Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies in neurology and additional new indications. A centerpiece of this role is A-005, Alumis’s CNS-penetrant TYK2 inhibitor with potential in neuroinflammatory and neurodegenerative diseases — a first-mover opportunity to bring a differentiated mechanism to patients with devastating neurological conditions. This high-impact role will shape Alumis’s expanding clinical portfolio from the ground up, from indication selection and study design through proof-of-concept readout, and will serve as a key scientific leader and external face of the program with investigators, regulatory authorities, and the broader medical community.

Key Responsibilities

Clinical Development Strategy & Leadership

• Lead the design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 in neurology (e.g., neurodegenerative diseases, movement disorders) and for additional pipeline molecules in inflammatory and immunologic indications
• Develop and refine clinical development plans, including study synopses, protocols, and integrated development strategies for new indications
• Provide clinical and scientific leadership to cross-functional study teams, ensuring alignment on program goals, timelines, and deliverables
• Collaborate with Translational Medicine and Research teams to evaluate and prioritize new indication opportunities based on scientific rationale, competitive landscape, and unmet medical need

Study Execution & Oversight

• Serve as the Medical Monitor for assigned Phase 1 and 2 studies, ensuring patient safety and scientific integrity
• Oversee medical aspects of study conduct, including safety surveillance, protocol amendments, and data review
• Partner with Clinical Operations, Biostatistics, and Regulatory Affairs to ensure efficient study execution and high-quality data generation
• Lead interactions with Data Safety Monitoring Boards (DSMBs) and provide medical input for safety analyses

Regulatory & External Engagement

• Contribute to regulatory strategy and serve as a clinical representative in interactions with FDA and international regulatory authorities (EMA, PMDA, etc.)
• Prepare and review clinical sections of regulatory submissions, including IND amendments, briefing documents, and meeting packages
• Represent Alumis at scientific conferences, advisory boards, and with Key Opinion Leaders (KOLs) to advance clinical programs and gather external insights
• Build and maintain relationships with investigators, academic collaborators, and the broader medical community

Cross-Functional Collaboration

• Work closely with Translational Sciences, Biomarker, and Pharmacology teams to integrate biomarker strategies into clinical study designs
• Collaborate with Commercial and Medical Affairs teams on disease landscape assessments and indication prioritization
• Provide clinical expertise to support business development activities, including evaluation of potential partnerships or in-licensing opportunities

Team Development

• Mentor and develop junior medical staff, fostering a culture of scientific excellence and collaboration
• Contribute to building Alumis's clinical development capabilities as the organization grows

Required Qualifications

• MD required; neurology experience required; board certification or fellowship training in Neurology highly desired; additional experience in inflammatory disease areas (e.g., rheumatology, dermatology) a plus
• 10+ years of pharmaceutical/biotechnology industry experience in clinical development, with a significant focus on neurology; experience in immunology or autoimmune diseases a plus
• Demonstrated experience leading Phase 1 and Phase 2 clinical studies from design through data readout
• Track record of successful regulatory interactions (FDA, EMA) and experience preparing IND/CTA submissions
• Deep understanding of early clinical development, including dose-finding strategies, biomarker integration, and adaptive trial designs
• Strong scientific acumen with the ability to critically evaluate preclinical and clinical data to inform development strategy
• Experience with JAK/TYK2 inhibitors or related immunomodulatory mechanisms, preferred
• Excellent leadership, communication, and interpersonal skills with the ability to influence cross-functional teams in a matrixed environment
• Strategic mindset with demonstrated ability to balance scientific rigor with business objectives

Preferred Qualifications

• Experience with indication expansion or lifecycle management for neurology or immunology assets
• Prior experience at a small or mid-sized biotechnology company; comfort operating in a fast-paced, resource-conscious environment
• Established relationships with KOLs in neurology; relationships in rheumatology, dermatology, or other inflammatory disease areas also valued
• Experience across multiple therapeutic indications, including neurological diseases (e.g., neurodegenerative diseases, movement disorders) and/or inflammatory conditions such as psoriasis, psoriatic arthritis, lupus, or atopic dermatitis
• Familiarity with regulatory pathways for expedited development (Breakthrough Therapy, Fast Track)

What We Offer

• Opportunity to shape the clinical development strategy for a best-in-class TYK2 inhibitor portfolio
• High-visibility leadership role with direct interaction with executive leadership and the CMO
• Collaborative, science-driven culture focused on transforming patient outcomes
• Competitive compensation package including base salary, annual bonus, and equity participation
• Comprehensive benefits including health, dental, vision, 401(k), and generous PTO

Travel Requirements

Travel required (approximately 20-30%) to support investigator meetings, scientific conferences, regulatory interactions, and site visits.

This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Remote candidates will be considered on a case-by-case basis.

The salary range for this position is $300,000 USD to $400,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.