Position Overview

Immunome is seeking a Senior Manager, Global Value and Access to support global health economics and outcomes research (HEOR) and market access activities in the US and ex-US for our oncology portfolio. This role will primarily lead the execution of HEOR studies and evidence-generation deliverables, while flexing into broader market access priorities as Immunome prepares for a potential launch of its lead asset, varegacestat.  

The successful candidate will combine strong HEOR technical and project management capabilities with a practical understanding of US and ex-US payer evidence needs, value communication including field tools, and new drug launch. This is a highly visible opportunity for an individual who thrives in a fast-paced environment, learns quickly, and is eager to take on new responsibilities. The level will be commensurate with experience; the ideal candidate will bring enough launch exposure to add value immediately while continuing to grow across Global Value and Access. 

Responsibilities

HEOR Strategy and Evidence Planning  

• Support integrated HEOR and real-world evidence strategies aligned with clinical development, medical, regulatory, and market access priorities. 
• Identify evidence gaps and translate payer, health technology assessment (HTA), and business questions into fit-for-purpose research plans and analyses. 
• Provide HEOR input to evidence-generation plans, value propositions, and launch- deliverables for the lead asset and broader portfolio.  

HEOR Study Execution  

• Lead real-world evidence studies, including burden of illness, treatment patterns, healthcare resource use, real-world comparative effectiveness, and epidemiology studies using claims, electronic health records, and other secondary data sources. 
• Develop cost-effectiveness and budget-impact models, from early economic models that inform development and pricing strategy to submission-ready models adapted for HTA bodies ex-US.  
• Conduct systematic literature reviews, indirect treatment comparisons and network meta-analyses. 
• Develop and review study protocols, analysis plans, reports, abstracts, posters, and manuscripts; ensure scientific rigor, timely delivery, and clear communication of decision-relevant findings.  

Launch Readiness and Market Access Support  

• Own the launch deliverables including AMCP dossier, global value dossier, budget-impact model, and cost-effectiveness models. 
• Flex into launch market access workstreams, contributing to payer value propositions, payer research, objection handling, and access field tools. 
• Translate clinical and economic evidence into clear payer narratives and materials that support reimbursement and patient access.  
• Monitor payer, HTA, reimbursement, policy, and competitive trends and assess implications for evidence strategy and launch execution.  

Vendor and Project Management  

• Manage HEOR consultants, data partners, and agencies, including scope, deliverables, timelines, budgets, and quality. 
• Own multiple concurrent projects, proactively resolving risks and adapting priorities in a rapidly changing environment.  
• Ensure work meets internal standards and applicable scientific, legal, regulatory, and publication requirements.  

Cross-Functional Collaboration and Communication  

• Serve as a Global Value and Access partner on asset and launch teams, collaborating with Clinical Development, Medical Affairs, Regulatory, Commercial, Finance, and other functions. 
• Influence without direct authority, communicate complex concepts clearly, and flex beyond core responsibilities with curiosity, urgency, sound judgment, and a team-first mindset.  

Qualifications

• Advanced degree (Ph.D., Pharm.D., M.S., M.P.H., or equivalent) in health economics, outcomes research, epidemiology, public health, pharmacy, health services research, or a related discipline preferred; a bachelor's degree with directly relevant experience will be considered. 
• Minimum of 3 years of work experience in HEOR, real-world evidence, market access, or a related function within biotechnology, pharmaceuticals, managed care, or consulting. 
• Demonstrated experience executing HEOR or real-world evidence studies from concept through final deliverable.  
• Track record of peer-reviewed publications and scientific presentations at HEOR or clinical congresses.
• Experience translating clinical, economic, and outcomes evidence into payer value messages or market access deliverables. 
• Launch experience preferred but not required. 
• Oncology, rare disease, or specialty product experience preferred.  
• Experience managing external research partners, consultants, data vendors, or agencies.  

Knowledge and Skills

• Strong project management skills and ability to independently drive multiple high-priority workstreams against tight timelines. 
• Ability to critically evaluate study designs and analyses and communicate actionable conclusions.  
• Sound understanding of U.S. and global payer, reimbursement, HTA, and evidence requirements.  
• Excellent written and verbal communication skills, including scientific writing and presentation capabilities.  
• High learning agility, intellectual curiosity, passion, and drive to take on new challenges and grow quickly.  
• Hands-on, resourceful, and comfortable operating with ambiguity in a fast-paced, dynamic biotechnology environment.  
• Collaborative working style with a willingness to flex across HEOR and market access priorities.  
• Exceptional organizational, analytical, problem-solving, and judgment skills, with close attention to detail.