This role will serve as a strategic and operational partner to the Vice President of Medical Affairs and Medical leadership team, and is responsible for ensuring that medical capabilities, processes, systems, and execution models are efficient, compliant, scalable, and aligned with Alumis’ growth strategy. The Senior Director, Medical Strategy and Operations, will be responsible for advancing key initiatives aimed at optimizing and showcasing the impact of the Medical Affairs team. This is a hands-on position that includes driving medical strategic initiatives, enhancing the Medical Affairs systems, supporting critical medical insights processes, and developing innovative solutions to measure and report on medical affairs performance and impact. The role demands an individual who combines scientific knowledge with strong operational leadership to thrive in a fast-paced, agile environment to elevate our medical affairs capabilities.

Key Responsibilities:

· Strategic Leadership: Lead and drive the development and execution of initiatives that elevate the strategic and operational effectiveness of the Medical Affairs team in a consistent and scalable manner.

· Medical Affairs Systems Optimization:

o Oversee the design, implementation, and optimization of our Medical Affairs systems to improve internal efficiencies, engagement and communications with key opinion leaders (KOLs), healthcare providers, and other relevant stakeholders.

o Lead continuous improvement initiatives to enhance efficiency, quality, and compliance across the Medical function.

o Implement best practices for operational metrics, KPIs, dashboards, and reporting to support data-driven decision-making.

· Medical Insights: Collaborate with Medical Affairs Leadership to collect, analyze, and integrate valuable medical insights that inform strategic decisions and optimize the impact of our medical programs.

· Content Management: Serve as Medical Affairs content owner through review and approval process for external-facing materials.

· Cross-functional Collaboration: Collaborate with other functional areas such as Clinical Development, Marketing, Market Access, Commercial, Analytics, Compliance, and Regulatory to ensure alignment and integration of medical excellence within the broader organizational strategy.

· Guidance and SOP Development: Leverage expertise to develop guidance documents and SOPs to foster consistency, clarity, and accountability across Medical Affairs.

· Planning, Budgeting & Resource Management

o Lead medical annual planning, forecasting, and budget management.

o Optimize headcount planning, vendor strategy, and external spend to maximize impact and efficiency.

o Provide transparency and insights into medical investments and their impact.

Qualifications:

· Experience: Minimum of 10 years in Medical Affairs leadership. Proven experience in managing and optimizing medical operations, systems, content, and medical insights. Experience in a fast-paced, small biotech environment a plus

  Education: Advanced degree (PhD, MD, MBA, PharmD or similar)

· Leadership Skills: Exceptional leadership abilities with a demonstrated ability to manage cross-functional teams and drive change across complex medical operations. Must have track record of effectively leading without authority

· Operational Expertise: Strong experience in developing and managing Medical Affairs dashboards and other qualitative outcomes to measure impact and performance.

· Strategic Thinking: Ability to develop and implement strategic initiatives aligned cross-functionally that drive organizational goals and enhance the impact of Medical Affairs functions.

· Strong Communication: Excellent communication and interpersonal skills, with the ability to engage and influence stakeholders at all levels, both internally and externally.

The salary range for this position is $265,00 to 310,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices degree and background.

Alumis Inc. is an equal opportunity employer.

Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.  

Other benefits include:

• Health insurance premiums paid at 90% for employee, 80% for dependents
• Free access to Genentech Bus & Ferry Share program
• $100 monthly cell phone stipend
• Unlimited PTO for Exempt employees
• Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate, challenge and nurture one another along the way.

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. 

The Director, Field Medical Excellence and Training will be responsible for overseeing and advancing key field-based initiatives that inform or support Medical Affairs strategies, and developing and executing a comprehensive medical training programs across therapeutic areas. The role demands an individual who combines experience in a fast-paced environment with scientific knowledge, excellence in field medical execution, and strong educational and operational leadership.

Key Responsibilities:

· Strategic Leadership:

· Lead and drive the development, implementation, and measurement of the effectiveness of field-based initiatives to inform or support launch and new product strategies.

· Assist with development and implement frameworks for field effectiveness, including KPIs, activity metrics, and qualitative impact measures.

· Support field medical launch readiness (territory design, targeting, resource planning)

· Training & Capabilities:

· Partner with Medical Training to identify capability gaps and support ongoing development of the field medical team

· Create tools and resources to improve field execution (e.g., engagement guides, scientific narratives)

· Fostering a team culture of accountability and develop a proactive approach to growing skillsets

· Medical Insights: Collaborate with Medical Affairs Leadership to develop and drive strategies to collect, analyze, and integrate valuable medical insights that inform strategic decisions.

· Field Resources: Assess field resources to ensure a high standard of tactical execution aligned with Medical Strategy.

· Cross-functional Collaboration: Collaborate with other functional areas such as Clinical Development, Commercial, Compliance and Regulatory to ensure alignment and integration of medical excellence within the broader organizational strategy.

Qualifications:

· Education: Advanced degree in life sciences (PhD, PharmD, masters or equivalent); degree or certificate in training or education a plus

· Experience: Minimum of 7+ years of Medical Affairs expereince, including 5 yrs in Field Medical. Proven experience in training Field Medical personnel and managing field-based initiatives.

· Leadership Skills: Must have track record of effectively leading without authority, a strong commitment to teamwork, coaching or mentoring, and emotional intelligence.

· Operational Expertise: Strong experience in utilizing systems to educate and manage field-based initiatives.

· Strategic Thinking: Ability to develop and implement strategic initiatives that drive organizational goals and enhance the impact of Medical Affairs functions.

· Strong Communication: Excellent communication and interpersonal skills, with the ability to engage and influence internal stakeholders at all levels.

Primarily US remote field-based with travel.

~25% travel required to professional conferences, internal meetings, and field co-rides, including some weekends

The salary range for this position is $220,00 to 265,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices degree and background.

Alumis Inc. is an equal opportunity employer.

Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.  

Other benefits include:

• Health insurance premiums paid at 90% for employee, 80% for dependents
• Free access to Genentech Bus & Ferry Share program
• $100 monthly cell phone stipend
• Unlimited PTO for Exempt employees
• Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate, challenge and nurture one another along the way.

We have recently completed our pivotal trials of envudeucitinib, our second-generation tyk2 inhibitor in moderate to severe plaque psoriasis and expect results from a potentially pivotal Phase 2b trial in SLE in the third quarter of 2026.

As a key member of the Alumis team, you will provide overall leadership for the Medical Affairs function, overseeing Medical Affairs, Field Medical Liaisons, and publications. The position will liaise closely with the clinicians responsible for carrying out Alumis’ clinical studies as well as our commercial group. Applicants should be a “leader/doer” capable of generating strategies and leading cross functionally. This VP, Medical Affairs will report directly to the Chief Medical Officer. 

Responsibilities

Lead the Medical Affairs function at Alumis 

• Develop and implement key Medical Affairs strategies and activities to support the development of our lead assets 
• Continue to build and scale the Medical Affairs organization
• Develop and present Medical Affairs operational plans to Development and Executive management 
• Represent company externally 
• Direct and oversee all aspects of Medical Affairs and pre-launch needs
• Lead medical launch preparations for our lead Psoriasis candidate, ensuring the scientific narrative is robust and well-vetted.

As a member of the Development Leadership Team, run and continue to build the Medical Affairs function 

• Build and lead a best-in-class global medical affairs team to support launches of multiple indications with a focus on psoriasis for our lead asset, envudeucitinib   
• Develop key performance indicators and generate analytical reports related to Medical Affairs plans and Medical Science Liaison group activities 
• Develop and implement Medical Communication and Disease State Awareness strategies 
• Partner with KOLs to gather information on current focused therapeutic area issues and questions 
• Collaborate with the Commercial team to develop educational material for providers and patients that are balanced and medically accurate 
• Provide direction and input into the development and implementation of successful reimbursement and market-access strategies 
• Work closely with the members of the clinical development and commercial leadership teams to develop the overall strategic direction for Alumis, evaluate alternative strategies, identify competitive issues, and develop and implement operating plans to achieve company objectives 
• Foster collaborative relationships with academic and clinical experts, publishers, medical and patient associations, and other relevant external and internal stakeholders
• Develop and manage departmental budgets that effectively achieve desired goals and are balanced with the financial objectives of the broader organization 
• Oversee the publication strategy, ensuring clinical data is presented at major congresses (e.g., AAD, EADV, ACR) and in high-impact peer-reviewed journals.

Education | Experience | Skill Requirements

• 10+ years of professional experience within Biotech/Pharma in Medical Affairs  
• 5+ years of people leadership experience 
• An understanding of government and industry guidelines, regulations, laws, etc., for appropriate scientific/medical exchange and communication with customers 
• Ability to lead by example, attract and develop talent, build interdependent partnerships, and create a culture of collaboration and teamwork that fosters open communication, constructive conflict resolution and organizational flexibility 
• Ability to prioritize and manage several complex projects simultaneously 
• Proven ability to develop internal relationships in a highly matrixed environment, as well as external relationships with Key Opinion Leaders and industry experts 
• Ability to communicate effectively at all levels and present complex and/or new ideas with clarity and simplicity 
• Ability to prioritize concurrent projects with tight deadlines and operate in a highly compliance-driven environment 
• Excellent written, verbal, and interpersonal skills, and the ability to communicate at all levels within the company 
• Travel (25-40%) may be required to represent the company at medical conferences, presentations, and other meetings
• Our headquarters are located in the San Francisco Bay Area and regular presence at headquarters is required
• Extensive prior experience in dermatology, particularly psoriasis is required. Prior experience in SLE is highly desirable. Prior experience taking a product form Phase 3 to a successful launch is also highly desirable. 
• Advanced degree (PharmD, Ph.D. or MD) is required, MD is preferred.

The salary range for this position is $315,000 USD to $370,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.   

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. 

We are seeking an experienced Regional Director of Medical Science Liaisons (MSLs) with expertise in medical dermatology. The successful candidate will be responsible for leading and overseeing MSLs, ensuring the effective dissemination of scientific and clinical information, building relationships with key opinion leaders (KOLs), and supporting the strategic goals of the Medical Affairs organization. This role will require a deep understanding of medical science, excellent leadership capabilities, and a strong ability to drive the success of cross-functional teams. We will be seeking one individual for the Western US and one for the Eastern US.

Responsibilities:

Field-based Leadership of Regional DPEGs and IDNs

Serve as primary point of contact with the clinical leaders, educational leaders, and C-suite executives of Dermatology Private Equity-backed Groups, DPEGs, to build trusting professional relationships

Develop deep understanding of DPEG structures, performance metrics, and educational needs

Develop cross-functional engagement strategy to build the groundwork for launch

Co-create data-driven value proposition to improve patient outcomes

Leadership & Team Management:

Lead, mentor, and manage a team of MSLs, fostering a collaborative, high-performing, and scientifically rigorous culture.

Provide guidance on the development and execution of territory plans, objectives, and key performance indicators (KPIs) for each MSL.

Conduct regular performance evaluations, identify skill gaps, and support MSL development through coaching, training, and career growth opportunities.

Collaborate with the Medical Affairs leadership team to align MSL activities with organizational priorities and strategic initiatives.

Strategic Planning & Execution:

Contribute to the development of MSL tactics in line with corporate and therapeutic area goals.

Drive the execution of MSL tactics within assigned region.

Ensure MSLs are equipped with the latest scientific data and clinical information, and support their integration into both regional and national-level initiatives.

Scientific Exchange & KOL Relationship Management:

Cultivate strong, long-lasting relationships with KOLs, healthcare providers, academic researchers, and key stakeholders through active field engagement in the region.

Serve as a scientific resource and point of contact for KOLs to address inquiries regarding the company’s pipeline, products, and scientific advancements.

Represent the company at scientific congresses, advisory boards, and other relevant forums to enhance scientific and therapeutic understanding.

Cross-Functional Collaboration:

Provide strategic input into the development of clinical trials, publication plans, and other medical activities by leveraging field insights and customer feedback.

Collaborate with the Medical Affairs leadership to ensure appropriate deployment of MSL resources to support clinical, regulatory, and commercial objectives.

Compliance & Reporting:

Ensure all MSL activities are conducted in compliance with regulatory, ethical, and company standards, including GxP (Good Clinical Practice) and HIPAA regulations.

Provide regular updates to MA management on team progress, KOL engagement, and other key initiatives, including metrics on impact and outcomes.

Stay abreast of the competitive landscape and emerging trends in dermatology, rheumatology, and neurology, ensuring MSL activities reflect the latest scientific advancements.

Qualifications:

Education:

o PhD, PharmD, MD, or other advanced degree in a relevant scientific discipline (e.g., Biology, Pharmacology, Medicine).

Experience:

o Minimum of 10 years of experience in Medical Affairs or related scientific roles, with leadership experience in managing a team of MSLs or scientific professionals.

o In-depth knowledge of medical dermatology, including clinical practice, research, and evolving treatment paradigms.

o Proven track record of successful relationship-building with KOLs, HCPs, and key stakeholders within the medical community.

o Experience working in cross-functional teams, with a demonstrated ability to collaborate effectively with commercial, clinical, regulatory, and other business functions.

Skills & Competencies:

o Excellent leadership and team management skills, with the ability to inspire and develop a high-performing team.

o Strong communication, presentation, and interpersonal skills, with the ability to engage effectively with internal and external stakeholders.

o Deep understanding of the pharmaceutical industry, including regulatory and compliance requirements, scientific data dissemination, and product lifecycle management.

o Ability to translate complex scientific information into actionable insights for diverse audiences, including KOLs, healthcare professionals, and internal teams.

o Strong problem-solving, strategic thinking, and decision-making skills.

Travel:

o Willingness to travel extensively (50-75%) as required for KOL engagement, scientific meetings, and team management activities.

Preferred Qualifications:

· Experience in therapeutic areas of medical dermatology.

· Previous experience working in a leadership role within a biopharmaceutical company or a global pharmaceutical organization.

· Familiarity with clinical trial processes, publication planning, and scientific communication in a corporate environment.

The salary range for this position is $220,00 to 250,000 USD annually. This salary range is an estimate, and the actual salary may very based on the Company’s compensation practices degree and background.

This position is primarily remote with travel.

Alumis Inc. is an equal opportunity employer.

Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.  

Other benefits include:

• Health insurance premiums paid at 90% for employee, 80% for dependents
• Free access to Genentech Bus & Ferry Share program
• $100 monthly cell phone stipend
• Unlimited PTO for Exempt employees
• Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate, challenge and nurture one another along the way.