Biohub
Pick a job to read the details
Tap any role on the left — its description and apply link will open here.
R&D Engineer, Laboratory Automation & Robotics
Share this job
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.
Our Vision
- We pursue large scientific challenges that cannot be pursued in conventional environments
- We enable individual investigators to pursue their riskiest and most innovative ideas
- The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond
Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.
The Opportunity
We are seeking an R&D Engineer to support the deployment, operation, and continuous improvement of an advanced automated laboratory platform. This role is responsible for ensuring reliable execution of complex workflows through the integration of robotics, instrumentation, and control systems.
You will play a key role in building and maintaining the infrastructure that enables scalable and efficient experimental operations.
What You'll Do
- Develop scalable, modular automation architectures to support evolving experimental needs across multiple hardware platforms
- Partner with computational teams to enable closed-loop / data-driven experimentation
- Evaluate and support installation, configuration, and integration of laboratory automation systems and instrumentation
- Optimize high-throughput experimental pipelines
- Program and coordinate robotic systems and instrument control software
- Perform routine maintenance, calibration, and validation of equipment
- Implement real-time monitoring and logging systems for workflow performance and data quality
- Monitor system reliability and implement improvements to increase efficiency and uptime
- Troubleshoot hardware and workflow issues to ensure consistent system performance
- Collaborate with scientific teams to translate experimental needs into automated processes
- Provide technical support and training to users of the platform
What You'll Bring
- BS or MS in Mechanical Engineering, Electrical Engineering, Bioengineering, Robotics, or a related field
- Hands-on experience with laboratory automation systems, robotics, or complex instrumentation
- Experience with hardware integration and control systems
- Programming or scripting experience (e.g., Python or vendor-specific platforms)
- Strong troubleshooting skills and attention to detail
- Ability to manage and maintain complex systems in a dynamic environment
- Effective communication skills and a collaborative mindset
- Strong problem-solving skills and a systems-level mindset
- Interest in data-driven experimentation and automated platforms
Compensation
The Chicago, IL base pay range for a new hire in this role is $130,000 - $138,550. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a onsite position requiring you to be onsite for at least 100% of the working month, approximately 5 days a week.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Onsite
Ready to apply?
Apply to Biohub
Senior Mechanical Engineer, Miniaturized Sensing Platforms
Share this job
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Diagnostics team develops next-generation sensing technologies for real-time molecular monitoring in living systems. We bring together engineers, chemists, biologists, and translational scientists to create wearable and implantable platforms that enable high-impact applications in healthcare, therapeutics, and disease monitoring.
The Opportunity
We are seeking a Senior Mechanical Engineer to lead the design and development of miniaturized sensing systems for wearable and implantable medical devices. This person will play a critical role in translating early-stage prototypes into robust, manufacturable products by driving the mechanical design of housings, connectors, enclosures, microdevice assemblies, and packaging solutions.
This is a highly cross-functional role that sits at the intersection of engineering, biology, materials science, and product development. The engineer will work closely with scientists and external manufacturing partners to develop compact, high-performance sensing systems that can operate reliably in demanding biological environments.
What You'll Do
- Lead the mechanical design and development of wearable, implantable, and miniaturized sensing platforms for biomedical applications
- Design and prototype components, connectors, enclosures, fixtures, and packaging solutions for sensor systems and associated electronics
- Work closely with multidisciplinary teams to integrate mechanical, electrical, biological, and materials requirements into a manufacturable product
- Collaborate with external vendors and manufacturing partners to source, fabricate, and refine high-precision components and assemblies
- Conduct prototyping, testing, failure analysis, and design optimization to improve reliability, manufacturability, and long-term device performance
What You'll Bring
- PhD in Mechanical Engineering, Biomedical Engineering, Materials Engineering, or a related discipline
- At minimum 2+ years of professional experience
- Strong industrial experience in medical device development, preferably involving wearable devices, implantable systems, or miniaturized sensing technologies
- Expertise in CAD tools such as SolidWorks, Creo, or Fusion 360 and experience designing precision mechanical systems
- Experience with medical-grade materials, hydrogels, soft materials, connectors, packaging, and biocompatible assemblies
- Strong communication skills and experience working with external vendors, contract manufacturers, and multidisciplinary technical teams
Compensation
The Chicago, IL base pay range for a new hire in this role is $130,000 - $137,700. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a onsite position requiring you to be in office approximately 5 days a week.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Onsite
Ready to apply?
Apply to Biohub
Post-Doctoral Fellow, High-Throughput Functional Genomics
Share this job
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.
Our Vision
- We pursue large scientific challenges that cannot be pursued in conventional environments
- We enable individual investigators to pursue their riskiest and most innovative ideas
- The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond
Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.
The Opportunity
Biohub Chicago seeks outstanding early-career experimental scientists with expertise in high-throughput profiling and quantitative biology to join as a Postdoctoral Research Scholar working on single-cell genomics problems in the inflammation space. We welcome candidates from diverse experimental backgrounds—whether rooted in sequencing, imaging, bioengineering, or other modalities—who bring rigorous quantitative thinking and a drive to tackle complex biological questions. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, bioengineering, and disease-focused discovery.
Postdoctoral Research Scholars will be embedded in interdisciplinary teams applying and developing high-throughput single-cell genomics approaches to understand inflammatory disease mechanisms. The successful candidate will design and execute quantitative experiments—using sequencing, imaging, bioengineering, or complementary profiling technologies—to dissect cellular heterogeneity, immune cell states, and tissue-level responses in complex biological systems. This role emphasizes both experimental rigor and computational fluency in the analysis of large-scale, high-dimensional datasets.
This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub's mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond.
What You'll Do
- Design and execute quantitative, high-throughput experiments linking perturbations to the function of immune and inflammatory systems.
- Develop, optimize, and apply perturbation readout workflows—including sequencing-based, imaging-based, or multimodal approaches—with rigorous method development, benchmarking, and quality control.
- Collaborate closely with interdisciplinary teams spanning immunology, genomics, computation, and bioengineering to address open questions in inflammation biology.
- Analyze and interpret large-scale, high-dimensional datasets using computational and statistical approaches, and communicate results clearly through figures, presentations, and internal discussions.
- Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science.
What You'll Bring
- PhD in genomics, bioengineering, quantitative biology, systems immunology, computational biology, or a related quantitative life-science field.
- Hands-on experience with core wet-lab molecular and cellular biology techniques, as well as high-throughput profiling methods.
- Demonstrated experience in quantitative molecular and cellular biology techniques and high-throughput profiling approaches.
- Demonstrated expertise in quantitative interpretation of complex, high-dimensional datasets.
- Strong record of scientific productivity, creativity, and collaborative problem-solving in interdisciplinary research environments.
- Motivation to pursue innovative, independent research aligned with the Biohub’s mission and to thrive in a hands-on, team-science culture.
- [Nice to have] Experience with high-throughput profiling platforms (e.g., single-cell RNA-seq, spatial transcriptomics, multiplexed imaging, flow/mass cytometry, or proteomics
- [Nice to have] Experience working with primary human cells.
- [Nice to have] Experience with technology or assay development, molecular barcoding, novel nucleic acid technologies, or quantitative imaging methods.
- [Nice to have] Background in immunology, inflammation biology, or related disease areas.
Compensation
The Chicago, IL base pay range for a new hire in this role is $71,000-$84,150. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a onsite position requiring you to be in office for 100% of the working month, approximately 5 days a week.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Onsite
Ready to apply?
Apply to Biohub
Research Associate, NGS Assay Development, Virtual Immune System
Share this job
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
Our decoding inflammation team builds tools to enable precise molecular-level measurements of inflammation within human tissues in real time, and develop proactive, early interventions that can be deployed when inflammation — which underlies the most significant causes of death worldwide — first flares in the body. You can learn more about our work here.
Our team collaborates with three powerhouse universities - Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign - to develop first-in-class technologies and make breakthroughs.
Our Vision
- Pursue large scientific challenges that cannot be pursued in conventional environments
- Enable individual investigators to pursue their riskiest and most innovative ideas
- Facilitate research by scientists and clinicians at our home institutions and beyond
We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.
The Opportunity
Biohub is seeking a Research Associate to join the Cell Decoder team within the Virtual Immune System initiative. This is a hands-on bench role centered on molecular biology, cell engineering, and genomics workflows, including bacterial and mammalian cell culture, plasmid cloning, lentiviral production, library preparation, and flow cytometry. You'll execute and optimize experiments that feed directly into a screening platform designed to map immune antigens in inflammation.
This position is ideal for someone who thrives on bench work, takes pride in reliable execution, and actively looks for ways to make things run better. That could mean optimizing a viral production protocol, reorganizing a reagent inventory system, or finding a more efficient way to coordinate a multi-day, multi-step experiment. You won't just follow protocols; you'll help build and refine them. You'll join a small, experienced team with direct mentorship and exposure to how AI/ML and computational approaches are shaping experimental immunology.
What You'll Do
- Perform molecular biology workflows including bacterial culture, plasmid cloning, mini/midi preps, and construct verification to generate reagents for cell engineering experiments.
- Maintain mammalian cell lines (Jurkat, 293T, K562) including passaging, selection, and banking — serving as a reliable backbone for ongoing assay development.
- Produce and package lentiviral vectors, troubleshoot viral production workflows, and execute transduction experiments.
- Execute single-cell genomics and sequencing workflows, including 10x Genomics library preparation and next-generation sequencing library QC.
- Perform flow cytometry experiments for immune cell phenotyping and functional assays.
- Design, optimize, and troubleshoot experimental protocols and SOPs, proactively identifying bottlenecks and opportunities to improve throughput, reliability, or efficiency.
- Maintain rigorous documentation of protocols, experimental conditions, results, and reagent inventory and take ownership of lab operations logistics including ordering and cataloging.
What You'll Bring
- Master's degree in biology, immunology, molecular biology, or a related field with 2-4 years of hands-on research experience, or a Bachelor's with equivalent additional experience.
- Proficiency in core molecular biology and cell engineering workflows, including bacterial culture, plasmid cloning, mammalian cell line maintenance, and lentiviral production, with the ability to troubleshoot
- Experience with flow cytometry, including sample preparation and instrument operation.
- Strong organizational skills and attention to detail across multi-step, multi-day experimental workflows — including documentation, reagent management, and coordination.
- A proactive, ownership-oriented approach — you identify bottlenecks, propose solutions, and communicate clearly in a collaborative, cross-functional environment.
- Nice to have:
- Experience with next-generation sequencing library preparation or single-cell genomics platforms (particularly 10x Genomics).
- Familiarity with T cell biology, TCR biology, or high-throughput screening assays.
- Basic programming skills (Python and/or R) for data processing and QC.
Compensation
The Chicago, IL base pay range for a new hire in this role is $70,000 - $73,950. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a onsite position requiring you to be onsite for at least 100% of the working month, approximately 5 days a week.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Onsite
Ready to apply?
Apply to Biohub
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
Our decoding inflammation team builds tools to enable precise molecular-level measurements of inflammation within human tissues in real time, and develop proactive, early interventions that can be deployed when inflammation — which underlies the most significant causes of death worldwide — first flares in the body. You can learn more about our work here.
Our team collaborates with three powerhouse universities - Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign - to develop first-in-class technologies and make breakthroughs.
Our Vision
- Pursue large scientific challenges that cannot be pursued in conventional environments
- Enable individual investigators to pursue their riskiest and most innovative ideas
- Facilitate research by scientists and clinicians at our home institutions and beyond
We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.
The Opportunity
Biohub seeks a Director of Engineering to build, scale, and automate next-generation molecular measurement technologies. This role will lead the design and deployment of integrated automation systems that enable high-throughput, high-content, and reproducible experimentation across functional genomics, multi-omics profiling, and advanced cellular systems, including organoids and complex co-culture models.
The Director of Engineering will translate cutting-edge biological objectives into robust, scalable, and automated laboratory infrastructure. The ideal candidate brings deep industry experience building and operating life science technology platforms, particularly in proteomics, functional genomics, transcriptomics, imaging-based assays, and/or organoid systems—combined with strong expertise in robotics, automation engineering, and instrument integration.
This leader will architect platforms that move beyond commoditized automation toward flexible, adaptive systems capable of executing complex biological protocols at scale, with tight integration between experimental workflows, data systems, and computational analysis pipelines.
What You'll Do
Automation, Robotics, Instrumentation
- Lead the development and integration of advanced robotic systems for liquid handling, organoid handling, environmental control, and assay execution.
- Oversee integration of molecular measurement technologies (e.g., spatial omics, proteomics, high-content imaging) directly into automated pipelines.
- Develop custom hardware, fixtures, and accessories where commercial solutions are insufficient.
- Ensure seamless integration between robotic systems, LIMS, data pipelines, and downstream analysis infrastructure.
Industry & Ecosystem Leadership
- Leverage deep industry knowledge to evaluate and implement best-in-class
- commercial instrumentation, robotics platforms, and automation software.
- Build and manage strategic relationships with automation vendors, instrument
- manufacturers, and contract engineering partners.
- Conduct rigorous technical diligence of vendors and outsourced development
- partners.
- Define clear technical specifications, milestones, and quality standards for
- external contributors.
- Identify opportunities to translate internally developed platform innovations into
- Broader partnerships or collaborative networks.
Team Building & Organizational Development
- Build and lead an interdisciplinary team of automation engineers, robotics engineers, platform scientists, and systems integration specialists.
- Recruit individuals with deep technical rigor and strong understanding of biological systems.
- Establish engineering best practices in documentation, validation, uptime management, and quality control.
- Foster a culture that blends industrial engineering discipline with scientific innovation.
- Develop and manage a blended team structure that includes internal staff and external partners.
What You'll Bring
Essential -
- Ph.D. or M.S. in Bioengineering, Mechanical Engineering, Robotics, Chemical Engineering, or related field; or equivalent industry experience.
- 10+ years of experience building and operating life science technology platforms in industry (biotech, pharma, or advanced technology companies).
- Demonstrated leadership in functional genomics, multi-omics platforms, or organoid-based systems.
- Deep expertise in laboratory automation, robotics, and systems integration.
- Proven experience deploying scalable, production-grade biological platforms.
- Strong track record of vendor management, outsourced engineering oversight, and technical diligence.
- Experience integrating automation systems with laboratory information systems and data pipelines.
- Demonstrated ability to recruit, mentor, and lead high-performing multidisciplinary teams.
Preferred -
- Experience scaling CRISPR screening platforms or large-scale screening systems.
- Background in organoid automation or complex tissue models.
- Experience integrating imaging-based phenotypic screening with molecular profiling.
- Experience building platforms designed for ML-ready or model-driven experimental workflows.
- Experience deploying multi-site or distributed automation platforms.
- Familiarity with regulatory, quality, and compliance considerations in industrial biotech environments.
- Direct experience with AI-guided experimental design or model-in-the-loop workflows.
Compensation
The Chicago, IL base pay range for a new hire in this role is $230,000 - $287,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Onsite
Ready to apply?
Apply to Biohub
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.
Our Vision
- We pursue large scientific challenges that cannot be pursued in conventional environments
- We enable individual investigators to pursue their riskiest and most innovative ideas
- The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond
Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.
The Opportunity
Biohub Chicago seeks outstanding early-career scientists and engineers to join its Quantitative Live Tissue Transcriptomics platform as a Postdoctoral Research Scholar in longitudinal and single-cell profiling. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, biology, and disease-focused discovery.
Postdoctoral Research Scholars will be embedded in interdisciplinary teams developing and applying next-generation transcriptomic workflows for non-destructive, time-resolved measurements from living cells and tissues. A central focus of this role is understanding how dynamic gene expression and cell-to-cell transcriptional heterogeneity shape the behavior of immune-competent organoid and ex vivo systems. The successful candidate will leverage emerging live-sampling technologies to interrogate cellular dynamics, immune–tissue interactions, and emergent phenotypes that are inaccessible with static, endpoint approaches.
This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub's mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond.
What You'll Do
- Design and execute longitudinal transcriptomics experiments to investigate dynamic gene expression and transcriptional heterogeneity in immune-competent organoid systems.
- Develop, optimize, and apply advanced RNA profiling workflows for non-destructive, time-resolved sampling from living cells and tissues, including method development, benchmarking, and quality control.
- Collaborate closely with interdisciplinary teams spanning tissue engineering, immunology, computation, and instrumentation to build and interrogate increasingly complex immune-organoid models.
- Analyze and interpret large-scale transcriptomics and lineage barcoding datasets using state-of-the-art computational pipelines, and communicate results clearly through figures, presentations, and internal discussions.
- Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science.
What You'll Bring
- PhD in genomics, bioengineering, quantitative biology, systems immunology, computational biology, or a related quantitative life-science field.
- Experience with quantitative molecular and cell biology techniques and high-throughput profiling.
- Demonstrated expertise in quantitative interpretation of complex, high-dimensional datasets.
- Strong record of scientific productivity, creativity, and collaborative problem-solving in interdisciplinary research environments.
- Motivation to pursue innovative, independent research aligned with the Biohub’s mission and to thrive in a hands-on, team-science culture.
- [Nice to have] Experience with sequencing platforms and transcriptomics workflows (e.g., RNA-seq, single-cell RNA-seq, or spatial transcriptomics).
- [Nice to have] Experience with RNA engineering, molecular barcoding, or novel nucleic acid technologies.
- [Nice to have] Background in immune cell biology, immune–tissue interactions, or organoid model systems.
Compensation
The Chicago, IL base pay for a new hire in this role is $84,150. This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Onsite
Ready to apply?
Apply to Biohub
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.
Our Vision
- We pursue large scientific challenges that cannot be pursued in conventional environments
- We enable individual investigators to pursue their riskiest and most innovative ideas
- The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond
Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.
The Opportunity
Biohub Chicago seeks outstanding early-career experimental scientists with expertise in high-throughput profiling and quantitative biology to join as a Postdoctoral Research Scholar working on single-cell genomics problems in the inflammation space. We welcome candidates from diverse experimental backgrounds—whether rooted in sequencing, imaging, bioengineering, or other modalities—who bring rigorous quantitative thinking and a drive to tackle complex biological questions. This role offers a unique opportunity to work hands-on in a generously funded, highly collaborative environment at the intersection of technology development, bioengineering, and disease-focused discovery.
Postdoctoral Research Scholars will be embedded in interdisciplinary teams applying and developing high-throughput single-cell genomics approaches to understand inflammatory disease mechanisms. The successful candidate will design and execute quantitative experiments—using sequencing, imaging, bioengineering, or complementary profiling technologies—to dissect cellular heterogeneity, immune cell states, and tissue-level responses in complex biological systems. This role emphasizes both experimental rigor and computational fluency in the analysis of large-scale, high-dimensional datasets.
This position provides strong mentorship alongside meaningful scientific independence within a team-science model that emphasizes collaboration across experimental, computational, and engineering domains. Projects align with the Biohub's mission to uncover fundamental disease mechanisms and to develop transformative measurement technologies that accelerate biomedical research. Biohub Chicago is deeply committed to training scientists for impactful careers in academia, industry, and beyond.
What You'll Do
- Design and execute quantitative, high-throughput experiments to investigate cellular heterogeneity and gene expression dynamics in immune and inflammatory systems.
- Develop, optimize, and apply single-cell profiling workflows—including sequencing-based, imaging-based, or multimodal approaches—with rigorous method development, benchmarking, and quality control.
- Collaborate closely with interdisciplinary teams spanning immunology, genomics, computation, and bioengineering to address open questions in inflammation biology.
- Analyze and interpret large-scale, high-dimensional datasets using computational and statistical approaches, and communicate results clearly through figures, presentations, and internal discussions.
- Disseminate research outputs through high-impact publications, preprints, and open scientific resources, contributing to a culture of open and collaborative science.
What You'll Bring
- PhD in genomics, bioengineering, quantitative biology, systems immunology, computational biology, or a related quantitative life-science field.
- Experience with quantitative molecular and cell biology techniques and high-throughput profiling.
- Demonstrated expertise in quantitative interpretation of complex, high-dimensional datasets.
- Strong record of scientific productivity, creativity, and collaborative problem-solving in interdisciplinary research environments.
- Motivation to pursue innovative, independent research aligned with the Biohub’s mission and to thrive in a hands-on, team-science culture.
- [Nice to have] Experience with high-throughput profiling platforms (e.g., single-cell RNA-seq, spatial transcriptomics, multiplexed imaging, flow/mass cytometry, or proteomics).
- [Nice to have] Experience with technology or assay development, molecular barcoding, novel nucleic acid technologies, or quantitative imaging methods.
- [Nice to have] Background in immunology, inflammation biology, or related disease areas.
Compensation
The Chicago, IL base pay for a new hire in this role is $84,150. This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Onsite
Ready to apply?
Apply to Biohub
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
Our decoding inflammation team builds tools to enable precise molecular-level measurements of inflammation within human tissues in real time, and develop proactive, early interventions that can be deployed when inflammation — which underlies the most significant causes of death worldwide — first flares in the body. You can learn more about our work here.
Our team collaborates with three powerhouse universities - Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign - to develop first-in-class technologies and make breakthroughs.
Our Vision
- Pursue large scientific challenges that cannot be pursued in conventional environments
- Enable individual investigators to pursue their riskiest and most innovative ideas
- Facilitate research by scientists and clinicians at our home institutions and beyond
We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.
The Opportunity
The Tissue Models team is dedicated to developing advanced in vitro systems that provide human-relevant platforms for studying inflammation. By creating comprehensive and physiologically relevant models, we aim to transform how inflammatory diseases are studied.
We are seeking a highly skilled and motivated scientist with a strong background in gastrointestinal disease, immunology, and organoid development. The ideal candidate will also have experience with bioprinting, extracellular matrix biology, and advanced microscopy techniques. This role will be highly collaborative, engaging in projects with engineering, AI, and proteomics teams in the Chicago Biohub as well as with investigators at our partner universities.
What You'll Do
- Cultivate advanced human 3-dimensional models of inflammatory gastrointestinal disease, including Celiac, Crohn’s, and Ulcerative Colitis.
- Working closely with engineering groups, develop a model system of disease that is compatible with in-house sampling and sensing platforms.
- Work collaboratively across platforms throughout the biohub to develop novel instrumented tissue models for measuring and mapping inflammation.
- Publish and disseminate impactful findings and the products of your research as preprints (medRxiv, bioRxiv), in peer-reviewed journals, and/or software repositories (e.g. GitHub).
- Regularly present findings to the team, university partners, and collaborators.
- Contribute to scientific publications and presentations at conferences.
What You'll Bring
Essential -
- PhD in Cell Biology, Immunology, or closely related
- Expertise in gastrointestinal biology and patterns of inflammation in GI disease
- Demonstrated leadership, track record of innovation, and ability to work collaboratively across disciplines
- > 4 years cell culture experience
- Hands-on experience with 3D culture model development
- Familiarity with standard molecular biology techniques
- Microscopy experience
- Excellent written and verbal communication skills
Nice to have -
- Experience with 3D bioprinting and extracellular matrix biology
- Multiphoton microscopy expertise
- Microfluidic device experience
- Flow Cytometry/FACS proficiency
- Supervisory or mentoring experience
Compensation
The Chicago, IL base pay for a new hire in this role is $84,150. This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Hybrid #LI-Onsite
Ready to apply?
Apply to Biohub