At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

The Senior Pharmacometrician will be responsible for the development and implementation of the model-informed drug development (MIDD) plan for drugs and other therapeutic agents in clinical development, in partnership with Clinical Pharmacology (CP) and other quantitative functions for the asset.

MIDD complements conventional drug development by integrating diverse data through PMx models to inform development decisions and regulatory assessments. MBMA adds a quantitative view of competitors and comparators. MIDD informs dose and regimen selection and clinical study hypotheses, while complementing clinical data to support regulatory assessment of clinical pharmacology and benefit-risk. PMx analyses can also inform approval decisions and, in some cases, serve as the primary basis for approval.

Model-based integration of data to generate insights, bridge data-gaps, inform and drive drug development decisions, and support health authority interactions. Pharmacometrics (PMx) applications including population pharmacokinetics/pharmacodynamics, exposure-response, disease progression, and model-based meta-analyses (MBMA). Understanding of modern PMx approaches such as mechanistic modeling (QSP and PBPK), scientific machine learning and agentic workflows are a significant bonus.

Key Responsibilities

• Partners with Clinical Pharmacology (CP) lead to specify MIDD components of PMx plan, with some supervision

• Works closely with other quantitative disciplines to formulate and execute on a coherent modeling and data plan

• Responsible for planning, executing, and reporting of formal PMx analyses included in CSRs, HA submissions, and responses to questions from HAs, with some supervision

• Serves as MIDD SME, to work closely with CP lead and other quantitative functions in the development of therapeutic agents, with some supervision

• Contributes to maintenance and refinement of PMx infrastructure, with some supervision

• Contributes to PMx and cross-functional initiatives

• Manages PMx analyses performed by vendors, with some supervision

• Participates in interactions with health authorities as MIDD SME, with some supervision

• Collaborates with internal and external SMEs to develop and enhance MIDD methodology and capability, with some supervision

Qualifications & Experience

• Advanced degree(s) in relevant field: MS, PhD, PharmD

• 2+ years' experience with demonstrated progression in PMx and CP knowledge

• Basic quantitative data analysis, data wrangling (merging and transforming data), visualization, advanced PPK and E-R

• Programming: R, NONMEM, Monolix, Pumas, Matlab, Python, Julia

• General knowledge of drug development process

• Knowledge of mechanistic modeling is desired

• Knowledge of current practices and issues in PMx and CP

• Strong written and oral communication skills necessary to report on and deliver scientific presentations

• Demonstrated ability to work in a dynamic team-oriented environment

• Local and international travel for conferences and regulatory meetings may be required depending on project needs, up to 5-10% of the time

#LI-Hybrid

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only:  If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

For roles based in Washington State only: If you live in or expect to work from Washington State if hired for this position, please visit this page for important information about the Washington Fair Chance Act.

Data Protection

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