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Department:

Position Summary

The Research Senior Associate will assist and support the center for antibody therapeutics (CAT) at the Pelotonia Institute for Immuno-Oncology (PIIO) under direct supervision of Dr. Zhiwei Hu, Managing Director of the PIIO CAT at the OSUCCC – James. Research Senior Associate will participate in planning, executing, and analyzing translational cancer research with focus on antibodies/proteins, antibody drug conjugates, bispecific antibodies, antibody-based CAR-NK and CAR-T cell immunotherapy using advanced molecular, cellular and antibody-based techniques.

Key Responsibilities

• Perform advanced in vitro and in vivo techniques including molecular biology skills such as: DNA, RNA extraction, RT-PCR, etc; production, purification and characterization of antibody, antibody drug conjugates, bispecific antibodies, CAR-T, CAR-NK and general cell culture skills such as mammalian and bacterial cell growth, etc; protein biochemistry such as antibody and protein purification, chromatography, SDS-PAGE, Western blotting, ELISA, flow cytometry, immunostaining, in vitro assays and development, ADCC, CDC, IncuCyte or RTCA cytotoxicity assays, biacore or other SPR assays, etc; and small animal skills such as tail vein, intraperitoneal and subcutaneous injections of cancer cells and tumor xenografts into mice to generate animal models of cancer and of therapeutic agents for experimental therapy, small animal in vivo imaging, etc.
• Collect, analyze, and interpret research data; assist with development and implementation of new methodologies.
• Collaborate with principal investigator to write manuscripts, abstracts and research reports for publication in peer-reviewed journals; assist with the development and preparation of grant proposals to obtain outside funding in support of research; conduct critical analysis of research literature related to research being investigated.
• Monitor and enforce laboratory safety procedures; ensure compliance with institutional and federal regulations.
• Train research staff and manage daily laboratory operations, including procurement and equipment maintenance.
• Perform additional duties as assigned.

Required Qualifications

• Master's Degree required, Doctor’s degree in biological or health sciences strongly preferred, or equivalent experience. 1 year of relevant experience required with Master's Degree, 3 years of relevant experience required with Bachelor's Degree.
• Ability to translate and apply academic knowledge in biological/health science research.
• Experience in antibody/protein, chromatography or antibody-based research capacity required.
• Strong analytical and communication skills.

Additional Information:

The OSUCCC – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities.

Pelotonia Institute for Immuno-Oncology (PIIO) is a comprehensive bench-to-bedside research initiative focused on harnessing the body’s immune system to fight cancer at all levels - from prevention to treatment and survivorship.

The Center for Antibody Therapeutics (CAT) at the PIIO is a specialized technology hub dedicated to the discovery, development, production, optimization, and translation of antibody-based therapeutics from basic science research to preclinical and clinical studies for cancer treatment. The Center will leverage cutting-edge technologies to develop monoclonal antibodies, bispecific antibodies (bsAb), antibody-drug conjugates (ADCs), antibody engineering, and other antibody-based immunotherapies including CAR-T and CAR-NK cells. This center will serve the PIIO research community, clinical teams, and external partners by providing essential expertise and infrastructure to accelerate immuno-oncology research from basic science discovery to translational research, commercialization towards clinical trials in alignment with the overall strategic growth goals of the PIIO.

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