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About this Structural Biologist III role at Tempus

Tempus · Onsite · Aliso Viejo

Compensation:

$120,000 - $170,000

Role Overview

The Structural Biologist III collaborates across biology, bioinformatics, software engineering, and clinical teams to design tools and methodologies leveraging biomolecular structural data to guide clinical decisions.

Key Responsibilities

  • Provide structural biology support for variant analyses through structure-function relationship interpretation.

  • Develop novel methods, protocols, and tools for structural modeling, molecular dynamics, and clinical variant assessment on internal platforms.

  • Partner with statisticians and data scientists to validate algorithms and data collection workflows.

  • Coordinate cross-functional efforts across Bioinformatics, R&D, and reporting teams for clinical research projects.

  • Write testable, production-grade code adhering to SDLC standards and code review best practices.

  • Maintain technical documentation, SOPs, and knowledge bases while mentoring junior staff.

  • Direct and lead the structural team through both soft and explicit leadership ensuring timely project completion

  • Support, inform, and educate leadership and stakeholders about project progress and blockers.

Qualifications & Competencies

  • Education: PhD in computational biology, structural biology, biophysics, bioinformatics, or equivalent.

  • Experience: Minimum 5 years of R&D experience in computational structural biology or related fields, including at least 2 years of post-doctoral or industrial experience and 2 years management experience.

  • Technical Skills: Fluency/proficiency in scripting/languages (Python, R, Perl, C/C++, Java, SQL) and bioinformatics/modeling software. Strong background in systems biology, molecular dynamics, and experimental techniques (X-ray, Cryo-EM).

PRIVACY NOTICES

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Equal Opportunity Employer


This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

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How this Biologist salary compares

This role pays $145,000/yr — in line with the typical range for Biologist roles.

$70,678 median $119,319 $191,850

Typical range $85,860–$150,088/yr, from 39 comparable Biologist listings on JobsRadar (pay annualized to USD). See Biologist salary insights →

About Tempus

Tempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics. We built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make s

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