Company

NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan.

We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Departments (8)

Offices (1)

Total jobs

open positions

Departments

hiring across

New today

last 24 hours

Worldwide

remote listings

2 positions

Senior/Research Associate

NewLimit

South San Francisco Vascular 3mos ago

Scientist/Senior Scientist

NewLimit

South San Francisco, CA Vascular 3mos ago

Pick a job to read the details

Tap any role on the left — its description and apply link will open here.

Senior/Research Associate

NewLimit · South San Francisco

Apply now

Vascular South San Francisco Posted Feb 9, 2026

About NewLimit

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.

Position

NewLimit is seeking an Senior/Research Associate with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases.

Your role will focus on supporting the development of in vitro assays and pre-clinical models to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our scientists as well as our technology-focused teams to help create the first reprogramming medicines for the vascular tissue.

What you'll do

In your role as a Senior/Research Associate, you will:

Isolate cells from primary tissues to optimize in vitro functional assays
Develop pre‑clinical models of age-related dysfunction
Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions at scale
Support the development of in vivo nucleic acid delivery methods for endothelial cells
Analyze and interpret experimental data to drive pre-clinical decision making

Requirements

Bachelor’s degree in cell biology, molecular biology, biochemistry or a related field with 2‑5 years of relevant industry or academic experience
Proficiency in primary mammalian cell culture and animal handling techniques for rodent models
Proficiency in flow cytometry techniques
Exceptional organizational skills, as demonstrated by detailed record-keeping in a lab notebook and an ability to effectively carry out multiple ongoing projects or experiments

Nice to have

Experience with isolation and functional characterization of primary cells
Experience developing animal models of cell dysfunction and/or injury
Experience with FACS and flow cytometry
Experience using computational tools to automate routine data analysis (e.g. Python, R, etc.)

Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

Health, dental, and vision insurance
401(k) with company match
Paid parental leave
Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
Meals and snacks on-site

Salary Range: $75,000 to $100,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

Ready to apply?

Apply to NewLimit

NewLimit

View all jobs →

Scientist/Senior Scientist

NewLimit · South San Francisco, CA

Apply now

Vascular South San Francisco Posted Feb 9, 2026

About NewLimit

Position

NewLimit is seeking an scientist with experience in discovery biology to join our Vascular therapeutic team. Our Vascular program is developing reprogramming medicines to restore youthful function in aged endothelial cells for the treatment of renal, cardiometabolic, and cognitive diseases.

Your role will focus on developing and deploying assays to measure the functional decline that occurs in endothelial cells with age. You will collaborate closely with our technology teams to help create the first reprogramming medicines for the vascular tissue that supports all others.

What you'll do

In your role as a Scientist, you will:

Develop functional assays and pre-clinical models to measure endothelial cell function
Collaborate with our Functional Genomics and Predictive Modeling teams to test reprogramming hypotheses at scale
Measure the impact of mRNA reprogramming medicines on endothelial cell function
Engineer in vivo nucleic acid delivery methods for endothelial cells
Analyze and interpret experimental data to drive pre-clinical decision making

Requirements

Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
Experience with primary cell isolation and functional characterization
Experience working with mouse models (e.g. kidney, cardiovascular, or cognitive disease models)
Experience with transgenic manipulation of primary cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)

Nice to have

History of contributing to a drug development program at the pre-clinical or clinical development stage
Experience leading the design and execution of pre-clinical studies in mouse models
Experience with single cell genomics methods
Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)

Benefits

NewLimit offers generous benefits to ensure our team can focus on our mission:

Health, dental, and vision insurance
401(k) with company match
Paid parental leave
Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
Meals and snacks on-site

Salary Range: $130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.

Ready to apply?

Apply to NewLimit

NewLimit

View all jobs →