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Position Description:

The Translational Metabolic Phenotyping and Nutrition Core within the University of Louisville School of Medicine Nutrition and Metabolic Health Center is seeking a Research Technician I to support pre-clinical and human translational studies focused on exercise, metabolism, nutrition, and cardiometabolic health. The position will provide hands-on technical support for experiments using advanced metabolic phenotyping and physiological instrumentation, including mouse metabolic phenotyping systems, exercise-testing platforms, extracellular flux analysis, body-composition technologies, and whole-room calorimetry for human studies. Working under the direction of the Core Director and established study protocols, the successful candidate will perform experiments, process and organize physiological and metabolic data, assist with implementation and refinement of experimental protocols, provide hands-on training in approved Core procedures, and communicate experimental progress and technical issues to the Core Director. This position is well suited for an individual with training or interests in bioengineering, biomedical engineering, physiology, quantitative biology, or related fields who enjoys hands-on experimental research, instrumentation, and data processing.

Essential Duties and Responsibilities:

• Conduct mouse-based research procedures, including animal handling, monitoring, metabolic phenotyping, exercise testing, and collection or processing of biological samples, as trained and in accordance with approved protocols.

• Set up, operate, calibrate, clean, and perform routine maintenance and first-line troubleshooting of advanced Core instrumentation, including Sable Promethion metabolic phenotyping systems, forced and voluntary exercise platforms, Seahorse extracellular flux analyzers, body-composition instrumentation, and related physiological monitoring systems, following established procedures and manufacturer guidance.

• Assist with setup and implementation of human metabolic phenotyping studies using whole-room calorimeters and complementary physiological measurements, including support for participant-facing experimental workflows as appropriate to the approved protocol. Contribute to protocol refinement and documentation as directed.

• Perform experimental procedures using established or Core-approved protocols with attention to accuracy, reproducibility, documentation, and quality control; assist with implementation of protocol updates as new Core capabilities are introduced.

• Collect, organize, quality-check, and process multiparametric data generated from exercise and metabolic phenotyping studies using established analysis workflows. Compile measurements across physiological, metabolic, behavioral, and instrument-derived datasets for review by the Core Director and collaborating investigators.

• Use instrument-specific software and established quantitative analysis tools to process data, prepare standardized summary outputs and visualizations, flag unusual or technically inconsistent results, and support review of findings by the Core Director and collaborating investigators.

• Assist with onboarding and hands-on training of students, junior investigators, and Core users in approved animal procedures, human-study workflows, instrument operation, data collection, data quality-control procedures, and established standard operating procedures.

• Communicate study status, experimental progress, equipment issues, troubleshooting needs, and resource requirements to the Core Director; participate in Core meetings and support ongoing improvements to experimental procedures and instrumentation workflows.

• Maintain laboratory readiness through preparation of materials, inventory and supply management, equipment logs, cleaning, and compliance with institutional animal care, human subjects research, biosafety, environmental health and safety, and Core requirements. Perform other duties as assigned.

Preferred Qualifications:

• Bachelor's degree in biomedical engineering, bioengineering, biological engineering, physiology, kinesiology, exercise science, biology, biochemistry, nutrition, or a closely related quantitative or biomedical field.

• Interest in applying engineering or quantitative approaches to human and preclinical research in physiology, exercise, metabolism, and nutrition.

• Prior hands-on experience with mice or other laboratory animals, including familiarity with animal handling, physiological phenotyping, or exercise-related research procedures.

• Experience operating or learning complex research instrumentation. Familiarity with metabolic phenotyping, indirect calorimetry, exercise physiology, extracellular flux analysis, physiological monitoring, or body-composition systems is desirable.

• Familiarity with quantitative data processing or analysis using tools such as MATLAB, Python, R, GraphPad Prism, Microsoft Excel, or related platforms is desirable.

• Experience assisting with implementation, documentation, or refinement of experimental protocols or instrumentation workflows in a research environment is desirable.

Target Compensation Maximum:

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Compensation will be commensurate to candidate experience.

Equal Employment Opportunity

The University of Louisville is an Equal Employment Opportunity employer. The University strives to provide equal employment opportunity on the basis of merit and without unlawful discrimination on the basis of race, sex, age, color, national origin, ethnicity, creed, religion, disability, genetic information, sexual orientation, gender, gender identity or expression, veteran status, marital status, or pregnancy. In accordance with the Rehabilitation Act of 1973 and the Vietnam Era Veteran Readjustment Act of 1974, the University prohibits job discrimination of individuals with disabilities, Vietnam era veterans, qualified special disabled veterans, recently separated veterans, and other protected veterans. The University acknowledges its obligations to ensure affirmative steps are taken to ensure equal employment opportunities for all employees and applicants for employment. It is the policy of the University that no employee or applicant for employment be subject to unlawful discrimination in terms of recruitment, hiring, promotion, contract, contract renewal, tenure, compensation, benefits, and/or working conditions. No employee or applicant for employment is required to endorse or condemn a specific ideology, political viewpoint, or social viewpoint to be eligible for hiring, contract renewal, tenure, or promotion.

Consistent with applicable law, demographic information is collected for aggregate reporting requirements. Demographic information provided through this application is not available to hiring managers/committees and is not considered in hiring or employment decisions.

Assistance and Accommodations

Computers are available for application submission at the Human Resources Department located at 2315 South First Street Walk, Room 02C - Louisville, Kentucky 40292.

If you require assistance or accommodation with our online application process, please contact us by email at [email protected] or by phone 502-852-6258.