We are seeking a results-driven Senior Scientist to join Regeneron’s Antibody Engineering team within the Bispecifics and Antibody Engineering Department. In this fast-paced, innovative group, you will design, produce, and characterize next-generation antibody and protein therapeutics across multiple therapeutic areas with a focus on myeloid cell biology.  Your work will directly contribute to the pipeline and help build new platform capabilities at a pivotal time for antibody engineering.

As a Senior Scientist, a typical day could require the following:

• Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity and developability.

• Perform molecular and structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools.

• Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems utilizing an assortment of molecular biology & biochemical techniques (i.e. AKTA systems and other chromatographic columns).

• Characterize binding affinities, binding kinetics & stability.  

• Design and implement high-throughput and properly controlled biochemical and cell-based assays (ELISA and AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays).

• Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations.

• Engage program stakeholders to communicate biologic designs with data updates to meet program objectives. 

• Clearly convey results to management during cross-departmental meetings and maintain timely, accurate entries using Benchling and research ELN.

This role may be a strong fit If You:

• Have expertise in myeloid, molecular, and protein biology.

• Learn new skills quickly and troubleshoot antibody production and functional assays effectively.

• Excel in data analysis and interpretation while supporting multiple projects simultaneously.

• Competently prioritize efforts to quickly adapt to evolving program directions.

• Possess exemplary organizational, communication, and presentation skills.

• Enjoy collaborating across diverse, cross-functional teams.  

To be considered for this role you must have a PhD in molecular biology, cell biology, biochemistry, immunology or a related field with at least one year of relevant experience in academia or industry. Core hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (i.e., using AKTA systems), and comprehensive protein characterization is desired; however, we’re excited to train motivated learners. Familiarity with cell-free expression and structural AI/ML-design is preferred but not required.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all  qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate.  The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.  Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.  If you have any questions, please speak with your recruiter. 

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)