About this EXECUTIVE DIRECTOR, TRANSLATIONAL SCIENCE & CLINICAL BIOMARKERS role at Adicet Bio
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Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.
EXECUTIVE DIRECTOR, TRANSLATIONAL SCIENCE & CLINICAL BIOMARKERS
Adicet Bio is seeking an Executive Director of Translational Science and Clinical Biomarkers to provide strategic leadership in advancing γδ T cell–based therapies from IND through clinical development. This individual will define and lead integrated translational and clinical biomarker strategies across the portfolio, enabling the successful translation of novel cell therapy programs from preclinical research into clinical studies.
The Executive Director will guide the design and implementation of clinical biomarker approaches to inform mechanism of action, pharmacokinetics, pharmacodynamics, patient selection, and clinical decision-making, supporting product candidates through first-in-human and subsequent clinical trials in close collaboration with cross-functional teams.
Key responsibilities:
- Leads the translational science strategy across Adicet Bio’s portfolio, integrating clinical biomarker strategies to inform target validation, clinical efficacy, and potential diagnostic development strategy.
- Provides executive oversight of translational biomarker programs, ensuring robust assay development, validation, and implementation to support clinical trials and decision-making.
- Partners cross-functionally with Clinical Development, Regulatory, CMC, Bioinformatics, and Nonclincal Research to advance translational strategies from discovery through clinical development.
- Drives biomarker and precision medicine strategies, including the development and regulatory advancement of companion diagnostics and patient-selection approaches.
- Provides portfolio-level oversight of translational programs, ensuring alignment of timelines, budgets, and deliverables with corporate milestones and clinical development goals.
- Represents translational sciences in governance and program leadership teams, influencing key development decisions and advancing platform capabilities.
- Leads preparation and review of translational/clinical biomarker components for regulatory submissions (e.g., INDs, IBs, BLAs), clinical protocols, and external scientific communications including abstracts and manuscripts.
- Establishes and manages strategic external collaborations with CROs, academic partners, and diagnostic companies to advance biomarker and translational initiatives.
- Builds and develops a high-performing translational medicine team, providing mentorship, scientific leadership, and organizational development.
Qualifications:
- PhD in immunology, cancer biology, molecular biology, or a related discipline with 10–15+ years of relevant experience, including significant experience in the biotechnology or pharmaceutical industry.
- Deep expertise in immunology and immuno-oncology, with a strong understanding of the tumor microenvironment, immune regulation, and mechanisms of immune dysfunction across oncology, autoimmunity, and other immune-mediated diseases.
- Demonstrated leadership in translational medicine and biomarker strategy, with experience advancing programs from IND to early and late stages of clinical development across oncology and/or immune-mediated disease indications.
- Experience with cellular immunology and cell-based therapeutics, including in-depth characterization of T cells, NK cells, and/or CAR-T/NK products, strongly preferred.
- Proven track record of leading cross-functional teams and influencing development strategy across research, translational medicine, and clinical development.
- Experience supporting regulatory submissions (e.g., INDs, IBs) and contributing to biomarker and translational components of clinical development programs.
- Strong leadership, communication, and collaboration skills, with the ability to effectively engage internal stakeholders, external partners, and senior leadership.
- Experience building and mentoring high-performing scientific teams, fostering innovation and advancing translational capabilities across the organization.
Adicet fosters a collaborative, high-performing environment by prioritizing in-person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.
Adicet fosters a collaborative, high-performing environment by prioritizing in-person engagement. To enhance teamwork and communication, employees are required to be onsite at least three days per week (Tuesday–Thursday mandatory), with some roles requiring full-time onsite presence.
At Adicet, our people are our greatest focus. We believe that attracting and retaining the best and brightest is the key to achieving our mission to deliver best-in-class gamma delta T cell therapies for patients fighting autoimmune diseases and cancer.
We offer a competitive compensation package including base salary, annual cash bonus, long-term incentives (equity), Employee Stock Purchase Plan (ESPP) and a 401(k) with ROTH and a 4.5% Company match.
To ensure the wellness of our employees and their loved ones, we offer comprehensive health plans (medical, dental, vision, etc.), Flexible Health and Commuter Spending Accounts (FSA) and a company matched Health Savings Account (HSA). We also offer a life, AD&D, short and long-term disability insurance, and legal, pet, and various other voluntary insurance programs.
We also believe our greatest ideas come when we are refreshed and focused, and we offer generous paid time-off including 13 company holidays, paid end-of-year winter break, vacation, sick time, and paid parental leave.
Adicet is located in a state-of-the-art facility and works to create an incredible office experience with an onsite gym and various other fitness options, onsite parking with electric vehicle charging stations and free shuttle (Caltrain), company-subsidized lunches (delivered onsite daily) and fully stocked breakrooms.
Adicet is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
