Medical Science Liaison (MSL), Oncology (Skin Cancers)

Territory: Central and Western United States

Role Overview

The MSL, Oncology (Skin Cancers) will join a fast-growing Field Medical Affairs team focused on commercializing the novel Signatera™ molecular residual disease (MRD) test. This role is dedicated to supporting oncologists and cancer researchers across solid tumors—with a primary emphasis on skin cancers—alongside complementary products and services within Natera’s oncology portfolio.

In 2019, the FDA designated Signatera as a Breakthrough Device, and Medicare proposed coverage for its use in patients with Stage II–III colorectal cancer as its first indication. We are seeking a smart, mission-oriented Medical Affairs professional who can communicate effectively to help transform the management of cancer worldwide. The MSL serves as a vital field-based scientific resource for clinicians, academic institutions, and professional organizations.

Primary Responsibilities

• Scientific Presentation: Deliver high-impact scientific and clinical presentations on Natera’s oncology products, specifically relevant to skin cancers.

• Information Support: Address the specific needs of customers by responding to requests for information about marketed and developing products across solid tumors.

• Internal Collaboration: Serve as a medical and scientific resource for Natera Sales and Marketing teams, including participation in scientific updates and training with an emphasis on skin cancer data.

• KOL Engagement: Identify, develop, and manage collaborative working relationships with Key Opinion Leaders (KOLs) in oncology, including dermatologists, surgeons, and medical oncology specialists.

• Research & Trials: Develop research collaborations with leading KOLs; assist with registry study enrollment and the management of Investigator-Initiated Trials (IITs) in solid tumors and skin cancer.

• Content Development: Review and develop educational materials and slide content for healthcare providers and patients—incorporating tumor-type–specific scientific context—subject to approval by Medical Affairs and Marketing.

• Events & Symposia: Assist in agenda planning and facilitation for Clinical Advisory Boards and Symposia involving cutaneous oncology experts.

• Compliance: Work regularly with Protected Health Information (PHI) in both paper and electronic forms, utilizing secure technologies to perform responsibilities.

Qualifications

• Advanced Degree: Health care professionals with relevant clinical sciences knowledge in oncology (e.g., Pharm.D, Ph.D., M.D., or DNP).

• Professional Experience: Prior MSL experience is highly preferred.

• Specialization: Prior involvement with cutaneous oncology or clinical laboratory tests (molecular diagnostics) is preferred.

Knowledge, Skills, and Abilities

• Communication: Independent thinker and persuasive communicator with an outgoing and confident demeanor.

• Relationship Building: Proven experience establishing strong, collaborative working relationships with internal stakeholders (Sales, Marketing, Regulatory, R&D) and external oncology customers.

• Presentation Skills: Outstanding oral presentation skills, particularly when conveying complex scientific concepts related to solid tumors.

• Autonomy: Ability to work independently and remotely while maintaining a strong teamwork ethic.

• Scientific Acumen: Strong knowledge of molecular biology and clinical oncology; familiarity with the cutaneous cancer treatment landscape is a significant plus.

Job Title: Medical Director, GU Oncology

Location: Remote with ~50% domestic and international travel

Position Summary:

Shape the future of cancer care as a Medical Director, Oncology at Natera. In this strategic leadership role, you will provide medical expertise for Natera's oncology portfolio, collaborating with cross-functional teams across research, development, commercial, and medical affairs. You will ensure the scientific integrity and clinical adoption of our oncology testing solutions.

Primary Responsibilities:

• Clinical Development:
• Collaborate with the Chief Medical Officer and other Medical Directors in Oncology on the clinical development of ctDNA-based diagnostics.
• Lead development and implementation of clinical strategies for Natera's oncology products, with a focus on GU cancers.
• Medical Education and Communication:
• Oversee medical education and scientific communication for healthcare providers on Natera's oncology offerings.
• Partner with the commercial team to develop and deliver compelling medical messages for Natera's oncology products.
• Representation and Advocacy:
• Represent Natera at medical conferences and industry events, in person and virtual.
• Foster a culture of scientific excellence and intellectual curiosity within the oncology team.
• Research and Development:
• Collaborate with research and development teams on clinical trial design, data analysis, and publication.

Key Skill Sets / Responsibilities:

• GU Cancer-Specific Expertise:
• Strong knowledge in GU (preferably bladder and kidney) cancers, with the ability to develop and implement strategies specific to GU oncology.
• Provide expert guidance and support on GU oncology cases and clinical trials.
• Comprehensive Oncology Knowledge:
• Ability to speak to all histologies and indications, ensuring broad expertise across the oncology spectrum.
• Stay updated on the latest advancements in various cancer types and integrate this knowledge into Natera’s oncology products.
• Cross-Disciplinary Collaboration:
• Work effectively with cross-functional teams including research, development, commercial, and medical affairs to drive the success of oncology initiatives.
• Coordinate with internal and external stakeholders to ensure the clinical relevance and adoption of Natera’s oncology solutions.

Qualifications:

• M.D. or D.O. degree with board certification in Oncology (required).
• At least 5 years of experience in oncology (required), with a background in clinical research and development (preferred). 
• Clinical experience and strong knowledge in GU cancer (preferred).
• Associate/full Medical Director designation commensurate with experience.

Knowledge, Skills, and Abilities:

• Ability to quickly learn Natera’s technology and that of our competitors, understanding the strengths and limitations of each, and articulate strong customer value propositions.
• Effective written and oral communication skills, with strong persuasive abilities and quick thinking.
• Project management skills, with the ability to balance and execute multiple projects simultaneously.
• Proven team player, capable of participating as a member of a cross-disciplinary team.
• Ability to manage conflict with poise.
• Strong knowledge of clinical trial methodology, protocol development, regulatory and compliance requirements, statistics, and epidemiology is preferred.

Physical Demands & Work Environment:

• Duties are typically performed in an office setting.
• This position requires the ability to use a computer keyboard, communicate over the telephone, and read printed material.
• Duties may occasionally require working outside normal working hours (evenings and weekends).

#LI-TR1

The Associate Medical Director, Genitourinary Oncology is a critical leadership role responsible for advancing clinical development, shaping medical strategy, contributing to foundational clinical evidence generation, and engaging external stakeholders in support of Natera’s molecular diagnostics in GU cancers (e.g., prostate, bladder, kidney, and other genitourinary malignancies). This individual, under the oversight of a Senior Medical Director, will contribute to an evolving understanding of cancer biology while driving the adoption of transformational diagnostics into routine clinical practice.

This role is ideal for a radiation oncologist with specialized expertise and interest in GU cancers who is excited to translate cutting-edge molecular diagnostics into clinical practice and shape the future of precision oncology at scale.

Primary Responsibilities:

• Partner with the Senior Medical Director, Genitourinary Oncology to develop and execute clinical strategies supporting Natera’s molecular diagnostic tools for GU cancers, including minimal residual disease (MRD) and ctDNA-based monitoring.
• Lead the design and implementation of clinical studies and treatment protocols that integrate Natera’s technology into standard GU oncology care.
• Recruit and engage leading principal investigators (PIs) and clinical sites in GU oncology to participate in company-sponsored studies; manage study timelines and budgets in collaboration with Clinical Trial Operations.
• Advise on product development for the GU oncology portfolio, identifying clinical unmet needs, new product opportunities, key product features, intended use, test report content, and minimum validation requirements.
• Provide post-launch medical affairs support, including interpretation of test results, clinical consultation for healthcare providers, and guidance on patient counseling (pre- and post-test).
• Serve as GU oncology expert for support of high-value engagement and events identified by Strategic Accounts, Area Sales and Marketing leaders, commercial or clinical leadership.
• Lead medical education initiatives, including external training, launch planning, and the creation of scientific and clinical materials specific to GU malignancies.
• Identify and recruit Key Opinion Leaders (KOLs) in GU oncology to serve on advisory boards and contribute to strategic planning.
• Support the publication strategy by collaborating with Scientific Communications on manuscripts, abstracts, and conference presentations in GU oncology.
• Contribute to regulatory strategy by providing medical input into submissions related to GU cancer diagnostic products.
• Represent Natera’s medical voice externally through public relations, industry panels, advisory boards, and medical conferences, with a focus on GU oncology.

Qualifications:

• M.D. required (board-certified or board-eligible in Radiation Oncology preferred)
• Residency training in Radiation Oncology
• At least 3 years of post-residency clinical experience in GU cancers (prostate, bladder, kidney, etc.) as a primary treating radiation oncologist
• Deep knowledge of treatment paradigms, clinical guidelines, and diagnostic workflows in GU cancers
• Minimum 3 years of clinical trial experience in academic, biotech, or pharmaceutical settings
• Willingness to travel 40% (primarily U.S.-based, with occasional international travel)

Knowledge, Skills, and Abilities:

• Expertise in clinical trial design, regulatory/compliance frameworks, and biostatistics
• Strong understanding of evolving treatment landscapes in GU cancers (including targeted therapies, immunotherapy, and biomarker-driven approaches)
• Excellent analytical skills and scientific communication ability across varied audiences
• Quick learner with the ability to critically assess Natera’s technology and competing platforms
• Strong project management skills; comfortable balancing multiple complex initiatives
• Proven ability to lead and collaborate across cross-functional teams
• Skilled communicator, persuasive in scientific discussions and presentations
• Patient-focused and passionate about improving outcomes in GU cancers
• Capable of navigating complex systems and influencing without direct authority

Preferred Qualifications:

• Experience with ctDNA, MRD, or liquid biopsy technologies
• Established relationships with GU oncology KOLs and academic networks
• Experience supporting product launches or diagnostic adoption in oncology

#LI-TR1

Location: Remote with ~50% domestic and international travel

Shape the future of cancer care as a Medical Director, Skin/IO at Natera. In this strategic leadership role, you will provide medical expertise and scientific leadership across Natera’s oncology portfolio, with a focus on melanoma, cutaneous malignancies, and immunotherapy applications across solid tumors. You will collaborate with cross-functional teams in research, development, medical affairs, and commercial functions to ensure the scientific integrity and clinical adoption of Natera’s oncology testing solutions.

Primary Responsibilities:

Clinical Adoption:

• Lead the clinical strategy and evidence generation for melanoma, non-melanoma skin cancers, and pan-tumor immunotherapy indications.
• Partner closely with clinical development, medical affairs, and commercial teams to translate emerging evidence into meaningful clinical practice applications.
• Collaborate with key opinion leaders (KOLs), cooperative groups, and academic investigators to validate and expand clinical use cases for ctDNA-based diagnostics in immuno-oncology.
• Provide field-facing education and strategic guidance to healthcare providers, payers, and advocacy organizations on clinical utility, interpretation, and impact of MRD and response monitoring in immune-treated populations.
• Identify and address barriers to adoption by aligning evidence generation, messaging, and stakeholder engagement with evolving standards of care and health system needs.

Medical Education and Communication:

• Serve as the medical and scientific spokesperson for skin and immuno-oncology programs, communicating clinical utility, study data, and product value to external experts and stakeholders.
• Partner with commercial teams to develop educational resources, medical content, and scientific training for healthcare providers and internal teams.
• Provide scientific leadership during advisory boards, symposia, and investigator meetings.

Representation and Advocacy:

• Represent Natera at national and international oncology and immunotherapy conferences, fostering relationships with key opinion leaders in melanoma and IO.
• Promote a culture of scientific rigor and innovation within the medical affairs and R&D organizations.

Research and Development:

• Collaborate on clinical trial design, data analysis, and publication strategy related to ctDNA applications in melanoma and other immune-responsive solid tumors.
• Identify and cultivate academic and cooperative group partnerships to advance clinical validation and translational research in skin and pan-tumor immuno-oncology.

Key Skill Sets / Responsibilities:

Skin and Immuno-Oncology Expertise:

• Deep clinical knowledge of melanoma and cutaneous oncology, including evolving standards of care, targeted therapy, and checkpoint inhibitor use.
• Expertise in immunotherapy mechanisms, response kinetics, and biomarker development across multiple solid tumor types.
• Provide expert medical guidance on immunotherapy-specific diagnostic development and clinical implementation.

Comprehensive Oncology Knowledge:

• Ability to engage across tumor types to support Natera’s broad oncology portfolio.
• Maintain awareness of emerging trends in liquid biopsy, precision medicine, and immune response monitoring.

Cross-Disciplinary Collaboration:

• Work collaboratively with research, development, commercial, and medical affairs to align medical strategy with business objectives.
• Partner with regulatory and clinical operations teams to ensure compliance, data quality, and clinical relevance.

Qualifications:

• MD. or D.O. degree with board certification in Medical Oncology (required).
• At least 5 years of experience in oncology, with clinical or research experience in melanoma, skin cancers, or immunotherapy (preferred).
• Strong publication or clinical trial background in immuno-oncology or translational oncology research (preferred).
• Associate or full Medical Director designation commensurate with experience.

Knowledge, Skills, and Abilities:

• Ability to rapidly learn Natera’s molecular testing technologies and apply clinical judgment to evaluate and communicate their relevance.
• Strong written and verbal communication skills, including scientific presentation and education.
• Demonstrated success working cross-functionally with commercial, R&D, and clinical teams.
• Understanding of immuno-oncology trial design, translational endpoints, and regulatory considerations.
• Effective project management and ability to balance multiple high-impact initiatives.
• Collaborative mindset and ability to build consensus across functions.

Natera is seeking an experienced Clinical Director, Oncology Clinical Development to provide medical and scientific leadership for Natera-sponsored oncology clinical trials focused on minimal residual disease (MRD).  In this pivotal role, you’ll drive the design and execution of biomarker-driven interventional and randomized studies that integrate MRD testing into precision oncology strategies to support regulatory, scientific, and strategic objectives.

We’re looking for an innovative clinical leader with deep oncology clinical development experience who thrives in a fast-paced, collaborative environment — and who’s passionate about transforming cancer care.

Natera’s MRD platform is redefining precision oncology—enabling earlier detection, improved monitoring, and smarter treatment decisions.  In this role, you’ll lead studies that directly shape how cancer is managed worldwide, bringing actionable insights to clinicians and patients when they matter most.

What You’ll Do

Clinical & Program Leadership

• Serve as the program-level medical lead for Natera-sponsored MRD clinical trials across assigned oncology indications, with ultimate accountability for clinical outcomes, data integrity, and patient safety.
  

• Define clinical development strategies that align study design, endpoints, and execution with regulatory and scientific objectives.
  

• Provide medical oversight across the full trial lifecycle, from design and protocol development through first patient in (FPI), data readout, and study close-out.
  

Study Design & Execution

• Provide strategic and medical guidance to Clinical Scientists, fostering collaboration on protocol design, data interpretation, and translational insights that drive clinical program success.
  

• Act as Medical Monitor, overseeing safety signal detection, adverse event review, and risk mitigation in compliance with GCP and regulatory requirements.
  

Cross-functional Leadership

• Partner cross-functionally with Clinical Science, Clinical Operations, Data Management and Biostatistics to ensure timely and successful study execution, operational feasibility, and data quality.
  

• Collaborate with Regulatory Affairs to support submissions, regulatory interactions, and responses, as appropriate.
  

Scientific & External Engagement

• Represent Natera as the clinical development lead in interactions with investigators, key opinion leaders, IRBs, and regulatory authorities.
  

• Guide interpretation of interim and final analyses, ensuring scientific accuracy and clinical relevance.
  

• Provide strategic leadership for clinical study reports, and other required study-related clinical and regulatory documentation in collaboration with cross-functional partners.
  

• Lead authorship and strategy for manuscripts, abstracts, and conference presentations in collaboration with Clinical Science, Biostatistics, Translational Medicine and Scientific Communications.
  

Organizational Excellence

• Shape and influence the evolution of Natera’s Clinical Development organization by establishing governance standards, decision frameworks, and best practices that ensure high-quality, audit-ready execution across sponsored studies.
  

• Provide senior-level mentorship and clinical leadership to Clinical Scientists, enabling consistent application of scientific rigor and regulatory standards across clinical programs.
  

What You’ll Bring

Required

• MD (or equivalent)
  

• ≥3 years of industry experience in oncology clinical development.
  

• Demonstrated experience serving as Medical Monitor or clinical lead for Phase II–III studies.
  

• Strong working knowledge of GCP, ICH guidelines, and regulatory expectations for interventional trials.
  

• Proven ability to interpret and communicate complex clinical data to internal and external stakeholders.
  

Preferred

• Board certification in Medical Oncology or Hematology/Oncology.
  

• Experience with biomarker-driven development, molecular diagnostics, or MRD-focused programs.
  

• Prior involvement in regulatory interactions (e.g., FDA meetings, briefing documents).
  

• Experience working within matrixed clinical development organizations.