Topos Bio

At Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease.

We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.

What you will do

• Develop and optimize mammalian cell-based assays for disordered protein targets

• Execute phenotypic and reporter-based screening campaigns to validate computational hits

• Characterize compound activity and support structure-activity relationship studies

• Collaborate with computational scientists to integrate experimental data with modeling workflows

• Establish robust assay protocols and quality control metrics

What we are looking for

• Strong foundation in mammalian cell culture and cellular assay development

• Experience with disease-relevant cellular models

• Ability to troubleshoot complex biological systems and optimize experimental protocols

• Track record of productivity and effective collaboration

Preferred

• PhD in cell and molecular biology with focus on disease models

• Industry experience in drug discovery or biotech

• Experience with reporter assays and high-throughput screening platforms

• Familiarity with oncology, neurodegeneration, or metabolic disease models

• Track record of developing novel cellular assays or screening approaches