The Team

The Diagnostics team develops next-generation sensing technologies for real-time molecular monitoring in living systems. We bring together engineers, chemists, biologists, and translational scientists to create wearable and implantable platforms that enable high-impact applications in healthcare, therapeutics, and disease monitoring.

The Opportunity

We are seeking a Senior Mechanical Engineer to lead the design and development of miniaturized sensing systems for wearable and implantable medical devices. This person will play a critical role in translating early-stage prototypes into robust, manufacturable products by driving the mechanical design of housings, connectors, enclosures, microdevice assemblies, and packaging solutions.

This is a highly cross-functional role that sits at the intersection of engineering, biology, materials science, and product development. The engineer will work closely with scientists and external manufacturing partners to develop compact, high-performance sensing systems that can operate reliably in demanding biological environments.

What You'll Do

• Lead the mechanical design and development of wearable, implantable, and miniaturized sensing platforms for biomedical applications
• Design and prototype components, connectors, enclosures, fixtures, and packaging solutions for sensor systems and associated electronics
• Work closely with multidisciplinary teams to integrate mechanical, electrical, biological, and materials requirements into a manufacturable product
• Collaborate with external vendors and manufacturing partners to source, fabricate, and refine high-precision components and assemblies
• Conduct prototyping, testing, failure analysis, and design optimization to improve reliability, manufacturability, and long-term device performance

What You'll Bring

• PhD in Mechanical Engineering, Biomedical Engineering, Materials Engineering, or a related discipline
• At minimum 2+ years of professional experience 
• Strong industrial experience in medical device development, preferably involving wearable devices, implantable systems, or miniaturized sensing technologies
• Expertise in CAD tools such as SolidWorks, Creo, or Fusion 360 and experience designing precision mechanical systems
• Experience with medical-grade materials, hydrogels, soft materials, connectors, packaging, and biocompatible assemblies
• Strong communication skills and experience working with external vendors, contract manufacturers, and multidisciplinary technical teams

Compensation

The Chicago, IL base pay range for a new hire in this role is $130,000 - $137,700. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.

This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.

Better Together

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a onsite position requiring you to be in office approximately 5 days a week. 

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

#LI-Onsite

The Team

The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

Biohub Chicago seeks outstanding early-career experimental scientists with expertise in high-throughput profiling and quantitative biology to join as a Postdoctoral Research Scholar working on single-cell genomics problems in the inflammation space. We welcome candidates from diverse experimental backgrounds—whether rooted in sequencing, imaging, bioengineering, or other modalities—who bring rigorous quantitative thinking and a drive to tackle complex biological questions. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, bioengineering, and disease-focused discovery.

Postdoctoral Research Scholars will be embedded in interdisciplinary teams applying and developing high-throughput single-cell genomics approaches to understand inflammatory disease mechanisms. The successful candidate will design and execute quantitative experiments—using sequencing, imaging, bioengineering, or complementary profiling technologies—to dissect cellular heterogeneity, immune cell states, and tissue-level responses in complex biological systems. This role emphasizes both experimental rigor and computational fluency in the analysis of large-scale, high-dimensional datasets.

This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub's mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond.

What You'll Do

• Design and execute quantitative, high-throughput experiments linking perturbations to the function of immune and inflammatory systems.
• Develop, optimize, and apply perturbation readout workflows—including sequencing-based, imaging-based, or multimodal approaches—with rigorous method development, benchmarking, and quality control.
• Collaborate closely with interdisciplinary teams spanning immunology, genomics, computation, and bioengineering to address open questions in inflammation biology.
• Analyze and interpret large-scale, high-dimensional datasets using computational and statistical approaches, and communicate results clearly through figures, presentations, and internal discussions.
• Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science.
  

What You'll Bring

• PhD in genomics, bioengineering, quantitative biology, systems immunology, computational biology, or a related quantitative life-science field.
• Hands-on experience with core wet-lab molecular and cellular biology techniques, as well as high-throughput profiling methods.
• Demonstrated experience in quantitative molecular and cellular biology techniques and high-throughput profiling approaches.
• Demonstrated expertise in quantitative interpretation of complex, high-dimensional datasets.
• Strong record of scientific productivity, creativity, and collaborative problem-solving in interdisciplinary research environments.
• Motivation to pursue innovative, independent research aligned with the Biohub’s mission and to thrive in a hands-on, team-science culture.
• [Nice to have] Experience with high-throughput profiling platforms (e.g., single-cell RNA-seq, spatial transcriptomics, multiplexed imaging, flow/mass cytometry, or proteomics
• [Nice to have] Experience working with primary human cells.
• [Nice to have] Experience with technology or assay development, molecular barcoding, novel nucleic acid technologies, or quantitative imaging methods.
• [Nice to have] Background in immunology, inflammation biology, or related disease areas.

Compensation

The Chicago, IL base pay range for a new hire in this role is $71,000-$84,150. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.

Better Together

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a onsite position requiring you to be in office for 100% of the working month, approximately 5 days a week. 

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

#LI-Onsite

The Team

The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

Biohub Chicago seeks outstanding early-career scientists and engineers to join its Quantitative Live Tissue Transcriptomics platform as a Postdoctoral Research Scholar in longitudinal and single-cell profiling. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, biology, and disease-focused discovery.

Postdoctoral Research Scholars will be embedded in interdisciplinary teams developing and applying next-generation transcriptomic workflows for non-destructive, time-resolved measurements from living cells and tissues. A central focus of this role is understanding how dynamic gene expression and cell-to-cell transcriptional heterogeneity shape the behavior of immune-competent organoid and ex vivo systems. The successful candidate will leverage emerging live-sampling technologies to interrogate cellular dynamics, immune–tissue interactions, and emergent phenotypes that are inaccessible with static, endpoint approaches.

This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub's mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond.

What You'll Do

• Design and execute longitudinal transcriptomics experiments to investigate dynamic gene expression and transcriptional heterogeneity in immune-competent organoid systems.
• Develop, optimize, and apply advanced RNA profiling workflows for non-destructive, time-resolved sampling from living cells and tissues, including method development, benchmarking, and quality control.
• Collaborate closely with interdisciplinary teams spanning tissue engineering, immunology, computation, and instrumentation to build and interrogate increasingly complex immune-organoid models.
• Analyze and interpret large-scale transcriptomics and lineage barcoding datasets using state-of-the-art computational pipelines, and communicate results clearly through figures, presentations, and internal discussions.
• Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science.

What You'll Bring

• PhD in genomics, bioengineering, quantitative biology, systems immunology, computational biology, or a related quantitative life-science field.
• Experience with quantitative molecular and cell biology techniques and high-throughput profiling.
• Demonstrated expertise in quantitative interpretation of complex, high-dimensional datasets.
• Strong record of scientific productivity, creativity, and collaborative problem-solving in interdisciplinary research environments.
• Motivation to pursue innovative, independent research aligned with the Biohub’s mission and to thrive in a hands-on, team-science culture.
• [Nice to have] Experience with sequencing platforms and transcriptomics workflows (e.g., RNA-seq, single-cell RNA-seq, or spatial transcriptomics).
• [Nice to have] Experience with RNA engineering, molecular barcoding, or novel nucleic acid technologies.
• [Nice to have] Background in immune cell biology, immune–tissue interactions, or organoid model systems.

Compensation

The Chicago, IL base pay for a new hire in this role is $84,150. This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.

Better Together

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

 #LI-Onsite

The Team

The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.

Our Vision

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

Biohub Chicago seeks outstanding early-career experimental scientists with expertise in high-throughput profiling and quantitative biology to join as a Postdoctoral Research Scholar working on single-cell genomics problems in the inflammation space. We welcome candidates from diverse experimental backgrounds—whether rooted in sequencing, imaging, bioengineering, or other modalities—who bring rigorous quantitative thinking and a drive to tackle complex biological questions. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, bioengineering, and disease-focused discovery.

Postdoctoral Research Scholars will be embedded in interdisciplinary teams applying and developing high-throughput single-cell genomics approaches to understand inflammatory disease mechanisms. The successful candidate will design and execute quantitative experiments—using sequencing, imaging, bioengineering, or complementary profiling technologies—to dissect cellular heterogeneity, immune cell states, and tissue-level responses in complex biological systems. This role emphasizes both experimental rigor and computational fluency in the analysis of large-scale, high-dimensional datasets.

This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub's mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond.

What You'll Do

• Design and execute quantitative, high-throughput experiments to investigate cellular heterogeneity and gene expression dynamics in immune and inflammatory systems.
• Develop, optimize, and apply single-cell profiling workflows—including sequencing-based, imaging-based, or multimodal approaches—with rigorous method development, benchmarking, and quality control.
• Collaborate closely with interdisciplinary teams spanning immunology, genomics, computation, and bioengineering to address open questions in inflammation biology.
• Analyze and interpret large-scale, high-dimensional datasets using computational and statistical approaches, and communicate results clearly through figures, presentations, and internal discussions.
• Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science.

What You'll Bring

• PhD in genomics, bioengineering, quantitative biology, systems immunology, computational biology, or a related quantitative life-science field.
• Experience with quantitative molecular and cell biology techniques and high-throughput profiling. 
• Demonstrated expertise in quantitative interpretation of complex, high-dimensional datasets.
• Strong record of scientific productivity, creativity, and collaborative problem-solving in interdisciplinary research environments.
• Motivation to pursue innovative, independent research aligned with the Biohub’s mission and to thrive in a hands-on, team-science culture.
• [Nice to have] Experience with high-throughput profiling platforms (e.g., single-cell RNA-seq, spatial transcriptomics, multiplexed imaging, flow/mass cytometry, or proteomics).
• [Nice to have] Experience with technology or assay development, molecular barcoding, novel nucleic acid technologies, or quantitative imaging methods.
• [Nice to have] Background in immunology, inflammation biology, or related disease areas.

Compensation

The Chicago, IL base pay for a new hire in this role is $84,150. This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.

Better Together

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

#LI-Onsite

Who Are We?

Prolaio believes that continuous learning and collaboration can make a significant difference in how heart care is administered. We are creating smarter ways to address heart disease and heart risks by uniting patients, care teams, and researchers on a secure, technology-enabled platform that drives clinical innovation and offers a path towards better patient outcomes.

This is precision cardiology, and we know it’s within reach.

What Will You Do?

The Overview

As a Data Science Intern on the Biomarkers Team, you will develop and validate advanced machine learning pipelines focused on long term time series analysis. Your primary objective is to leverage Foundational Time Series Models and Transfer Learning - such as adapting models from cardiac arrhythmia ECG detection to extract novel physiological insights from wearable and clinical sensor data. This role is essential for advancing our understanding of patient health by translating raw signal data into validated digital biomarkers.

The Specifics

• Model Development & Transfer Learning: Test existing and fine-tune deep learning architectures for time series data, specifically utilizing transfer learning techniques to adapt pre-trained ECG-based cardiac models for new physiological signal tasks.
• Signal Processing Pipeline: Build and optimize Python-based signal processing workflows to handle noisy, real-world sensor data, including filtering, feature extraction, and artifact removal.
• Foundational Model Implementation: Research and implement emerging foundational time series models to evaluate their zero-shot or few-shot performance on proprietary longitudinal cardiac datasets.
• Validation & Benchmarking: Design rigorous validation frameworks comparing model outputs against a clinician-verified "ground truth" to establish metrics like Mean Absolute Error (MAE) and Intraclass Correlation (ICC).
• Codebase Delivery: Maintain a clean, documented, and reproducible code repository that transforms raw high-frequency signals into structured, analysis-ready biomarker datasets.

Why Prolaio?

• Impactful Work: You will join in the fight against heart failure (HF) and hypertrophic cardiomyopathy (HCM) with the goal of extending and saving the lives of our patients while also being at the forefront of changing the healthcare industry through technology.
• Innovative Environment: You will be part of an organization doing something that’s never been done before.
• Professional Growth: You will join a growing team and have a substantial impact on our daily and future operations with the opportunity to continuously learn and grow.
• Collaborative Team: You will be part of a team of collaborative, curious, and committed individuals focused on the collective good, inclusiveness, scientific excellence, and advancing digital health for cardiology.

Who You Are?

• Academic Background: Currently enrolled in a Master’s or PhD program in Data Science, Electrical Engineering, Biomedical Engineering, Computer Science, or a related quantitative field.
• Technical Proficiency: Strong proficiency in Python and deep learning frameworks (e.g., PyTorch or TensorFlow) with a specific focus on time series or signal data.
• Signal Processing Expertise: Familiarity with digital signal processing (DSP) techniques, such as Fourier transforms, wavelet analysis, and windowing methods for physiological data.
• Machine Learning Knowledge: Solid understanding of modern ML architectures (CNNs, RNNs, Transformers) and experience with Transfer Learning or fine-tuning large-scale models.
• Data Handling: Experience working with real-world sensor data, handling irregular sampling rates, and managing large-scale longitudinal datasets.

Compensation: The expected hourly rate for this internship is $50/hour.

**At this time, relocation and housing stipends are not offered for this internship.**