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Postdoctoral Research Fellow - Pharmacogenomics & Precision Medicine Lusi Zhang Lab Division of Translational and Clinical Pharmacology Cincinnati Children’s Hospital Medical Center (CCHMC)

The Lusi Zhang Lab in the Division of Translational and Clinical Pharmacology at Cincinnati Children’s Hospital Medical Center (CCHMC) is seeking highly motivated postdoctoral research fellows to join a newly established pharmacogenomics and precision medicine research program.

The lab integrates pharmacogenomics, population genomics, pharmacoepidemiology, biomedical informatics, real-world evidence, and multi-omics approaches to advance precision medicine and optimize medication outcomes, with a particular emphasis on mental health conditions.

Research areas may include:

• · Psychiatric pharmacogenomics and precision psychiatry
• · Pharmacogenomics implementation and clinical decision support
• · Real-world evidence and pharmacoepidemiology using EHR and claims data
• · Population genomics and polygenic risk prediction
• · Multi-omics integration and biomarker discovery
• · AI/ML-enabled translational pharmacology and predictive modeling
• · Medication safety, treatment response, and health equity research

The fellow will have opportunities to lead independent and collaborative projects leveraging large-scale clinical, genomic, and real-world datasets, including EHRs, biobanks, and national research resources. The position offers extensive interdisciplinary collaboration opportunities across CCHMC, the University of Cincinnati, and national and international research networks spanning pharmacology, human genetics, psychiatry, biomedical informatics, and translational science. Fellows will be encouraged to develop independent research directions and career development plans within a collaborative and highly interdisciplinary team-science environment.

MAJOR DUTIES AND RESPONSIBILITIES:   

• Develop the skills and knowledge (critical thinking and analysis of data, devising specific aims, long-term project planning and experimental design) to become an independent scientist
• Design, execute, and record laboratory experiments, and analyze data, which may affect decisions regarding future patient care.
• Research and improve current methods and evaluate innovative techniques. protocol and assay accuracy by conducting regular quality and reproducibility checks. Implement this knowledge in the Division/Department. Troubleshoot and correct erroneous results or problems with laboratory equipment. 
• Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis.      
• Present research at laboratory meetings, journal clubs, seminars, and meetings. Develop skills to critically review and discuss data being presented.
• Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
• Progressively increasing responsibilities with mentorship of research staff and fiscal administration
• Maintain currency in field through continuing education, literature, and seminars. Be an active participant in the process through intellectual discussions with PI and other faculty, trainees and research staff. Solicit feedback on career trajectory from PI, mentoring committee and others who can provide coaching and insight.
• Attend required Cincinnati Children’s training sessions and ensure regulatory compliance with all institutional (i.e. Infection Control, ORCRA and others as applicable) policies and procedures
• Perform other duties as assigned.

 Required:

• PharmD, PhD, MD or equivalent

At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a holistic team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s. 

 Cincinnati Children's is: 

• Recognized by U.S. News & World Report as a top 10  best Children's Hospitals in the nation for more than 15 years 

• Consistently among the top 3 Children's Hospitals for National Institutes of Health (NIH) Funding 

• Recognized as one of America’s Best Large Employers  (2025), America’s Best Employers for New Grads (2025) 

• One of the nation's America’s Most Innovative Companies as noted by Fortune 

• Consistently certified as great place to work 

• A Leading Disability Employer as noted by the National Organization on Disability 

• Magnet® designated for the fourth consecutive time by the American Nurses Credentialing Center (ANCC) 

 We Embrace Innovation—Together.  We believe in empowering our teams with the tools that help us work smarter and care better. That’s why we support the responsible use of artificial intelligence. By encouraging innovation, we’re creating space for new ideas, better outcomes, and a stronger future—for all of us.

Comprehensive job description provided upon request.

Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability