file and reach out when an opportunity arises.*

Want to get paid to become a piercer at Studs? Apprentices undergo a minimum 6-week paid piercing training program inclusive of classroom style learning, observation, and hands-on training. We are always looking for Apprentices to join our training program! Upon successful completion of the program, graduated Apprentices will become eligible for a Part Time or Full Time Associate Piercer position at one of our studio locations.

Hourly Rate:

• Graduated apprentices make $24/hour as Associate Piercers, plus tips
  During the 6-week training program, apprentices make $18/hour, plus tips

Key Responsibilities:

REVENUE 

Service Oriented 

• Embodies our performance-oriented culture by meeting and exceeding expectations 
• Serves as a brand ambassador: educates clients on the unique Studs’ experience through our selling cycle 
• Delivers confident, clear, and professional communication with clients during their entire Studs’ experience 

OPERATIONS 

Decision Quality & Execution 

• Leverages Studs’ resources and policies in decision making  
• Becomes well-versed in piercing operating procedures and regulations to ensure client experience and work safety standards are met 
• Shows consistent and detailed record keeping of all maintenance, sterilized inventory and tools

TALENT 

Integrity

• Prioritizes Studio compliance and is accountable to standard operating procedures and company policy 
• Admits mistakes and is not afraid to escalate when help is needed 
• Lives out our Core Values 
• Shows consistency by providing best in class service to everyone in the Studio 
• Provides solutions-oriented feedback and is open-minded to receiving it 

Requirements:

• 3 years of relevant work experience
• At least two years as a Medical Assistant or Phlebotomist (performing venipunctures and/or finger sticks) preferred
• Full Time:
  • Must be available to work a flexible schedule up to 5 days per week (32+ hours), including evenings, weekends, and holidays. Must maintain consistent availability
  • Weekend availability (Friday, Saturday, Sunday) is required, excluding approved PTO
  • Schedules may vary based on business needs, and Full-Time employees are expected to prioritize Studs as their primary employment commitment
• Part Time:
  • Must be available to work a flexible schedule of varying days and hours, including evenings, weekends, and holidays
  • Must have availability to work on Saturday and Sunday, excluding approved unscheduled time away
  • Reliably attend work as scheduled for up to 29 hours per week, in line with local laws and subject to any approved accommodations
• Must pierce a minimum 18 appointments a day
• Must be able to visually inspect ear anatomy to execute advanced piercings
• Must be able to deliver piercings with a steady hand
• Must be able to lift 20 lbs
• Must be able to handle chemicals safely
• Travel to one of our studio locations for the duration of the training program (paid by Studs)
• Driven, creative problem solver that consistently acts with integrity and speaks up
• Owner’s mindset, with the ability to approach feedback and problems with a positive attitude.

Benefits & Perks:

Full Time:

• Comprehensive Medical, Dental, and Vision Insurance (including $0 in-network mental health visits)
• Access to Mental Health and Work/Life Resources  including Online Therapy, Gender Affirmation Support Services, and Employee Assistance Program (EAP)
• Voluntary Life Insurance
• Health and Commuter Tax-Advantaged Accounts
• 401(k) Retirement Savings Plan
• Paid Time Off and Paid Safe & Sick Leave Accruals
• Paid Parental Leave
• Paid Sabbatical After 4 Years of Service
• Exclusive Employee Discounts on Piercings and Jewelry (we’ve got your friends and family covered too!)
• Access to PerkSpot and additional benefits such as pet insurance, discounted tickets, personal finance coaching, healthy rewards, and more!

Part Time:

• Paid Safe & Sick Leave Accrual
• FSA Health and Commuter Tax-Advantaged Accounts
• 401(k) Retirement Savings Plan
• Exclusive Employee Discounts on Piercings and Jewelry (we’ve got your friends and family covered too!)

We’re looking to hire a Strategic Deployment Manager to join us in our mission to improve human health and quality of life through the development, distribution, and application of advanced computational methods!

As a member of our Enterprise Informatics team, you’ll play a vital role in all stages of the Schrödinger Platform deployment for customers, from initial project scoping through to long term successful adoption. By serving as the bi-directional voice for these customers, you’ll also help drive future product development strategy.

Click here for more information about how the Schrödinger Platform is helping shape the future of collaborative therapeutic design. 

Who will love this job:

• A pharmaceutical or chemical enterprise software technology expert who’s knowledgeable about industry best practices and enjoys interacting with medicinal chemists, computational chemists, biologists, and project leadership
• A scientist who understands project management in a corporate research setting (direct experience with pharmaceutical drug discovery is a huge plus!)
• An effective communicator with excellent organizational skills
• A customer-service oriented deployment manager who’s passionate about helping drive user success

What you’ll do:

• Manage LiveDesign implementation projects from early-stage discussions through deployment, training, and growth
• Ensure long-term customer success through use of the Schrödinger Platform
• Collaborate internally with Account Managers, Applications Scientists, Solutions Architects, and the Education team to ensure success of the account by enabling substantial growth and usage
• Help drive the product roadmap and development by working closely with product management and engineering, representing real-world customer needs

What you should have:

• B.Sc. in a life science (M.Sc. or Ph.D. preferred)
• At least three years of experience in a life sciences field related to drug discovery
• Experience with computational chemistry or cheminformatics in a research setting

Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time. Our Administrative and Human Resources departments also plan a myriad of fun company-wide events. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces. 

Sound exciting? Apply today and join us!

The Opportunity

Proton is building the industry cloud for distribution—an $8 trillion market that technology forgot.

Our first product is an AI-powered CRM built specifically for distributors—it helps their sales teams know which customers to call, what to sell them, and when. We're at ~$10M ARR with 120%+ NDR. Our second product, PIM (Product Information Management), helps distributors manage their product catalogs—think millions of SKUs with specs, images, and pricing that need to stay accurate across systems. PIM is growing fast. Another product launches in March, with more on the roadmap.

We're looking for a Senior Financial Analyst to be our finance lead. You'll own the function—building our operating model, running FP&A, managing reporting and compliance, and working directly with the CEO on financial decisions. You'll have one direct report (our bookkeeper) and full ownership of how finance runs at Proton.

If you succeed, you'll have built the finance infrastructure that supports Proton's growth from $10M to $50M+ ARR. 

We are looking to hire someone in the greater Boston area who is open to a hybrid schedule (3 days in office, Havard square). The target salary range for this role is $140,000- $170,000. Final offers will be based on your skills and previous experience.

What You'll Do

Own FP&A (40%)

• Build and maintain our operating model and budget
• Prepare monthly budget vs. actuals reporting
• Track and report on SaaS metrics (ARR, NDR, CAC, LTV, magic number, etc.)
• Prepare board materials and investor reporting
• Build bespoke financial analysis for business decisions

Run Financial Operations (40%)

• Oversee accounting: revenue recognition, month close, AP/AR
• Own billing, collections, and cash management
• Ensure compliance: corporate tax, sales tax, R&D tax credit, 409a valuations
• Calculate and manage variable compensation and partner commissions
• Lead Fiona (bookkeeper) and manage external accounting relationships

Partner with the CEO (20%)

• Be a thought partner on financial decisions
• Support fundraising preparation when needed
• Identify opportunities for financial process improvement

Who You Are

Non-Negotiables:

• SaaS metrics fluency. You understand ARR, NDR, CAC, LTV, burn multiple, and magic number cold.
• Financial modeling skills. You've built operating models from scratch and can maintain them as the business evolves.
• Startup experience. You've worked at a Series A or B stage company and understand the pace and ambiguity.
• Based in Boston. In office 3x/week in Kendall Square.
• Exceptional attention to detail. Your models are airtight. Your reports are accurate. You catch things others miss.

What Sets You Apart:

• You're reliable. When you say something will be done, it gets done—on time and correctly.
• You're curious. You dig into the numbers to understand what's really happening in the business.
• You communicate clearly. You can explain financial concepts to non-finance people and help them make better decisions.

About Proton

Distribution is an $8 trillion industry that technology forgot. 75,000+ distributors globally. Half of their sales reps still don't use a CRM. The ones that do are stuck with generic tools built for tech companies—not businesses managing millions of SKUs and thousands of customer relationships.

We're building the industry cloud for distribution—and every product is AI-native from the ground up. We're not bolting AI onto legacy software. We're rebuilding the entire stack with AI at the core.