About this Tothova Lab - Postdoc role at Dana-Farber Cancer Institute
The position will involve the study of hematologic malignancies, and projects will integrate analysis of human cell lines, engineered mouse models, and primary human samples. Technical skills involving tissue culture, flow cytometry, and standard molecular and cell biology techniques are highly desirable.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
A full-time Postdoctoral Fellow position is available in the laboratory of Zuzana Tothova, MD, Ph.D. at Dana-Farber Cancer Institute (https://tothovalab.dana-farber.org/). We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. The ideal candidate is collegial, creative, and highly motivated, with a strong record of productivity during graduate training. The position will involve the study of hematologic malignancies, and projects will integrate analysis of human cell lines, engineered mouse models, and primary human samples. Technical skills involving tissue culture, flow cytometry, and standard molecular and cell biology techniques are highly desirable. Prior experience with MDS/leukemia mouse models is a plus but not required. A PhD, MD, or MD/PhD is required.
This is an ideal position for someone who enjoys being in the world of cutting-edge laboratory research. A growth mindset and a willingness to take on challenging learning opportunities will be sought out traits. Ideal candidates will possess strong interpersonal skills along with a desire to help others to succeed. The successful candidate will have a major influence in setting the tone for an intellectually engaging, rigorous, productive, and positive lab environment. They will be provided with significant intellectual freedom and ample opportunities to form collaborations and develop a national and international reputation in the field of myeloid neoplasms.
Projects will be tailored to a candidate’s interests, experience and goals, within the areas of laboratory focus, including (1) the effect of cohesin mutations on chromatin organization during disease progression from clonal hematopoiesis to MDS/AML; (2) mechanisms of transcriptional deregulation and splicing in cohesin-mutant cells; (3) the role of DNA damage in cohesin-driven MDS/AML development; (4) the role of transposable elements in cohesin-mutant cancers; and (5) immuno-oncology directed targeting of ERVs in cohesin-mutant myeloid malignancies.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
Technical proficiency, scientific creativity, collaboration with others, and independent thought.
Design, conduct, and troubleshoot hypothesis-testing experiments.
Interpret and discuss research findings with lab members and the principal investigator.
Analyze and present data both informally and formally.
Use existing computational tools to analyze complex data sets, including next generation sequencing data sets, and/or fluently and effectively collaborate with computational biologists to accomplish this.
Provide advice and training for junior members of the lab.
Maintain a detailed and understandable electronic lab notebook.
Develop figures to depict research findings, write research and review papers, career development grants, and present at scientific meetings.
QUALIFICATIONS:
PhD, MD or MD/PhD training with track record of scientific accomplishments
excellent communication skills (written and verbal)
experience with tissue culture, flow cytometry, standard molecular, cell biology and biochemistry techniques
experience with basic immunology techniques is a plus
experience with basic bioinformatics analysis
outstanding planning, organizational, multi-tasking skills
experience with mouse models of MDS/leukemia is a plus but not required
experience with mentoring students is a plus but not required
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionate professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
EEO Poster
.Pay Transparency Statement
The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.
For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).
$72,000.00 - $76,385.00
