Based in Fremont, California, Personalis is a genome-oriented diagnostics company pioneering new paradigms in cancer management. We transform patient care through genomic characterization of tumors and ultrasensitive detection of disease recurrence or progression.  To achieve this, we leverage whole-genome, exome, and bespoke targeted sequencing with proprietary algorithms to provide unmatched genetic accuracy.

Join a world-class, multidisciplinary team to drive impactful R&D projects to improve our cutting-edge clinical offerings. Your work will advance a new generation of precision medicine products used by global biopharma and clinicians to transform cancer diagnostics and therapeutics.

Responsibilities:

• Organize and help perform internal proof of principle projects, development projects, and verification and validation exercises for liquid biopsy products in the Personalis portfolio.
• Work with the broader R&D organization to scope, track and troubleshoot liquid biopsy projects with internal and external collaborators and customers.
• Collaborate with process development, tech transfer, and operations teams to shepherd early stage products, product revisions, and early projects through to operations.
• Work with bioinformatics teams to plan experiments and analyze results.
• Identify problems in current processes and come up with troubleshooting approaches and
• Participate in meetings and present results.
• Use effective two-way communication to create and maintain a collaborative working environment.
• Support and ensure compliance with all department and company policies and procedures.

Education and Experience:

• Ph.D or MS with a minimum of 8 or 12 years of experience.
• Minimum of 2 years of laboratory experience in NGS and/or liquid biopsy focused molecular biology.
• Solid understanding of DNA/RNA manipulation.
• Excellent organization, documentation and communication skills.
• Passion for exploring new assays, hands-on experiment execution and creative thinking to solve problems.
• Excellent ability to multitask and troubleshoot complex protocols.
• Experience with automation (Hamilton or other liquid handlers) helpful.
• ISO13485 validation experience helpful.
• Data analysis skills with experience in Excel, JMP, R or Python.
• Prior experience working with a LIMS directed environment.
• Prior experience in cancer biology is strongly desired.

The hiring range for this position is $170,000 to $200,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

Personalis is a genome-scale diagnostics company with a mission to pioneer genome guided medicine. Our priority is to obtain the most accurate genetic data from each sample, and then to draw the most reliable medically-focused conclusions from these. Our tests are based on whole human genome and exome sequencing, conducted in our state-of-the art laboratory.  We analyze results utilizing proprietary databases, advanced human reference sequences, and sophisticated algorithms. Personalis is based in Fremont, California.

Summary:

We are looking for a dynamic and experienced Senior Director of Advanced Technologies to lead a team in scoping, evaluating, and implementing cutting-edge advancements in sequencing, sample preparation and new assay creation. This role will drive innovation in our proprietary technologies, enhancing performance and expanding capabilities. Your contributions will play a key role in shaping the next generation of genomics-based precision medicine products, supporting immuno-oncology, cancer clinical trials, diagnostics, and therapeutics used by pharma, biotech, hospitals, and clinicians.

Responsibilities:

• Develop and execute the advanced technology strategy, ensuring alignment with company objectives and long-term vision.
• Lead efforts to evaluate and integrate new technologies that expand and improve Personalis products.
• Participate in forward-looking strategic planning and influence company-wide technology adoption.
• Identify new initiatives and build consensus across various stakeholder groups with clear success measures.
• Work closely with bioinformatics teams to design experiments and validate new procedures and analytics.
• Partner with the operations teams to ensure the smooth adoption of new technologies.
• Collaborate across functions to troubleshoot issues and implement solutions that drive efficiency.
• Influence company policy and strategy by partnering executive leadership.
• Recruit, mentor, and manage a high-performing team of scientists to drive innovation and operational excellence.
• Foster a culture of continuous learning, inclusion, and professional growth for all team members.
• Ensure accountability for results and provide strategic focus to support both short- and long-term organizational success.
• Demonstrate strong leadership, communication, and influence across all levels of the organization.
• Model and promote Personalis values, fostering collaboration and valuing diversity.
• Drive continuous innovation by encouraging the team to identify process efficiencies and new solutions.
• Support compliance with all department and company policies, ensuring regulatory and quality adherence.
• Work cooperatively across functions to achieve broader company objectives and business success.

Education & Experience:

• Ph.D in a related field with 10+ years of relevant experience, preferably in molecular biology.
• Minimum of 5 years of management experience, with a proven ability to set a clear vision, establish expectations, and motivate teams to achieve results.
• Demonstrated success in driving performance, achieving objectives, and leading teams to meet departmental goals.
• Strong communication, presentation, and influencing skills, with the ability to effectively engage and gain support from senior leadership.
• Expertise in strategic thinking, decision-making, and negotiation, ensuring smooth daily business operations.

The hiring range for this position is $240,000 to $285,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1 #LI-Onsite

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

The Senior Process Automation Engineer within the Research, Product Development and Technology Transfer Group contributes to the development and implementation of automation systems and workflows to support the processing of samples in a clinical diagnostics and research laboratory environments.  This individual collaborates within a team of scientists and engineers upon projects to conceptualize, design, develop, and implement solutions designed to optimize the performance and increase the efficiencies of the laboratory processes.

Responsibilities:

• Principal responsibilities of this position include automation projects leadership.
• Lead the development and integration of the automation systems and related software tools, preparing the documentation for equipment validation and operating procedures.
• Develop scripts for liquid handling robots and other lab automation instruments.
• Building rapport with end-users, lab supervisors and process owners, and coordinate with cross functional teams to ensure the successful implementation in the labs.
• Define and lead the automation systems development, testing and qualification requirements.
• Support the documentation efforts for equipment validation and operating procedures.
• Lead troubleshooting efforts, analyze data and help drive key process related decisions.
• Collaborate with external vendors to assess and implement new solutions.

Requirements:

• Bachelor's degree in engineering/biochemistry field and a minimum of 5 years of experience, or Advanced degree in engineering/biochemistry field and a minimum of 3 years of experience in NGS lab as an automation programmer. 
• Technical proficiency and experience in automation systems development and integration for the life science industry; especially with robotics and liquid handling systems is required.
• Hamilton Venus 4 or 6 programming experience is required.
• Experienced in deploying automation methods using GitHub/GitLab.
• Good Project management, organizational and written and verbal communication skills.
• Able to communicate effectively across teams to understand problems, come up with solutions and explain methodological details and results from analysis.
• Mentor, develop and provide guidance to other team members.
• Experienced in drafting user requirements, testing and Standard Operating Procedures, and related documentations; and overseeing the functional and validation testing, IQ/OQ/PQ.
• Flexibility and self-initiative required to support several simultaneous projects.
• Able to work independently on identification and resolution of open-ended problems of diverse scope.  
• Able to work on complex problems in which analysis of situations or data requires an in-depth evaluation of various factors. Exercises judgment within broadly defined practices and policies in selecting methods, techniques, and evaluation criteria for obtaining results.

The hiring range for this position is $135,000 to $165,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.) 

#LI-KK1  #LI-Onsite