About Alltrna 

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.

Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics. 

For more information, visit www.alltrna.com

Sr. Director Program Management & Business Operations

Position Summary:

Alltrna is seeking a talented and highly motivated Sr. Director Program Management and Business Operations, reporting to the President & CFO.  The successful candidate is a proven leader with extensive experience in leading research and early drug development program teams from research through the clinic with a particular initial focus on IND enabling and early/mid-stage clinical development. The candidate will be a member of the Company’s Leadership Team and will serve as Chief of Staff to the team to drive collaboration, cross-functional clarity, alignment and execution on key priorities and initiatives required to meet the goals of the organization.

Key Responsibilities:

Program Management:

• Work closely with the Chief Medical Officer to lead the program team for the Company’s lead program, AP003, and future programs instilling a culture of scientific rigor, open debate, collaborative teamwork, sense of urgency and accountability
• Possess a comprehensive understanding of the drug discovery process to guide program teams to define the key scientific questions, program strategy and objectives, translating these into optimal deliverables, cross-functional plans, timelines and budgets
• Identify bottlenecks, risks, issues and proactively develop appropriate mitigation proposals with input from team members
• Ensure all key decisions are identified and properly assessed as to their impact and alternative scenarios developed and evaluated, where appropriate
• Work closely with finance and functional teams to develop the operational plans to support program activities with realistic timelines, budget, and resource planning and monitor performance against plans
• Interface with and drive collaboration between the various functional teams and with the Leadership Team on program-related matters.
• Be the key accountable person for communicating matters related to the programs to management including strategy, work product, updates and issues; producing the one “source of truth” for program-related topics and timelines
• Point person for alliance management and coordination, as needed
• Lead and/or manage strategic or platform development projects as required and collaborate with Chief Scientific Officer and Research Leadership Team to coordinate relevant content for quarterly business review meetings

Operations:

• Collaborate with Leadership Team in development of strategic plans, company goals, long-range planning assumptions, portfolio-level reports and analyses to support business processes and strategic discussions
• Develop and deliver impactful presentations that effectively distill complex issues to the critical points and lead to increased understanding and optimized strategic planning & decision-making

• Prepare strategic communications utilizing a clear understanding of the business strategy and issues; develop and maintain consistent, relevant content for use in executive-level communications and to further organizational and business goals

• Lead the Scientific Communications process, working with the Scientific Communications Committee

• Manage schedule, agenda, and content for Leadership Team, Board of Directors and Town Hall meetings

• Proactively seek opportunities for organizational improvements (e.g. team structure, processes, communication, etc.)

Other:

• Support CEO / LT with partnership discussions and negotiations, including background research, preparation of presentation materials, supporting diligence activities, participating in analysis of terms, etc.
• Assist in mapping competitive landscape and proactively identify potential and emerging competitive threats and opportunities
• Promote strategic discussions on external trends, competitor strategies, and potential disruptors, and translate these into strategic choices/ recommendations
• Collect insights and intelligence from a variety of sources including literature searches, reviewing analyst research, KOL and patient group interactions, etc.

Key Competencies:

• This is a highly visible leadership role that requires exceptional interpersonal and communication skills, creative thinking, and early drug development experience that allows one to recognize opportunities/challenges and modify strategy accordingly
• The individual will need to have self-confidence and poise to manage complicated programs and projects with multiple stakeholders

• The individual will need a sense of urgency and can-do attitude to develop therapies for patients with significant unmet medical needs

Minimum Qualifications:

• BS/MS Degree in a scientific discipline, ideally life science or chemistry.
• At least 15 years relevant experience in pharma or biotech drug discovery and development, as well as a comprehensive understanding of drug discovery (preclinical and clinical).
• 10+ years of Program Management experience, preferably in early-stage drug discovery and development.
• Experience in the development of advanced therapies to treat rare genetic disease is a plus
• Demonstrated experience leading cross-functional teams; strong interpersonal and communication skills
• Scientific curiosity and passion for discovering new, innovative medicines.
• Openness to embrace new technologies and digital approaches in drug discovery
• Proven track record in driving successful, collaborative drug discovery teams.

The salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

About Alltrna 

Alltrna is the first clinical-stage biotech company advancing tRNA medicines to address shared disease-causing mutations across many indications. The company’s initial therapeutic programs are designed to restore full-length protein production in diseases caused by premature termination codons (PTCs), collectively referred to as Stop Codon Disease, which affect approximately 10% of people with a rare genetic disease.

Alltrna’s lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid nanoparticle. AP003 is being developed for the arginine-to-TGA (Arg-TGA) PTC in patients with liver Stop Codon Disease, including phenylketonuria, organic acidemias, and urea cycle disorders. Founded in 2018 by Flagship Pioneering, Alltrna has built an integrated platform to design, optimize, and deliver engineered tRNA therapeutics. 

For more information, visit www.alltrna.com

Sr. Director Program Management & Business Operations

Position Summary:

Alltrna is seeking a talented and highly motivated Sr. Director Program Management and Business Operations, reporting to the President & CFO.  The successful candidate is a proven leader with extensive experience in leading research and early drug development program teams from research through the clinic with a particular initial focus on IND enabling and early/mid-stage clinical development. The candidate will be a member of the Company’s Leadership Team and will serve as Chief of Staff to the team to drive collaboration, cross-functional clarity, alignment and execution on key priorities and initiatives required to meet the goals of the organization.

Key Responsibilities:

Program Management:

• Work closely with the Chief Medical Officer to lead the program team for the Company’s lead program, AP003, and future programs instilling a culture of scientific rigor, open debate, collaborative teamwork, sense of urgency and accountability
• Possess a comprehensive understanding of the drug discovery process to guide program teams to define the key scientific questions, program strategy and objectives, translating these into optimal deliverables, cross-functional plans, timelines and budgets
• Identify bottlenecks, risks, issues and proactively develop appropriate mitigation proposals with input from team members
• Ensure all key decisions are identified and properly assessed as to their impact and alternative scenarios developed and evaluated, where appropriate
• Work closely with finance and functional teams to develop the operational plans to support program activities with realistic timelines, budget, and resource planning and monitor performance against plans
• Interface with and drive collaboration between the various functional teams and with the Leadership Team on program-related matters.
• Be the key accountable person for communicating matters related to the programs to management including strategy, work product, updates and issues; producing the one “source of truth” for program-related topics and timelines
• Point person for alliance management and coordination, as needed
• Lead and/or manage strategic or platform development projects as required and collaborate with Chief Scientific Officer and Research Leadership Team to coordinate relevant content for quarterly business review meetings

Operations:

• Collaborate with Leadership Team in development of strategic plans, company goals, long-range planning assumptions, portfolio-level reports and analyses to support business processes and strategic discussions
• Develop and deliver impactful presentations that effectively distill complex issues to the critical points and lead to increased understanding and optimized strategic planning & decision-making

• Prepare strategic communications utilizing a clear understanding of the business strategy and issues; develop and maintain consistent, relevant content for use in executive-level communications and to further organizational and business goals

• Lead the Scientific Communications process, working with the Scientific Communications Committee

• Manage schedule, agenda, and content for Leadership Team, Board of Directors and Town Hall meetings

• Proactively seek opportunities for organizational improvements (e.g. team structure, processes, communication, etc.)

Other:

• Support CEO / LT with partnership discussions and negotiations, including background research, preparation of presentation materials, supporting diligence activities, participating in analysis of terms, etc.
• Assist in mapping competitive landscape and proactively identify potential and emerging competitive threats and opportunities
• Promote strategic discussions on external trends, competitor strategies, and potential disruptors, and translate these into strategic choices/ recommendations
• Collect insights and intelligence from a variety of sources including literature searches, reviewing analyst research, KOL and patient group interactions, etc.

Key Competencies:

• This is a highly visible leadership role that requires exceptional interpersonal and communication skills, creative thinking, and early drug development experience that allows one to recognize opportunities/challenges and modify strategy accordingly
• The individual will need to have self-confidence and poise to manage complicated programs and projects with multiple stakeholders

• The individual will need a sense of urgency and can-do attitude to develop therapies for patients with significant unmet medical needs

Minimum Qualifications:

• BS/MS Degree in a scientific discipline, ideally life science or chemistry.
• At least 15 years relevant experience in pharma or biotech drug discovery and development, as well as a comprehensive understanding of drug discovery (preclinical and clinical).
• 10+ years of Program Management experience, preferably in early-stage drug discovery and development.
• Experience in the development of advanced therapies to treat rare genetic disease is a plus
• Demonstrated experience leading cross-functional teams; strong interpersonal and communication skills
• Scientific curiosity and passion for discovering new, innovative medicines.
• Openness to embrace new technologies and digital approaches in drug discovery
• Proven track record in driving successful, collaborative drug discovery teams.

The salary range for this role is $213,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Alltrna currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Alltrna's good faith estimate as of the date of publication and may be modified in the future.

About the Role

We are seeking a highly motivated Finance Analyst to join our growing team. In this role, you’ll partner closely with the Finance, Accounting and operational teams, as well as cross-functional stakeholders, to support strategic decision-making and optimize financial operations across the business. This is a high-impact role where you’ll gain hands-on experience supporting the financial operations of a rapidly scaling healthcare technology company. You will also play a key role in evolving our financial systems and infrastructure, particularly as we expand our joint venture (JV) partnerships and build for scale.

Responsibilities

• Develop and maintain robust financial models to evaluate revenue performance, key business metrics, and strategic growth initiatives
• Prepare and present monthly reports to key business stakeholders, offering clear insights and transparency into financial performance
• Support the automation and accuracy of reports as the company builds out an EDW and implements Adaptive Insights
• Provide strategic analysis and actionable recommendations to support decision-making across the business 
• Enhance forecast accuracy through deep understanding of financial and operational drivers
• Strengthen financial infrastructure and reporting processes to support scalability, efficiency, and accuracy
• Foster strong collaboration between finance and business partners; work closely with operational teams to define department-level KPIs and identify opportunities for performance improvement
• Contribute to high-impact financial initiatives, including board materials, investor communications, and other core finance functions

What We’re Looking For

Required Qualifications

• 2–3 years of experience in investment banking, consulting, or in a corporate finance / FP&A related role at a high-growth startup
• Strong financial modeling, analytical and problem-solving skills, with attention to detail
• Familiarity with accounting principles and financial reporting
• Demonstrated interest in corporate finance and business operations
• Proficiency in Excel and PowerPoint, with strong presentation skills and the ability to communicate financial insights clearly to both technical and non-technical audiences
• Strong written, verbal, and interpersonal communication skills
• Proven ability to work independently and manage cross-functional projects
• High level of ownership and a desire to learn and grow

Preferred Qualifications

• Prior experience with accounting systems (e.g., NetSuite)
• Accounting experience or relevant certification (e.g., working towards CFA certification)

Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.  

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.  

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. 

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

Why Flagship?
At Flagship Pioneering, YOU get: inspiring leadership, great company culture, competitive compensation packages, best in class benefits, generous PTO, beautiful office space stocked with unlimited snacks and free lunch delivered daily, and impactful work with endless career growth.

The Position: 

The Sr. Manager or Associate Director of Business Development, depending on experience, will be a core part of the team responsible for strengthening our business through helping capture and implement learnings about the biopharma deal environment by operationalizing BD processes and analytics for Flagship and our ecosystem companies. This role will report to the Director of BD and will be critical in accelerating the growth of the FSP BD team. This individual should have a passion for working at the intersection of science and business and have an analytical mindset who thrives in a fast-paced, dynamic, and deadline driven environment. This individual should have a can-do attitude, be open to change and be excited about understanding the biopharma business development landscape. 

Key Responsibilities: The successful candidate will work both independently and as part of a collaborative team to: 

• Actively participate in the analytics of an effective and efficient business development effort/team 
• Lead pharma profiling in terms of characterizing their positioning in the partnering landscape, understanding their structure and decision-making process, capturing the knowledge gained from deepening FSP relationships and driving additional knowledge capture on behalf of FSP and our companies 
• Own pharma contact interface and leverage for BD analytics 
• Prepare opportunity assessments with scientific/portfolio rationale, partnership framework and financial assessment, analysis of competitive landscape and comparable deal terms 
• Build internal champions to amplify FSP BD reach, including for biopharma account management and ask KOLs for data review 
• Support deal activities including campaign design, outreach, tracking, deal structure design, term sheet assessment, research planning 
• Track progress, including coordinating the definition and reporting of the KPIs, as well as leading periodic health checks to monitor the strength and effectiveness of the partnership 
• Build strategy for and communication of intelligence acquisition gained through medical conference attendance, analyst report review 
• Partner with CBDO to own and share history and best practices across the ecosystem   

Preferred Qualifications: 

• 2-5 years life sciences experience in a business development function in a biotechnology/pharmaceutical company, Life Science Consulting form or biopharma investment banking 
• Knowledgeable about trends and technologies in biopharmaceutical R&D and partnering 
• Comfort in the start-up environment, passion for understanding emerging data and navigating ambiguity in a dynamic environment 

Basic Qualifications: 

• BS or other graduate degree in the life sciences required 
• Understanding of biopharmaceutical R&D, the drug development process, and the role and processes of business development 
• Excellent analytical/quantitative, conceptual problem-solving, organizational and time management skills and are comfortable working independently 
• Clear communicator in writing and speech and creative in terms of visual presentation of trends and data 
• Strong attention to detail 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies:  Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates.  The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team.   Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

#LI-TD1

The salary range for this role is $128,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering's good faith estimate as of the date of publication and may be modified in the future.

BioMed Realty is seeking a dynamic, strategic, highly motivated Senior Analyst, Investments and Asset Management to provide analytical and decision support, including investment underwriting and financial analysis across acquisitions, dispositions, development, redevelopment, leasing, and restructurings, as well as transactional due diligence for potential real estate investment opportunities, management of existing assets, and identification of creative growth opportunities.

What You’ll Do

• Run a comprehensive underwriting process, including creation of detailed financial models (Excel and ARGUS), development of market assumptions, and analyses supporting Investments and Asset Management activities, capital markets, and other strategic capital allocation opportunities to enhance asset value and performance.
• Identify growth opportunities and recommend strategies using knowledge of market trends, financial data, and industry benchmarks.
• Contribute to the preparation of investment presentations for the Investment Committee.
• Prepare ad hoc analyses and industry research in support of potential investment, leasing, or development opportunities.
• Support the transactional due diligence process and manage communication with counterparties.
• Collaborate cross-functionally with legal, accounting, leasing, development, finance, and operations teams to aggregate, interpret, and communicate information for internal and external stakeholders.
• Prepare comprehensive business plans for assets, outlining key initiatives, alternative strategies, and financial projections.
• Conduct diligence to assess operating performance, utilization, capital expenditure needs, and competitive positioning; evaluate strategic importance, risk factors, and financial feasibility of assets.
• Contribute to reports, presentations, and recommendations for senior management and the executive team.
• Manage and track timelines for strategic plans, including key milestones, intermediate decisions, and deliverables.
• Provide additional support to the Investments and Asset Management team as needed.
• Leverage AI tools to streamline workflows and deliver timely, accurate, and efficient analytics; prior experience with AI is a plus.

What You Bring

• Bachelor’s degree in finance, real estate, or a related technical field, with demonstrated experience in commercial real estate, corporate finance, private equity, or investment banking, and a proven ability to quickly step into the role and operate with a high degree of independence.
• Advanced financial modeling expertise, with proven experience in commercial real estate transactions and a strong understanding of real estate fundamentals.
• Life sciences industry experience is a plus.
• Proven ability to analyze financial statements, leases, and related documents for forecasting, underwriting, and tenant credit analysis.

Competencies Critical for Success

• Tool/Software Literacy – Advanced proficiency in Microsoft Excel, PowerPoint, and ARGUS.
• Data Gathering and Analysis – Ability to collect, consolidate, and analyze relevant information; identify patterns, diagnose issues, and develop practical solutions.
• Attention to Detail – Applies a thorough and detail-oriented approach to all work.
• AI Mindset – Demonstrates a growth mindset and willingness to adopt and apply AI tools to enhance team effectiveness and workflows.
• Quality Orientation – Sets high standards for work quality and continuously seeks improvement.
• Problem Solving – Identifies and resolves complex issues with limited guidance.
• Conceptual Thinking – Synthesizes multiple sources of information to identify key issues in complex situations.
• Teamwork – Contributes effectively as part of a collaborative, high-performing team.
• Oral Communication – Communicates ideas clearly and effectively.
• Written Communication – Produces clear, well-structured, and professional written materials.
• Continuous Learning – Actively seeks feedback and pursues ongoing development.
• Initiative – Proactively identifies opportunities and takes action.
• Results Orientation – Demonstrates persistence and accountability in achieving measurable outcomes.
• Professional Confidence – Demonstrates confidence in one’s abilities while remaining open to feedback; communicates effectively, exercises sound judgment, and handles challenges constructively.

Salary: $97,000 - $120,000 per year + bonus + long term incentive + benefits

The above represents the expected salary range for this job requisition. Ultimately, in determining pay, we’ll consider location, experience, and other job-related factors.

Benefits 

At BioMed Realty, we make sure you have the support and resources to leverage and develop your skills, secure your financial future, and take care of your health and well-being. BioMed Realty continually seeks to provide a workplace where everyone can be their authentic self. Through BioMed Realty’s competitive benefits offerings and various training and development opportunities, we have you covered with our Benefits Program which includes:

• Medical, Dental, and Vision Insurance
• Paid Time Off and Paid Family Leave Benefits
• 401(k) Retirement Savings Plan
• Tuition Reimbursement
• Flexible Spending Accounts
• Commuter Benefits
• Lifestyle Spending Account
• Pet Insurance
• ID Theft Insurance
• Legal Insurance
• Employee Assistance Program
• 100% Employer-Paid Life & AD&D Insurance, Short and Long Term Disability

Amenities  

• Offsite Gym
• Complimentary Snacks and Beverages 
• Offsite parking

Notice to Recruiters and Third-Party Agencies 

The Talent Acquisition team manages the recruitment and hiring process to ensure a consistent and equitable experience for all parties. We only accept resumes from agencies with a fully executed search agreement in place. Agencies are not authorized to contact BioMed Realty employees directly to present candidates. Any unsolicited resumes submitted without a prior agreement will be considered referrals and will not incur any fees or obligations.

#LI-EW1

The Opportunity

Proton is building the industry cloud for distribution—an $8 trillion market that technology forgot.

Our first product is an AI-powered CRM built specifically for distributors—it helps their sales teams know which customers to call, what to sell them, and when. We're at ~$10M ARR with 120%+ NDR. Our second product, PIM (Product Information Management), helps distributors manage their product catalogs—think millions of SKUs with specs, images, and pricing that need to stay accurate across systems. PIM is growing fast. Another product launches in March, with more on the roadmap.

We're looking for a Senior Financial Analyst to be our finance lead. You'll own the function—building our operating model, running FP&A, managing reporting and compliance, and working directly with the CEO on financial decisions. You'll have one direct report (our bookkeeper) and full ownership of how finance runs at Proton.

If you succeed, you'll have built the finance infrastructure that supports Proton's growth from $10M to $50M+ ARR. 

We are looking to hire someone in the greater Boston area who is open to a hybrid schedule (3 days in office, Havard square). The target salary range for this role is $140,000- $170,000. Final offers will be based on your skills and previous experience.

What You'll Do

Own FP&A (40%)

• Build and maintain our operating model and budget
• Prepare monthly budget vs. actuals reporting
• Track and report on SaaS metrics (ARR, NDR, CAC, LTV, magic number, etc.)
• Prepare board materials and investor reporting
• Build bespoke financial analysis for business decisions

Run Financial Operations (40%)

• Oversee accounting: revenue recognition, month close, AP/AR
• Own billing, collections, and cash management
• Ensure compliance: corporate tax, sales tax, R&D tax credit, 409a valuations
• Calculate and manage variable compensation and partner commissions
• Lead Fiona (bookkeeper) and manage external accounting relationships

Partner with the CEO (20%)

• Be a thought partner on financial decisions
• Support fundraising preparation when needed
• Identify opportunities for financial process improvement

Who You Are

Non-Negotiables:

• SaaS metrics fluency. You understand ARR, NDR, CAC, LTV, burn multiple, and magic number cold.
• Financial modeling skills. You've built operating models from scratch and can maintain them as the business evolves.
• Startup experience. You've worked at a Series A or B stage company and understand the pace and ambiguity.
• Based in Boston. In office 3x/week in Kendall Square.
• Exceptional attention to detail. Your models are airtight. Your reports are accurate. You catch things others miss.

What Sets You Apart:

• You're reliable. When you say something will be done, it gets done—on time and correctly.
• You're curious. You dig into the numbers to understand what's really happening in the business.
• You communicate clearly. You can explain financial concepts to non-finance people and help them make better decisions.

About Proton

Distribution is an $8 trillion industry that technology forgot. 75,000+ distributors globally. Half of their sales reps still don't use a CRM. The ones that do are stuck with generic tools built for tech companies—not businesses managing millions of SKUs and thousands of customer relationships.

We're building the industry cloud for distribution—and every product is AI-native from the ground up. We're not bolting AI onto legacy software. We're rebuilding the entire stack with AI at the core.