At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary: 

This role offers the opportunity to gain experience in a fast-paced cutting-edge clinical lab environment. The Accessioner will work in a team environment which includes project managers and clinical lab ops specialists. As an Accessioner, daily tasks will involve patient specimen intake, accessioning, and fulfilling client requests for returns or destructions. This will entail following SOPs and working with Laboratory Information Management System (LIMS) and other software. This role will also perform shipping / receiving, recording, and inventorying of samples sent for laboratory testing.

Available Shift: 

Tuesday - Saturday - 10:30am - 7:00pm

Responsibilities: 

• Confirming daily incoming specimens such as blood, plasma, and tissue meet acceptability standards for testing
• Labeling specimens with associated unique lab identifiers & maintaining sample inventory logs.
• Promptly fulfill client requests to return or destroy specimens. 
• Prepare and ship specimens to various client testing sites. 
• Logging test reports and other sample data into LIMS.
• Work closely with the Lab Processing Team to provide consistent and ongoing support to the entire Lab Operations department.
• Assist and/or lead team projects or various initiatives and help train incoming staff members. 
• Other duties as assigned.

Requirements: 

• Bachelor of Arts or Science preferred with 0-2 years relevant experience.
• Proficient computing skills.
• Attention to detail and the ability to accomplish/complete a task while demonstrating a thorough concern for all the areas involved.
• Capable communicator with the ability to maintain open communication with internal employees and managers.

The hiring range for this position is $24 to $25.50 per hour, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

Based in Fremont, California, Personalis is a genome-oriented diagnostics company pioneering new paradigms in cancer management. We transform patient care through genomic characterization of tumors and ultrasensitive detection of disease recurrence or progression.  To achieve this, we leverage whole-genome, exome, and bespoke targeted sequencing with proprietary algorithms to provide unmatched genetic accuracy.

Join a world-class, multidisciplinary team to drive impactful R&D projects to improve our cutting-edge clinical offerings. Your work will advance a new generation of precision medicine products used by global biopharma and clinicians to transform cancer diagnostics and therapeutics.

Responsibilities:

• Organize and help perform internal proof of principle projects, development projects, and verification and validation exercises for liquid biopsy products in the Personalis portfolio.
• Work with the broader R&D organization to scope, track and troubleshoot liquid biopsy projects with internal and external collaborators and customers.
• Collaborate with process development, tech transfer, and operations teams to shepherd early stage products, product revisions, and early projects through to operations.
• Work with bioinformatics teams to plan experiments and analyze results.
• Identify problems in current processes and come up with troubleshooting approaches and
• Participate in meetings and present results.
• Use effective two-way communication to create and maintain a collaborative working environment.
• Support and ensure compliance with all department and company policies and procedures.

Education and Experience:

• Ph.D or MS with a minimum of 8 or 12 years of experience.
• Minimum of 2 years of laboratory experience in NGS and/or liquid biopsy focused molecular biology.
• Solid understanding of DNA/RNA manipulation.
• Excellent organization, documentation and communication skills.
• Passion for exploring new assays, hands-on experiment execution and creative thinking to solve problems.
• Excellent ability to multitask and troubleshoot complex protocols.
• Experience with automation (Hamilton or other liquid handlers) helpful.
• ISO13485 validation experience helpful.
• Data analysis skills with experience in Excel, JMP, R or Python.
• Prior experience working with a LIMS directed environment.
• Prior experience in cancer biology is strongly desired.

The hiring range for this position is $170,000 to $200,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

Personalis is a genome-scale diagnostics company with a mission to pioneer genome guided medicine. Our priority is to obtain the most accurate genetic data from each sample, and then to draw the most reliable medically-focused conclusions from these. Our tests are based on whole human genome and exome sequencing, conducted in our state-of-the art laboratory.  We analyze results utilizing proprietary databases, advanced human reference sequences, and sophisticated algorithms. Personalis is based in Fremont, California.

Summary:

We are looking for a dynamic and experienced Senior Director of Advanced Technologies to lead a team in scoping, evaluating, and implementing cutting-edge advancements in sequencing, sample preparation and new assay creation. This role will drive innovation in our proprietary technologies, enhancing performance and expanding capabilities. Your contributions will play a key role in shaping the next generation of genomics-based precision medicine products, supporting immuno-oncology, cancer clinical trials, diagnostics, and therapeutics used by pharma, biotech, hospitals, and clinicians.

Responsibilities:

• Develop and execute the advanced technology strategy, ensuring alignment with company objectives and long-term vision.
• Lead efforts to evaluate and integrate new technologies that expand and improve Personalis products.
• Participate in forward-looking strategic planning and influence company-wide technology adoption.
• Identify new initiatives and build consensus across various stakeholder groups with clear success measures.
• Work closely with bioinformatics teams to design experiments and validate new procedures and analytics.
• Partner with the operations teams to ensure the smooth adoption of new technologies.
• Collaborate across functions to troubleshoot issues and implement solutions that drive efficiency.
• Influence company policy and strategy by partnering executive leadership.
• Recruit, mentor, and manage a high-performing team of scientists to drive innovation and operational excellence.
• Foster a culture of continuous learning, inclusion, and professional growth for all team members.
• Ensure accountability for results and provide strategic focus to support both short- and long-term organizational success.
• Demonstrate strong leadership, communication, and influence across all levels of the organization.
• Model and promote Personalis values, fostering collaboration and valuing diversity.
• Drive continuous innovation by encouraging the team to identify process efficiencies and new solutions.
• Support compliance with all department and company policies, ensuring regulatory and quality adherence.
• Work cooperatively across functions to achieve broader company objectives and business success.

Education & Experience:

• Ph.D in a related field with 10+ years of relevant experience, preferably in molecular biology.
• Minimum of 5 years of management experience, with a proven ability to set a clear vision, establish expectations, and motivate teams to achieve results.
• Demonstrated success in driving performance, achieving objectives, and leading teams to meet departmental goals.
• Strong communication, presentation, and influencing skills, with the ability to effectively engage and gain support from senior leadership.
• Expertise in strategic thinking, decision-making, and negotiation, ensuring smooth daily business operations.

The hiring range for this position is $240,000 to $285,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

Under the direction of the department supervisor, technical/clinical consultant, and laboratory director, the Histotechnician 2 will be responsible for processing FFPE specimens for microscopic evaluation to support our molecular diagnostics test offerings.

Available Shifts:
1) Tuesday - Saturday, 12:00pm - 8:30 pm
2) Tuesday - Saturday, 8:00pm - 4:30am

Responsibilities:

• Perform sectioning of tissue using a microtome and mounting on glass slides
• Perform routine staining of tissue sections with automated and/or manual staining techniques
• Perform automated and/or manual coverslipping of slides
• Generate digital slide images for pathologist examination
• Perform manual and automated macrodissection
• Operate and perform instrument maintenance
• Perform histology lab functions while following laboratory safety and quality policies
• Comply with standard laboratory operating policies and procedures
• Use of good documentation practices to record specimen data manually or in Laboratory Information Management Systems
• Help meet TAT goals while maintaining high-quality productivity
• Maintain clean and organized work areas within the laboratory
• Report problems to the department supervisor/manager to ensure timely resolution
  
  

Requirements:

• Associate's degree in chemical/physical/biological science or completion of a NAACLS-accredited Histotechnology program; Bachelor’s degree in a laboratory science curriculum preferred
• Minimum of 3+ years experience working in a high-volume histology laboratory performing microtomy of various tissue types, H&E staining, and tissue embedding
• HT or HTL certification from ASCP required
• Experience working in IHC and digital imaging, tissue/tumor identification, and proficiency in reading pathology reports, a plus
• Excellent attention to detail, organization, and time management skills
• Ability to communicate effectively with excellent interpersonal skills
• Physical demands include stooping, turning, bending, squatting, kneeling, and the ability to lift up to 25 lbs.

The hiring range for this position is $40.00 to $50.00 per hour, which may factor in various geographic regions. This shift is eligible for a shift differential pay bonus. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contact you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.

Summary:

We are seeking a Software Engineer II to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment.

Onsite: Monday, Tuesday, and Thursday 

Responsibilities:

• Design, develop, test, and maintain software systems and features supporting laboratory operations.
• Develop and optimize backend services and APIs using Python and/or Java.
• Implement solutions using a variety of database technologies, including relational and graph databases.
• Take ownership of deploying and maintaining services in our AWS cloud environment.
• Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability.
• Troubleshoot and resolve complex technical issues in development and production environments.
• Collaborate with cross-functional teams to translate business requirements into robust technical solutions.

Qualifications:

• B.S. degree in Computer Science, Engineering, or a related technical field.
• 2-5 years of professional software development experience.
• Strong proficiency in at least one programming language such as Python or Java.
• Proven experience building and deploying applications on AWS.
• Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs.
• Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts.
• Excellent problem-solving skills and the ability to work independently on complex tasks.

Preferred:

• Experience with web frameworks like Flask or FastAPI.
• Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js).
• Experience in the life sciences, healthcare, or another regulated industry.
• Familiarity with containerization technologies (e.g., Docker).
• Exposure to graph databases or NoSQL technologies.

What You’ll Gain:

• Opportunity to take ownership of significant features and projects from design to deployment.
• Deepen your expertise in AWS services and cloud architecture.
• Gain valuable experience working in a regulated life sciences environment.
• Clear pathways for career growth into a senior engineering role through mentorship and impactful work.

The hiring range for this position is $130,000 to $155,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Hybrid

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

A CLS Supervisor performs and reports on clinical laboratory testing that aids physicians in diagnosing and treating patients. A key part of the role is supervising team members and ensuring that all laboratory procedures are followed for specimen handling, next-generation sequencing (NGS) processes, test analyses, and the accurate maintenance of patient records.

In our lab, we foster a positive, friendly, and team-based environment. We all pitch in to achieve our common goals and support each other. You'll work in a dynamic atmosphere, gaining hands-on experience at multiple benches, including extractions, library preparation, and sequencing. You'll also partner with our lab assistants to coordinate pre-analytical and post-analytical tasks.

Available Shifts:

• Sun - Thu, 10:00pm - 6:30am

Responsibilities: 

• Perform and report clinical laboratory testing on patient samples to aid physicians diagnose and treat patients. This includes the following areas:
• Extractions
• Library Preparation
• Enrichments
• Sequencing
• Handle and process all patient specimens according to laboratory procedures, ensuring accurate and timely record-keeping and reporting of results.
• Select, implement, and evaluate quality control materials for statistical process control of laboratory assays.
• Troubleshoot assays and equipment when quality control materials fail to perform as expected.
• Document all corrective actions taken when test systems deviate from established performance specifications.
• Assist in audits by regulatory bodies like CAP and external customers.
• Participate in activities that support the laboratory's necessary licensure, including quality management and on-site inspections.
• Identify and correct problems that may negatively affect test performance or result reporting. If a problem cannot be immediately corrected, notify a supervisor, clinical consultant, or director.
• Train other CLS and lab personnel on laboratory methods.
• Monitor the activities of non-licensed staff.
• Provide guidance to team members on troubleshooting and deviation investigations.
• Assist in assay development activities.
• Demonstrate strong analytical skills and independent critical thinking.
• Apply technical and functional knowledge to help the team meet its goals.
• Work independently to identify and resolve complex, open-ended problems.

Requirements:

• Education: Bachelor's degree, preferably in sciences or related discipline.
• Licensure: Valid California Clinical Laboratory Scientist (CLS) or Clinical Genetic Molecular Biologist Scientist (CGMBS) license.
• Experience: At least four years of CLS experience in a clinical laboratory environment. Minimum 1 year experience in a Lead role is required.
• Preferred Skills: Experience with manual DNA/RNA extractions, manual library preparation, and automated liquid handlers.

The hiring range for this position is $72.10 to $81.70 per hour plus applicable shift differential. The offer will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contact you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Shifts Available:

• Friday - Tuesday: 10pm - 6:30am (3rd Shift)
• Tuesday - Saturday: 10pm - 6:30am (3rd Shift)

Training hours may be different from your shift schedule. 

Responsibilities:

• Perform nucleic acid extraction from various sample types in a Biosafety Level 2 laboratory (e.g., FFPE, blood, plasma, and more)
• Quantify extracted materials by following QC protocols
• Prepare extracted materials for library prep using automated and manual procedures. 
• Record sample processing workflows in real-time through a Laboratory Information Management System (LIMS)
• Maintain robotic liquid handlers and other instruments for optimal performance 
• Assists in data transfer and basic QC evaluation of data 
• Perform troubleshooting and system evaluations when necessary, in communication with the automation support team, laboratory supervisor, and/or third-party technical support teams 
• Escalates issues to a supervisor when problems arise with sample processing 
• Maintain appropriate supplies and equipment to maximize department efficiency and meet established budgetary and quality goals 
• Support and ensure compliance with the laboratory’s quality control procedures and policies 
• Document all corrective actions taken when test systems deviate from the laboratory’s established performance specifications 
• Demonstrate knowledge of laboratory safety protocols 
• Demonstrate commitment to quality and continuous improvement 
• Use effective two-way communication and participate in general laboratory meetings 
• Perform other duties as assigned, including performing workflows outside of extractions

Requirements:

• BA/BS in a biological discipline 
• 0-2 years of relevant laboratory experience 
• Familiarity with Hamilton, or other robotic liquid handlers, is desired 
• Familiarity with LIMS or sample management tracking systems is desired 
• Familiarity with Quality control of samples and quantification devices (e.g., TapeStation, Qubit, qPCR) 
• Flexible and adaptive in a frequently changing environment 
• Strong communication skills, ensuring effective communication when issues arise.
• Strong organizational skills and attention to detail 
• Ability to analyze and solve basic problems 
• Ability to work as part of a team in a highly collaborative environment 
• Ability to work independently with minimal supervision 
• Desire to learn new skills and grow his/her knowledge of next-generation sequencing technologies 
• Strong desire to work in a demanding, high-energy, hands-on environment
  
  

The hiring range for this position is $27.50 to $34.60 per hour, which may factor in various geographic regions. This shift is eligible for an additional shift premium. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

The hiring range for this position is $36 to $44 per hour. This shift is eligible for an additional shift premium.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity for Employer/Minorities/Females/Veterans/Disabilities. 

#LI-KK1  #LI-Onsite

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited.

Days Onsite: Monday & Tuesday (Hybrid)

Summary:

The Sr. Payroll Analyst is responsible for processing the Company’s payroll using the ADP platform on a regular basis in accordance with the Company’s policy and ensuring accurate reflection of payroll data in the financial statements. This position will work closely with Accounting and Human Resources team members to perform the scope of work, and provide exceptional service to the entire employee base. The position will also flex to support other areas in accounting, as needed.

Responsibilities:

• Responsible for full cycle processing of all payroll functions including, time & attendance, time-off, security master, reporting, and workflow administration for all U.S. employees.
• Prepare accounting transactions, including journal entries for semi-monthly payroll/payroll accruals and reconcile payroll related accounts monthly.
• Prepare payroll account reconciliations and flux commentaries for financial statement close review.
• Enforce payroll policies and procedures to ensure proper internal controls and efficient processes in compliance with SOX 404 requirements.
• Manage new state registrations for withholding tax, SUI (state unemployment insurance) and any applicable local taxes.
• Review and audit employee 401(k) contributions as well as make contribution deposits to 3rd party 401(k) administrator in a timely manner.
• Work closely with HR team to ensure employee new hires, terminations, LOA’s, and other changes that affect payroll are processed accurately and timely.
• Review voluntary deductions including medical benefits, FSA, ESPP, 401(k) contributions and loans as well as involuntary deductions, such as garnishments.
• Enter equity related income for NQ exercises and RSU releases. Reconcile YTD taxes to payroll accounting system.
• Responds to employee questions and addresses any payroll issues/updates/edits required.
• Ensure timely and accurate W-2 preparation at the end of each calendar year.
• Creating and run payroll related reports as required for interdepartmental and cross functional charges and reference.
• Other ad-hoc related tasks as required

Qualifications - Required:

• Bachelor’s degree in Accounting, Finance, Business Administration, or related field.
• 5-8 years of progressive payroll experience 
• Experience with supporting month-end close for payroll related accounts and account reconciliations
• Multi-state payroll experience with ADP Workforce Now and other related systems such as Time & Attendance using time card and Time Off module etc.
• Great team player, flexible and able to adapt to a changing environment. Ability to multi-task and meet challenges with resourcefulness, effectively handle competing demands, take responsibility for fulfillment of obligations and willing to put in extra time as necessary to complete work and achieve goals.  
• Attention to detail with a high-quality focus as well as timeliness.
• Excellent communication and interpersonal skills.

Qualifications - Preferred:

• Experience working with U.S. public company with between 100 to 500 employees

The hiring range for this position is $98,000 to $115,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-Hybrid #LI-KK1

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Shift(s) Available:

• Sunday - Thursday: 10pm - 6:30am (3rd Shift)
• Tuesday - Saturday: 2pm - 10:30pm (PM Shift)

Training hours may be different from your shift schedule. The PM and 3rd shift would be eligible for an additional shift premium.

Summary:

A CLS Supervisor performs and reports on clinical laboratory testing that aids physicians in diagnosing and treating patients. A key part of the role is supervising team members and ensuring that all laboratory procedures are followed for specimen handling, next-generation sequencing (NGS) processes, test analyses, and the accurate maintenance of patient records.

In our lab, we foster a positive, friendly, and team-based environment. We all pitch in to achieve our common goals and support each other. You'll work in a dynamic atmosphere, gaining hands-on experience at multiple benches, including extractions, library preparation, and sequencing. You'll also partner with our lab assistants to coordinate pre-analytical and post-analytical tasks.

Responsibilities: 

• Perform and report clinical laboratory testing on patient samples to aid physicians diagnose and treat patients. This includes the following areas:
• Extractions
• Library Preparation
• Enrichments
• Sequencing
• Handle and process all patient specimens according to laboratory procedures, ensuring accurate and timely record-keeping and reporting of results.
• Select, implement, and evaluate quality control materials for statistical process control of laboratory assays.
• Troubleshoot assays and equipment when quality control materials fail to perform as expected.
• Document all corrective actions taken when test systems deviate from established performance specifications.
• Assist in audits by regulatory bodies like CAP and external customers.
• Participate in activities that support the laboratory's necessary licensure, including quality management and on-site inspections.
• Identify and correct problems that may negatively affect test performance or result reporting. If a problem cannot be immediately corrected, notify a supervisor, clinical consultant, or director.
• Train other CLS and lab personnel on laboratory methods.
• Monitor the activities of non-licensed staff.
• Provide guidance to team members on troubleshooting and deviation investigations.
• Assist in assay development activities.
• Demonstrate strong analytical skills and independent critical thinking.
• Apply technical and functional knowledge to help the team meet its goals.
• Work independently to identify and resolve complex, open-ended problems.

Requirements:

• Education: Bachelor's degree, preferably in sciences or related discipline.
• Licensure: Valid California Clinical Laboratory Scientist (CLS) or Clinical Genetic Molecular Biologist Scientist (CGMBS) license.
• Experience: At least four years of CLS experience in a clinical laboratory environment. Minimum 1 year experience in a Lead role is required.
• Preferred Skills: Experience with manual DNA/RNA extractions, manual library preparation, and automated liquid handlers.

The hiring range for this position is $72.10 to $81.70 per hour plus applicable shift differential. The offer will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contact you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)

#LI-KK1 #LI-Onsite

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary: 

This role offers the opportunity to gain experience in a fast paced cutting edge clinical lab environment. The Sample Accessioner will work in a team environment which includes project managers and clinical lab ops specialists. As an Accessioner, daily tasks will involve patient specimen intake, accessioning and fulfilling client requests for returns or destructions. This will entail following SOPs and working with Laboratory Information Management System (LIMS) and other software. This role will also perform shipping / receiving, recording and inventorying of samples sent for laboratory testing.

Available Shifts: Mon-Fri, 10:30 am - 7:00 pm OR Tues - Sat, 10:30am - 7:00pm

Responsibilities: 

• Confirming daily incoming specimens such as blood, plasma, and tissue meet acceptability standards for testing
• Labeling specimens with associated unique lab identifiers & maintaining sample inventory logs.
• Promptly fulfill client requests to return or destroy specimens. 
• Prepare and ship specimens to various client testing sites. 
• Logging test reports and other sample data into LIMS.
• Work closely with the Lab Processing Team to provide consistent and ongoing support to the entire Lab Operations department.
• Assist with team projects or various initiatives and help train incoming staff members. 
• Other duties as assigned.

Requirements:

• Bachelor of Arts or Science preferred with 0-2 years relevant experience.
• Proficient computing skills.
• Attention to detail and the ability to accomplish/complete a task while demonstrating a thorough concern for all the areas involved.
• Capable communicator with ability to maintain open communication with internal employees, managers.
  

The hiring range for this position is $24.00 to $25.00 per hour.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know.

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

We are seeking an accomplished and strategic Director of Laboratory Operations to lead and scale our NeXT Personal laboratory. In this high-visibility role, you will drive operational maturity, ensuring our high-complexity liquid biopsy laboratory functions at the gold-standard. Beyond overseeing daily operations, you will have the autonomy to shape the future of the lab, reporting directly to the VP of Operations with full accountability for departmental AOPs and OKRs.

As a Director of Laboratory Operations, you will lead a multidisciplinary team of supervisors and associates to meet increasing demand, directly influencing patient outcomes in oncology. By joining us, you become a catalyst for growth, driving continuous improvement across our RUO, GLP, and CLIA/CAP operations. We are looking for a leader who thrives in a "Team Above Self" environment - someone who will act as a dedicated mentor to develop the next generation of laboratory leaders while ensuring that every sample processed reflects our unwavering commitment to patient care and diagnostic integrity.

Responsibilities:

The Director of Laboratory Operations will be responsible for management and oversight of the RUO, GLP and CLIA/CAP laboratory operation and personnel.

• Accountability for overall laboratory operations and clinical test performance in accordance with federal and state regulations
• Oversee recruiting, training, and managing testing personnel, ensuring that all employees are adequately qualified and motivated to perform their duties
• Oversee validation, assay transfer, and verification of LDTs
• Prepare and attend Audits and Inspections(e.g. by pharma clients, CLIA / CAP, NYS, etc.)
• Lead a team of CLSs and Technical / General Supervisors
• Actively assist and lead, as needed, laboratory related NCs and CAPAs
• Attend and actively contribute to the monthly Personalis laboratories Quality Assurance meeting.
• Identify and advocate cross functionally for scalable solutions that enhance quality and efficiency
• Develop strategic plan and AOP for their department
• Champion and lead OKR’s development, execution, and monitoring
• Architect capacity models to better understand our labor and equipment requirements
• Develop cost models to estimated cost and profit across product lines
• Drive an analytical approach to decision making and problem solving
• Act as a teacher, mentor, and advocate for personal growth with our young leaders and prepare them for achieving the next levels in their career.
• Cultivate both short and long term logistical planning for patient sample processing.
• Will own the TAT for the product line and endeavor to continually improve our delivery times 
• Spearhead a high-performance culture rooted in harmony and a 'team-above-self' mindset. You will champion a solution-focused environment that prioritizes open communication, a sense of belonging, and a commitment to winning as a unified organization.

Education & Experience:

• Education: Bachelor’s Degree in a relevant scientific field (Advanced degree preferred).
• Licensure: Current and valid California Clinical Laboratory Scientist (CLS) License preferred. (Generalist or Limited Molecular Biology).
• Four (4) to six (6) plus years of experience as California CLS to qualify as Senior Technical Supervisor for the Personalis Molecular Pathology Clinical Laboratory required  preferred
• Experience: Minimum 10+ years of extensive experience in high-complexity laboratory operations. Must have experience in high volume settings.
• Leadership: Minimum 5+ years of management experience with a proven ability to set vision, manage managers, and motivate teams for results.
• Technical Proficiency: Deep experience with NGS technologies, root cause analysis, logistics, capacity modeling, and LIMS.

The hiring range for this position is $210,000 to $245,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Days Onsite: Tuesday - Saturday from 9:30am - 6pm

Summary:

The QA Specialist is an integral member of the Quality team. The primary responsibilities are to assist in the implementation and management of the Quality Management System. This individual helps drive the Quality Management System implementation in accordance with CLIA, CAP, ISO 15189, ISO 13485, 21 CFR 820 and other regulations and guidance as applicable.  The Sr. QA Specialist has knowledge and experience working in ISO 15189 and/or ISO 13485 or 21 CFR 820 regulated environments and sufficient knowledge and experience working in Quality to operate with minimal supervision. This role will be required to work an offset schedule (e.g. Tueday through - Saturday) to ensure support for the Reagent Manufacturing and Clinical Laboratory Operations over the weekend.This position reports to the Director of Quality Assurance.

Responsibilities:

• Timely performance of Quality review and audits of Clinical Study data in compliance with GCP / GCLP to ensure the accuracy, consistency, and traceability
• Performance of incoming inspection and release of raw and in house materials to assure operations continuity over weekends
• Review of laboratory production records including batch history record, equipment records, and environmental monitoring records, etc
• Preparation of data audit reports for provision to study sponsor
• Verification that laboratory activities and clinical processes adhere to Good Clinical Laboratory Practice (GCLP) and Good Clinical Practice (GCP) guidelines
• Evaluation of  internal Standard Operating Procedures (SOPs) to identify gaps in the workflow that could compromise data integrity.
• Partner with the study project manager to ensure execution of study specific requirementsInitiate and investigate nonconformances / deviations from procedure or specification
• Maintain policies and SOPs to implement effective processes for Quality Audits and oversight of clinical studies
• Help drive continuous improvement initiatives in support of all Quality Systems 
• Actively engage with process owners to resolve documentation errors and nonconformances
• Assist in the investigation and root cause analysis teams for CAPAs, deviations and non-conformances.
• Additional duties as assigned

Requirements:

• Bachelor's degree with a minimum of 3-5 years in a Quality role within the medical device or biotech industry.
• Strong working knowledge of ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate)
• Demonstrated experience auditing laboratory data under GCLP and clinical data under GCP
• Ability to compile data and summarize results
• Excellent written and verbal communication skills
• Experience in authorship of standard operating procedures
• Experience with ISO Standards and FDA-regulated environment highly desirable
• Experience in quality system methodologies including but not limited to CAPA, Lean, 5 Why's, Pareto Analysis
• Must have proven interpersonal, and communication skills
• Strong desire to work in a demanding, high-energy, hands-on environment
• Expert level use of Word, Excel, and Google Suite / Apps and experience with electronic document management systems

The hiring range for this position is $85,000 to $95,000 per year, which may factor in various geographic regions. This position is also eligible for overtime pay. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

The Senior Process Automation Engineer within the Research, Product Development and Technology Transfer Group contributes to the development and implementation of automation systems and workflows to support the processing of samples in a clinical diagnostics and research laboratory environments.  This individual collaborates within a team of scientists and engineers upon projects to conceptualize, design, develop, and implement solutions designed to optimize the performance and increase the efficiencies of the laboratory processes.

Responsibilities:

• Principal responsibilities of this position include automation projects leadership.
• Lead the development and integration of the automation systems and related software tools, preparing the documentation for equipment validation and operating procedures.
• Develop scripts for liquid handling robots and other lab automation instruments.
• Building rapport with end-users, lab supervisors and process owners, and coordinate with cross functional teams to ensure the successful implementation in the labs.
• Define and lead the automation systems development, testing and qualification requirements.
• Support the documentation efforts for equipment validation and operating procedures.
• Lead troubleshooting efforts, analyze data and help drive key process related decisions.
• Collaborate with external vendors to assess and implement new solutions.

Requirements:

• Bachelor's degree in engineering/biochemistry field and a minimum of 5 years of experience, or Advanced degree in engineering/biochemistry field and a minimum of 3 years of experience in NGS lab as an automation programmer. 
• Technical proficiency and experience in automation systems development and integration for the life science industry; especially with robotics and liquid handling systems is required.
• Hamilton Venus 4 or 6 programming experience is required.
• Experienced in deploying automation methods using GitHub/GitLab.
• Good Project management, organizational and written and verbal communication skills.
• Able to communicate effectively across teams to understand problems, come up with solutions and explain methodological details and results from analysis.
• Mentor, develop and provide guidance to other team members.
• Experienced in drafting user requirements, testing and Standard Operating Procedures, and related documentations; and overseeing the functional and validation testing, IQ/OQ/PQ.
• Flexibility and self-initiative required to support several simultaneous projects.
• Able to work independently on identification and resolution of open-ended problems of diverse scope.  
• Able to work on complex problems in which analysis of situations or data requires an in-depth evaluation of various factors. Exercises judgment within broadly defined practices and policies in selecting methods, techniques, and evaluation criteria for obtaining results.

The hiring range for this position is $135,000 to $165,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1  #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

We are seeking a results-driven, hands-on Process Development Scientist to join our exciting team.  In this role, you will be responsible for translating R&D breakthroughs into reagent production processes, specifically focusing on formulations, packaging, and QC assays/specifications.    This position bridges R&D and Manufacturing, ensuring that new products are robust, scalable, cost-effective, and compliant with ISO 13485/GMP standards.

Responsibilities:

• Formulation Process Development: Develop and optimize manufacturing methods for reagent formulations to ensure consistency, functionality, and stability.
• Reagent Packaging Process Development: Design and implement accurate and reproducible filling, dispensing, labeling, and sealing processes for liquid reagents into tubes and multi-well plates.
• Scale-Up: Transition laboratory-scale formulations and manual filling processes into robust, automated, or semi-automated production-scale processes.  Evaluate outsourcing to contract manufacturers, as needed.  Design scaled up and practical manufacturing processes, while identifying Critical Process Parameters and Critical Quality Attributes.
• QC Assay Development & Specs: Develop relevant in-process and finished product test methods (e.g. pH/conductivity, absorbance, real time PCR, library prep, sequencing, etc.) to ensure release of high-quality products.
• Validation: Generate validation plans/reports and execute studies to release robust new production processes, QC assays, and new equipment into Reagent Manufacturing.
• Technology Transfer: Collaborate with R&D for new product introduction (NPI) and transfer processes to Manufacturing, including drafting Standard Operating Procedures (SOPs) and Batch Records (BRs).
• Troubleshooting: Investigate and resolve manufacturing issues, including production failures and out-of-specification (OOS).  Identify root cause and quickly implement effective solutions.
• Quality & Compliance: Ensure all developed processes and documentation comply with ISO 13485, GMP, and internal quality standards. 

Requirements:

• Education: PhD in Molecular Biology, Biochemistry, Chemistry, or Chemical Engineering with 1-3+ years of industry experience; or Master's degree with 3-5+ years; or Bachelor’s degree with 5+ years.
• Technical Skills: 
  • Hands-on experience with molecular biology techniques (qPCR, PCR, enzyme assays, Library Preparation, Next Gen Sequencing).
  • Experience with oligonucleotides, enzymes, reagent formulation, mixing, and filling.
  • Expertise in scale up and technology transfer.
  • Knowledgeable in high throughput liquid handling automation (e.g., Tecan, Hamilton) and reagent packaging technology for tube/plate dispensing and labeling, a plus.

• Experience: Proven track record of independent achievements in reagent process development, NPI/technical transfer, or manufacturing support within a regulated IVD, clinical, or biotechnology environment.
• Software: Proficiency in data analysis software (e.g., JMP, Minitab, Excel) and LIMs Systems.  Familiarity with PLM, ERP, and MES systems, a plus.
• Documentation: Strong technical writing skills for SOPs/batch records, validation protocols, and technical reports.
• Quality Systems: Strong understanding of ISO13485, GLP/GMP, and operating under strict SOPs. 

Core Competencies:

• Detailed-oriented and analytical with excellent problem-solving skills and a process improvement mindset.
• Strong collaboration skills, working across R&D, Manufacturing, and QA/QC.
• Capable of managing multiple projects in fast-paced, cross-functional teams, with the ability to identify/execute to high-impact tasks and adjust to changing priorities.

The hiring range for this position is $120,000 to $150,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Hybrid - Onsite on Monday & Tuesday

The hiring range for this position is $63,000 to $76,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity for Employer/Minorities/Females/Veterans/Disabilities. 

#LI-KK1  #LI-Hybrid

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

The hiring range for this position is $30 to $38 per hour.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity for Employer/Minorities/Females/Veterans/Disabilities. 

#LI-KK1  #LI-Hybrid

Personalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform® is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing operations globally and is currently the sole sequencing provider to Veterans Affairs' Million Veteran Program. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale and efficiency. The laboratory is GxP-aligned as well as Clinical Laboratory Improvement Amendments of 1988-certified and College of American Pathologists-accredited. Personalis is based in Fremont, California.

Days Onsite: Monday & Tuesday (Hybrid)

Summary:

The Clinical Research Associate is responsible for managing clinical operations projects, which includes biospecimen management, GCP documentation, and compliance requirements related to Personalis clinical research studies and CRO partnerships. This individual will require an understanding of oncology molecular testing using Next Generation Sequencing (NGS) platforms, medical devices, and will interact with external partners to execute clinical operations, monitoring, regulatory, and clinical quality documentation.

Responsibilities:

• Lead clinical operations activities.
• Manage Clinical study operations (internal and external) in coordination with CRO, IRB, regulatory, and quality teams.
• Support the program sponsor in preparation of clinical study operations.
• Collaborate in the execution of clinical validation studies to support clinical programs.
• Oversee clinical site initiation, monitoring, and closeout activities.
• Participate in Site Monitoring activities.
• Manage CRO partnerships.
• Manage the clinical study biospecimen repository and data management.
• Track Timelines, Milestones, Deliverables, Resources, and Costs.
• Ensure internal and external milestones, deliverables, and obligations are met.
• Partner collaboratively with the Regulatory and Quality teams to ensure that all internal SOPs and compliance documentation meet quality standards.
• Take ownership of key partner-related issues and work with appropriate internal teams to resolve them.

Requirements:

• BS or MS in biological science, computer science or a related field.
• Minimum of 2+ years working in industry or academics in clinical operations for medical devices.
• Experienced with products in a clinical or regulated environment (such as with IRB, FDA, CAP/CLIA etc).
• Familiarity with Electronic Data Capture (EDC) platforms and Trial Master File (TMF) organization and structure.
• Experience with Onsite or Remote clinical study monitoring
• Experience with Case Report Form (CRF) creation
• Proficiency in MS Word, Excel, and PowerPoint.
• Experience with Good Clinical Practice (GCP) and clinical quality compliance.
• Demonstrated history of successfully managing multiple concurrent initiatives.
• Strong interpersonal skills, collaboration, and problem-solving with colleagues.
• Strong communication and excellent written and oral skills.
• Detail-oriented, with solid organization and time management skills.
• Able to work under pressure, self-starter, and team player.
• Travel 0-25%.

Desired Experience:

• 3+ years working in industry or academics in clinical operations for medical devices.
• 2+ years program management experience
• Experienced with products for ex-US regulatory agencies (EU, Japan, Australis etc).
• Familiarity with Electronic Data Capture (EDC) platforms and Trial Master File (TMF) setup and validation.
• Experience Metadata Statistical analysis.

The hiring range for this position is $120,000 to $145,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Hybrid

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Onsite: Monday, Tuesday & Thursday

Summary:

We are seeking a highly skilled and versatile Senior Network & Infrastructure Engineer to join our growing team. This role is designed for a technical "bridge" builder—someone who possesses deep expertise in high-performance networking (HPC) and Cisco security, but who is also comfortable managing a modern, hyperconverged infrastructure stack.

The successful candidate will lead the architecture and maintenance of our Cisco Nexus fabric, secure our perimeter with NextGen firewalls, and support a robust environment consisting of VxRail, VMware, and petabyte-scale HPC storage. You will be equally at home in a CLI environment as you are performing hands-on hardware management within our colocation data centers.

Responsibilities:

Network & Security Architecture (60%)

• HPC Networking: Architect, deploy, and optimize Cisco Nexus switches within a High-Performance Computing (HPC) environment, ensuring low latency and high throughput.
• Security & Firewalls: Full lifecycle management of Cisco NextGen Firewalls (NGFW). You must be proficient in configuring security policies, routing, and VLAN segmentation.
• VPN Management: Lead the setup and maintenance of VPN connections (Site-to-Site and Remote Access) on Cisco platforms.
• Circuit Operations: Oversee the provisioning, monitoring, and troubleshooting of network circuits and ISP handoffs.
• Cloud Connectivity: Act as a subject matter expert for hybrid-cloud networking, supporting connectivity between on-premise hardware and AWS/GCP (Direct Connect/Cloud Interconnect).

Infrastructure & Systems Management (30%)

• Virtualization: Administer and scale VMware clusters running on Dell VxRail hyperconverged infrastructure.
• HPC Storage: Support high-performance storage environments, specifically VAST Data and Dell Isilon, ensuring data availability for intensive workloads.
• Systems Administration: Provide tier-3 support for Linux (RHEL/Ubuntu/CentOS) and Active Directory environments.
• Enterprise Tech: Manage Cisco Meraki wireless and edge networking for corporate office connectivity.
• Data Protection: Ensure the integrity of the environment through rigorous backup schedules and disaster recovery testing.

Physical Operations  (10%)

• Data Center Ops: Perform hardware installations (Rack & Stack), cable management, and physical troubleshooting in Colocation (Colo) and Data Center environments.

Requirements:

• Experience: 5–8+ years of hands-on experience in network engineering and infrastructure.
• Cisco Mastery: Advanced knowledge of Cisco Nexus (NX-OS) and Cisco NextGen Firewalls.
• Networking Fundamentals: Deep understanding of BGP, OSPF, VLANs, LACP, and VPN protocols (IPsec/SSL), WAN technologies. 
• Hardware Knowledge: Proven experience with Dell server hardware and VxRail.
• Storage Proficiency: Exposure to high-performance file systems (VAST, Isilon).
• Physical: Ability to work on-site at data centers and office/labs, including lifting up to 50 lbs and working within server racks.

Preferred "Plus" Skills:

• Cloud: Experience with AWS (VPC, Transit Gateway) or GCP (Cloud Router).
• Certifications: CCNP (Data Center/Security), VCP (VMware Certified Professional), or AWS Solutions Architect.
• Environment: Prior experience working in R&D, scientific, or lab environments.
• Automation: Experience with Python, Ansible, or Terraform for infrastructure-as-code.

The hiring range for this position is $150,000 to $170,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Hybrid

Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency.

Days Onsite: Monday & Tuesday

Summary:

The Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Senior Bioinformatics Scientist will work closely with our clinical evidence generation teams, applying our cell-free technology solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection.

Responsibilities:

• Design and develop novel cell-free technologies and products
• Collaborate closely with laboratory scientists to design experiments to develop and evaluate novel applications for cell-free DNA assays
• Draw on deep experience with genomics and statistics to model and improve performance of cell-free assays and features
• Synthesize large datasets to develop and evaluate new biological and technological hypotheses
• Partner with the clinical evidence generation team to ensure the applicability and evaluate the performance of novel assays or feature improvements
• Maintain a strong working knowledge of literature covering technological developments in the cell-free DNA and liquid biopsy space
• Publish results and present at conferences in exciting areas, including cell-free DNA and cancer genomics

Requirements:

• Advanced degree (Ph.D.) in bioinformatics, genomics, or a related field
• Extensive experience with cancer genomics
• Extensive experience with somatic mutational detection and filtering
• Experience with cancer liquid biopsy analysis
• Proficiency in the application of statistical methods to genomic applications
• Proficiency with at least one common programming language (e.g., Python, R)
• A track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects
• Experience publishing and presenting scientific results

The hiring range for this position is $155,000 to $190,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Hybrid

Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency.

Days Onsite: Monday & Tuesday

Summary: 

The Bioinformatics Senior Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Bioinformatics Scientist will be working alongside our clinical evidence generation teams, applying our cell-free solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment.  Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection.

Responsibilities:

• Design, develop, and build upon our novel cell-free platforms and products, including our NeXT Personal MRD liquid biopsy platform
• Work cross-functionally to translate collaborative findings into actively developed cutting-edge products
• Design and execute scientific projects and experiments focused on product feature feasibility, demonstrating feature performance and clinical advantages of our cell-free platforms
• Modeling and analysis of large, complex genomics datasets using novel methods to generate biological insights
• Work with scientific teams to translate scientific findings into actively developed groundbreaking products
• Publish results and present at conferences in exciting areas, including cell-free DNA and cancer genomics

Requirements:

• Advanced degree (Ph.D.) in bioinformatics, genomics, or a related field
• Extensive experience with cancer genomics
• Extensive experience with somatic mutational detection and filtering
• Experience with cancer liquid biopsy analysis
• Proficiency with at least one common programming language (e.g., Python, R)
• A track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects
• Experience publishing and presenting scientific results
  
  

The hiring range for this position is $155,000 to $190,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Hybrid