“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone.  Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor.  Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”

Mineralys is a fully remote company.

Director, Total Rewards

The Director, Total Rewards will lead the design, implementation, and administration of the company’s total rewards strategy—including compensation, equity, benefits, and wellness programs—to attract, motivate, and retain top scientific, technical, and commercial talent in a highly competitive biotech environment.

This role partners closely with executive leadership, HR business partners, Finance, Legal, and external advisors to ensure total rewards programs are market-competitive, scalable, compliant, and aligned with business objectives and company culture.

Key Responsibilities

Total Rewards Strategy & Governance

• Develop and execute a comprehensive total rewards strategy aligned with business goals, organizational growth stage (e.g., pre‑clinical, clinical, commercial), and talent needs.
• Serve as the subject-matter expert for compensation, benefits, and equity programs, ensuring alignment with company philosophy and values.
• Establish governance processes, policies, and controls to support consistent and compliant rewards practices globally.

Compensation & Executive Pay

• Lead the design, administration, and ongoing evaluation of base pay, annual incentive, long-term incentive, and equity programs. Partner with Finance on equity programs.
• Partner with Finance and Legal on executive compensation, including preparation of materials for the Compensation Committee and Board of Directors.
• Manage annual compensation cycles, including merit increases, bonus planning & payout, equity refresh grants, and market adjustments.
• Conduct market pricing, benchmarking, and pay equity analyses to support competitive and equitable pay practices.
• Design, implement and oversee sales incentive plans, including creation of plan documentation, the quarterly objective setting process and the calculation of payouts in partnership with Commercial Leadership and Finance.

Equity & Long-Term Incentives

• Partner with Legal, Finance, and external vendors on equity compliance, disclosures, and governance.

Benefits & Wellness

• Design and manage competitive, cost-effective benefits programs, including health and welfare, retirement, time-off, allowances, fleet and wellbeing initiatives.
• Ensure benefits programs meet the needs of a diverse, global workforce while maintaining cost control and compliance.
• Lead benefits renewals, vendor selection, and broker relationships.
• Oversee leave of absence programs, including FMLA, STD/LTD, parental leave, and accommodations, ensuring compliance and a positive employee experience.

Compliance, Analytics & Operations

• Ensure compliance with all applicable compensation and benefits regulations (e.g., wage and hour, pay transparency, SEC, ERISA, global labor laws).
• Develop dashboards and analytics to evaluate program effectiveness, cost trends, and talent impact.
• Oversee total rewards operations, systems, and vendors to ensure accuracy, efficiency, and positive employee experience.

Leadership & Collaboration

• Serve as a strategic advisor to HRBPs and business leaders on rewards-related decisions.
• Lead, mentor, and develop total rewards team members (as applicable).
• Partner cross functionally to support organizational growth, M&A, and transformation initiatives.
• Manage and coordinate employee training and communications regarding compensation and wellness- benefit enrollment and updates.

Qualifications

Required

• Bachelor’s degree in human resources, Business Administration, Finance, or a related field.
• 10+ years of progressive total rewards experience, including compensation and benefits leadership
• Experience in a biotech, pharmaceutical, life sciences, or similarly complex, regulated industries in a commercial stage organization.
• Strong knowledge of equity compensation and long-term incentive programs.
• Proven experience partnering with executive leadership and Boards or Compensation Committees.
• Proficiency with HRIS and compensation management platforms (e.g., Workday, Radford/WTW) and equity administration systems.

Preferred

• Master’s degree (MBA, MHRM, or equivalent).
• Experience supporting high-growth commercial biotech organizations.
• Professional certifications such as CCP, CBP, GRP, or CEBS.
• Global total rewards experience across multiple regions.

Key Competencies

• Strategic thinking with strong execution capability
• Data-driven decision making and financial acumen
• Executive presence and communication skills
• Change management and scalability mindset
• High attention to detail with ability to operate in ambiguity

Success Measures

• Competitive and compliant total rewards programs aligned to business strategy
• Strong attraction and retention of key scientific and leadership talent
• Effective cost management and ROI on rewards investments measured through benefits utilization, total rewards statement adoption and employee perceived value of programs.

Travel 

• This position requires up to 10% travel.  Frequently travel is outside the local area and overnight. Some of the travel may be international. 

These positions are eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level.

US Salary Range:  $190,000 - $215,000

#LI-REMOTE

“Mineralys Therapeutics is a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension and related comorbidities such as chronic kidney disease (CKD), obstructive sleep apnea (OSA) and other diseases driven by dysregulated aldosterone.  Its initial product candidate, lorundrostat, is a proprietary, orally administered, highly selective aldosterone synthase inhibitor.  Mineralys is headquartered in Radnor, Pennsylvania. For more information, please visit https://mineralystx.com. Follow Mineralys on LinkedIn, Twitter and Bluesky”

Mineralys is a fully remote company.

Vice President, Talent Management

Position Summary

The Vice President, Talent Management is a transformational leader who will design, build and lead a best-in-class, full-lifecycle talent organization at a pivotal moment in our company's history. As we transition from a development-stage company to a commercial enterprise, this leader will serve as the architect of our talent strategy — ensuring we attract, develop, engage and retain the exceptional people needed to bring life-changing therapies to patients.

This is a role for a builder — someone who thrives in ambiguity, can construct scalable systems from the ground up and brings the vision, energy and operational excellence to transform talent into a true competitive advantage. The VP, Talent will be a trusted advisor to the organization and a champion of our culture and values across every dimension of the employee experience.

Mineralys operates a hub-based remote model, with organizational anchors in Philadelphia, Boston and Boulder. This leader must be equally fluent in building distributed workforce practices and leveraging our hubs as cultural and community touchpoints.

Key Responsibilities

Talent Strategy & Leadership

• Develop and execute a comprehensive talent strategy aligned to the company's commercial launch priorities and long-range business plan
• Serve as a thought partner and advisor to the executive leadership team on all matters related to people, organizational design and workforce planning
• Lead a high-performing talent team, establishing clear roles, accountabilities and a culture of excellence within the function
• Establish talent metrics, KPIs and dashboards that provide data-driven insights to inform business decisions and demonstrate ROI of talent investments

Talent Acquisition & Employer Brand

• Architect and lead a proactive, full-cycle talent acquisition function capable of scaling rapidly to support commercial launch hiring across commercial, medical affairs, market access and G&A functions
• Champion and amplify a compelling employer brand that distinguishes Mineralys in a competitive biotech talent market
• Develop a hub-anchored sourcing strategy centered around our Philadelphia, Boston and Boulder locations, while drawing from the broader national talent pool for roles suited to fully distributed workforce
• Develop strategic sourcing pipelines and partnerships with executive search firms to access top-tier talent across all three hub markets and beyond

Onboarding & Integration

• Design a remote-first onboarding experience that intentionally builds cultural connection, peer relationships and role clarity in the absence of daily physical presence — including digital welcome journeys and manager-led integration rituals
• Establish role-specific onboarding tracks, with particular rigor for commercial field, medical and leadership hires, that reflect the complexity and compliance requirements of a commercial-stage biopharmaceutical organization
• Implement 30/60/90-day check-in frameworks and early-tenure engagement touchpoints to identify and address integration risks

Performance Management & Talent Development

• Oversee the design of a modern performance management philosophy balances accountability with growth, grounded in regular feedback, meaningful coaching conversations and a shared commitment to continuous development
• Oversee a leadership development infrastructure including competency frameworks, succession planning and high-potential identification that grows our leaders from within
• Partner with functional heads to identify capability gaps and design targeted learning and development interventions, including both internal programs and curated external resources
• Oversee the establishment of career pathing frameworks across functions to create visibility into growth opportunities and improve retention of high performers

Employee Experience & Culture

• Own the end-to-end employee experience with a relentless focus on creating an environment where talented people choose to do their best work
• Serve as a steward and amplifier of company culture — partnering with leadership to articulate, reinforce and evolve cultural norms as the organization grows
• Architect a remote employee experience that proactively addresses the unique challenges of distributed work — including digital fatigue, social isolation and access to leadership visibility — through purposeful virtual engagement programming and inclusive communication practices
• Establish remote-specific recognition practices and virtual moments of connection that build belonging and reinforce culture regardless of where employees are located
• Design and administer engagement surveys, pulse checks and listening mechanisms that generate actionable insight; ensure leaders are equipped and accountable to act on feedback
• Build recognition and rewards programs — both formal and informal — that celebrate achievement, reinforce values and create a culture of appreciation

Workforce Planning & Organizational Effectiveness

• Partner with the HR Business Partner, Finance, and functional leaders to develop dynamic workforce plans that balance near-term hiring urgency with long-term organizational design discipline
• Advise on organizational structure decisions, span-of-control optimization and role design as the company scales through launch and beyond
• Develop and manage headcount and talent acquisition budgets with financial rigor and strategic prioritization

Remote Work Infrastructure & Policy

• Establish and govern Mineralys' hub-based remote work policies, ensuring clarity, consistency and equity across all employee populations
• Design frameworks that define when and how hub presence is expected or encouraged, balancing flexibility with the cultural and collaborative benefits of in-person connection

Total Rewards Partnership

• Collaborate closely with the Total Rewards function to ensure compensation, equity and benefits programs are competitive, equitable and aligned to talent attraction and retention goals
• Conduct regular competitive benchmarking against the biotech/biopharma peer set and make recommendations to maintain market competitiveness

Compliance & Risk Management

• Ensure all talent practices comply with applicable employment laws and regulations
• Manage the regulatory complexity of a hub-based remote, multi-state workforce including state-by-state employer registration, varying leave and wage laws, pay transparency mandates and remote work policy governance
• Establish compliant, auditable processes for documentation, background screening, licensure verification and records management

Qualifications

Required

• 15+ years of progressive HR/talent leadership experience, with at least 7 years in a senior leadership role
• Demonstrated experience building or significantly scaling a talent function within a life sciences, biotech, or biopharma organization
• Experience supporting or leading talent strategy through a major organizational inflection point
• Proven track record of designing and implementing talent acquisition functions that successfully hired across commercial, scientific and operational functions under time pressure
• Deep expertise across the full talent lifecycle: acquisition, onboarding, performance management, development, engagement and retention
• Demonstrated experience building or leading a hub-based remote or fully distributed workforce, with a track record of maintaining high engagement, performance and retention in a virtual environment
• Data-driven mindset with proficiency in HRIS platforms and people analytics tools
• Exceptional communication skills — written and verbal — with the ability to inspire and align diverse audiences
• Bachelor's degree required; advanced degree in Human Resources, Organizational Psychology, Business Administration, or related field preferred
• Familiarity with field force hiring (sales, MSLs, market access) and the compliance considerations unique to pharmaceutical commercial organizations

Preferred

• Background in organizational design and change management within a distributed workforce model
• Familiarity with the Philadelphia, Boston, and/or Boulder biotech talent markets
• SHRM-SCP, SPHR, or equivalent certification

Travel

• This position requires up to 20% travel. Frequently travel is outside the local area and overnight.

This position is eligible for standard Company benefits including medical, dental, vision, time off and 401K, as well as participating in Mineralys incentive plans are contingent on achievement of personal and company performance. Actual compensation may vary from posted hiring range based on geographic location, work experience, education, and/or skill level.

US Salary Range:  $240,000 - $270,000

#LI-Remote