POSITION SUMMARY:

Natera is seeking a highly motivated and experienced Clinical Scientist to support the development and execution of our innovative Oncology programs.

The Director, Clinical Science will ensure the successful execution of clinical development programs and deliverables in partnership across the organization, with external vendors, and with external academicians and collaboration partners. The Director, Clinical Science will be accountable to jointly develop clinical program strategy and work collaboratively together with other functional representatives to assure that activities are executed within expected scope, compliance, budget, and timelines. Specifically, the candidate will work closely with colleagues cross functionally in clinical development, clinical operations, data management safety/pharmacovigilance, regulatory, biostatistics, translational medicine, and program leadership.

PRIMARY RESPONSIBILITIES:

• Develop study concepts, including study design, schedule of assessments, objectives/endpoints, and eligibility criteria  
• Collaborate cross-functionally to develop Protocol and ICF documents / amendments and present these to governance committee and early clinical development team meetings as required
• Provide protocol training and contribute to CRF design
• Ensure study manuals align with protocol and engage investigators in study design
• Seek input from key investigators on study design and methodology to ensure alignment with research objectives, and actively participate in pre-site selection discussions, site initiation visits, and investigator meetings to support successful study execution
• Contribute to and oversee real-time clinical data reviews (including oversight of CROs when applicable)
• Serve as a clinical science representative on internal and external meetings 
• Develop clinical project execution timelines and provide status updates to senior management to ensure the timely delivery of program milestones
• in collaboration with Data Management will develop Data Review Plan, and monitor clinical data for specific trends, ensure CRF design adequately supports data collection in alignment with the protocol in collaboration with Data Management/Programming
• Support meetings (advisory boards, etc) and deliver presentations
• Drive clinical research plans, including company and investigator-initiated studies
• Effectively interact with senior members in other functional areas for strategic planning to ensure optimized clinical development in accordance with corporate objectives 
• Build relationships with KOLs, consortiums, and sites
• Provide scientific input into design & implementation of clinical trial(s), their delivery, clinical data review and data cleaning, interpretation of results, reporting successfully on time, and activities required for registration of the product 
• As appropriate, participates in ongoing enhancements/development of team processes, structures, systems, tools, and other resources; As appropriate, coaches and guides less experienced Clinical Scientists
• Manage one or more direct reports including being responsible for hiring, training, developing, and retaining talent on staff, as needed
• As appropriate, participates in competitive intelligence and/or other market/industry assessment activities and projects
• Maintains scientific and clinical knowledge in the specific therapeutic and disease area(s) of assignment
• Ensure HIPAA/PHI compliance and maintain training requirements
• Perform other duties as assigned

QUALIFICATIONS:

• Advanced degree in Life Sciences (MD, PhD, Pharm D, MS, RN or similar scientific field) preferred
• 10+ years of pharma/biotech industry experience in clinical development in oncology clinical trials
• Deep understanding and preferably experience in oncology molecular diagnostics, oncology companion diagnostics or early cancer detection 
• Experience in data review, data cleaning, managing and interpreting clinical trials results as well in writing clinical trial protocols
• Possesses sound foundational knowledge of FDA and other major country regulations and detailed knowledge of Good Clinical Practice other regulations governing clinical research
• Experience with managing direct reports, ensuring that roles are performed in accordance with job descriptions and that training is conducted and maintained appropriately

KNOWLEDGE, SKILLS, AND ABILITIES:

• Problem-solving skills and a fast learner
• Strong communication (oral and written) and attention to detail
• Ability to work independently and collaboratively
• Analytical and creative thinking
• Familiarity with Google and Microsoft suites
• Desire to work in a dynamic environment
• "Hands-on" leadership and a strong work ethic
• Ability to apply business knowledge, exercise judgment, and escalate issues appropriately
• Strong project management, organizational, and interpersonal skills
• Adaptability, initiative, and team-building skills
• Demonstrated success in working in a cross-functional environment
• Successful and superior influencing skills across all levels of the organization and external collaborators
• Conflict resolution and follow-through skills
• Results and goal-oriented
• Strategic and flexible thinking

PHYSICAL DEMANDS & WORK ENVIRONMENT:

• Office or home office setting with internet access
• Ability to use a computer, phone, and read materials 
• Flexibility to work with colleagues in a global setting
• Able to engage in work-related travel up to 25%

POSITION SUMMARY:

Natera is seeking a highly motivated and experienced Clinical Scientist to support the development and execution of our innovative Oncology programs.

The Associate Director, Clinical Science will ensure the successful execution of clinical development programs and deliverables in partnership across the organization, with external vendors, and with external academicians and collaboration partners. The Associate Director, Clinical Science will be accountable to jointly develop clinical program strategy and work collaboratively together with other functional representatives to assure that activities are executed within expected scope, compliance, budget, and timelines. Specifically, the candidate will work closely with colleagues cross functionally in clinical development, clinical operations, data management safety/pharmacovigilance, regulatory, biostatistics, translational medicine, and program leadership.

PRIMARY RESPONSIBILITIES:

• Develop study concepts, including study design, schedule of assessments, objectives/endpoints, and eligibility criteria  
• Collaborate cross-functionally to develop Protocol and ICF documents / amendments and present these to governance committee and early clinical development team meetings as required
• Provide protocol training and contribute to CRF design
• Ensure study manuals align with protocol and engage investigators in study design
• Seek input from key investigators on study design and methodology to ensure alignment with research objectives, and actively participate in pre-site selection discussions, site initiation visits, and investigator meetings to support successful study execution
• Contribute to and oversee real-time clinical data reviews (including oversight of CROs when applicable)
• Serve as a clinical science representative on internal and external meetings 
• Develop clinical project execution timelines and provide status updates to senior management to ensure the timely delivery of program milestones
• in collaboration with Data Management will develop Data Review Plan, and monitor clinical data for specific trends, ensure CRF design adequately supports data collection in alignment with the protocol in collaboration with Data Management/Programming
• Support meetings (advisory boards, etc) and deliver presentations
• Drive clinical research plans, including company and investigator-initiated studies
• Effectively interact with senior members in other functional areas for strategic planning to ensure optimized clinical development in accordance with corporate objectives 
• Build relationships with KOLs, consortiums, and sites
• Provide scientific input into design & implementation of clinical trial(s), their delivery, clinical data review and data cleaning, interpretation of results, reporting successfully on time, and activities required for registration of the product 
• As appropriate, participates in ongoing enhancements/development of team processes, structures, systems, tools, and other resources; As appropriate, coaches and guides less experienced Clinical Scientists
• Manage one or more direct reports including being responsible for hiring, training, developing, and retaining talent on staff, as needed
• As appropriate, participates in competitive intelligence and/or other market/industry assessment activities and projects
• Maintains scientific and clinical knowledge in the specific therapeutic and disease area(s) of assignment
• Ensure HIPAA/PHI compliance and maintain training requirements
• Perform other duties as assigned

QUALIFICATIONS:

• Advanced degree in Life Sciences (MD, PhD, Pharm D, MS, RN or similar scientific field) preferred
• 8+ years pharma/biotech industry experience in clinical development in oncology clinical trials
• Deep understanding and preferably experience in oncology molecular diagnostics, oncology companion diagnostics or early cancer detection 
• Experience in data review, data cleaning, managing and interpreting clinical trials results as well in writing clinical trial protocols
• Possesses sound foundational knowledge of FDA and other major country regulations and detailed knowledge of Good Clinical Practice other regulations governing clinical research
• Experience with managing direct reports, ensuring that roles are performed in accordance with job descriptions and that training is conducted and maintained appropriately

KNOWLEDGE, SKILLS, AND ABILITIES:

• Problem-solving skills and a fast learner
• Strong communication (oral and written) and attention to detail
• Ability to work independently and collaboratively
• Analytical and creative thinking
• Familiarity with Google and Microsoft suites
• Desire to work in a dynamic environment
• "Hands-on" leadership and a strong work ethic
• Ability to apply business knowledge, exercise judgment, and escalate issues appropriately
• Strong project management, organizational, and interpersonal skills
• Adaptability, initiative, and team-building skills
• Demonstrated success in working in a cross-functional environment
• Successful and superior influencing skills across all levels of the organization and external collaborators
• Conflict resolution and follow-through skills
• Results and goal-oriented
• Strategic and flexible thinking

PHYSICAL DEMANDS & WORK ENVIRONMENT:

• Office or home office setting with internet access
• Ability to use a computer, phone, and read materials 
• Flexibility to work with colleagues in a global setting
• Able to engage in work-related travel up to 25%

Principal Clinical Scientist, ECD

About the Role

We are seeking a Principal Clinical Scientist to lead execution of key components of clinical development for our early cancer detection (ECD) program. This role is central to driving study design, clinical data review, and scientific insights across multiple studies.

You will serve as a clinical science lead within cross-functional teams – partnering with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory to advance study execution and shape clinical strategy. This is a high-impact role for someone who can operate independently, manage complexity across studies, and influence decision-making at the study and program level.

PRIMARY RESPONSIBILITIES

Lead Clinical Development & Study Design

• Lead substantial aspects of ECD clinical studies or multiple studies

• Drive study design, including objectives, endpoints, eligibility criteria, and schedules of assessments

• Author and review protocols, ICFs, CRFs, and study documents

• Contribute meaningfully to clinical development strategy and study-level decision-making

• Contribute to process improvements and development of best practices

Drive Data Review & Strategic Insight

• Lead medical and clinical data review to ensure data quality and integrity

• Analyze complex datasets to identify trends, risks, and opportunities

• Translate data into actionable insights that inform study and program decisions

• Partner with safety and medical teams on signal detection and escalation

Lead Cross-Functional Execution

• Lead cross-functional study teams and coordinate execution across functions

• Collaborate with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory

• Influence decisions and align stakeholders across competing priorities

• Represent Clinical Science in internal and external forums (e.g., investigators, KOLs)

Drive Study Performance & Program Value

• Oversee enrollment, site performance, and key study metrics across studies

• Identify risks and proactively adjust study-level strategies

• Prioritize activities across studies to ensure quality, timelines, and program impact

• Contribute to forecasting, planning, and milestone delivery

Advance Scientific Communication

• Lead development of abstracts, presentations, and manuscripts

• Translate clinical and statistical results into clear scientific narratives

• Support internal decision-making and external evidence generation

Required Qualifications

• Advanced degree (PhD, PharmD, MD, or equivalent; MS/RN with experience considered)

• 8–12 years of experience in clinical research, clinical science, or related field

• Strong experience leading clinical studies and contributing to study design

• Experience with clinical data review and interpretation

Preferred Qualifications

• Experience in oncology, diagnostics, or early cancer detection

• Experience working across multiple studies or programs

• Track record of scientific publications and conference presentations

Key Competencies

• Ability to lead complex clinical studies or multiple workstreams independently

• Strong analytical skills with ability to synthesize complex data into decisions

• Effective influencer across functions and senior stakeholders

• Strong ownership mindset with ability to prioritize across competing demands

• Excellent scientific communication skills

• Ability to operate effectively in a fast-paced, ambiguous environment

We are seeking an Associate Director of Real-World Evidence & Observational Research to drive the execution of real-world evidence initiatives for our early cancer detection portfolio. This role is central to generating the evidence needed to support product adoption, inform clinical use, and demonstrate value to physicians and payers.

As a seasoned clinical research professional, you will contribute to both the strategy and execution of observational research across a defined product area. You will serve as the internal subject matter expert for RWE methodologies and execution—partnering across Clinical Science, Medical Affairs, Product, and Market Access to translate key questions into actionable evidence.

This is a highly cross-functional, hands-on role requiring strong scientific judgment, operational ownership, and the ability to balance rigor, speed, and business impact.

PRIMARY RESPONSIBILITIES

Lead Real-World Evidence Strategy & Execution

• Lead the design and execution of real-world evidence studies, including retrospective database analyses and prospective observational studies

• Contribute to clinical evidence strategy for a defined product area, identifying where RWE can address key evidence gaps

• Translate clinical, scientific, and business questions into robust, decision-oriented study designs

• Proactively identify risks to study execution and implement mitigation strategies

• Lead to protocol development, including objectives/endpoints, eligibility criteria, data collection approaches, and analysis plans

• Partner with biostatistics and data science to ensure high-quality data analysis, interpretation, and reporting

• Drive medical data review, interpretation, and synthesis of findings

Turn Evidence into Decisions

• Deliver clear, actionable insights that inform product strategy, clinical positioning, and market access

• Evaluate real-world product performance and identify opportunities to improve adoption, utilization, and outcomes

• Partner with Product and Medical Affairs to ensure real-world insights are fed back into product development

Shape and Prioritize Evidence Generation

• Contribute to evidence planning by identifying where RWE can most effectively address key gaps

• Support prioritization of studies based on business impact, feasibility, and timing

• Ensure alignment between RWE, clinical studies, and broader evidence generation efforts

Enable External Impact

• Support development of publications, abstracts, and presentations to communicate evidence externally

• Partner with Medical Affairs and Market Access to translate evidence into compelling narratives for clinicians, KOLs, and payers

Required Qualifications

• Advanced degree (PhD, MPH, MS, PharmD, or equivalent) in epidemiology, health outcomes research, biostatistics, or related field

• 7–10+ years of experience in real-world evidence, observational research, or HEOR, ideally in industry

• Demonstrated experience leading the design and execution of observational studies across the full lifecycle (protocol through analysis and dissemination)

• Strong understanding of real-world data sources (claims, EHR, registries) and their application to clinical and business questions

Preferred Qualifications

• Experience in early cancer detection

• HEOR experience

• Experience working cross-functionally with product, medical, and commercial teams

• Track record of translating analyses into business-relevant insights (not just publications)

Key Competencies

• Strong scientific and operational judgment across the full clinical evidence lifecycle

• Ability to independently lead complex projects with limited oversight

• Skilled at balancing scientific rigor, speed, and resource constraints

• Effective at influencing cross-functional stakeholders and navigating ambiguity

• Clear and compelling communicator across technical and non-technical audiences

POSITION SUMMARY: 

The Senior Clinical Scientist, Oncology will leverage their scientific and medical expertise in oncology to lead and execute clinical development activities for one or more assigned studies in molecular residual disease monitoring. Acting as a key leader on study teams and departmental initiatives, they will drive the development of clinical strategy, incorporating insights from the competitive landscape and aligning with the broader company vision to advance innovative solutions in oncology.

PRIMARY RESPONSIBILITIES: 

• Develop study concepts, including overall study design, schedule of assessments, objectives / endpoints, and eligibility criteria. Integrate feedback from internal and external stakeholders including senior leadership, key investigators, internal stakeholders, and regulatory agencies
• Contribute to authoring of the study protocol and provide critical feedback and review of supporting documents; help to respond to health authority feedback
• Provide protocol trainings to internal and CRO teams
• Work with the Clinical Operations team to contribute to the design of study-specific case report form (CRF), ensure CRFs are aligned with study requirements during user acceptance testing, and author study-specific sections of the CRF completion guidelines
• Ensure study manuals, etc. are aligned with the study protocol
• Seek input from key investigators on study design and methodology to ensure alignment with research objectives, and actively participate in pre-site selection discussions, site initiation visits, and investigator meetings to support successful study execution
• Serve as clinical science representative on internal and external meetings
• Contribute to and oversee real-time clinical data reviews (including oversight of CROs when applicable)
• Support advisory boards, steering committee meetings, consultant meetings and investigator meetings, including preparation and delivery of presentations
• Engage Natera medical directors, medical science liaisons for clinical projects, abstract writing and content creation
• Deliver presentations/posters at scientific meetings and company promotional events as needed; represent company at trade shows and medical conferences (<10% travel)
• This role works with PHI on a regular basis both in paper and electronic form and has access to various technologies to access PHI (paper and electronic) in order to perform the job.
• Employee must complete training relating to HIPAA/PHI privacy, General Policies and Procedure Compliance training and security training as soon as possible but not later than the first 30 days of hire
• Must maintain a current status on Natera training requirements
• Performs other duties as assigned

QUALIFICATIONS: 

• PhD/RN/MS 
• At least 5-8 years experience as a Clinical Scientist preferred with preference given to oncology clinical strategy and execution
• Experience with randomized controlled trials preferred
• Experience with project management, clinical research and scientific writing
• Periodic travel (~15-20; includes overnight domestic and international travel to study sites, conferences, and meetings)

KNOWLEDGE, SKILLS, AND ABILITIES: 

• Demonstrated ability to identify problems and develop right-sized solutions 
• Fast learner who can develop in-depth technical understanding of Natera’s products 
• Exceptional communication skills (oral and written) and attention to detail 
• Demonstrated ability to work independently AND collaborate with team members
• Analytical thinker
• Motivated to be creative and brainstorm innovative solutions 
• Familiarity with Google and Microsoft suite of work products 
• A desire to work for a dynamic molecular diagnostic laboratory and manage growth for optimal success 

POSITION SUMMARY:

As a market leader in cfDNA-based diagnostics, we are expanding our Early Cancer Detection (ECD) portfolio to deliver transformative clinical impact at scale. The Senior Director, ECD Product Strategy & Lifecycle will lead the strategy, development, and lifecycle management of a portfolio of ECD products, from concept through launch, growth, and optimization.

This role is accountable for defining product vision and strategy, translating unmet clinical and customer needs into differentiated products, and driving execution through strong cross-functional leadership. The Senior Director will build and manage a high-performing product management team and partner closely with R&D, clinical, regulatory, commercial, medical affairs, and operations to ensure successful delivery of business and patient outcomes.

POSITION LOCATION:

This position can be out of our San Carlos, CA office or Remote, USA. 

PRIMARY RESPONSIBILITIES: 

Product Strategy & Portfolio Leadership

• Own the product vision, strategy, and roadmap for the Early Cancer Detection portfolio, aligned with corporate strategy and long-term growth objectives
• Lead annual and multi-year strategic planning for ECD products, including investment prioritization, sequencing, and resource allocation
• Identify, size, and segment new market opportunities using top-down and bottom-up analyses, incorporating clinical, commercial, and customer insights
• Define clear value propositions and differentiation strategies based on competitive intelligence, customer needs, and evolving standards of care

Product Lifecycle Management

• Lead products across the full lifecycle, from concept and feasibility through development, launch, post-launch optimization, and eventual sunset
• Drive definition of product requirements, success metrics, and launch readiness in partnership with cross-functional teams
• Guide trade-off decisions across performance, features, timelines, and investment, particularly in technically complex genomic and algorithm-driven products

Customer & Market Insights

• Lead qualitative and quantitative customer research with clinicians, health systems, payers, partners, and internal stakeholders
• Translate insights into clear product requirements, roadmap decisions, and business cases
• Monitor competitive landscape, emerging technologies, and regulatory or reimbursement changes impacting early cancer detection

Financial & Business Planning

• Build and oversee robust business cases, including revenue forecasts, unit economics, ROI, and NPV analyses for new and existing products
• Pressure-test assumptions, evaluate sensitivities, and make data-driven investment recommendations
• Partner with finance and commercial leadership to align product strategy with financial objectives

People & Cross-Functional Leadership

• Lead, and develop a team of Product Managers supporting innovation and lifecycle initiatives within Early Cancer Detection
• Establish and scale product management best practices, processes, and metrics
• Act as a senior product leader and influencer across R&D, clinical, regulatory, medical affairs, commercial, and executive leadership
• Clearly communicate product vision, strategy, and priorities to align stakeholders and inspire teams

QUALIFICATIONS: 

• Bachelor’s degree required; advanced degree (PhD, MD, or MBA) strongly preferred
• 10+ years of experience in product management, product strategy, consulting, or related roles within diagnostics, biotechnology, medical devices, or health technology
• Prior experience with early cancer detection products strongly preferred
• Demonstrated experience managing products across the full lifecycle, including successful product launches
• Proven people leadership experience, including hiring, coaching, and developing product managers
• Experience developing regulated clinical products and working closely with clinical trials and regulatory pathways

KNOWLEDGE, SKILLS, AND ABILITIES: 

• Strategic, analytical thinker with the ability to translate complex data into clear product and business decisions
• Strong market research capabilities, including customer interviews and quantitative analysis
• Comfortable diving deep into technical, algorithmic, and molecular concepts and translating them into customer-facing product features
• Hands-on financial modeling and business case development expertise
• Exceptional cross-functional leadership, communication, and influence skills
• Entrepreneurial mindset with a bias toward action, accountability, and results