Profluent is seeking a Principal Infrastructure & Security Engineer to serve as the primary owner of Profluent’s security posture across scientific systems, lab automation environments, cloud and business infrastructure, endpoints, identity systems, and core operational workflows.

This person will be accountable for the design, implementation, operation, and continuous improvement of the technical controls, security standards, and operating practices that protect Profluent’s systems and data. This includes security architecture, access controls, hardening, monitoring, incident readiness, vendor and customer security assurance, and the systems and evidence required to achieve and maintain compliance commitments.

This is not a narrow compliance-only or infrastructure-only role. It is a broad ownership role for security across Profluent’s environments, with close partnership across Operations, Machine Learning, Bioinformatics, and Lab Automation.

Responsibilities

• Own Profluent’s overall security and compliance posture across company systems, scientific computing, lab automation, endpoints, identity, SaaS, cloud infrastructure, networking, and data-handling workflows, and be accountable for the ongoing maturity of security controls and practices across those environments
• Lead the implementation and operational maturity work required for Profluent to achieve and maintain SOC 2 and related compliance certification requirements, including control operation, evidence collection, monitoring, and repeatable processes
• Serve as the primary owner for security and compliance readiness across company systems, ensuring that Profluent can meet ongoing audit, certification, and customer assurance requirements over time 
• Own the translation of customer agreements, internal policies, and compliance requirements into concrete technical and operational controls
• Standardize and harden bioinformatics, lab informatics, and machine learning environments to align with security, reliability, and compliance requirements
• Define and drive adoption of secure baseline configurations, access controls, logging, backup practices, patching standards, and change management processes
• Own and evolve how Profluent approaches security more broadly, identifying gaps, prioritizing risks, and driving improvements beyond minimum compliance scope
• Drive standardization of Windows-based lab automation environments, balancing security, uptime, vendor constraints, and usability in laboratory settings
• Collaborate with stakeholders to document controls, system boundaries, standard operating procedures, and technical evidence needed for audits, certification efforts, and customer reviews
• Support vendor and platform evaluations related to security, observability, endpoint management, and infrastructure operations
• Improve identity, access, and account lifecycle management across company systems, including onboarding, offboarding, least-privilege access, and periodic access review support 
• Monitor key systems and respond to operational issues with an emphasis on root-cause analysis and durable remediation
• Maintain asset, system, and environment documentation so that critical processes are auditable, supportable, and repeatable

Qualifications

• Experience operating with broad ownership across infrastructure, security, and compliance in regulated, audit-conscious, or security-sensitive environments
• Experience serving as the most senior or primary security owner in a startup or scaling environment, even without a large dedicated security team
• Breadth across infrastructure security, corporate security, IAM, endpoint management, logging and monitoring, vulnerability reduction, incident response, vendor risk, and compliance
• Demonstrated ability to take ownership in ambiguous environments and set direction, not just execute within a narrowly defined specialty
• Familiarity with Windows-based lab automation systems and the realities of instrument-connected or vendor-managed environments
• Experience implementing or operating against security and compliance frameworks such as SOC 2, ISO 27001, NIST CSF, or similar
• Strong understanding of identity and access management, SSO, MFA, endpoint management, logging, patching, vulnerability reduction, and system hardening
• Ability to translate compliance and contractual data-handling requirements into concrete technical and operational controls
• Strong documentation skills, with the ability to create policies, procedures, standards, and technical runbooks that others can follow
• Experience preparing organizations for, achieving, or maintaining external compliance certifications or audit readiness
• Experience with infrastructure as code and/or configuration management tools such as Terraform, Ansible, or equivalent
• Experience administering Windows environments, preferably including systems used in laboratory, automation, manufacturing, or instrument-connected settings

Preferences (but not required)

• Familiarity with audit evidence preparation, control testing, and coordination with external auditors
• Familiarity with networking fundamentals including firewalls, routing, VLANs, NAT, VPNs, and secure remote access
• Experience influencing cross-functional teams and improving organizations mature security practices without relying on rigid bureaucracy

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We’re looking for a Senior Software Engineer to help design, build, and scale Profluent’s data platform. This platform houses data from protein engineering campaigns, including protein designs, experimental results, partner datasets, analytical outputs, and model-ready training data. It enables rapid machine learning, biological discovery, and secure collaboration across internal and external programs.

This role is ideal for an engineer who enjoys building robust data systems: secure ingestion pipelines, well-structured warehouses, reliable data models, access controls, auditability, and infrastructure that makes complex scientific data usable at scale. You will work closely with ML, bioinformatics, and program teams to ensure Profluent’s data is organized, governed, accessible, and protected.

Responsibilities

• Design, build, and maintain scalable data infrastructure for protein engineering campaigns, including ingestion, transformation, validation, storage, and retrieval of large scientific datasets
• Develop secure data pipelines for internal and partner-generated data, with strong attention to access control, data siloing, provenance, auditability, and compliance with data use restrictions
• Own core components of Profluent’s data warehouse and data platform, using Python, GCP, PostgreSQL, BigQuery, and related cloud-native technologies
• Build systems that transform raw experimental, computational, and partner data into structured, reliable, analysis-ready and model-ready datasets
• Establish best practices for data modeling, metadata management, data quality checks, schema evolution, versioning, and documentation
• Collaborate with ML engineers, computational biologists, data scientists, and program stakeholders to understand data requirements and translate them into scalable technical systems
• Improve engineering quality through thoughtful system design, code review, testing, CI/CD, observability, and maintainable development workflows
• Contribute to architectural decisions for how Profluent stores, secures, organizes, and uses data across programs and partnerships

Qualifications

• 5+ years of software engineering, data engineering, or data platform experience
• Strong proficiency in Python and modern software development practices, including git, testing, code review, CI/CD, and production deployment
• Experience designing and operating production data pipelines, data warehouses, and data models at scale
• Hands-on experience with cloud platforms, preferably GCP, and technologies such as BigQuery, PostgreSQL, object storage, workflow orchestration, and containerized services
• Strong understanding of data security, access control, data partitioning or siloing, audit logging, and managing sensitive or restricted datasets
• Experience working with complex, heterogeneous datasets and building systems that make them reliable, discoverable, and usable
• Ability to work independently, make sound technical decisions, and drive projects from ambiguous requirements to production systems
• BS, MS, or PhD in Computer Science, Engineering, Data Science, Bioinformatics, or a related technical field, or equivalent practical experience

Preferences (but not required)

• Experience with scientific, biological, clinical, genomic, laboratory, or high-throughput experimental data
• Experience managing external partner, customer, or restricted-access datasets
• Familiarity with data governance, lineage, metadata systems, schema registries, or data catalogs
• Experience with research data systems, LIMS, ELNs, Benchling, or adjacent scientific platforms
• Background working with ML, data science, computational biology, or cross-disciplinary technical teams
• Interest in learning biology, gene editing, protein design, or machine learning concepts

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We’re looking for a hands-on engineering manager to lead Profluent’s Lab Informatics Platform team. This team builds the systems scientists use to design experiments, track samples, capture assay data, integrate with Benchling and lab automation, and make experimental data usable for analysis and machine learning.

The ideal candidate is both an experienced people manager and a strong technical lead. You’ll formally manage and mentor a small team while remaining deeply involved in architecture, data modeling, database design, and technical execution. You’ll work closely with wet-lab scientists, automation engineers, data scientists, and ML experts to build practical, scientist-facing tools that make complex experimental workflows scalable, traceable, and actionable.

Responsibilities 

• Lead, mentor, and grow a software engineering team focused on lab informatics systems, scientific data infrastructure, and scientist-facing applications
• Architect and deliver the roadmap for systems that support sample tracking, assay data capture, Benchling integration, lab automation, experimental metadata, and analysis workflows
• Design robust data models for protein engineering and gene editing experiments, including constructs, samples, reagents, cell systems, assay results, metadata, and experimental lineage across mammalian and bacterial workflows
• Partner closely with scientists to translate complex laboratory requirements into scalable software solutions that accelerate Profluent’s design-build-test-learn cycle
• Build and maintain backend systems, APIs, databases, data pipelines, and web applications using technologies such as Python, Django, PostgreSQL, BigQuery, GCP, and modern development workflows
• Establish strong engineering practices across architecture, code review, testing, CI/CD, documentation, and agile delivery

Qualifications 

• 7+ years of software engineering experience, including at least 2 years managing or leading engineers
• BS, MS, or PhD in Computer Science, Bioinformatics, Computational Biology, Engineering, or a related field, or equivalent experience
• Strong technical leadership skills, with a track record of architecting and delivering production-quality software systems
• Proficiency with Python, backend development, databases, APIs, and modern software engineering workflows
• Experience building lab informatics systems, scientific data platforms, LIMS/ELN integrations, research software, or scientist-facing applications
• Experience with data modeling and database design for complex scientific, operational, or experimental workflows
• Demonstrated ability to work closely with scientists and translate ambiguous laboratory workflows into reliable software systems

Preferences (but not required)

• Experience with Benchling, lab automation, instrument data ingestion, sample tracking, or high-throughput experimental data
• Experience with data generated from mammalian or bacterial cell systems, gene editing, protein engineering, or related biological workflows
• Frontend web development experience and interest in building intuitive scientist-facing user interfaces

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We're looking for a Protein Design Scientist to own the development and deployment of agentic workflows for protein design. In this role, you will build systems that orchestrate protein language models, structure predictors, fitness scoring tools, and experimental feedback into automated or semi-automated design pipelines - closing the loop between computation and the wet lab.

This is a hands-on, high-ownership role. You'll work across the full stack of a design workflow: selecting and integrating models, defining agent logic and iteration strategies, building robust infrastructure for deployment, and collaborating closely with ML scientists, protein design scientists, and biologists to ensure your systems produce experimentally actionable results.

As an early employee, you will shape how Profluent approaches workflow automation and help define best practices for agentic systems in protein engineering.

Responsibilities

• Design, build, and deploy end-to-end agentic workflows that take protein function specifications and produce ranked candidate sequences for experimental validation
• Integrate protein language models, structure prediction tools, and scoring functions into multi-step pipelines with iteration, feedback loops, and human-in-the-loop checkpoints
• Own the full lifecycle of workflow systems: architecture, implementation, testing, deployment, monitoring, and iteration based on experimental outcomes
• Collaborate with ML scientists to evaluate and integrate new models into workflows, and with protein design scientists and biologists to translate scientific goals into computational specifications and ensure workflows align with experimental realities
• Develop tooling for experiment tracking, logging, reproducibility, and versioning of design campaigns
• Evaluate and benchmark workflow performance against experimental results, using outcomes to improve agent strategies and model selection
• Partner with ML scientists to identify where existing models fall short in agentic contexts and inform priorities for model development, fine-tuning, and evaluation

Qualifications

• PhD (or equivalent industry experience) in Computational Biology, Bioinformatics, Computer Science, Machine Learning, Biochemistry, or a related field
• Minimum of 3+ years of experience as a protein design scientist
• Strong software engineering skills: you write clean, modular, production-quality code (Python required; experience with workflow orchestration frameworks is a plus)
• Hands-on experience with protein language models (e.g., ESM, ProGen, ProtTrans) for sequence generation, scoring, or representation
• Demonstrated understanding of protein engineering principles: structure-function relationships, fitness landscapes, and how computational predictions connect to wet-lab validation
• Experience building multi-component systems that chain model inference with data processing, filtering, and decision logic

Preferences (but not required)

• Experience with agentic AI systems, LLM tool-use patterns, or multi-step reasoning pipelines
• Familiarity with structure prediction tools (AlphaFold, RoseTTAFold, ESMFold) and inverse folding methods (ProteinMPNN, LigandMPNN)
• Track record of computational designs that were experimentally validated
• Experience with cloud compute platforms (GCP, AWS, Azure) and containerized deployment (Docker, Kubernetes)
• Publications in protein design, protein engineering, or ML for biology at major conferences or journals
• Familiarity with directed evolution, rational design, or de novo protein design strategies

What We Offer 

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We're looking for an experienced Machine Learning Engineer to build and improve the models and ML systems that drive our protein design efforts. In this role, you'll deploy and optimize large-scale generative models for protein design, and develop the surrounding infrastructure and tooling that enable our ML and protein design scientists to work faster and more confidently. As an early member of a small, fast-moving engineering team, you'll have significant ownership over our ML stack and the opportunity to shape how our platform evolves.

Responsibilities

• Build robust, reproducible and user-friendly pipelines for automated model fine-tuning, alignment and evaluation 
• Design and implement  modular, easy-to-maintain, multi-model pipelines for protein design.
• Develop highly scalable ETL pipelines to process petabyte-scale protein data for model pretraining
• Optimize model training and inference code to maximize throughput and resource utilization when deployed at scale
• Develop software and infrastructure that enable the ML team to work quickly and frictionlessly in distributed and multi-cloud environments
• Partner with ML and protein design scientists to prototype research ideas and bring them into production

Who You Are

• You're comfortable taking ownership and working independently in a fast-moving environment
• You're an execution-oriented engineer who maintains high standards, and focuses on the highest-impact work
• You're comfortable owning the full stack of your work, from training code to the infrastructure it runs on
• You care deeply about model quality, efficiency, and reliability
• You're willing to step beyond your core responsibilities when the team needs it

Representative Projects

• Building hyperparameter search frameworks for SFT and Alignment workflows
• Increasing protein language model throughput during long context generation
• Updating existing model architectures to work and run efficiently on new GPU hardware
• Implementing a protein design pipeline that integrates prompt retrieval, sequence generation, attribute prediction, and structure prediction
• Establishing an ETL pipeline for sampling and tokenizing training datasets from an internal database of billions of sequences
• Developing a benchmarking and evaluation system for newly trained sequence generation models
• Contributing to the development of an internal service that provides transparent multi-node job submission for ML scientists

Qualifications

• BS or MS in Computer Science, Machine Learning, or a related field
• 3+ years of hands-on experience building and training ML models in PyTorch
• Strong Python and software engineering fundamentals, including testing, code quality, and version control
• Experience profiling, benchmarking, and optimizing ML model training and inference
• Experience implementing or optimizing transformer-based architectures
• Familiarity with cloud infrastructure and containerization (GCP, AWS, Azure, Kubernetes, Docker)
• Strong fundamentals in ML, statistics, and/or linear algebra

Preferences (but not required)

• Familiarity with protein language models or computational biology
• Experience with GPU-level optimization (CUDA, Triton)
• Experience with distributed training (DDP, FSDP, multi-node GPU clusters)
• Experience with databases and data processing pipelines
• Experience orchestrating multi-step ML workflows
• Experience building backend systems that serve ML models in production
• Contributions to open source ML projects or published research

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We’re looking for a strategic and hands-on Talent & People Operations Lead to own the full recruiting lifecycle and strengthen our people operations as part of the Operations team. You will play a critical role in building Profluent’s team and culture - ensuring we attract, hire, and retain top talent while creating an employee experience that enables people to thrive.

This role will begin with a strong focus on talent acquisition alongside core people operations, with the opportunity to expand into broader ownership across people operations and HR. This is an excellent opportunity to directly shape our team and culture during a pivotal stage of growth.

Responsibilities

• Lead full-cycle recruiting across technical and G&A functions, from sourcing to closing
• Define, lead and execute strategy to ensure we meet the approved hiring plan
• Partner with hiring managers and leadership to define roles, set hiring strategies, and ensure efficient processes
• Build and maintain a strong candidate pipeline through sourcing, networking, and outreach
• Develop and strengthen Profluent’s employer brand to attract top talent; ensuring postings, candidate experience, and external presence reflect our mission and culture
• Own and improve HR processes, including onboarding, benefits, compliance, and offboarding
• Drive initiatives that enhance employee experience such as team events, onboarding programs, and recognition efforts
• Lead performance management and employee engagement programs
• Collaborate across operations, scientific, and leadership teams to anticipate and address people-related needs
• Act as the primary point of contact for all HR and Ops questions, and effectively triage and escalate as appropriate

Qualifications 

• At least 5 years of experience in dedicated recruiting, with additional experience in people operations, ideally in a high-growth environment
• Experience as a full stack recruiter
• Experience sourcing technical talent
• Understanding of or a desire to learn HR fundamentals, including compliance and employee relations
• Excellent interpersonal, project management, and communication skills
• Ability to thrive in ambiguity, build structure, and drive outcomes independently
• Ability to maintain the highest standards of confidentiality when handling sensitive business information

Preferences (but not required)

• Experience in biotech, life sciences, or AI/tech startups 
• 2 years+ of experience at an early stage (Series B or earlier) company
• Familiarity with ATS, HRIS, and other people systems (e.g., Greenhouse, Rippling)
• Exposure to compensation planning and organizational development
• HR experience outside of recruiting 

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We are seeking a motivated and creative Research Associate to join our Platform Discovery team. You will work closely with more senior team members to design, execute, and optimize high throughput screening campaigns to support the discovery, characterization, and optimization of our novel gene editing tools. Your work will be critical for enabling new therapeutic opportunities.

The ideal candidate will have extensive experience with molecular cloning, mammalian cell culture techniques, NGS library preparation, and lab automation. This is an excellent opportunity to work cross-functionally with a diverse team of experts across AI and machine learning, protein design, cell biology, and gene editing.   

Responsibilities

• Design, execute, and optimize robust molecular and/or cell-based assays to measure on- and off-target activity of novel gene editing systems using a combination of targeted and genome-wide analytical methods
• Own execution of NGS-based screening workflows, including library preparation, assay QC, sequencing submission coordination, and final data quality assessment
• Partner with High Throughput Operations to build and optimize robust workflows to improve assay reproducibility, throughput, and operational robustness
• Analyze experimental data, interpret results, and clearly communicate findings to support data-driven prioritization and critical go/no-go decisions
• Maintain organized tracking of physical samples, reagents, consumables, and assay materials to support efficient high-throughput screening operations, including inventory management, sample traceability, and procurement coordination

Qualifications

• BS or MS in molecular biology, biochemistry, or a related field
• 0-5 years of academic or biotechnology industry research experience
• Extensive hands-on experience with molecular biology techniques and mammalian cell culture
• Experience with molecular or cell-based assay development and execution, employing qPCR/dPCR, NGS, and/or flow cytometry techniques
• Hands-on experience and/or a deep understanding of key concepts and challenges related to genetic medicine, gene editing systems, DNA repair, etc.  

Preferences (but not required)

• Experience with process automation and workflow scaling to support high-throughput molecular biology, cell-based assay, or NGS screening workflows, ideally in a biotechnology or industry research setting.
• Experience using Benchling as an electronic lab notebook and laboratory information management systems to document experiments, track sample metadata, and manage workflows.
• Experience operating automated liquid handling workflows for molecular biology, NGS library preparation, cell-based assays, or high-throughput screening applications

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We are seeking an energetic, highly organized, and adaptable Operations Associate I/II to serve as the backbone of our office and laboratory environment. This is a dynamic role where you will manage the daily pulse of our workspace while supporting our technical teams in facility expansion and lab maintenance.

The ideal candidate thrives in a startup atmosphere - moving seamlessly from coordinating a team social to assisting with lab safety protocols or assembling furniture for the office.

Responsibilities

Primary Operations & Office Management 

• Act as the primary stakeholder for reception, greeting and managing all incoming vendors, visitors, and deliveries
• Oversee all shipping/receiving, mail sorting, and courier pickups
• Maintain a high standard for the pantry, fridge, and stationery stock; ensure general kitchen and office cleanliness
• Manage room bookings, food orders for meetings, and desk/office setups for new hires; fulfill other administrative responsibilities assigned as needed
• Assist in planning and executing monthly team activities and quarterly off-site vendor visits
• Lead purchasing for office supplies, IT equipment, and social events

Lab & Facility Support

• Assist the Lab and Operations Manager in setting up new office and lab spaces, including furniture assembly and equipment placement
• Support the wet lab through inventory management, specialized waste management, and routine equipment maintenance
• Maintain in-depth knowledge of safety/emergency protocols; ensure the site remains compliant and safe for all staff
• Act as a buyer for the Bioinformatics, Machine Learning, and Biology teams, managing Purchase Orders (POs) and maintaining current vendor information
• Assist with account reconciliation and maintaining up-to-date vendor records
• Fulfill additional support on projects assigned as needed

Qualifications

• BA or BS or AA/AS +2 years relevant work experience
• Must be able to lift at least 25 lbs
• Previous experience managing Purchase Orders (POs) 
• Previous customer service experience or prior public-facing roles
• Exceptional interpersonal communication, excellent customer-facing skills, elite time management, and a high degree of organizational efficiency
• Ability to be adaptable/flexible in the day-to-day

Preferences (but not required)

• BS in STEM  
• 1+ years of experience in a wet lab environment
• Familiarity with BSL2 safety standards and hazardous waste protocols
• Proficiency with Rippling, Ramp, Google Drive, and Notion
• Ability to lift 40 lbs
• Desire to learn new skills and initiate and own new tasks or projects 

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

As we continue to push the boundaries of what is possible, we’re seeking an ML Platform / MLOps Engineer on the machine learning team to build and operate the infrastructure that powers our machine learning systems. You will work closely with machine learning scientists, protein design scientists, and engineers to enable reliable, scalable platforms for training, evaluating, and deploying large-scale generative biology models.

As an early member of the company, you’ll have significant ownership over the systems and tools that enable our research team to move quickly from experiments to production models.

What You'll Work On

• Infrastructure supporting large-scale generative models for proteins
• Systems that process massive biological datasets
• Experimentation platforms that enable rapid iteration by ML researchers
• Production services powered by machine learning models

Responsibilities

• Develop infrastructure that enables researchers to run large-scale ML training and inference workloads reliably and efficiently on GPU clusters
• Implement and maintain security best practices across our ML infrastructure, including access control, secrets management, and least-privilege policies
• Monitor and optimize infrastructure performance, reliability, and cost
• Evaluate different open source infrastructure solutions and cloud providers
• Build and maintain machine learning pipelines to support model inference workloads
• Implement CI/CD pipelines for machine learning models and services
• Develop tooling that helps researchers move quickly from experiments to production models

Qualifications

• BS in Computer Science or a related field
• 3+ years of experience building or operating production ML systems
• Experience with MLOps, ML infrastructure, or ML platform engineering
• Strong experience with cloud infrastructure (GCP preferred)
• Experience working with containerized workloads and orchestration systems (Kubernetes, Docker)
• Experience building data or ML pipelines
• Familiarity with CI/CD and infrastructure-as-code practices

Preferences (but not required)

• Experienced with the challenges of working with large scale ML models
• Experience with transitioning research ideas into production
• Familiarity with ML frameworks such as PyTorch, MLFlow
• Interested in the intersection between biology and AI

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We're looking for a motivated and creative Machine Learning (ML) Scientist to drive research into new technologies for biomolecular design. This position offers an opportunity to work at the forefront of generative modeling research across language processing, representation learning, and protein engineering. You should be a self-directed researcher who has the ability to rapidly prototype and evaluate new models and algorithms in the biomolecular domain. 

As an early employee, you will proactively shape the direction of our machine learning efforts and collaborate across diverse teams of computational and experimental scientists.

Responsibilities

• Design and develop state-of-the-art deep learning methods for protein sequence, structure, and function prediction and apply them to protein design
• Curate relevant datasets and design tasks for rigorous evaluation of generative models 
• Collaborate with Biology team to design and characterize novel designed biomolecules
• Implement, analyze, and interpret multiple computational approaches and present results to colleagues in regular update meetings
• Work within a collaborative, fast-paced, interdisciplinary team across biology and machine learning to help shape the scientific and strategic vision of the company

Qualifications

• PhD (or equivalent industry experience) in Computer Science, Machine Learning, Natural Language Processing, Applied Math, Computational Biology, Statistics, or a related field
• Experience with conceiving of, implementing, and evaluating novel machine learning techniques
• Publications at major machine learning conferences (NeurIPS, ICML, ICLR) or scientific journals (Nature, Science, Nature Biotech, Nature Methods, PNAS)
• Experience with modern deep learning frameworks such as Pytorch or Jax

Preferences (but not required)

• Familiarity with foundational biology of proteins and nucleic acids
• Experience developing machine learning models for proteins (language models, structure prediction, design)
• Previous experience in data extraction and curation from bioinformatics data sources
• Familiarity with wet lab experimental assays and associated limitations
• Experience with cloud compute platforms (GCP, AWS, Azure)

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We’re seeking an experienced computational scientist to lead the design, development, and operation of the NGS analysis platform that powers Profluent’s gene editing and protein design programs. You’ll work at the intersection of computational biology, software engineering, and experimental biology to build scalable systems that extract clear, actionable insights from large-scale sequencing data.

In this role, you’ll architect core bioinformatics infrastructure, define analytical strategy, and collaborate closely with experimental and ML teams to accelerate design-build-test-learn cycles. You’ll also mentor team members, promote software engineering best practices, and help shape the future of Profluent’s computational biology capabilities.

Responsibilities 

• Lead design and implementation of scalable NGS analysis pipelines supporting gene editing and protein engineering workflows
• Develop clear, intuitive visualizations and reports to communicate sequencing results and biological insights
• Manage cloud-based compute environments and data systems for large-scale datasets
• Partner with biology teams to analyze results, troubleshoot, and optimize experimental design
• Collaborate with machine learning teams to curate data for model training
• Establish best practices for code review, testing, and CI/CD in computational workflows
• Mentor junior scientists and foster a culture of rigor, reproducibility, and innovation

Qualifications

• PhD or MS in Bioinformatics, Computational Biology, Computer Science, or a related quantitative field
• 5+ years of experience analyzing NGS datasets (e.g., amplicon sequencing, high-throughput editing, or screening experiments)
• Strong programming skills in Python (pandas, numpy, biopython, etc.)
• Expertise with workflow orchestration tools (Nextflow, Snakemake) and cloud environments (GCP, AWS)
• Experience with containerization (Docker, Kubernetes) and scalable compute infrastructure
• Deep understanding of Linux, git-based version control, and software engineering best practices
• Proven ability to transform complex sequencing data into actionable biological insights

Preferences (but not required)

• Experience with gene editing technologies (CRISPR, base or prime editing; strongly preferred)
• Familiarity with SQL and data modeling for biological or experimental data
• Experience with LIMS platforms (e.g., Benchling) and lab data integration
• Track record of developing production-quality scientific software or open-source bioinformatics tools

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.