Are you a technical system manager with deep understanding of clinical operations and clinical trial supply process and data flows? Do you think holistically, act with ambition, and ensure the right functionality and system stability?  

Can you ensure great technical solutions, inspection-readiness and a great end-user experience for clinical users?  

If so, you may be our new Technical System Manager. 

Ascendis Pharma is a global biopharmaceutical company committed to making a meaningful difference in patients’ lives. Guided by our core values of Patients, Science, and Passion, we are applying our innovative TransCon® technology platform to fulfill our mission of developing new therapies that demonstrate best-in-class potential to address unmet medical needs.  

At our headquarters in Hellerup, Denmark, research facilities in Heidelberg, Germany, and additional offices across Europe and the United States, we are advancing programs in our Endocrinology Rare Disease and Oncology portfolios. We also collaborate with partners on the development of TransCon-based products in other therapeutic areas and markets. 

Our context  

This position is based in our Global IT organization. In Global IT, we have spent the past five years building and maturing a product-driven organization. We operate with a strong focus on product management and lifecycle thinking, where long-lived teams take full ownership- from problem discovery to solution delivery and continuous improvement - ensuring we address real business needs. 

Our structure combines clear leadership intent with empowered teams: each team member is supported by both a People Leader focused on development and a Functional Leader guiding strategy and delivery. We foster autonomy and self-organization to enable fast flow, clear accountability, and minimal dependencies. 

The Clinical domain currently consists of three product teams and a data team, supporting our Clinical Operations, Clinical Development, Biometrics, Clinical Data Management and Clinical Trial Supply functions. 

We are seeking a passionate Technical System Manager. You will be responsible for finding the right technical solutions for our clinical operations and clinical trial supply teams focusing on IRT, CTMS and eTMF solutions.  

Practically speaking, you will be the technical expert in how systems are configured and maintained. All of these are SaaS solutions. When our SaaS solutions fall short, you will find ways to deliver functionality in collaboration with our Automation, Integration, AI and Analytics teams.  

You will report to Ivanna Rosendal, Global Head of Digitalization, and Jakob Monajemzadeh Thrane People Leader. You will be based in Hellerup, Denmark. 

Your key responsibilities will be to 

• Be the technical expert of eTMF, CTMS and IRT solutions 

• Translate business needs to specifications of configuration needed in our SaaS applications 

• Either implement the configurations yourself, or work with the managed services provider or vendor to implement the configuration 

• Ensure systems are in a validated state and are inspection-ready  

• Prepare and present our systems and the related documentation during audits and inspections  

• Oversee system support and act as escalation point for tickets 

• Maintain operational oversight over vendors  

• Facilitate end-user training and user groups    

• Be visionary in improving our technical capabilities and suggest and implement improvements for automation, integration and seamless data flows  

• Assist with documentation and validation of solutions  

• Collaborate within and across the IT product teams when solving problems and delivering solutions 

Qualifications and experience 

You hold a relevant academic degree – preferably a Master’s degree, with a background as an Engineer, System Manager or an equivalent technical role.   

You have Solid experience with clinical systems from a pharma context, minimum +5 years of relevant experience across complex organizations. 

Furthermore, you have: 

• Strong understanding of Clinical Operations and Clinical Trial Supply and their systems 

• Experience with working with SaaS vendors  

• Experience with GxP processes for system management 

Key competencies: 

You are a strong team player, analytical, and have a can-do attitude.    

You possess an entrepreneurial mindset and can thrive in an informal, open environment where innovation and change are key.    

To succeed in this role, we also expect you to be good at collaborating with business in complex and ambiguous settings, handling conflicts constructively, and helping groups move forward. 

What we offer 

We offer an exciting and challenging position in an entrepreneurial and international company with short decision paths. You will work with highly skilled colleagues and play a key role in shaping how Global IT delivers sustainable value to Ascendis Pharma and, ultimately, to patients. 

Travel: 10-15 days per year 

Office: Tuborg Boulevard 12, 2900 Hellerup 

Flexibility: Some of the Clinicial organization is located in the US, and meetings in the afternoon and evening will occur 

Apply now.  

We evaluate applications when received, so we encourage you to apply as soon as possible. Please note that we conduct interviews on a rolling basis and reserve the right to remove the job posting at any time.     

To ensure your application is reviewed, please submit it through the specified platform - applications sent by email or other channels will not be evaluated. 

For more details about the position or the company, please contact Jakob Monajemzadeh Thrane, People Leader, jmt@ascendispharma.com.   

You can learn more about Ascendis by visiting our website,       

Applications must be submitted in English and will be treated confidentially.  

As the summer holiday period approaches, you may experience a longer response time than usual. We truly appreciate your patience and thank you for your understanding. We look forward to reviewing your application as soon as possible. 

A note to recruiters:   

We do not allow external search party solicitation.  Presentation of candidates without written permission from the Ascendis Pharma HR team (specifically from: Talent Acquisition Partner or Human Resources Director) is not allowed.  If this occurs, your ownership of these candidates will not be acknowledged.