Profluent is seeking a Principal Infrastructure & Security Engineer to serve as the primary owner of Profluent’s security posture across scientific systems, lab automation environments, cloud and business infrastructure, endpoints, identity systems, and core operational workflows.

This person will be accountable for the design, implementation, operation, and continuous improvement of the technical controls, security standards, and operating practices that protect Profluent’s systems and data. This includes security architecture, access controls, hardening, monitoring, incident readiness, vendor and customer security assurance, and the systems and evidence required to achieve and maintain compliance commitments.

This is not a narrow compliance-only or infrastructure-only role. It is a broad ownership role for security across Profluent’s environments, with close partnership across Operations, Machine Learning, Bioinformatics, and Lab Automation.

Responsibilities

• Own Profluent’s overall security and compliance posture across company systems, scientific computing, lab automation, endpoints, identity, SaaS, cloud infrastructure, networking, and data-handling workflows, and be accountable for the ongoing maturity of security controls and practices across those environments
• Lead the implementation and operational maturity work required for Profluent to achieve and maintain SOC 2 and related compliance certification requirements, including control operation, evidence collection, monitoring, and repeatable processes
• Serve as the primary owner for security and compliance readiness across company systems, ensuring that Profluent can meet ongoing audit, certification, and customer assurance requirements over time 
• Own the translation of customer agreements, internal policies, and compliance requirements into concrete technical and operational controls
• Standardize and harden bioinformatics, lab informatics, and machine learning environments to align with security, reliability, and compliance requirements
• Define and drive adoption of secure baseline configurations, access controls, logging, backup practices, patching standards, and change management processes
• Own and evolve how Profluent approaches security more broadly, identifying gaps, prioritizing risks, and driving improvements beyond minimum compliance scope
• Drive standardization of Windows-based lab automation environments, balancing security, uptime, vendor constraints, and usability in laboratory settings
• Collaborate with stakeholders to document controls, system boundaries, standard operating procedures, and technical evidence needed for audits, certification efforts, and customer reviews
• Support vendor and platform evaluations related to security, observability, endpoint management, and infrastructure operations
• Improve identity, access, and account lifecycle management across company systems, including onboarding, offboarding, least-privilege access, and periodic access review support 
• Monitor key systems and respond to operational issues with an emphasis on root-cause analysis and durable remediation
• Maintain asset, system, and environment documentation so that critical processes are auditable, supportable, and repeatable

Qualifications

• Experience operating with broad ownership across infrastructure, security, and compliance in regulated, audit-conscious, or security-sensitive environments
• Experience serving as the most senior or primary security owner in a startup or scaling environment, even without a large dedicated security team
• Breadth across infrastructure security, corporate security, IAM, endpoint management, logging and monitoring, vulnerability reduction, incident response, vendor risk, and compliance
• Demonstrated ability to take ownership in ambiguous environments and set direction, not just execute within a narrowly defined specialty
• Familiarity with Windows-based lab automation systems and the realities of instrument-connected or vendor-managed environments
• Experience implementing or operating against security and compliance frameworks such as SOC 2, ISO 27001, NIST CSF, or similar
• Strong understanding of identity and access management, SSO, MFA, endpoint management, logging, patching, vulnerability reduction, and system hardening
• Ability to translate compliance and contractual data-handling requirements into concrete technical and operational controls
• Strong documentation skills, with the ability to create policies, procedures, standards, and technical runbooks that others can follow
• Experience preparing organizations for, achieving, or maintaining external compliance certifications or audit readiness
• Experience with infrastructure as code and/or configuration management tools such as Terraform, Ansible, or equivalent
• Experience administering Windows environments, preferably including systems used in laboratory, automation, manufacturing, or instrument-connected settings

Preferences (but not required)

• Familiarity with audit evidence preparation, control testing, and coordination with external auditors
• Familiarity with networking fundamentals including firewalls, routing, VLANs, NAT, VPNs, and secure remote access
• Experience influencing cross-functional teams and improving organizations mature security practices without relying on rigid bureaucracy

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We’re looking for a strategic and hands-on Talent & People Operations Lead to own the full recruiting lifecycle and strengthen our people operations as part of the Operations team. You will play a critical role in building Profluent’s team and culture - ensuring we attract, hire, and retain top talent while creating an employee experience that enables people to thrive.

This role will begin with a strong focus on talent acquisition alongside core people operations, with the opportunity to expand into broader ownership across people operations and HR. This is an excellent opportunity to directly shape our team and culture during a pivotal stage of growth.

Responsibilities

• Lead full-cycle recruiting across technical and G&A functions, from sourcing to closing
• Define, lead and execute strategy to ensure we meet the approved hiring plan
• Partner with hiring managers and leadership to define roles, set hiring strategies, and ensure efficient processes
• Build and maintain a strong candidate pipeline through sourcing, networking, and outreach
• Develop and strengthen Profluent’s employer brand to attract top talent; ensuring postings, candidate experience, and external presence reflect our mission and culture
• Own and improve HR processes, including onboarding, benefits, compliance, and offboarding
• Drive initiatives that enhance employee experience such as team events, onboarding programs, and recognition efforts
• Lead performance management and employee engagement programs
• Collaborate across operations, scientific, and leadership teams to anticipate and address people-related needs
• Act as the primary point of contact for all HR and Ops questions, and effectively triage and escalate as appropriate

Qualifications 

• At least 5 years of experience in dedicated recruiting, with additional experience in people operations, ideally in a high-growth environment
• Experience as a full stack recruiter
• Experience sourcing technical talent
• Understanding of or a desire to learn HR fundamentals, including compliance and employee relations
• Excellent interpersonal, project management, and communication skills
• Ability to thrive in ambiguity, build structure, and drive outcomes independently
• Ability to maintain the highest standards of confidentiality when handling sensitive business information

Preferences (but not required)

• Experience in biotech, life sciences, or AI/tech startups 
• 2 years+ of experience at an early stage (Series B or earlier) company
• Familiarity with ATS, HRIS, and other people systems (e.g., Greenhouse, Rippling)
• Exposure to compensation planning and organizational development
• HR experience outside of recruiting 

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.

We are seeking an energetic, highly organized, and adaptable Operations Associate I/II to serve as the backbone of our office and laboratory environment. This is a dynamic role where you will manage the daily pulse of our workspace while supporting our technical teams in facility expansion and lab maintenance.

The ideal candidate thrives in a startup atmosphere - moving seamlessly from coordinating a team social to assisting with lab safety protocols or assembling furniture for the office.

Responsibilities

Primary Operations & Office Management 

• Act as the primary stakeholder for reception, greeting and managing all incoming vendors, visitors, and deliveries
• Oversee all shipping/receiving, mail sorting, and courier pickups
• Maintain a high standard for the pantry, fridge, and stationery stock; ensure general kitchen and office cleanliness
• Manage room bookings, food orders for meetings, and desk/office setups for new hires; fulfill other administrative responsibilities assigned as needed
• Assist in planning and executing monthly team activities and quarterly off-site vendor visits
• Lead purchasing for office supplies, IT equipment, and social events

Lab & Facility Support

• Assist the Lab and Operations Manager in setting up new office and lab spaces, including furniture assembly and equipment placement
• Support the wet lab through inventory management, specialized waste management, and routine equipment maintenance
• Maintain in-depth knowledge of safety/emergency protocols; ensure the site remains compliant and safe for all staff
• Act as a buyer for the Bioinformatics, Machine Learning, and Biology teams, managing Purchase Orders (POs) and maintaining current vendor information
• Assist with account reconciliation and maintaining up-to-date vendor records
• Fulfill additional support on projects assigned as needed

Qualifications

• BA or BS or AA/AS +2 years relevant work experience
• Must be able to lift at least 25 lbs
• Previous experience managing Purchase Orders (POs) 
• Previous customer service experience or prior public-facing roles
• Exceptional interpersonal communication, excellent customer-facing skills, elite time management, and a high degree of organizational efficiency
• Ability to be adaptable/flexible in the day-to-day

Preferences (but not required)

• BS in STEM  
• 1+ years of experience in a wet lab environment
• Familiarity with BSL2 safety standards and hazardous waste protocols
• Proficiency with Rippling, Ramp, Google Drive, and Notion
• Ability to lift 40 lbs
• Desire to learn new skills and initiate and own new tasks or projects 

What We Offer

• High-growth opportunity with meaningful impact on the future of protein design
• Competitive compensation package with equity participation
• 401(k) with a strong employer match
• Comprehensive benefits including health/dental/vision insurance
• Generous PTO policy and commitment to work-life balance
• Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.

Work Authorization Requirement

Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.

Employment Eligibility Verification

Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.