At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary
Caris is seeking a board-certified expert in Hematology and Medical Oncology, with deep experience in malignant hematology, to join our dynamic Medical Affairs team as Senior Medical Director. This individual will serve as a key strategic leader, reporting to the Senior Vice President of Medical Affairs and Chair of the Precision Oncology Alliance (POA). The Senior Medical Director will utilize their clinical depth, scientific acumen, and executive presence to shape and support Caris' innovative precision medicine solutions, while cultivating impactful relationships with internal and external stakeholders to support business growth and clinical excellence.

Job Responsibilities

• Serve as a senior clinical leader representing Caris’ malignant hematology expertise with credibility, business maturity, and strong executive communication in external and internal engagements.
• Cultivate and lead strategic relationships with key opinion leaders (KOLs), clinical collaborators, POA institutions, and industry partners to elevate the Caris brand and drive scientific engagement.
• Provide strategic direction and clinical guidance in partnership with Research & Development, Medical Affairs, Commercial, and Business Development teams to support innovation, market expansion, and product refinement.
• Act as a trusted advisor and internal leader, supporting cross-functional teams by translating scientific insights into business-aligned actions and product evolution.
• Collaborate closely with field sales (Key Account Directors and Executive Sales Management) and the Business Development team to advance Caris’ visibility, strengthen customer trust, and identify new partnership opportunities.
• Lead high-impact scientific communications, including public speaking engagements at national/international forums, advisory boards, investigator meetings, and Caris-sponsored events.
• Drive scientific and educational strategies: oversee content development for publications, slide libraries, clinical education materials, and professional/continuing education programs.
• Mentor and provide training to field-based medical professionals, including Medical Science Liaisons, supporting their development and alignment with business goals.
• Represent Medical Affairs on the Caris Evidence Team, contributing thought leadership to the development of evidence frameworks, clinical association rules, and product positioning.
• Review marketing, promotional, and educational materials to ensure alignment with clinical data, regulatory guidelines, and Caris’ strategic messaging.
• Provide a critical communication bridge between the marketplace and internal R&D/Product Development teams, ensuring the voice of the clinician and evolving clinical trends inform product strategy.

Required Qualifications

• MD or DO, board-certified in Hematology and Medical Oncology.
• Minimum of 3 years recent clinical practice focused on malignant hematologic diseases, including acute leukemia, myelodysplastic syndromes, myeloproliferative disorders, and multiple myeloma.
• Demonstrated leadership in clinical or industry roles, with a strong ability to lead cross-functional teams and influence senior-level stakeholders.
• Significant experience with public speaking and scientific presentation, with the ability to communicate complex ideas effectively to both scientific and non-scientific audiences.
• Proven track record of integrating clinical knowledge into product strategy, including experience with product lifecycle planning, clinical value positioning, and market readiness.

Preferred Qualifications

• Advanced knowledge of molecular oncology and its application in hematologic malignancies.
• At least 3 years of experience in a senior Medical Affairs, Medical Director, or equivalent leadership role in the biotech or pharmaceutical industry.
• Experience building or managing collaborative research networks or multi-institutional clinical programs.

Physical Demands

• Must be comfortable with frequent national and occasional international travel, including evenings and weekends as required by business needs.
• Physical demands include typical office activities (sitting, using standard equipment, lifting routine office supplies).

Required Training

• All job specific, safety, and compliance training are assigned based on the job functions associated with this employee.

Conditions of Employment:  Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification.

This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.