About Us:

The wholesale distribution industry is ready for a revolution, and Proton is leading the charge. The world relies on distributors to sell nearly every physical product, but despite its massive contribution to the global economy, this industry has been left behind in terms of technology. Proton is changing that with AI-powered CRM software. Distributors using Proton see 10x ROI, faster new hire ramp-up, and happier sales teams.

In 2022, we raised a $20M Series A backed by Felicis Ventures (investors in Twitch, Shopify, Opendoor, and many others) and Battery Ventures. This year, we’re laser-focused on driving customer growth. If you’re excited about the opportunity to wear multiple hats, and continuously learn and experiment, now’s the time to join the Proton team.

About the role:

Reporting to the Head of Marketing and working closely with the CEO, you’ll be on the frontlines of maintaining our rapid growth in the industry. Your key responsibility will be to ensure Proton is the first name that comes to mind for distributors looking for a CRM. Focusing on potential Proton CRM buyers, your role is central to uncovering sales opportunities and fuelling our sales pipeline.

We’re looking for someone who is passionate about creating processes from scratch. The ideal candidate will not only thrive in their core responsibilities but will also play a vital role in developing the future of Proton’s business development strategies and team.  If you’re fascinated by the psychology behind sales, thrive on the challenge of breaking through to the right contact, and see each “no” as a step towards an eventual “yes”, this role could be your perfect match. If you’re at the beginning of your career, gritty, and eager to be part of a fast-growing tech startup’s journey from the early stages, this is an opportunity for you.

This is a hybrid role, based in the greater Boston area (Kendall Square).

Comp: 80k + 30k variable

Your responsibilities:

• You'll lead the charge in cold outreach—cold calls, emails, LinkedIn—aiming to turn the heads of those who've barely engaged with Proton.
• Qualify leads and arrange meetings for our sales executives. You're often the first Proton contact for potential customers, so making a strong impression is key.
• You'll also nurture leads from events and previous interactions, nudging them towards setting up a meeting.

What You’ll Do:

• Conduct thorough research on target accounts, pinpointing decision-makers who need to know about Proton.
• Be relentless on the phone, turning those conversations into bookings for our sales team.
• Work closely with the Head of Marketing to craft messages and emails that pull prospects to our website, events, and discovery calls.
• Keep engaged with, nurture, and qualify leads from events and sponsorships, drawing them in with content that converts them into opportunities.
• Keep our CRM up to date with all prospecting activities, including key info like a prospect’s renewal timeline.
• Use insights from prospect interactions to refine content strategies and provide valuable input to the Sales and Marketing teams.
• Proactively invite prospects from target accounts to events Proton is attending.
• Handle inbound inquiries from non-target accounts.
• Regularly reconnect with previous prospects, keeping Proton on their radar with relevant updates and reigniting potential conversations.

We'll measure your success through:

• Activity benchmarks like the volume of cold calls made and emails sent
• The effectiveness of your outreach, judged by email open rates and click-through rates.
• The total number of meetings booked with prospects

Your qualities:

• You communicate clearly: You bring excellent verbal, written, and interpersonal communication skills to the table. Each interaction with a prospect is well-researched, personalized, and executed thoughtfully, positioning you as a trusted advisor.
• You are curious: You have a natural curiosity that drives you to understand Proton's products, mission, and the problems we solve. You dive into sales calls, interviews, and educational content to become a subject matter expert
• You are a good listener: Ability to understand customer needs and concern
• You are resilient: The word "No" doesn’t deter you. You see it as a challenge that motivates you. Instead, it motivates you to push harder and find new ways to achieve your objectives.
• You have a proven track record: You've been in the trenches before, with relevant experience in a business development or outbound sales role and a track record of successful results to show for it.
• You are determined: Your grit and drive power you through challenges. Your mantra is "the more effort you put in, the greater the rewards."
• You are creative: You have an innate knack for problem-solving, finding innovative ways to achieve your goals and overcome obstacles.
• You are ambitious: You don’t just meet goals, you strive to exceed them, constantly pushing to better your performance.

Benefits

• Competitive Salaries + Company Stock Options - we want to pay you well (and equitably!) and make you feel like an owner.  
• Unlimited PTO + 10 Company Paid Holidays - we even have tools implemented to detect burnout to make sure folks recharge regularly.
• 401k with Employer Contribution (US only, for now!) - we know work isn’t forever, so we contribute up to 3% of your salary to help you prepare whether you directly contribute or not.
• Medical, Dental, and Vision Insurance - we cover one medical plan 100% in the USA and cover a premium plan 100% for international employees (for US- this includes a HSA!) and cover 50% for dependents on all our medical plan options.
• 12 Weeks Fully Paid Parental Leave - that goes for primary and secondary caregivers; even if you’re adopting or fostering!
• Company off-sites - time for us to be together, brainstorm, and make magic happen.

About the Role

As the Director, Site Performance & Solutions (Cardiology), you will report to the VP, Growth and own the performance of Iterative Health’s central clinical services that are delivered to our cardiology research sites as performance-enabling solutions, including pre-screening, regulatory support, and eSource. Your two core mandates are: owning the operating model for the central research support services we deliver to sites, and ensuring the network consistently hits and improves its activation and randomization targets.

This is a role for someone who is deeply grounded in research operations, relentlessly data-driven, and capable of diagnosing performance improvement opportunities quickly and implementing solutions at a high standard. You will serve as a “product owner” for our suite of site solutions, continuously improving how they are designed and delivered. When performance gaps emerge, you will be the person who figures out what is wrong and drives the fix.

Responsibilities

Network Performance Ownership

• Own activation and randomization performance across IH’s cardiology site network as the single accountable leader.
• Monitor site and network-level performance metrics continuously, identifying trends, risks, and gaps before they escalate.
• Understand the key levers that drive enrollment performance and ensure they are being optimized, consistently and systematically, across the network.
• When performance falls short, diagnose root causes quickly, develop a clear plan of action, and drive execution until the issue is resolved.

Operating Model & Solution Ownership

• Serve as the accountable owner for IH’s cardiology central research support services, including regulatory support, pre-screening and eSource.
• Own the design, execution, and continuous improvement of the operating model for each service, treating them as products with clear performance standards and measurable outcomes.
• Define and track service-level KPIs for each function; use performance data to surface improvement opportunities and raise the quality bar.
• Develop scalable workflows and best practices that can be deployed consistently across the network.
• Serve as the connective tissue between site-level performance trends and central service teams, ensuring the right resources are allocated where they will have the greatest impact.
• Collect and synthesize site feedback to inform service improvements and partner with cross-functional teams to implement solutions.

Team Leadership & Management

• Directly manage and develop a multidisciplinary team of clinical research specialists, e-source specialists, pre-screeners, and regulatory specialists
• Set clear goals and performance expectations for each function, provide ongoing coaching and development, and foster a high-performance team culture
• Ensure each team is properly resourced, trained, and equipped to deliver their services at the standard required to drive strong site outcomes

Required Qualifications

• BS/BA or higher degree
• 10+ years of clinical research experience, with deep familiarity with research operations and trial execution
• Demonstrated proficiency with clinical research systems and tools, including CTMS and pre-screening workflows
• Proven ability to use data to diagnose performance problems, identify improvement opportunities, and drive decisions
• Track record of building and improving operating models or service delivery processes in a clinical research context
• Proven people management experience, with a track record of leading, developing, and holding accountable clinical research teams
• Ability to manage multiple priorities, meet deadlines, and operate effectively in a fast-paced, evolving environment

Preferred Qualifications

• Prior experience in a director-level or senior management role within a site network, CRO, or health tech organization
• Experience owning enrollment or operational performance metrics at a network or program level
• Cardiology-specific clinical research experience

Why Join Us?

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines that unlock high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. 

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and AR^ON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

The Senior Manager, Supply Chain will lead the end-to-end operational management of investigational product (IP) and clinical trial materials across global Phase I–III studies. This role is responsible for ensuring timely, compliant, and efficient delivery of clinical supplies, while partnering cross-functionally with Clinical Operations, Quality, Regulatory, CMC, and external vendors to support study execution.

• Develop and maintain study-level supply plans and forecasts aligned with enrollment, protocol design, and site activation timelines
• Coordinate packaging, labeling, release, and global distribution of investigational products and ancillary materials
• Oversee inventory across depots and study sites, proactively mitigating risks to avoid shortages or excess
• Serve as business owner of the IRT system, including setup, configuration, validation, and ongoing management
• Partner cross-functionally to align supply strategy with clinical and regulatory requirements and ensure seamless execution
• Author and maintain supply-related documentation, including SOPs, Pharmacy Manuals, and study-specific materials
• Ensure compliance with GxP, GDP, and ICH-GCP standards, supporting audits and inspection readiness
• Manage global logistics, vendor oversight, and third-party partners to ensure uninterrupted supply across regions

What you’ll need to be successful:

• Bachelor’s degree in Supply Chain, Life Sciences, or related field (Master’s preferred)
• Minimum 5 years of global clinical supply chain experience within biotech, pharma, or medical device
• Hands-on experience with IRT/IXRS systems (e.g., 4G Clinical, Almac, Endpoint)
• Experience supporting global Phase I–III clinical trials (commercial launch experience preferred)
• Proficiency with Microsoft Office and inventory/ERP systems
• Strong understanding of GxP, GDP, and ICH-GCP regulations
• Proven ability to manage complex global supply operations and mitigate risk
• Strong analytical, organizational, and problem-solving skills
• Effective cross-functional collaboration and communication across internal teams and external partners
• Experience drafting SOPs, Pharmacy Manuals, and clinical supply documentation preferred
• Familiarity with cold chain and temperature-controlled distribution preferred
• APICS/CSCP or PMP certification a plus
• Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus
• Able to work on-site and attend in-person meetings
• Ability to travel up to 15%

Core Values

Parabilis is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent.We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused.We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In.We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary target for this position is $153,000-$180,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines (PM), an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments.

Position Summary:

We are seeking an Executive Director, CMC (Chemistry, Manufacturing & Controls) with a proven track record of driving portfolio-level CMC strategy and execution across multiple emerging modality programs simultaneously. This is a senior leadership role operating at the intersection of science, strategy, and operations—requiring the ability to set direction across a complex multimodality pipeline, and build CMC function as a competitive advantage for Pioneering Medicines. This position reports to the SVP, CMC & Technical Operations.

This role will serve as the strategic and operational owner of CMC across the full PM portfolio from research interface through early and late clinical development. This leader will be equally comfortable shaping long-range CMC strategy at the portfolio level and resolving complex technical challenges at the program level. They will define how PM approaches emerging modalities, build and leverage a best-in-class external Contract Development and Manufacturing Organizations (CDMO) network, combined with the strategic acumen to make portfolio-level resourcing decisions. They will be a thought leader in innovative approaches and champion adoption of AI-enabled CMC tools.

Responsibilities:

• Serve as a key member of the Technical Operations leadership team. Lead CMC functions including Drug Substance Development, Drug Delivery / Pre-formulation, Analytical Development, Product Development and Regulatory CMC. Accountability for all aspects of CMC functional strategy and portfolio deliverables.
• Responsible for building and scaling the CMC organization and defining its strategic direction. Recruit, develop, and retain a high-performing CMC team; invest in talent and cultivate a culture of excellence, accountability, and continuous improvement
• Own and drive end-to-end CMC execution across an increasing portfolio of multimodality compounds, ensuring programs advance on time and on strategy; accountable for portfolio-level CMC risk identification, prioritization, and mitigation
• Build and manage a high-performing external CDMO network in partnership with VP, CMC Operations. This includes selection, assessment and establishment of strategic relationships; Maintain a forward-looking view of the CDMO landscape to anticipate portfolio capacity and manufacturing needs
• Oversee the identification, evaluation, and implementation of novel technologies and innovations to drive greater program / portfolio value. Leverage emerging AI-driven technical development, manufacturing and advanced analytics approaches to accelerate CMC timelines and improve efficiency across the portfolio
• Engage and align key stakeholders across Technical Operations, Research, Translational Medicine, and Regulatory Affairs to establish CMC development paradigms, resolve cross-functional trade-offs, and ensure portfolio decisions reflect both scientific rigor and operational reality
• Oversee CMC handoffs and establishing fit-for-purpose development and manufacturing pathways for novel modalities originating within the FSP ecosystem. Act as CMC strategic advisor, as needed
• Serves as an ambassador of PM for external stakeholders and industry as a whole

Requirements:

• PhD in a relevant scientific discipline with 15+ years of progressive CMC experience (MS with 18+ or BS with 20+ considered); Minimum 5 years in senior leadership with direct accountability for CMC strategy across multiple simultaneous programs
• Deep hands-on expertise in small molecules and biologics. Expertise is preferred (but not required) in advanced modalities incl. nucleic acids, cell or gene therapies
• Demonstrated track record of filing and defending regulatory dossiers (INDs, CTAs, BLAs/NDAs, or MAAs) across multiple programs and modalities; Current working knowledge of global regulatory expectations (FDA, EMA, PMDA) and direct experience in agency interactions on CMC topics.
• Proven ability of owning CMC strategy and execution across a multi-program portfolio simultaneously, including developing and managing CMC budgets, risk management, and delivery against aggressive timelines
• Extensive experience identifying, selecting, contracting, and managing CDMOs and CROs with specialized emerging modality capabilities, including leading technology transfer and resolving technical challenges at external sites
• Thought leadership in innovation, including novel delivery, high-throughput process development, and platform-based approaches to elevate program / portfolio value
• Strong understanding of AI/ML, digital process development tools, and data-driven manufacturing platforms to improve development speed and efficiency
• Executive presence and demonstrated ability to influence and align cross-functional PM and platform company leaders; Strong communicator who can translate complex CMC strategy and risk for non-specialist audiences
• Experience partnering with GxP Quality to establish quality systems appropriate for a development-stage organization, including SOPs, change control, and deviation management in a GxP environment
• Entrepreneurial builder energized by creating structure in ambiguous, fast-moving environments; high accountability orientation with a bias for action and the ability to make sound decisions with incomplete information
• Collaborative, low-ego leadership style with genuine investment in team development and cross-functional relationships

About Flagship 

Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond. 
 
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. 
 
 Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company’s annual list of the World’s Most Innovative Companies. 

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto. 

The salary range for this role is $228,000 - $313,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.

As the Clinical Operations Manager, you will report to the VP, Growth and work closely with our Clinical Research and Life Sciences teams to integrate Iterative Health (IH) services and AI solutions at clinical research sites throughout the US. This external-facing role will require strong communication, customer engagement and deep expertise in clinical research, in addition to a strong strategic skill set. You will engage with partners such as sponsors, CROs and key sites to drive executive operational alignment, providing strategic recommendations both internally and externally with a focus on improving research operations focused on biological sample collections trials. You’ll also be working directly with your portfolio of sites to deliver day-to-day support that encourages research best practices, drives the adoption of IH services and products, and ensures our sites achieve their research goals. 

Key Responsibilities: 

• Own end-to-end clinical research operations for biological sample collections trials, serving as the primary accountable party for trial execution quality and sponsor satisfaction outcomes
• Build and manage DCT (decentralized clinical trial) vendor relationships, including performance management, metrics tracking, and oversight to ensure biological sample collections trial delivery
• Own the information flow between sites and sponsors - including internal study education, site engagement protocols, and issue escalation pathways
• Serve as leading sponsor-facing owner for active studies - leading alliance management meetings by providing study updates, reviewing metrics, discussing site accomplishments and ongoing issues, and gathering information to relay to site-based staff, driving sponsor satisfaction, and owning escalation resolution
• Drive direct QC enforcement with site CRCs/staff, including data quality expectations-setting and direct communication on compliance gaps
• Own site performance improvement through metrics, change management, and direct intervention - proactively identifying and resolving performance gaps before sponsor escalation
• Demonstrate advanced knowledge of clinical research processes and tools, such as CTMS, pre-screening, and/or feasibility, and enhance these processes and outputs to effectively support our sites or internal teams. 
• Serve as a subject matter expert on clinical research workflows, in line with specific requirements of each protocol, optimized with Iterative Health (IH) services and AI solutions
• Support and lead weekly meetings with site-based staff to review enrollment progress, address operational issues, and provide guidance for performance improvement.
• Manage customer relationships with a high degree of professionalism and expertise ensuring timely responses, escalations of site issues, and building trust needed to help sites achieve IH goals
• Leverage IH solutions and services to help build best practice research sites, accelerate clinical trials, and build capacity at IH sites to execute high-quality clinical trials. 
• Deliver customized training for different clinical research user groups and devise process maps/workflows, tools, and techniques to help sites incorporate IH services
• Travel to customer sites to support study site activation, drive patient screening, and standby support for randomization activities 
• Collect, analyze, and communicate the voice of IH customer successes, concerns, and product adoption issues/competency gaps and collaborate with IH cross-functional teams to design and deliver solutions 

Required skills: 

• BS/BA or higher degree. 
• Minimum 4 years of clinical research coordinator experience
• At least 8 years of experience with biological sample collection trials and/or phase 2-4 pharma-sponsored clinical trials, including study start-up, CDA, feasibility, regulatory/standard operating procedures, study protocols, and regulations governing clinical research 
• Experience coordinating, evaluating, and following patients’ participation through clinical trials.
• Fluent in the use of Microsoft Office/Google Apps products. 
• Ability to navigate ambiguity and willingness to be flexible/adapt to changing work environments. 
• Desire to work with new tools and technology
• Ability to manage multiple projects, meet deadlines, and adjust priorities appropriately.
• Willingness to travel to customer sites (~30%) 

Preferred skills: 

• 5+ years as a Clinical Research Coordinator (CRC) working with biological sample collections trials or equivalent experience
• Experience with CTMS systems - preferably RealTime, Clinical Conductor, or CRIO

The Opportunity

The Senior Director, Market Insights is a highly visible, enterprise-level leadership role responsible for defining and driving the end-to-end insights strategy to support U.S. commercialization and global expansion. The Senior Director will serve as the strategic owner of the insights function, ensuring that market intelligence, analytics, and evidence generation are fully integrated into corporate decision-making across the product lifecycle.

Reporting into the Vice President, Commercial Operations, the Senior Director will act as a key advisor to commercial and executive leadership, shaping commercial strategy through forward-looking insights that inform launch readiness, lifecycle management and portfolio prioritization. This role requires the ability to operate at both a strategy and operational level, building scalable capabilities and frameworks to support a multi-asset, multi-market organization.

Responsibilities

• Define and own the enterprise-wide market insights strategy, aligning U.S. and ex-U.S. perspectives to support global commercialization and long-term portfolio growth, ensuring readiness across multiple markets and stakeholder groups
• Lead and execute market research projects influencing key decisions related to product launch strategy, lifecycle planning, new product planning, and as necessary, key market access strategies; ensure project deliverables are actionable, archived, and accessible
• Lead cross-functional integration of insight, ensuring alignment across Marketing, Medical, Market Access, Regulatory, R&D, and Executive Leadership to support decision-making
• Build and scale the market insight’s function, including defining operating models, processes, tools, and governance to support increasing organizational complexity
• Oversee and evolve global competitive intelligence strategy, ensuring proactive identification and ongoing communication of market shifts, competitive threats, and strategic opportunities
• Partner with Business Development (BD) colleagues to rapidly build market assessments, competitive landscape modeling, value creation theses, and financial modeling to facilitate executive decision-making
• Drive development of advanced analytics capabilities, including integration of primary research, real-world data, and secondary data sources into a cohesive insight ecosystem
• Establish KPIs and measurement frameworks (customer engagement, brand tracking, etc.) to evaluate commercial effectiveness and inform ongoing strategic adjustments
• Lead external partnerships and vendor strategy, including selection, governance, and optimization of research and analytics partners
• Develop and mentor future capabilities, including team build-out as the organization scales
• Lead insights efforts with a focus on post-bariatric hypoglycemia (PBH), Wolfram syndrome, progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)

Required Qualifications

• Bachelor’s degree required; advanced degree (PhD, MD, PharmD, or MBA) preferred
• 12+years of experience in pharmaceutical or biotech market research, insights, or analytics, with increasing levels of responsibility
• Proven experience generating insights across the product lifecycle, including early-stage development, launch, and post-launch optimization
• Demonstrated expertise in competitive intelligence, including conference coverage and strategic synthesis of competitor activity
• Strong understanding of global market dynamics, including U.S. and ex-U.S. commercialization considerations
• Experience building or scaling capabilities, functions, or operating models
• Advanced analytical and strategic thinking skills, with the ability to translate complex data into actionable, enterprise-level decisions
• Exceptional communication and executive presence
• Experience in endocrinology is preferred
• Strong vendor management, budget oversight, and project management skills
• High degree of initiative, curiosity, and comfort with ambiguity in a fast-paced, mission-driven environment

Work Location and Conditions

** Preference will be given to candidates residing in the Boston area or elsewhere on the East Coast.

• At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee.
• You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested.
• You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location.

Philo: a streaming service for TV and movie lovers

At Philo, we're a group of technology and product people who set out to build the future of television, marrying the best in modern technology with the most compelling medium ever invented — in short, we're building the TV experience that we've always wanted for ourselves. In practice this means leveraging cloud delivery, modern tech stacks, machine learning, and hand-crafted native app experiences on all of our platforms. We aim to deliver a rock solid experience on the streaming basics, while cooking up next generation multi-screen and multi-user playback experiences.

Data at Philo

Data underpins everything we do at Philo: making informed business decisions; analyzing and improving the quality of our streaming experience; running product experiments to optimize our signup flows and improve user journeys; and making it effortless for our users to find the perfect thing to watch. Philo serves over a billion streams to its users every year, generating a wealth of data that we leverage at all levels of the organization. Philo's data platform operates at a very large scale, processing trillions of events annually in a petabyte-scale data lake and supporting thousands of data workflows and analytical queries that power decision-making across the company.

Philo's Data Engineering team encompasses both data engineering and analytics engineering. As an analytics engineer at Philo, you'll own the data modeling layer that turns raw event and application data into the clean, trusted data products the entire company relies on — from metric definitions and dimensional models to the governed semantic layer that ensures everyone is looking at the same numbers. You'll work closely with data scientists, analysts, and business stakeholders across the organization to understand their analytical needs and translate them into well-modeled, well-documented, and performant data products in dbt and Snowflake.

We are passionate about providing a high-quality, trustworthy data platform for the entire company, using both cutting-edge technologies and proven engineering practices in close collaboration with every department. Our analytics engineering stack centers on dbt and Snowflake, supported by tools like Segment, Avo, and BigEye for event tracking, data quality, and observability.

Some of the recent projects that analytics engineers at Philo have worked on include building new models for key financial data, dbt model design and refactoring, metric definition and governance, per-query cost optimization in Snowflake, and developing data quality testing and documentation frameworks.

The Role

We're looking for a Senior Analytics Engineer to own and elevate the data modeling layer that powers decision-making across Philo. In this role, you'll be the person who transforms raw, messy application and event data into clean, trusted, well-documented data products that the entire company relies on. You'll design and maintain dimensional models, define and govern key business metrics, and ensure semantic consistency across our data stack — so that when someone asks "what does this number mean?", there's always a clear, reliable answer.

This is a high-impact IC role: you'll partner directly with stakeholders across Finance, Product, Marketing, Ad Sales, and Engineering to deeply understand their analytical needs and translate them into scalable, performant dbt models and data products. You'll also work closely with the data engineering side of the team to ensure the underlying infrastructure supports your modeling work, and with analysts and data scientists to make sure the data you deliver is easy to use, well-tested, and trustworthy.

The ideal candidate has strong opinions about how analytics engineering should be done — how to structure a dbt project, when to denormalize, how to manage slowly changing dimensions, how to build a metric layer that people actually trust — and the experience to back those opinions up.

Responsibilities:

• Design, build, and maintain Philo's core dimensional models and data marts in dbt, serving as an owner of the analytics engineering layer of our data stack
• Define and govern key business metrics and KPIs, ensuring consistent definitions and reliable calculations across all downstream reporting and analytics
• Partner with stakeholders across the organization (Finance, Product, Marketing, Ad Sales, Content, and others) to understand their data needs and translate business questions into well-modeled, performant data products
• Establish and enforce best practices for dbt project structure, model design patterns, documentation, and testing — raising the quality bar for analytics engineering at Philo
• Build and maintain comprehensive data documentation and a data catalog so that analysts, data scientists, and business users can confidently self-serve
• Implement and maintain data quality checks and monitoring (e.g., via dbt tests, BigEye, or similar tools) to proactively catch issues before they reach stakeholders
• Optimize query performance and warehouse cost efficiency in Snowflake through thoughtful model design, materialization strategies, and incremental processing patterns
• Collaborate with data engineers on pipeline design and data ingestion to ensure raw data lands in forms that support clean, efficient downstream modeling
• Drive alignment across teams on data definitions, naming conventions, and a single source of truth — building stakeholder trust in data and reporting over time
• Contribute to the evolution of Philo's overall data platform strategy, particularly as it relates to the semantic/metric layer, data governance, and analytics engineering tooling

Key Qualifications:

• 8+ years of professional experience in analytics engineering, data modeling, or a closely related role, with significant hands-on experience building and maintaining production dbt projects or a similar data transformation tool
• Deep expertise in SQL and dbt, including advanced model design patterns (dimensional modeling, incremental models, slowly changing dimensions, and snapshot strategies)
• Experience developing in a BI tool that leverages semantic layers, such as Mode, Looker, Omni, SSAS Cubes, or similar
• Strong experience with Snowflake or a comparable cloud data warehouse, including performance tuning and cost optimization
• Proven ability to translate ambiguous business questions into clean, well-structured data models that stakeholders trust and rely on
• Experience defining, governing, and maintaining business metrics and KPIs across an organization
• Strong communication skills — you can explain data modeling decisions to a VP of Finance just as clearly as to a fellow engineer
• A strong sense of ownership and quality: you care deeply about data accuracy, documentation, testing, and making the data stack better over time
• Experience working with data quality and observability tools (e.g., BigEye, Elementary, dbt tests, Great Expectations, or similar)

Ideal Qualifications:

• Experience in the media, streaming, or entertainment industry, with familiarity with video delivery analytics, content performance metrics, or advertising data
• Familiarity with event tracking design and tools like Segment or Avo
• Experience with Apache Iceberg, Spark, or other large-scale data processing frameworks
• Familiarity with data governance frameworks and building organizational alignment around a single source of truth
• Experience mentoring junior analytics engineers or analysts

More about Philo

At Philo, we're a company that puts people first—both our subscribers and our team. We empower our colleagues to do their best work while supporting one another in pursuing shared goals. We value pragmatism, pride in our work, and passion, with transparency and openness as fundamental parts of our culture.

We're committed to diversity, equity, inclusion, and accessibility as we grow the Philo team and shape the future of TV. We believe that a diverse range of voices and perspectives enables us to innovate faster and create the best experiences for our subscribers. Philo is proud to be an Equal Opportunity Employer. We're committed to supporting every candidate and employee. If you need an accommodation at any stage of the process, please email recruiting@philo.com and we'll work with you to meet your needs.

Philo offers 70+ top-rated networks streaming live and on-demand, including AMC, BET, CMT, Comedy Central, Discovery Channel, Food Network, Hallmark Channel, HGTV, HISTORY, Investigation Discovery, Lifetime, MTV, Nickelodeon, OWN, VH1, We TV, and more. It also includes all the groundbreaking originals and blockbuster movies available with AMC+ and access to HBO Max Basic With Ads and discovery+. Our extensive library boasts over 85,000 titles, and our unlimited DVR allows users to save their favorite shows and movies for up to a year, skipping ads for a seamless viewing experience. Stream on up to three devices simultaneously, whether on your phone, tablet, laptop, or TV using Roku, Apple TV, Fire TV, Samsung TV, Android TV, Vizio TV, or Chromecast.

Philo is headquartered in San Francisco, with offices in New York City and Cambridge, MA. Our leadership team includes alums from HBO, Tubi, and Meraki, and is backed by NEA and industry partners like Warner Brothers Discovery, Viacom, AMC, and A&E.

Join us at Philo and be part of a team that's shaping the future of TV!

Status: Full-time
Location: San Francisco, CA, Brooklyn, NY, Cambridge, MA, or remote within the U.S.
Compensation: Includes annual salary, company stock options, and health benefits. Salary is determined by experience and location:

• San Francisco, New York City: $170K - $205K
• Boston, DC Metro, Los Angeles, Seattle: $160K - $195K
• Denver, Atlanta, Austin, Las Vegas, Sacramento, Chicago: $155K - $185K
• Texas, Florida: $145K - $175K

We value a diverse and inclusive workplace and we welcome people of different backgrounds, experiences, skills, and perspectives. Philo is an equal opportunity employer. We believe that everyone does their best work when they are supported by each other and the company, and we offer a generous set of benefits to make sure the Philo team is happy and healthy. Here is a sampling of the benefits we offer our team:

• Full health, dental and vision coverage for you and your family
• 401(k) plan with employer contributions (we match 100% of deferrals up to 3% of pay and 50% of the next 2% of pay)
• Flexible working hours
• Up to 20 weeks of fully paid parental leave
• Unlimited paid time off for vacation and sick leave
• $2,000 annual vacation bonus (we pay you to take a two week vacation)
• $5,250 annually for professional development and educational assistance
• $1,250 annual home office + TV stipend during first year of employment ($250 annually thereafter)
• $500/month ($6,000/year) bonus for employees who commit to working at least 3 days per week in our offices, plus generous commuter benefits ($315/month towards transit, rideshare, bike rental, or parking at our HQ office in San Francisco)
• Free Gympass subscription — an all-in-one corporate benefit that gives employees the largest selection of gyms, studios, classes, training and wellness apps
• Dog-friendly office
• And much more!

For California Residents: Philo's CCPA Notice at Collection – Employees, Applicants, Owners, Directors, Officers and Contractors

Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.